Circulating immunoregulatory B cell and autoreactive antibody profiles predict lack of toxicity to anti-PD-1 checkpoint inhibitor treatment in advanced melanoma by Akshay Patel, Yin Wu, Sophie Papa, Sean Whittaker, Ashley Di Meo, Ioannis Prassas, Katie E Lacy, Eleftherios P Diamandis, Sophia N Karagiannis, Thomas J Tull, Sophia Tsoka, Dhruva Biswas, Jitesh Chauhan, Katie Stoker, Zena N Willsmore, Lucy Booth, Amanda Fitzpartick, Matthaios Kapiris, Esperanza Perucha, Gary W Middleton

“…In paired blood samples pretreatment and post-treatment, these humoral immune response profiles were monitored and correlated with the onset of toxicity.Results We found increased circulating IL-10+ (Interleukin-10+) plasmablasts and double-negative (DN) B cell frequencies, higher PD-L1 (programmed death ligand 1), TGFβ (Transforming Growth Factorβ) and CD95 expression by B cells, alongside higher IgG4 and IgE serum levels in patients with stage III/IV melanoma. …”
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Seismic Performance Analysis of Energy Dissipation Building with Non-preload Variable Friction Inerter Under Extremely Rare Earthquake by ZHAO Guifeng, LIU Wei, MA Yuhong, KONG Sihua, CHEN Jiachuan, CHEN Zhaosheng

“…A Bouc‒Wen elastoplastic model was employed in the SDOF system with a yield strength of 24 kN and post-elastic stiffness of 200 kN/m. The SDOF system with and without the proposed NVFI was considered and denoted as SDOF‒NVFI and SDOF, respectively. …”
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Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Notably, integrated transcriptomic and rescue experiments revealed that LINC00339 and PARP1 coregulate CDC42 expression through post-transcriptional regulatory mechanisms. Conclusions: The identification of the LINC00339-PARP1-CDC42 regulatory axis elucidates a novel molecular mechanism contributing to osteoporosis pathogenesis. …”
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Millinovae: A New Class of Transient Supersoft X-Ray Sources without a Classical Nova Eruption by Przemek Mróz, Krzysztof Król, Hélène Szegedi, Philip Charles, Kim L. Page, Andrzej Udalski, David A. H. Buckley, Gulab Dewangan, Pieter Meintjes, Michał K. Szymański, Igor Soszyński, Paweł Pietrukowicz, Szymon Kozłowski, Radosław Poleski, Jan Skowron, Krzysztof Ulaczyk, Mariusz Gromadzki, Krzysztof Rybicki, Patryk Iwanek, Marcin Wrona, Mateusz J. Mróz

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Rapid intravenous symptom-inhibiting fentanyl induction (SIFI) to optimize rotation onto oral opioid agonist therapy among individuals who use unregulated fentanyl: protocol for an... by Pouya Azar, Martha J. Ignaszewski, Marianne Harris, Zoran Barazanci, Ruth Davison, James S. H. Wong, Anil Maharaj, Nickie Mathew, David Hall, Silvia A. Guillemi, Julie Foreman, Rolando Barrios, Julio S. G. Montaner

“…Abstract Background Most opioid use disorder (OUD) treatment guidelines target community medical settings, and the subsequent recommendations were established to prioritize safety and reduce diversion prior to the fentanyl era. …”
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Footprint in fitting $$B\rightarrow D$$ B → D vector form factor and determination for D-meson leading-twist LCDA by Sheng-Bo Wu, Hai-Jiang Tian, Yin-Long Yang, Wei Cheng, Hai-Bing Fu, Tao Zhong

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Problems of analysis of the relationship between the learning context and TIMSS testing results by L. M. Nurieva, S. G. Kiselev

“…TIMSS statistics is regularly posted in the public domain on the IEA website so that specialists can independently conduct research in any aspect of their interest. …”
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Inspiring Social Capital Through Community Green Space: Pathways and Implications by Lin YE, Shi HE, Yinghao LI, Zhaohui YAN, Lei HUANG

