The impact of ultrasound-guided erector spinae plane block combined with paravertebral block on postoperative rebound pain following thoracoscopic lobectomy by Yihang He, Dongxu Chen, Youbo Zuo, Jing Lin

“…BackgroundThoracic paravertebral block (TPVB) is the mainstream analgesic regimen for post-video-assisted thoracoscopic surgery (VATS) pain management. …”
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Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation by Raghavi Sudharsan, Natalia Dolgova, Jennifer Kwok, Alexa Gray, Yu Sato, Agustin Luz Madrigal, Praveen Joseph Susaimanickam, Emil Kriukov, Petr Baranov, John H. Wolfe, Gustavo D. Aguirre, David M. Gamm, William A. Beltran

“…Single-cell RNA sequencing (scRNAseq) was performed on transplanted PRPCs 3 days post-transplantation into normal canine retinas, as well as on host retinal cells to identify molecular pathways associated with early donor cell loss. …”
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Multi-peak light sources can improve the physical and mechanical properties of a zirconia- and diatomite-based dental resin: an in vitro study by Jucivaldo Martins Gonçalves, Thalles Arievo Mota Sales, Cauã Santiago Figueiredo, Rafael Pinto de Mendonça, Jefferson Pires da Silva Júnior, Tânia Mara da Silva, Sérgio Eduardo de Paiva Gonçalves, Hércules Bezerra Dias

“…Data were analyzed using two-way ANOVA followed by Tukey’s post hoc test (5%), after verification of normality (Shapiro-Wilk test). …”
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Actionable loss of SLF2 drives B‐cell lymphomagenesis and impairs the DNA damage response by Le Zhang, Matthias Wirth, Upayan Patra, Jacob Stroh, Konstandina Isaakidis, Leonie Rieger, Susanne Kossatz, Maja Milanovic, Chuanbing Zang, Uta Demel, Jan Keiten‐Schmitz, Kristina Wagner, Katja Steiger, Roland Rad, Florian Bassermann, Stefan Müller, Ulrich Keller, Markus Schick

“…Tumor cells lacking SLF2 are characterized by a high level of DNA damage, which leads to alterations of the post‐translational SUMOylation pathway as a safeguard. …”
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Music-induced cognitive change and whole-brain network flexibility: a pilot study by E. Lydia Wu-Chung, Melia E. Bonomo, Anthony K. Brandt, Bryan T. Denny, Christof Karmonik, Christof Karmonik, J. Todd Frazier, Karl Blench, Christopher P. Fagundes, Christopher P. Fagundes, Christopher P. Fagundes, Christopher P. Fagundes

“…Using a semi-randomized clinical trial design (ClinicalTrials.gov; NCT04137913), we examined whether (1) music creativity altered whole-brain network indices (modularity, flexibility) and (2) whether music-related effects on cognition depended on whole-brain network indices.MethodsFifty-two older adults (Mean age = 75 years; 54% female; 84% White) were randomized to a 6-week music creativity intervention (n = 25) or a no-treatment control condition (n = 27) and completed resting-state fMRI scans and the Montreal Cognitive Assessment at baseline and follow-up (post-intervention).ResultsThe music creativity intervention did not alter network flexibility or modularity over time. …”
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Toxoplasma gondii-induced host’s high secretion of 25-hydroxycholesterol for immunoprotection by Zi-Han Yang, Wei-Ling Wu, Jia-Jia Zheng, Chi Zhang, Ying-Ying Lu, Hong-Juan Peng

“…Methods The metabolic alterations in brain tissues of sv129 mice infected by T. gondii at 9 days post-infection (DPI) were analyzed through untargeted metabolomic detection. …”
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Tibetan medicine pain relieving plaster for treatment of knee osteoarthritis: protocol for a multi-center, randomized, and positive drug controlled trial by Yi Yuan, Ying-jie Wang, Ai Guo, Wei-guo Wang, Wei Wang, Pei-lai Liu, Zhi-xiu Shen, Jian-rong Xie, Kai-lie Liu, Min Zhao, Jing-ling Zuo, Kai Liu, Ze-yang Shi, Zhao-lan Liu, Xi-sheng Weng, Jian-ping Liu

“…All participants will undergo a 7-day treatment period followed by 14-day post-treatment monitoring. We will assess pain severity by the pain dimension score of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale, and evaluate knee joint function using the stiffness and joint function dimension scores of the WOMAC scale and knee joint range of motion. …”
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Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells via injectable microfluidic-templated microgels for retinal regeneration by Ying Wei, Cong Ma, Chuanfeng An, Yujie Zhang, Haoyue Zhang, Qiyou Li, Li Kong, Huanan Wang, Xiang Ma

