HIPEC after Interval Debulking Surgery as Best Clinical Practice in Ovarian Cancer Patients: Case Series and Literature Review by Stefano Restaino, Jessica Mauro, Stefano Cianci, Alessandro Buda, Claudia Andreetta, Elena Poletto, Enrico Maria Pasqual, Alice Poli, Cosimo Vittorio Agrimi, Doriana Armenise, Alice Buzzelli, Domenico Caccamo, Lorenza Driul, Giuseppe Vizzielli

“…Conclusions: The addition of HIPEC to interval debulking surgery should be offered to all eligible patients, considering that the association of HIPEC to IDS seems to improve patients’ outcomes in terms of OS and DFS, without increasing post-operative morbidity .…”
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Screening and Risk Analysis of Atrial Fibrillation After Radiotherapy for Breast Cancer: Protocol for the Cross-Sectional Cohort Study “Watch Your Heart (WATCH)” by Laura Saint-Lary, Baptiste Pinel, Loic Panh, Gaelle Jimenez, Julien Geffrelot, Youlia Kirova, Jeremy Camilleri, David Broggio, Marie-Odile Bernier, Corinne Mandin, Christelle Levy, Serge Boveda, Juliette Thariat, Sophie Jacob

“…Cross-sectional screening for AF at the time of the scheduled 5-year post-RT visit will be conducted by recording data from a Withings ScanWatch smartwatch for 1 month, confirmed by an electrocardiogram (ECG), and validated by a physician. …”
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Succession characteristics and assembly process of soil microbiome at reclaimed farmlands in coal mining area by Jianhua Li, Jianhua Li, Zixu Li, Yanwen Sun, Jinjing Lu, Jinjing Lu, Qiang Zhang, Xinhua He, Xinhua He, Xinhua He, Minggang Xu, Minggang Xu

“…We analyzed soil microbial diversity, composition, co-occurrence network structure, and assembly processes using 16S rDNA/ITS sequencing and null models at 0 (R0), 1 (R1), 6 (R6), and 10 (R10) years of post-reclamation. Results showed that (1) Compared to R0, the R10 treatment resulted in significant increases in soil organic matter (SOM), total nitrogen (TN), available phosphorus (AP), and available potassium (AK) by 2.1-fold, 1.3-fold, 1.5-fold, and 0.4-fold, and also in activities of β-glucosidase (BG), N-acetyl-β-glucosaminidase (NAG), and leucine aminopeptidase (LAP), by 17-fold, 8.7-fold, and 1.8-fold, respectively (p < 0.05). (2) Rising bacterial diversity (Shannon, Chao1) over time, contrasting with fungal diversity that declined initially before recovering. (3) As the reclamation progressed, the network complexity was increased for both bacteria and fungi, improving stability. …”
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The growth mechanism and corrosion resistance of laser-assisted plasma electrolytic oxidation (PEO) composite coating on AZ31B magnesium alloy by Guolong Wu, Lin Li, Xianghui Chen, Lebin Zhu, Ye Wang, Chen Wen, Jianhua Yao

“…The results demonstrated that laser-assisted irradiation not only induced plasma discharge on the anode surface, but also limited the plasma discharge size in the post-processing stage, which significantly increased the proportion of corrosion-resistant phase Mg2SiO4 (the proportion of Mg2SiO4 increased from 23.70% to 39.22%), thickness and density in the coating, and obviously reduced the oxygen vacancy defects and microcracks in the coating. …”
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Does constipation affect the effectiveness of washed microbiota transplantation in treating autism spectrum disorders? by Zihao Pan, Zheng Gao, Junyi Chen, Yongxi Quan, Jiating Xu, Xiaofeng Liang, Wenrui Xie, Xingxiang He, Xingxiang He, Lihao Wu, Lihao Wu

“…After one course of WMT, constipation group showed an obvious increase in microbial diversity and a significant increase in the relative abundance of Bifidobacteria compared to non-constipation group.ConclusionPost WMT, core symptoms and sleep disorders were significantly improved in both groups. …”
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Gender Disparities in COVID-19 Survivors with Impaired Quality of Life, Effort Intolerance, and Cardiopulmonary Symptoms: A Prospective Cohort Study by Krista Zachariah, Dustin Wessells, Prianca Tawde, Mahniz Reza, Caitlin Chiu, Pablo Villar Calle, Alexander Volodarskiy, Evelyn M. Horn, Parag Goyal, Jonathan Weinsaft, Jiwon Kim

“…Conclusion: Whereas males have greater morbidity during acute COVID hospitalization, females are disproportionately impacted by post-COVID impaired functional status despite higher biventricular ejection fraction and smaller infarct size.…”
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Biological maturation determines the beneficial effects of high-intensity functional training on cardiorespiratory fitness in male adolescents by Jarosław Domaradzki, Cristian Alvarez, Rafał Szafraniec, Dawid Koźlenia