“…Temporal keyword evolution identifies three developmental stages: The early phase (2000–2010) emphasized macro-level urban green infrastructure planning and public health outcomes; the middle phase (2010–2018) shifted focus to micro-level community gardens as mental health interventions and food security solutions; the current phase (post-2018) explores multifunctional green spaces as social capital incubators within precision governance frameworks. …”
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Preliminary Study on the Total Carbon, Organic Carbon Content, and Degradation Rates of Shells in Filter-Feeding Shellfish by Duyu CHEN, Jihong ZHANG, Wei SUN, Yi LIU, Wenguang WU, Xue GONG, Bing LI

“…Filter-feeding shellfish not only achieve long-term carbon sequestration through shell calcification but also significantly impact the marine carbon cycle through their physiological activities and post-mortem degradation processes. Filter-feeding bivalves, as a crucial group in coastal aquaculture ecosystems, play a substantial role in carbon sequestration by filtering particulate organic carbon, such as phytoplankton and organic debris, during their growth processes. …”
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Avaluació de la qualitat docent i promoció de professorat universitari by Josep Carreras

“…The procedures for selecting faculty members provided for in each of these included elements that permitted various aspects of the teaching quality of candidates to be evaluated; but throughout the period in which these laws were in force, there were no generally established practices for evaluating university lecturers, due to the reluctance among the faculty members to subject themselves to evaluation and to the persistence of the competitive examination system for acceding to a teaching post that was assured for life. During the early years of the transition to democracy, various attempts were made to introduce a law that might bring the organisation and the functions of the universities in line with the country’s new socio-political situation; but they were all to fail because of a lack of parliamentary support, until that is in 1983 when the socialist government introduced the University Reform Act. …”
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Physical, psychological, cognitive, social health outcomes, and health-related quality of life in out-of-hospital cardiac arrest survivors and their caregivers: Protocol of the qua... by Pin Pin Pek, Megan Chua, Le Xuan Liew, Christina Chen, Shir-Lynn Lim, Felix Maverick Rubillar Uy, Vui Kian Ho, Yew Woon Chia, Jia Min Chua, Ee Ling Goh, Lai Peng Tham, Pei Lin Koh, Kai Lee Woo, Cheryl Ting Zhen Woo, Iylia Muhammad Afiq, Kexin Fang, Han Nee Gan, Benjamin Sieu-Hon Leong, Desmond Ren-Hao Mao, Nausheen Edwin Doctor, Wei Ming Ng, Ying Zi Oh, Kah Hua Peck, Ruth Weixian Chen, Michael Yih-Chong Chia, Wei Ling Tay, Shun Yee Low, Andrew Yunkai Li, Shu-Ling Chong, Jia Min Kang, S. Priyalatha, Audrey Qing Qing Chia, Nur Shahidah, Benny Jun Heng Ng, Kai Yi Lee, Nan Luo, Marcus Eng Hock Ong, Andrew Fu Wah Ho

“…Advances in resuscitation and post-resuscitation care have improved survival, precipitating greater scientific interest in OHCA patients’ survivorship. …”
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Hypertension-gut microbiota research trends: a bibliometric and visualization analysis (2000–2025) by Qilin Chen, Qilin Chen, Qilin Chen, Qilin Chen, Chunzhen Ren, Chunzhen Ren, Chunzhen Ren, Chang Shu, Chang Shu, Chang Shu, Xue Yang, Hugang Jiang, Hugang Jiang, Hugang Jiang, Xiaodong Zhi, Xiaodong Zhi, Xiaodong Zhi, Chunling Wang, Chunling Wang, Chunling Wang, Kai Liu, Kai Liu, Xinke Zhao, Xinke Zhao, Xinke Zhao, Yingdong Li, Yingdong Li, Yingdong Li

“…Cluster analysis identified 10 groups—including short-chain fatty acids and TMAO—spanning basic to clinical research. Post-2017 foci like Akkermansia muciniphila, Mendelian randomization, and pulmonary hypertension signal a shift to precision mechanisms and personalized interventions.ConclusionThis study establishes a quantitative analytical framework for hypertension-gut microbiota research, revealing a collaborative landscape led by China and the United States with multidisciplinary integration. …”
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Observations of surface energy fluxes and meteorology in the seasonally snow-covered high-elevation East River watershed during SPLASH, 2021–2023 by C. J. Cox, J. M. Intrieri, B. J. Butterworth, B. J. Butterworth, G. de Boer, G. de Boer, G. de Boer, G. de Boer, M. R. Gallagher, M. R. Gallagher, J. Hamilton, J. Hamilton, E. Hulm, T. Meyers, S. M. Morris, J. Osborn, P. O. G. Persson, P. O. G. Persson, B. Schmatz, M. D. Shupe, M. D. Shupe, J. M. Wilczak

