The ASSIST Trial: Acute Effects of Manipulating Strength Exercise Volume on Insulin Sensitivity in Adults Living With Obesity: A Randomized Controlled, Crossover, Clinical Trial by Luis Filipe Rocha Silva, Paulo H. Evangelista Silva, Jordan Ottoni do Carmo, Bruna Caroline Chaves Garcia, Elizabethe Adriana Esteves, Zachary Aaron Mang, Fabiano Trigueiro Amorim, Marco Fabrício Dias‐Peixoto, Fernando Gripp, Valmor Tricoli, Flavio de Castro Magalhaes

“…Results One‐way repeated measure analysis of variance followed by Tukey as post hoc showed that indexes of insulin sensitivity improved after the high‐volume session (p < 0.05) but not after the low‐volume session (p > 0.05) (effect size [EF] for high and low volume, respectively): insulin area under the curve (AUC) [−0.53 and −0.05], C‐peptide AUC [0.58 and 0.18], Cederholm index [0.59 and 0.11], skeletal muscle index [0.89 and 0.60], Gutt index [0.78 and 0.20], Stumvoll index [0.81 and 0.18], and the simple index [0.52 and 0.16]). β‐cell function showed a strong tendency to improve (p < 0.06) after the high‐volume session (EF for high and low volume, respectively): C‐peptidogenic index [0.58 and −0.20], C‐peptide oral disposition index [0.72, −0.33]. …”
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Newborn Screening for Gaucher Disease: The New Jersey Experience by Caitlin Menello, Shaney Pressley, Madeline Steffensen, Sarah Schmidt, Helio Pedro, Reena Jethva, Karen Valdez-Gonzalez, Darius J. Adams, Punita Gupta, Lorien Tambini King, Milen Velinov, Sharon Anderson, Peyman Bizargity, Beth Pletcher, Allysa Tuite, Christina Kresge, Debra Lynn Day-Salvatore, Ryan Kuehl, Can Ficicioglu

“…Three type I GD patients started enzyme replacement therapy, with the youngest starting at 28 months of age. Post-treatment data are available for these individuals. …”
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Effects of histone acetyltransferase and deacetylase inhibitors on the expression of S100A genes after TLR4 and TLR2 stimulation in human dental pulp cells by Holger Jungbluth, Dominik Kraus, Diana Lalaouni, Sarah Hossam Fahmy, Jochen Winter, Søren Jepsen

“…Analysis of variance (ANOVA) followed by tukey post-hoc-test was calculated. Results: HDAC and HAT inhibitors significantly altered the expression of S100A genes in hDPCs both in presence and absence of LPS and Pam3CSK4, respectively. …”
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10-year experience in orthotopic heart transplantation in Kuzbass by L. S. Barbarash, O. L. Barbarash, E. V. Grigoriev, D. L. Shukevich, T. B. Pecherina, M. G. Zinets, A. V. Sotnikov, I. K. Khalivopulo, T. S. Golovina, E. M. Kurguzova, A. V. Ivanova, Yu. S. Ignatova, A. V. Yurkina, D. P. Golubovskaya, P. G. Parfenov, J. I. Gusel’nikova, E. V. Dren’

“…At the same time, there is lower perioperative mortality and higher survival in the post-OHT long-period.Objective: to analyze OHT outcomes in Kuzbass over a 10-year period.Material and methods. …”
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Senescence-associated alterations in histone H3 modifications, HP1 alpha levels and distribution, and in the transcriptome of vascular smooth muscle cells in different types of sen... by Agnieszka Gadecka, Marta Koblowska, Helena Kossowska, Roksana Iwanicka-Nowicka, Dorota Janiszewska, Grażyna Mosieniak, Krzysztof Bojakowski, Krzysztof Goryca, Anna Bielak-Zmijewska

“…Methods We investigated the level and distribution of HP1α and H3 modifications that are markers of hetero- and euchromatin (H3K9me3, H3K27me3, H3K4me3, H3K9Ac - WB and IF), alterations in the transcriptomic profile (DNA microarray, qPCR), H3K4me3, H3K9me3 and HP1α protein distribution in the genome (ChIP-seq), and expression of enzymes involved in histone post-translational modifications (DNA microarray, qPCR, WB, IF). …”
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Primary aldosteronism diagnosis in the intensive care unit: resistant alkalosis and hypokalemia during severe sepsis with hyperlactatemia: a case report by Yug Garg, Madhumati S. Vaishnav, Reshma Harsha, Nidhi Garg, Siddhartha Dinesha, Leena Lekkala, Thummala Kamala, Kavitha Muniraj, Sathyanarayana Srikanta, Samatvam Endocrinology Diabetes Collaborative Group

