Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study by Qingli Mu, Kejing Zhang, Yue Chen, Yuwei Xu, Shaohua Hu, Manli Huang, Peng Zhang, Dong Cui, Shaojia Lu

“…ANCOVAs revealed significant BSAGE differences among three groups in the bilateral putamen (PU), left cerebellar white matter (CB), left cuneus (CUN), left fusiform gyrus (FuG), left subcallosal area (SCA), left superior occipital gyrus (SOG), left triangular inferior frontal gyrus (IFG-Tri), right lateral ventricle (L-V), right superior frontal gyrus medial segment (SFG-SM), right opercular inferior frontal gyrus (IFG-Oper), right precuneus (pre-CUN), right posterior insula (INS-Post), and right superior temporal gyrus (STG). Compared to HCs, the MDD-WA group showed significant BSAGE increase in all of the aforementioned brain regions, while the MDD-WoA group showed limited BSAGE increase in the CB, FuG, and SCA of left hemisphere only. …”
Get full text

Development of BK polyomavirus-associated nephropathy risk prediction in kidney transplant recipients by Junji Yamauchi, Katalin Fornadi, Divya Raghavan, Duha Jweehan, Suayp Oygen, Silviana Marineci, Michelle Buff, Michael Fenlon, Motaz Selim, Michael Zimmerman, Miklos Z. Molnar

“…Background With the development of potential prevention therapies for BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN), risk prediction models are needed to identify kidney transplant recipients at high risk for BKPyVAN.Methods This single-center retrospective study aimed to develop a risk prediction model and an integer-based risk score for BKPyVAN development, defined as plasma BKPyV-DNA >10,000 copies/mL and/or biopsy-proven BKPyVAN, within 1-year post-transplant, using donor and recipient characteristics at the time of transplantation. …”
Get full text

Effects of electron beam irradiation on microbial loads, physicochemical properties, stability of active ingredients, and antioxidant activity in Angelica sinensis Radix by Yunxia Hu, Haijun Wang, Zhijun Xin, Wensheng Gou, Zhuanzi Wang, Xiao Liu, Xihong Lu, Aimei Yang, Xuehu Li, Libin Zhou

“…Antioxidant activity remained elevated post-irradiation, correlating with the enrichment trends of volatile oil and phenolic acids. …”
Get full text

The differential expression of MAGI2 in glomerulopathies and its application as a molecular discriminator of podocytopathies by Florian Siegerist, Eleonora Hay, Elke Hammer, Anna Iervolino, Claudia Weber, Juan Saydou Dikou, Eleni Stamellou, Linus Butt, Thomas Benzing, Thorsten Wiech, Paul T. Brinkötter, Uwe Zimmerman, Giovambattista Capasso, Christos Chatziantoniou, Christos E. Chadjichristos, Tobias B. Huber, Uwe Völker, Maximilian Schindler, Nicole Endlich

“…This downregulation was also conserved in a zebrafish model of focal and segmental glomerulosclerosis (FSGS), and the podocyte-specific MAGI2 ortholog Magi2a was reduced post podocyte injury. CRISPR/Cas9-generated zebrafish mutants for magi2a exhibited marked glomerular filtration barrier defects and downregulation of nephrin, underscoring MAGI2's critical role in podocyte function. …”
Get full text

Uso do retalho miogorduroso segmentar do músculo latíssimo do dorso em decúbito único para reconstrução da mama pós-quadrantectomia externa Use of latissimus dorsi muscle segment w... by João Batista Fortaleza de Araújo, Luiz Gonzaga Porto Pinheiro, Sérgio Saboya Pinheiro de Sousa, João Ivo Xavier Rocha, Patrícia Lopes Gaspar, Leila Yasmim Maria Cidrão Fortaleza

“…In the case of external quadrant tumors, there is no option of rotation of the entire latissimus dorsi muscle, which usually exceeds the actions necessary for repairing lost volume. A new option for post-quadrantectomy reconstruction in external quadrants is proposed in this study. …”
Get full text

Sequential 90Y Selective Internal Radiation Therapy (SIRT) and Stereotactic Body Radiation Therapy (SBRT) using 90Y PET-based Absorbed Dose Maps: Interim Analysis of a Phase 1 Stud... by Daniel F. Polan, PhD, Justin K. Mikell, PhD, Kellen Fitzpatrick, MS, Joseph J. Gemmete, MD, Jared A. Christensen, MD, Hassan Anbari, MD, Molly Roseland, MD, Joseph R. Evans, MD, PhD, Daniel T. Chang, MD, Mamadou Sanogo, MD, Baljendra S. Kapoor, MD, Matthew J. Schipper, PhD, Yue Cao, PhD, Madhava P. Aryal, Theodore S. Lawrence, MD, PhD, Kyle C. Cuneo, MD, Yuni K. Dewaraja, PhD