“…The purpose of this article is to document the ASFS deployment at SPLASH, to document the data acquisition and post-processing of measurements, and to serve as a guide for interested users of the data sets, which are archived at Zenodo (<a href="https://doi.org/10.5281/zenodo.10313363">https://doi.org/10.5281/zenodo.10313363</a>, Cox et al., 2023b; <a href="https://doi.org/10.5281/zenodo.10327409">https://doi.org/10.5281/zenodo.10327409</a>, Cox et al., 2023c; <a href="https://doi.org/10.5281/zenodo.10313894">https://doi.org/10.5281/zenodo.10313894</a>, Cox et al., 2023d; <a href="https://doi.org/10.5281/zenodo.10307825">https://doi.org/10.5281/zenodo.10307825</a>, Cox et al., 2023e; <a href="https://doi.org/10.5281/zenodo.10310520">https://doi.org/10.5281/zenodo.10310520</a>, Cox et al., 2023f) with the Creative Commons Attribution 4.0 International license.…”
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Electroacupuncture attenuates retinal ischemia/reperfusion injury by protecting the outer blood-retina barrier via enkephalins activate delta opioid receptor by Ping CHEN, Xian-dan ZHU, Run-jie GUO, Yong XIA, Jing-ling JIN, Nan-ge JIN, Ying-min GU, Xue-song TIAN

“…Results: It was found that 2 Hz EA treatment increased enkephalins (methionine-enkephalin and leucine-enkephalin) levels (P < 0.01), restoring the increased retinal thickness (P < 0.05) and mitigating RGCs loss (P < 0.05) post-RIR injury. FITC-dextran leakage in the outer retina was ameliorated by 2 Hz EA (P < 0.05), reversibly countered by Naltrindole(P < 0.05), a DOR antagonist. …”
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Autoradiographic comparison between [11C]PiB and [18F]AZD4694 in human brain tissue by Antonio Aliaga, Joseph Therriault, Kely Quispialaya, Arturo Aliaga, Peter Kunach, Arthur C. Macedo, Robert Hopewell, Nesrine Rahmouni, Jean-Paul Soucy, Gassan Massarweh, Marie-Christine Guiot, Tevy Chan, Jesse Klostranec, Aida Mary Abreu Diaz, Andreia Rocha, Giovanna Carello-Collar, Luiza S. Machado, Marco Antônio De Bastiani, Débora Guerini de Souza, Diogo O. Souza, Aline R. Zimmer, Serge Gauthier, Tharick A. Pascoal, Eduardo R. Zimmer, Pedro Rosa-Neto

“…The purpose of this study is to compare the in vitro binding properties of the amyloid-PET radiotracers [11C]PiB and [18F]AZD4694 in post-mortem human brain tissue. Total binding was assessed by autoradiography in prefrontal, inferior parietal, posterior cingulate cortices and hippocampal sections of healthy control (HC) and AD autopsy-confirmed brain tissues. …”
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Transperineal laser ablation of the prostate as a treatment for benign prostatic hyperplasia and prostate cancer: The results of a Delphi consensus project by Andrea Cocci, Marta Pezzoli, Fernando Bianco, Franco Blefari, Pierluigi Bove, Francois Cornud, Gaetano De Rienzo, Paolo Destefanis, Danilo Di Trapani, Alessandro Giacobbe, Luca Giovanessi, Antonino Laganà, Giovanni Lughezzani, Guglielmo Manenti, Gianluca Muto, Gianluigi Patelli, Novello Pinzi, Stefano Regusci, Giorgio I. Russo, Juan I.M. Salamanca, Matteo Salvi, Luigi Silvestri, Fabrizio Verweij, Eric Walser, Riccardo G. Bertolo, Valerio Iacovelli, Alessandro Bertaccini, Debora Marchiori, Hugo Davila, Pasquale Ditonno, Paolo Gontero, Gennaro Iapicca, Theo M De Reijke, Vito Ricapito, Pierluca Pellegrini, Andrea Minervini, Sergio Serni, Francesco Sessa