“…RCS rats treated with microcarriers showed significantly improved visual function, evidenced by increased B-wave amplitudes and the preservation of the inner nuclear layer at 8 weeks post-surgery. In conclusion, our innovative delivery system Fib@GHMS for hESC-RPE cell transplantation presents a potential therapeutic graft for retinal tissue engineering. …”
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Distinct immune responses to proton and photon radiotherapy: implications for anti-PD-L1 combination therapy in colorectal cancer by Hélène Burckel, Anaïs Nicol, Carole Mura, Marc Rousseau, Jolie Bou-Gharios, Lisa Froidurot, Corentin Richard, Véronique Morgand, Pierre-Antoine Laurent, Emeric Limagne, Romain Boidot, Georges Noël, Céline Mirjolet

“…Methods Balb/c mice bearing subcutaneous CT26 colon tumors were treated with RT or PT, delivered with 3 × 8 Gy. Seven days post-treatment, transcriptomic analysis and immune response assessments to characterize lymphoid cells, myeloid cells, and PD-L1 expression were performed. …”
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Glutamine potentiates cefoperazone-sulbactam activity against Pseudomonas aeruginosa by increasing membrane permeability and cellular uptake by Jiao Xiang, Xin Wang, Huiyin Lin, Lifen Yang, Xiaoxia Huang, Yuetao Chen, Yingyue Zeng, Shaohua Li, Xianliang Zhao, Shiwen Wang, Yuan Tao, Huanzhe Fu, Zhengqi Shi, Kuihai Wu, Xuanxian Peng, Hui Li, Jin Tang, Zhuanggui Chen

“…Glutamine slows the development of SCF resistance, delays the post-antibiotic effect, and reduces mutation frequency. …”
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It takes two: Aberrant repair and low-grade inflammation characterize bronchiolitis obliterans syndrome after lung transplantation in serum proteomic analysis by Eline A. van der Ploeg, Alen Faiz, Greta J. Teitsma, Alejandro Sánchez Brotons, Natalia Govorukhina, Jannie M.B. Sand, Diana J. Leeming, Barbro N. Melgert, Peter Horvatovich, Janette K. Burgess, C. Tji Gan

“…Only patients for whom lung function and longitudinal serum samples post-LTx were available were included. Enzyme-linked immunosorbent assays were performed for neoepitopes of collagen types I, III, and VI and osteoprotegerin (OPG) in serum. …”
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Autoimmune neutropenia: a rare complication of allogeneic hematopoietic stem cell transplantation? by María Isabel Benítez Carabante, María Isabel Benítez Carabante, Mariona Morell Daniel, Mariona Morell Daniel, María Luz Uría Oficialdegui, María Luz Uría Oficialdegui, Enric Casanovas López, Melissa Panesso Romero, Melissa Panesso Romero, Laura Alonso García, Laura Alonso García, Cristina Díaz-de-Heredia, Cristina Díaz-de-Heredia

“…We identified two patients with specific human neutrophil alloantigen antibodies (anti-HNA), one of whom had a secondary graft failure.ConclusionsAIN may be a more frequent complication in post-HSCT pediatric patients than previously reported. …”
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OsMas1, a novel maspardin protein gene, confers tolerance to salt and drought stresses by regulating ABA signaling in rice by Fei-bing WANG, Chen-zhong WAN, Hao-fei NIU, Ming-yang QI, Gang LI, Fan ZHANG, Lai-bao HU, Yu-xiu YE, Zun-xin WANG, Bao-lei PEI, Xin-hong CHEN, Cai-yong YUAN

“…OsMas1-OE plants exhibited enhanced hypersensitivity, while OsMas1-RNAi plants showed less sensitivity to exogenous ABA treatment at both germination and post-germination stages. ABA, proline and K+ contents and superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and photosynthesis activities were significantly increased. …”
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Long-Term Efficacy of Chlorine-Based Disinfectants Vs Multi-Enzymatic Detergent with Hypochlorous Acid for Waterline Disinfection in Inactive Dental Chair Units by Zheng YY, Wang YY, Guo Q, Shen CY, Huang R, Wang L, Sun H