“…Methods and Materials: In this ongoing, single-center prospective trial, patients received standard-of-care 90Y SIRT with glass microspheres for the treatment of unresectable primary or secondary liver cancer. Post-SIRT dosimetry was performed using 90Y positron emission tomography/computed tomography to calculate mean lesion absorbed doses. …”
Get full text

Analysis of the results of treatment of patients with malignant tumors of the salivary glands by V. T. Vayradyan, A. M. Mudunov, V. D. Ermilova, R. I. Azizyan, I. A. Zaderenko, S. B. Aliyeva, E. L. Dronova

“…In case of other MSGN localizations, prophylactic lymphadenectomy does not improve long-term outcomes. Radiotherapy in the post-op period significantly improves long-term results of treatment in comparison with a group of preoperative radiotherapy (local recurrence rates are 29.5 and 9.7 %, respectively, p = 0.0002). …”
Get full text

Supported implementation of tailored multicomponent fall prevention interventions in hospital: a feasibility study by Bethan Richards, Vasi Naganathan, Catherine Sherrington, Leanne Hassett, Matthew Jennings, Andrew Hallahan, Abby Haynes, Charlotte McLennan, Wendy Tilden, Tamsin McVeigh, Veethika Nayak

“…Reach: 28/38 (74%) survey respondents were aware of the multicomponent fall prevention interventions on their ward, with 24 (86%) reporting a positive impact on clinical practice post implementation. Adoption: delivery of multicomponent hospital fall prevention interventions increased 1.1/10 points between preimplementation (n=61) postimplementation (n=38) surveys. …”
Get full text

A universal testing and treatment intervention to improve HIV control: One-year results from intervention communities in Zambia in the HPTN 071 (PopART) cluster-randomised trial. by Richard Hayes, Sian Floyd, Ab Schaap, Kwame Shanaube, Peter Bock, Kalpana Sabapathy, Sam Griffith, Deborah Donnell, Estelle Piwowar-Manning, Wafaa El-Sadr, Nulda Beyers, Helen Ayles, Sarah Fidler, HPTN 071 (PopART) Study Team

“…Data from four communities in Zambia receiving the full intervention (including immediate ART for all individuals with HIV) were used to determine proportions of participants who knew their HIV status after the CHiP visit; proportions linking to care and initiating ART following referral; and overall proportions of HIV-infected individuals who knew their status (first 90 target) and the proportion of these on ART (second 90 target), pre- and post-intervention. We are not able to assess progress towards the third 90 target at this stage of the study. …”
Get full text

Application of the Fitness and Nutrition Program for Seniors (FANS) to improve Physical Activity and Kinanthropometric Measures among Community-Dwelling Older Adults living with Fr... by Pei-Shan Li, Chia-Jung Hsieh, Nae-Fang Miao, Chuan-Hsiu Tsai, Chieh-Yu Liu, Hung-Ru Lin, Shu-Fang Vivienne Wu, Jordan Koh

Get full text

Optimizing High-Power Performance of [001]-Oriented Pb(Mg_1/3Nb_2/3)-PbTiO₃ Through Combined DC and AC Polarization Above Curie Temperature by Yuliang Zhu, Xiaobo Wang, Wenchao Xue, Xinran Wen, Chengtao Luo

“…Pb(Mg_1/3Nb_2/3)O₃-PbTiO₃ single crystals (PMN-PT SCs) are widely utilized in high-performance piezoelectric devices due to their exceptional piezoelectric properties. Among the various post-processing techniques for domain engineering in PMN-PT SCs, alternating current polarization (ACP) has become a widely adopted method for enhancing piezoelectric performance. …”
Get full text

Safety and effectiveness of multimodal opioid-free anaesthesia for pain and recovery after laparoscopic surgery: a systematic review and meta-analysis by Jiang Liu, Li Jing, Lin Cheng, Sifan Qin, Xinyan Geng, Shirong Fang

“…The secondary outcomes included the incidence of postoperative nausea and vomiting (PONV), antiemetic use, extubation time (measured in minutes), post-anaesthesia care unit discharge time (measured in minutes), shivering, bradycardia, hypotension and pruritus.Data extraction and synthesis Meta-analyses were performed using Stata16 software, using the DerSimonian and Laird’s method and inverse variance to summarise effect sizes for each outcome under a random effects model for all outcomes. …”
Get full text

Stationary Cycling Exercise With Virtual Reality to Reduce Depressive Symptoms Among People With Mild to Moderate Depression: Randomized Controlled Trial by Na Zhang, Chenlu Hong, Yuejia Wang, Haiqin Chen, Yueli Zhu, Miao Da, Zhongxia Shen, Xudong Zhao, Jiali Xu, Jiaxiu Sheng, Yanan Luo, Meiying Xu

“…Response rate, remission rate, satisfaction, compliance, and adverse events were assessed post intervention. Outcomes were analyzed using an ITT approach. …”
Get full text