“…Pre-procedural assessment, technical aspects, post-procedural catheterization, pharmacological therapy, and expected outcomes were discussed, leading to statements and recommendations. …”
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Ambient air pollution and thyroid function in Spanish adults. A nationwide population-based study (Di@bet.es study) by Sergio Valdés, Viyey Doulatram-Gamgaram, Cristina Maldonado-Araque, Ana Lago-Sampedro, Eva García-Escobar, Sara García-Serrano, Marta García-Vivanco, Luis Garrido Juan, Mark Richard Theobald, Victoria Gil, Fernando Martín-Llorente, Pilar Ocon, Alfonso Calle-Pascual, Luis Castaño, Elías Delgado, Edelmiro Menendez, Josep Franch-Nadal, Sonia Gaztambide, Joan Girbés, F Javier Chaves, José L Galán-García, Gabriel Aguilera-Venegas, Carolina Gutierrez-Repiso, José Carlos Fernández-García, Natalia Colomo, Federico Soriguer, Eduardo García-Fuentes, Gemma Rojo-Martínez

“…No significant heterogeneity was seen in the results between groups of men, pre-menopausal and post-menopausal women. Conclusions Exposures to PM2.5 in the general population were associated with mild alterations in thyroid function.…”
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The drawing of the dome of Borromini? San Carlino alle Quattro Fontane: canonic oval? by Marco Canciani

“…O è invero una sorta di “traduzione geometrica post-operam”, operata da Borromini per evidenziare le sue intenzioni progettuali, in parte modificate dalla realizzazione.…”
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Advancing the application of remote sensing for forest information needs in Canada: Lessons learned from a national collaboration of university, industrial and government stakehold... by Nicholas C. Coops, Alexis Achim, Paul Arp, Christopher W. Bater, John P. Caspersen, Jean-François Côté, Jeffery P. Dech, Adam R. Dick, Karin van Ewijk, Richard Fournier, Tristan R. H. Goodbody, Chris R. Hennigar, Antoine Leboeuf, Olivier R. van Lier, Joan E. Luther, David A. MacLean, Grant McCartney, Gaetan Pelletier, Jean-Francois Prieur, Piotr Tompalski, Paul M. Treitz, Joanne C. White, Murray E. Woods

“…The project supported 24 post-doctoral fellows, PhD and MSc students that examined the roles that advanced three-dimensional remote sensing technologies can play in the development of accurate forest inventory systems across Canada. …”
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Interactions between gut microbiota, plasma metabolome and brain function in the setting of a HIV cure trial by Alessandra Borgognone, Anna Prats, Anna Prats, Ashish Arunkumar Sharma, Ignacio Martinez-Zalacaín, Ignacio Martinez-Zalacaín, Carles Soriano-Mas, Carles Soriano-Mas, Carles Soriano-Mas, Christian Brander, Christian Brander, Christian Brander, Christian Brander, Bonaventura Clotet, Bonaventura Clotet, Bonaventura Clotet, Bonaventura Clotet, Bonaventura Clotet, José Moltó, José Moltó, José Moltó, Beatriz Mothe, Beatriz Mothe, Beatriz Mothe, Beatriz Mothe, Beatriz Mothe, Rafick-Pierre Sekaly, Roger Paredes, Roger Paredes, Roger Paredes, Roger Paredes, Roger Paredes, Roger Paredes, Roger Paredes, Jose A. Muñoz-Moreno, Jose A. Muñoz-Moreno, Jose A. Muñoz-Moreno

“…Here, we analyzed longitudinal gut microbiome, plasma metabolome and brain functioning data to identify potential associations and novel putative biomarkers of HIV-associated neurocognitive disorders (HAND).MethodsData from fecal shotgun metagenomics, plasma metabolome, cognitive (standardized neuropsychological test score covering 6 cognitive domains, NPZ-6), functional (neuropsychiatric symptoms) and neuroimaging assessments were obtained and evaluated in 18 participants before and after RMD administration, and at the study end (post-MAP follow-up) in the BCN02 trial.ResultsParticipants with neurocognitive impairment (Lower vs. …”
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