“…Patient improved with supportive care and was discharged on day 10 with reinstituted antihypertensive medications. Post-hospitalization, endocrine evaluation confirmed primary aldosteronism with plasma renin activity 0.62 ng/mL/hour, serum aldosterone 43.2 ng/dL (1.20 nmol/L), and aldosterone–renin ratio 69.7. …”
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Listening effort and stress in tinnitus: a multidimensional approach by Giovanna Giliberto, Maria Itati Palacio, Giulia Cartocci, Emiliano Fernandez-Villalba, Dario Rossi, Nieves Minguez, Maria Botia, Maria Botia, Jose Domingo Cubillana, Jose Joaquin Ceron, Jose Joaquin Ceron, Fabio Babiloni, Maria Trinidad Herrero

“…Salivary amylase increased post-task (p = 0.016), electrodermal activity differed between the initial and final quiet phases (p &lt; 0.001), and heart rate varied according to noise levels (p = 0.008). …”
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Measurement of Intratumor Heterogeneity and Its Changing Pattern to Predict Response and Recurrence Risk After Neoadjuvant Chemotherapy in Breast Cancer by Mingxi Zhu, Qiong Wu, Xiaochuan Geng, Huaying Xie, Yan Wang, Ziping Wu, Yanping Lin, Liheng Zhou, Shuguang Xu, Yumei Ye, Wenjin Yin, Jia Hua, Jingsong Lu, Yaohui Wang

“…Patients with increased heterogeneity exhibited a higher risk of recurrence approaching two years post-surgery, particularly within the non-pCR population. …”
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Determination of the optimal ejaculate concentration of a buffalo bull for successful semen cryopreservation by Krishna Bansal, Krishna Bansal, Dinesh Jhamb, Usha Yadav, Usha Yadav, Mamta Meel, Mamta Meel, Akanksha Gupta, Akanksha Gupta, Renu Bala, Meenakshi Virmani, Meeti Punetha, Dharmendra Kumar, Pradeep Kumar

“…The second objective was to evaluate the post-thaw sperm quality of ejaculates that initially met the criteria for cryopreservation. …”
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Inhibition of Mitochondrial Dynamics by Mitochondrial Division Inhibitor-1 Suppresses Cell Migration and Metastatic Markers in Colorectal Cancer HCT116 Cells by Mehmood T, Nasir Q, Younis I, Muanprasat C

“…Moreover, Mdivi.1 decreased dynamin-related protein-1 (Drp1) and phosphorylated-Drp1 expression and increased mitofusin-2 (Mfn2) expression in a concentration-dependent manner at 48 and 72 h post-treatment. Notably, Mdivi.1 induced inhibition of translocation of Drp1 from the cytosol to the outer mitochondrial membrane. …”
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Supplementation of live yeast (Saccharomyces cerevisiae) as natural feed additives on growth performance, meat quality and physiological status of broiler chickens by Maruf Hossain, Amio Kante Das, Kanan Talukder, Md Momotaj Hossen, Kanon Das, Chondhon Bormon, Mansur Ahmed, Mohammad Al Mamun, Mohammad Abujar Shuva, Mahmoud Azzam, Shad Mahfuz

“…At 42 days of age, the broilers fed diets containing live yeast had a lower 7-day drip loss, a lower cooking loss, and a higher breast muscle pH at 45 min post-mortem (P < 0.05) than the control group. Supplementing with live yeast also decreased serum triglycerides, total cholesterol, and heterophil/lymphocyte ratio (P < 0.05). …”
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Efficacy of sacubitril/valsartan on improving clinical symptoms in patients with acute myocardial infarction complicated with heart failure: a retrospective study by Guiping Wang, Ruolin Zhang, Xuyang Li, Shuping Zuo, Boheng Zhang, Yanan Zhao, Suya Sun, Juanjuan Zhang, Xiaokun Liu