Enhanced T-cell immunity and lower humoral responses following 5-dose SARS-CoV-2 vaccination in patients with inborn errors of immunity compared with healthy controls by Vitor Gabriel Lopes da Silva, Gabriela Justamante Händel Schmitz, Kathleen E. Sullivan, Júlia Barbate, Maria Izabel de Haro Azinar, Carolina Sanchez Aranda, Maria Isabel de Moraes-Pinto

“…T-cell responses to Spike were stronger in patients with IEI post-booster (405 vs. 149 spot-forming cells/million PBMC; p = 0.002). …”
Get full text

Polymorphisms in the GNAS Gene as Predictors of Ventricular Tachyarrhythmias and Sudden Cardiac Death: Results From the DISCOVERY Trial and Oregon Sudden Unexpected Death Study by Heinrich Wieneke, Jesper Hastrup Svendsen, Jeffrey Lande, Sebastian Spencker, Juan Gabriel Martinez, Bernhard Strohmer, Lauri Toivonen, Hervé Le Marec, F. Javier Garcia‐Fernandez, Domenico Corrado, Adriana Huertas‐Vazquez, Audrey Uy‐Evanado, Carmen Rusinaru, Kyndaron Reinier, Csaba Foldesi, Wieslaw Hulak, Sumeet S. Chugh, Winfried Siffert

“…In the DISCOVERY trial, genotypes of 2 SNPs in the GNAS gene were nominally significant in the prospective screening and significantly associated with VT when viewed as recessive traits in post hoc analyses (TT vs CC/CT in c.393C>T: HR 1.42 [CI 1.11‐1.80], P=0.005; TT vs CC/CT in c.2273C>T: HR 1.57 [CI 1.18‐2.09], P=0.002). …”
Get full text

Theory-screened Prussian blue analogues-based nanozymes for promoting diabetic wound healing via ferroptosis inhibition by Qingrong Dong, Xiaomei Shen, Ge Fang, Jia Shi, Xiafeng Zhu, Jiangfeng Du, Hui Zhang, Cuicui Ge

“…Through computational and experimental methods, the optimized Prussian blue analogues (MPBs) with highest iron chelating efficiency and efficacy (CuPBs) are screened out and both the CuPBs and the post-chelated products have been demonstrated to exhibit reactive oxygen species (ROS)-scavenging activities. …”
Get full text

Diagnostic value of microRNA-27 and -339 in heart transplant recipients with myocardial fibrosis by O. P. Shevchenko, D. A. Velikiy, S. O. Sharapchenko, O. E. Gichkun, A. V. Marchenko, A. A. Ulybysheva, V. S. Pavlov, N. P. Моzheikо, N. N. Кoloskovа, A. O. Shevchenko

“…The combination of molecular-genetic and proteomic biomarkers in one test improves the diagnostic characteristics of these expressions with respect to post-transplant complications in heart recipients.…”
Get full text

Regulation of retinoic acid inducible gene I signal transduction by bluetongue virus through the ubiquitin-proteasome system by Danfeng LU, Zhenxing ZHANG, Zhanhong LI, Pei ZHU, Zhuoran LI

“…Treatment with the proteasome inhibitor MG-132 significantly suppressed RIG-I degradation induced by BTV infection; The nuclear translocation ratio of IRF3 in MG-132 treated SPAE cells increased by 9.67 and 8.66 percentage points compared with their untreated counterparts at 24 hours post-infection (24 hpi) and 48 hpi; The expression level of IFN-α increased by 2.18-fold comparing with that of the corresponding untreated group at 48 hpi; The genomic copy numbers of BTV decreased to 74% and 85% of those of the untreated counterparts at 24 and 48 hpi, respectively. …”
Get full text

Biochemical investigation of association of arsenic exposed polymorphic variants and disease susceptibility by Syed Muhammad Shoaib, Samina Afzal, Muhammad Sajid Hamid Akash, Kanwal Rehman, Amjad Hussain, Ahmed Nadeem, Asif Shahzad, Sabry M. Attia

“…The groundwater exhibited significantly elevated arsenic concentrations (68.18 ± 21.28 μg/L) in comparison to both water and sanitation agency Faisalabad (WASA)-supplied water (9.81 ± 1.2 μg/L) and locally filtered water (8.12 ± 1.42 μg/L), as determined by one-way ANOVA followed by Bonferroni's post-test at P < 0.05. An association was established between arsenic concentration and the incidence of disease, such as diabetes mellitus. …”
Get full text

The role of ubiquitination and deubiquitination in urological tumours by Lifeng Gan, Lifeng Gan, Lifeng Gan, Peiyue Luo, Peiyue Luo, Peiyue Luo, Junrong Zou, Junrong Zou, Wei Li, Wei Li, Wei Li, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Liying Zheng, Biao Qian, Biao Qian

“…Ubiquitination, a form of post-translational modification, occurs in eukaryotic cells and involves several key components, such as Ub-activating enzymes, Ub-binding enzymes, and Ub-protein ligases. …”
Get full text