A single-center case-control study of the association between dorsal striatal damage and nicotine addiction by Chuya Jing, Chuya Jing, Chuya Jing, Chuya Jing, Chuya Jing, Xingkai An, Xingkai An, Xingkai An, Xingkai An, Xingkai An, Xingkai An, Xingkai An, Jie Fang, Jie Fang, Jie Fang, Jie Fang, Jie Fang, Jie Fang, Jie Fang, Jie Fang, Jie Fang

“…However, our prior retrospective study indicates that the dorsal striatum may also play a role in nicotine addiction.ObjectiveOur research aims to evaluate the alterations in nicotine addiction among patients with dorsal striatum lesions at 1 month, 3 months, 6 months, and 12 months post-injury.MethodsWe collected data from patients of the First Affiliated Hospital of Xiamen University between August 2021 and August 2024. …”
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PERBEDAAN RANGE OF MOTION ARTICULATIO HUMERI DAN CUBITI ANTARA LANSIA YANG BERENANG DAN YANG TIDAK BERENANG by Zahira Rikiandraswida, Erie BPS Andar

“…Metode : Bentuk Penelitian ini adalah quasy-experimental dengan desain post test only control group design. Sampel penelitian 16 lansia renang (R) dan 16 lansia tidak renang (TR) . …”
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Effect of opioid-free anaesthesia on postoperative delirium in elderly patients undergoing gastrointestinal surgery: study protocol for a single-centre, prospective, randomized con... by Yuehan Du, Mengjie Liu, Xiaoling Yang, Jianbo Wu, Xiaojun Gao, Qiuyue Liu, Lina Chen, Xiaxuan Sun, Min Zhang, Yongtao Sun

“…The secondary outcomes are all-cause mortality within 30 days after surgery, intraoperative haemodynamic changes, the 15-item quality of recovery (QoR-15) scores at 24 h, 48 h, and 72 h after surgery, complications during postoperative hospitalization, pain numerical rating scale (NRS) score at 72 h after surgery, incidence of nausea and vomiting at 72 h after surgery, morphine milligram equivalent for analgesics at 72 h after surgery, duration of anaesthesia (from induction to discontinuation), duration of surgery (from skin incision to the last suture), duration of post-anaesthesia care unit (PACU) stay, and length of hospital stay. …”
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Impact of Vaccine-Elicited Anti-Spike IgG4 Antibodies on Fc-Effector Functions Against SARS-CoV-2 by Katrina Dionne, Alexandra Tauzin, Étienne Bélanger, Yann Desfossés, Mehdi Benlarbi, Ling Niu, Guillaume Beaudoin-Bussières, Halima Medjahed, Catherine Bourassa, Josée Perreault, Marzena Pazgier, Renée Bazin, Andrés Finzi

“…The emergence of new variants of concern and the decline in neutralizing activity observed several weeks post-vaccination reinforced the call for repeated mRNA vaccination. …”
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Collaborating With Schools for Public Health Research in England: Lessons Learned for Successful Partnerships by Ivelina Tsocheva, Jasmine Chavda, James Scales, Rosamund Dove, Harpal Kalsi, Helen E Wood, Grainne Colligan, Louise Cross, Luke Sartori, Jessica Moon, Aisling Murray, Sarah Van Den Berg, Alice Hirst, Jessica Mitchell, Jason Le, Frances Balkwill, Kristian Petrovic, Esther Lie, Mia Keating, Britzer Vincent Paul Raj, Pavani Kotala, Gurch Randhawa, Ian S Mudway, Chris Griffiths

“…Measures included height, weight, pre- and post- bronchodilator spirometry, physical activity monitoring, cognitive assessment, epigenetic markers of disease risk, SARS-CoV-2 IgE and IgM antibody testing, and heavy metals testing. …”
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Factors influencing the transition phase in acute respiratory distress syndrome: an observational cohort study by Anne-Fleur Haudebourg, Louise Chantelot, Safaa Nemlaghi, Luc Haudebourg, Pascale Labedade, Mohamed Ahmed Boujelben, Guillaume Voiriot, Armand Mekontso Dessap, Muriel Fartoukh, Guillaume Carteaux

“…Methods This bicentric observational cohort study included patients with moderate-to-severe ARDS requiring NMBA continuous infusion within 72 h post-intubation. The transition phase was defined as the 72 h following the first NMBA weaning attempt. …”
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The anti-diabetic PPARγ agonist Pioglitazone inhibits cell proliferation and induces metabolic reprogramming in prostate cancer by Emine Atas, Kerstin Berchtold, Michaela Schlederer, Sophie Prodinger, Felix Sternberg, Perla Pucci, Christopher Steel, Jamie D. Matthews, Emily R. James, Cécile Philippe, Karolína Trachtová, Ali A. Moazzami, Nastasiia Artamonova, Felix Melchior, Torben Redmer, Gerald Timelthaler, Elena E. Pohl, Suzanne D. Turner, Isabel Heidegger, Marcus Krueger, Ulrike Resch, Lukas Kenner