“…Yu-Ying Zheng,1,2,* Yuan-Yuan Wang,1,3,* Qian Guo,1,4 Chan-Yuan Shen,1,5 Rong Huang,1,2 Li Wang,1,6 Huan Sun1,2 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, People’s Republic of China; 2Department of Comprehensive Emergency, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, 430079, People’s Republic of China; 3Center for Oral and Maxillofacial Surgery, School & hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 4Center for Orthodontics and Pediatric Dentistry, School & hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 5Department of Center for Emergency and General Dentistry, School & hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 6Department of Nursing, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, 430079, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huan Sun, Department of Comprehensive Emergency, School & Hospital of Stomatology, Wuhan University, No. 237 of Luoyu Road, Hongshan District, Wuhan, 430079, Hubei Province, People’s Republic of China, Tel +86 13986003844, Email sunhuansh01@163.com Li Wang, Department of Nursing Department, School & Hospital of Stomatology, Wuhan University, No. 237 of Luoyu Road, Hongshan District, Wuhan, 430079, Hubei Province, People’s Republic of China, Tel +86 027-87686387, Email liwangwlwl@126.comObjective: This study aimed to evaluate the long-term efficacy of two disinfection methods for waterline systems in inactive dental chair units (DCUs).Methods: On-site sampling and quantitative bacterial analysis were conducted to compare the effectiveness of chlorine-based disinfectants and a combination of multi-enzymatic detergent with hypochlorous acid in controlling microbial contamination in waterline systems of inactive DCUs.Results: No statistically significant differences in disinfection efficacy were observed between the treatment and control groups immediately after disinfection or on the third day post-disinfection (p > 0.05). However, significant differences were observed on the fifth day and seventh day following disinfection (p < 0.001).Conclusion: Both chlorine-based disinfectants and the combination of multi-enzymatic detergent with hypochlorous acid effectively controlled contamination in waterline systems for DCUs inactive for up to three days. …”
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Removing seasonal confectionery from prominent store locations and purchasing behaviour within a major UK supermarket: Evaluation of a nonrandomised controlled intervention study. by Carmen Piernas, Georgina Harmer, Susan A Jebb

“…Multivariable hierarchical models were used to investigate pre/post differences in weekly sales of confectionery in intervention versus control stores. …”
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Successful multidisciplinary treatment including repeated metastasectomy for recurrent squamous cell esophageal carcinoma: a case report by Kosuke Hirose, Hiroshi Saeki, Yuichiro Nakashima, Tomohiro Kamori, Yoshiaki Fujimoto, Tetsuro Kawazoe, Hiroya Matsuoka, Yasuhiro Haruta, Shun Sasaki, Tomoko Jogo, Qingjiang Hu, Yasuo Tsuda, Koji Ando, Eiji Oki, Ryuzo Hiratsuka, Yoshinao Oda, Masaki Mori

“…Multiple mediastinal and abdominal lymph node (LN) metastases were detected in the right lung a year later, which necessitated chemoradiation to a dose of 50.4 Gy with concomitant CDDP and 5-FU. Post-treatment computed tomography (CT) showed a good response. …”
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Prescription of benzodiazepines, z-drugs, and gabapentinoids and mortality risk in people receiving opioid agonist treatment: Observational study based on the UK Clinical Practice... by John Macleod, Colin Steer, Kate Tilling, Rosie Cornish, John Marsden, Tim Millar, John Strang, Matthew Hickman

“…We identified episodes of prescription of benzodiazepines, z-drugs, and gabapentinoids and used linear regression and Cox proportional hazards models to assess the associations of co-prescription (prescribed during OAT and up to 12 months post-treatment) and concurrent prescription (prescribed during OAT) with treatment duration and mortality. …”
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Effect of Ticagrelor on Glycaemic Parameters and Inflammatory Mediators in High Fat Diet and Streptozotocin Induced Diabetic Rats: An Experimental Study by Sachin Patel, Nayana K Hashilkar, Vidya Mahalmani

“…One-way Analysis of Variance (ANOVA) followed by Bonferroni’s post hoc test was used for the analysis of study variables, and paired data were analysed using the paired t-test. …”
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Amorphous calcium zinc phosphate promotes macrophage-driven alveolar bone regeneration via modulation of energy metabolism and mitochondrial homeostasis by Shuze Wang, Lei Cao, Caihao Huang, Junyi Wang, Jialin Liu, Yeyuan Wang, Qiang Wang, Qing Zhou, Xing Zhang, Dan Zhang

“…Our results demonstrated that ACZP can inhibit the IP3R/MCU pathway in macrophages, restoring their anti-inflammatory capabilities and ultimately achieving significant effects in the alveolar bone defects of New Zealand white rabbits. Twelve weeks post-surgery, the defects in the ACZP group were filled with nearly 70 % newly formed bone tissue. …”
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Docosahexaenoic Acid and Nervonic Acid Synergically Enhance Cognitive Memory in Normal Mice via Brain Fatty Acids Remodeling by Hai‐Yan Ou, Lei Feng, Rui‐Ye Chen, Hui‐Yun Lu, Shuang Cai, Zhi‐You Yang

“…Lipidomic analyses suggest levels of NA, dihomo‐γ‐linolenic acid, EPA, DHA, and linoleic acid were increased in the white matter post low dose of DHA + NA treatment, as well as increased levels of dihomo‐γ‐linolenic acid, EPA, and DHA in the gray matter compared with control mice. …”
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