“…Follow-up assessments were conducted 1 year post-discharge to evaluate NT-proBNP levels, and symptom progression. …”
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The Risk of Developing Tinnitus and Air Pollution Exposure by Po-Yu Lai, Chang-Yin Lee, Kuang-Hsi Chang, Yu-Kang Chang, Yi-Chao Hsu, Ing-Ming Chiu, Stella Chin-Shaw Tsai, Der-Yang Cho, Cheng-Li Lin, Tsung-Hsing Lin, Wu-Lung Chuang

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Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms by Xi-Meng Sun, Ze-Ni Luo, Wei Wang, Chun-Yue Hao, Zhi-Ang Li, Saeed El-Ashram, Xin-Ping Zhu

“…Foxp3eGFP mice subsequently received intraperitoneal injections of TsAES (20 µg/mouse) biweekly for a total of three doses. On day 8 post-model induction, mice were euthanized and colonic tissues collected for immunofluorescence and flow cytometric analysis to assess pTreg populations. …”
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Diagnosis and treatment of synthetic mid-urethral sling complications by Helen E. O’Connell, Christopher K. Harding, Gaurav Khatri, Phyllis Glanc, Eric Bautrant, Sarah Love-Jones, Karen Ward, Henry H. Yao, Ventia Hoe, Charlotte Korte, Nicolle Germano, Sanjeevan Kalavampara, Sherif Mourad, Hashim Hashim

“…Complications arise in a small proportion, occurring acutely in the perioperative stage, post-operatively and in a delayed fashion many years after implantation. …”
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Associations of neurodegenerative and cerebrovascular neuropathology with frailty in a diverse sample by Felipe Bozi-Soares, Márlon Juliano Romero Aliberti, Alberto Fernando Oliveira Justo, Renata E. P. Leite, Lea T. Grinberg, Vitor R. Paes, Roberta D. Rodriguez, Carlos A. Pasqualucci, Eduardo Ferrioli, Claudia Kimie Suemoto

“…Frailty was measured using a frailty index from 33 health deficits, and cognitive impairment was defined as a Clinical Dementia Rating ≥ 0.5, both based on post-mortem informant reports with the next of kin. …”
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Comparing the efficacy of hyaluronic acid products with various molecular weights as mono and combined with chondroitin sulfate regimens in treatment of patients with stage I–III k... by V. E. Bialik, M. A. Makarov, E. I. Bialik, S. A. Makarov, V. A. Nesterenko, M. R. Nurmukhametov

“…IA HA injections were performed 160 patients with primary and post-traumatic knee OA of the I–III stages at the department of traumatology-orthopedics, V.A. …”
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The Vertebral Bone Marrow clot as cell therapy and multifunctional bioscaffold for spinal fusion surgery: protocol for a randomized clinical trial by Maria Sartori, Giuseppe Tedesco, Paolo Spinnato, Antonio Mazzotti, Antonio Mazzotti, Alessandro Gasbarrini, Alessandro Gasbarrini, Cesare Faldini, Cesare Faldini, Marco Miceli, Gianluca Giavaresi, Francesca Salamanna

“…Complications are also recorded and classified as early (major and minor) or late, according to the time of occurrence and findings at 12 months post-surgery. Finally, the preclinical project outcome is to define the biological and anti-inflammatory properties of vBMA clot and demonstrate its antibacterial effect, assessing age and gender differences and including an examination of their interactions.Clinical trial registrationClinicalTrials.gov, identifier NCT05947175.…”
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Perceptions and satisfaction with the quality of clinical training placements among nursing and midwifery students in Northern Ghana by Abubakari Wuni, Mudasir Mohammed Ibrahim, Maximous Diebieri, Brenda Abena Nyarko, Mohammed Awal Salifu, Hussein Abubakar Abdul-Karim, Godfred Prince Kwaku Atiku, Tina Wepeamo Wepeba, Waliu Jawula Salisu, Sufyan Bakuri Suara, Iddrisu Sisala Mohammed

“…Hypothetical relationships between students’ perceptions of clinical training quality, satisfaction, and demographics were tested using One-way ANOVA, t-tests, and Pearson correlation. Tukey LSD post hoc analysis assessed pairwise differences, and statistical significance was pegged at P < 0.05. …”
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Proportion and factors associated with fertility desires among human immunodeficiency virus-positive adults receiving antiretroviral therapy in Northeast Ethiopia by Abel Endawkie, Biresaw Derese, Kidist Adamu, Getaw Walle

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