“…In addition, diabetic PCa patients treated with PPAR agonists post-radical prostatectomy implied no biochemical recurrence over five to ten years compared to non-diabetic PCa patients. …”
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Prior metabolic surgery attenuates the weight-loss efficacy of liraglutide in patients with mild obesity by Yuqin Ouyang, Yuqin Ouyang, Xinyue Xiang, Xinyue Xiang, Xinyun Hu, Xinyun Hu, Xuehui Chu, Wenjuan Tang, Wenjuan Tang, Wenhuan Feng, Wenhuan Feng, Wenhuan Feng

“…Adjusted odds ratios indicated strong inverse associations, with MS history showing an OR of 6.78 (95% CI: 1.95–23.61; p <.01) and elevated BMI (≥30.5 kg/m²) yielding an OR of 4.79 (95% CI: 1.46–15.71; p <.01).ConclusionA history of MS significantly affects liraglutide’s responsiveness in patients with mild obesity, emphasizing the need for personalized therapeutic strategies in post-surgical patients. These findings highlight the importance of a comprehensive medical history in guiding obesity pharmacotherapy.…”
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Assessing the effects of Turkey berry (Solanum torvum) tea consumption on cardiometabolic indices in people living with hypertension by Hamdia Ibrahim Seidu, Marina Aferiba Tandoh, Isaac Amoah, Judith Odei Owusu-Asante, Redeemer Kofi Agbolegbe

“…We hypothesized that Turkey berry (Solanum torvum) tea may improve blood pressure outcomes in people living with hypertension. Methods In this pre-post interventional pilot study, thirty (30) adults, constituting 27 females and 3 males aged 18 years and above with hypertension, were recruited from the Mampong Government Hospital Chronic Care Center in the Ashanti Region of Ghana. …”
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Dosimetric study on radioembolization with 166Ho poly L-lactic acid microspheres: dead time effects on prediction power by Bartolomeo Cassano, Ludovica Miseo, Sara Ungania, Marco D’Andrea, Federica Murtas, Massimiliano Pacilio, Marta Bottero, Daria Maccora, Rosa Sciuto, Giulio Eugenio Vallati, Antonella Soriani, Giuseppe Iaccarino

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Dysregulated Adaptive Immune Responses to SARS-CoV-2 in Immunocompromised Individuals by Núria Mayola Danés, Demi Brownlie, Rebecca Folkman, Anna Nordlander, Kim Blom, Renata Varnaite, Julia Niessl, Oskar Karlsson Lindsjö, Sandra Söderholm, Mira Akber, Puran Chen, Marcus Buggert, Andreas Bråve, Jonas Klingström, Piotr Nowak, Nicole Marquardt, Klara Sondén, Ola Blennow, Sara Gredmark-Russ

“…We evaluated their serological, humoral, and cellular immune responses at <30 days and >90 days post-symptom onset. ICC patients showed robust B and T cell responses against SARS-CoV-2, indicated by detectable antibody levels, memory antibody-secreting cells (mASCs) towards the spike protein and spike-specific CD4⁺ and CD8⁺ T cells. …”
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Prime-boost vaccination of mice and rhesus macaques with two novel adenovirus vectored COVID-19 vaccine candidates by Shengxue Luo, Panli Zhang, Bochao Liu, Chan Yang, Chaolan Liang, Qi Wang, Ling Zhang, Xi Tang, Jinfeng Li, Shuiping Hou, Jinfeng Zeng, Yongshui Fu, Jean-Pierre Allain, Tingting Li, Yuming Zhang, Chengyao Li

“…In macaques, prime-boost regimen induced high titers of 103.16 anti-S, 102.75 anti-RBD binding antibody and 102.38 pseudovirus neutralizing antibody (pNAb) at 2 months, while pNAb decreased gradually to 101.45 at 7 months post-priming. Robust T-cell response of IFN-γ (712.6 SFCs/106 cells), IL-2 (334 SFCs/106 cells) and intracellular IFN-γ in CD4+/CD8+ T cell (0.39%/0.55%) to S peptides were detected in vaccinated macaques. …”
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Investigation of <italic>&#x03C7;</italic>⁽²⁾-Translated Optical Frequency Combs Tunability in Gallium Phosphide-on- Insulator Resonators by Pengzhuo Wu, Weiren Cheng, Ning Ding, Xingyu Tang, Zhaoting Geng, Zhenyu Liu, Mingjian You, Xiaolun Yu, Yi Li, Qiancheng Zhao

“…The sum-frequency (SF) comb at 775 nm has a geometric tuning sensitivity of 354 GHz&#x002F;nm, and a thermal tuning sensitivity of 24.8 GHz&#x002F;K, paving the way for post-fabrication trimming and in-situ spectral shaping, with a broader potential to realize highly efficient, wide-spectrum, and tunable on-chip nonlinear sources.…”
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Effects of the Informed Health Choices secondary school intervention on the ability of lower secondary students in Kenya to think critically about health choices: 1-year follow-up... by Faith Chesire, Margaret Kaseje, Violet Gisore, Michael Mugisha, Ronald Ssenyonga, Matt Oxman, Allen Nsangi, Daniel Semakula, Christopher James Rose, Laetitia Nyirazinyoye, Simon Lewin, Nelson K. Sewankambo, Sarah Rosenbaum, Jenny Moberg, Andrew D. Oxman

“…Within the intervention group, 728 out of 1369 students (53.2%) achieved a passing score after 1 year, compared to 61.7% immediately post-intervention. In contrast, in the control group, 347 out of 1077 students (32.2%) had a passing score after 1 year. …”
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Etiological shifts and clinical outcomes of acute pancreatitis between urban and rural areas: evidence from a 20-year retrospective database by Ximei Cao, Ximei Cao, Zide Liu, Jingwen Rao, Jie Wu, Xin Huang, Liang Xia, Lingyu Luo, Xu Shu, Yin Zhu, Nonghua Lu, Wenhua He

“…Temporal trends revealed accelerated HTG-AP growth post-2020 in both groups, paralleling metabolic syndrome escalation.ConclusionThese findings underscore the imperative for dual interventions: urban-focused metabolic risk mitigation and rural-targeted biliary disease management, informed by evolving etiological landscapes.…”
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Impacts of multisectoral cash plus programs after four years in an urban informal settlement: Adolescent Girls Initiative-Kenya (AGI-K) randomized trial. by Beth Kangwana, Karen Austrian, Erica Soler-Hampejsek, Nicole Maddox, Rachel J Sapire, Yohannes Dibaba Wado, Benta Abuya, Eva Muluve, Faith Mbushi, Joy Koech, John A Maluccio

“…We used ANCOVA to estimate intent-to-treat (ITT) impacts of each study arm and of pooled study arms VE, VEH, and VEHW relative to the V-only arm, on primary outcomes of fertility and herpes simplex virus-2 (HSV-2) infection, and secondary outcomes of education, health knowledge, and wealth creation. Post-hoc analysis was carried out on older girls who were 13-14-years-old at baseline. …”
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Serological Markers of Intestinal Barrier Function and Inflammation as Potential Predictors of Recurrent Primary Sclerosing Cholangitis by Hlavaty M, Brezina J, Osadcha T, Fabian O, Vajsova A, Drastich P, Cahova M, Bajer L

“…The cohort included 26 subjects with PSC recurrence (rPSC), 87 subjects without PSC recurrence (non-rPSC), and a unique control group consisting of post-LT patients (n = 113) transplanted due to alcohol cirrhosis. …”
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The outcome of complete coronary artery surgical revascularization on left ventricular function by Zaid Mohammed Abdulwahhab Al-Noori, Laith Saleh Al-Kaaby, Heba Khaled Hatem

“…Variables analyzed included left ventricular ejection fraction (LVEF), left ventricular internal diameters, and wall thicknesses.No significant changes in LVEF or ventricular dimensions were observed within two weeks post-surgery. However, at one-year follow-up, patients with preoperative EF <50% (n=15) demonstrated a 10% increase in LVEF. …”
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Prognostic value of gut microbiota and low-density lipoprotein cholesterol subfractions in patients with ST-segment elevation myocardial infarction by Siliang Xia, Yun Liu, Mengzhu Wang, Dandan Liu, Xiaobing Zhang, Ling Lin, Ming Wen, Shushen Ji, Jiaying Li, Xiangming Zhang, Huihui Jiang

“…These findings highlight the role of gut microbiota in post-STEMI risk stratification, underscoring its potential as a target for future cardiovascular interventions.…”
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The Effect of Specific Treadmill Protocol on Aerobic Performance Parameters in Flat-Terrain-Trained Athletes by Ming-Chang Tsai, Edward Lin, Scott Thomas

“…The data were analyzed using one-way repeated measures ANOVA with Tukey’s post hoc procedure. No significant differences were observed in the physiological markers for the inclined and flat protocols across all the intensities. …”
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