“…The MO role in the HIFT intervention was tested by MANCOVA and ANCOVA with post hoc detailed comparisons. Results MO contributed to the studied model more than CA (Wilk’s Λ = 0.49, ηp2 = 0.24, p < 0.001; Wilk’s Λ = 0.83, ηp2 = 0.07, p < 0.063, respectively). …”
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Prediagnosis Insights Into Amyotrophic Lateral Sclerosis: Clinical Symptoms and Medication Use by Chunyang Pang, Wen Cao, Jiali Xie, Yaojia Li, Luyi Zhu, Huan Yu, Dongsheng Fan, Binbin Deng

“…In the ALS cohort, the male‐to‐female ratio was 2.9, with a median age at onset of 64.61 years (Interquartile range (IQR): 56.80–71.31) and a median survival time post‐diagnosis of 9.08 months (IQR: 3.18–18.98), while females (log‐rank p = 0.038) and individuals with earlier (< 64.61 years) disease onset (log‐rank p < 0.001) had longer survival periods. …”
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Dexamethasone-eluting cochlear implants reduce inflammation and foreign body response in human and murine cochleae by Muhammad Taifur Rahman, Brian J Mostaert, Peter Eckard, Shakila Mahmuda Fatima, Rachel Scheperle, Ibrahim Razu, Bryce Hunger, Rafal T. Olszewski, Shoujun Gu, Cristina L. Garcia, Nashwaan Ali Khan, Douglas M Bennion, Jacob Oleson, Jonathon R. Kirk, Ya Lang Enke, Robert D. Gay, Robert J. Morell, Keiko Hirose, Michael Hoa, Alexander D. Claussen, Marlan R. Hansen

“…This study aims to investigate the long-term efficacy of dexamethasone-eluting cochlear implant and locally delivered dexamethasone, a potent anti-inflammatory glucocorticoid, on the intracochlear FBR and electrical impedance post-implantation in a murine model. Preliminary impedance data in humans are also provided as a complement to the murine data to illustrate generalizability and reinforce implications related to clinical application. …”
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Cardiac protection of wogonin in mice with pulmonary fibrosis by regulating Sirt1/ γ-H2AX pathway by Libo Wang, Libo Wang, Fei Lin, Runran Miao, Tianhao Zhao, Yuan Liu, Lin Yang, Min Zhang, Min Zhang

“…This gap in understanding complicates the management and treatment of HF in patients with PF.ObjectivesTo investigate the effects of PF on cardiac function and myocardial fibrosis using a mouse PF model and evaluate the therapeutic potential of wogonin, a flavonoid compound known for its anti-PF properties.MethodsA PF mouse model was established via intratracheal administration of bleomycin (BLM). Starting on day 8 post-BLM treatment, wogonin (50 mg/kg) was intraperitoneally administered every 2 days for 2 weeks. …”
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In Vitro Evaluation of the Antiviral Activity of Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG) Against Mayaro Virus by Pâmela Jóyce Previdelli da Conceição, Gabriela Miranda Ayusso, Tamara Carvalho, Maria Leticia Duarte Lima, Mikaela dos Santos Marinho, Fábio Rogério Moraes, Paola Elaine Galán-Jurado, José González-Santamaría, Cíntia Bittar, Bo Zhang, Ana Carolina Gomes Jardim, Paula Rahal, Marilia Freitas Calmon

“…Finally, it also showed significant inhibition in the post-entry stages of the MAYV replication cycle, acting on the replication of the genetic material and late stages, such as assembly and release. …”
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The effect of infectious bursal disease virus infection on gut microbiota of broiler chicken and the role of prebiotics and probiotics on correction of gut dysbiosis using analysis... by M. I. Mosa, H. M. Salem, M. Hassan, M. A. El-Saied, M. A. Bastamy, M. M. Amer

“…The clinical signs, postmortem lesions (PM), mortality, bursal index (BI), immune response, body weight gain (BWG), feed intake (FI), feed con-version rate (FCR), caecum villi morphometry and gut microbiome profile were studied. At 3 days post infection (dpi), significant decrease in caecum total mucosal thickness (P<0.05) were observed in CP group (204±12.6 µm) compared to CN group (266±16 µm) while it was corrected in infected pro-phylaxis groups P1 (310±10.5 µm), P2 (320±13.4 µm), P3 (267±13.9 µm) and P4 (265±10.6 µm). …”

Safety and pharmacokinetics of dolutegravir in pregnant mothers with HIV infection and their neonates: A randomised trial (DolPHIN-1 study). by Catriona Waitt, Catherine Orrell, Stephen Walimbwa, Yashna Singh, Kenneth Kintu, Bryony Simmons, Julian Kaboggoza, Mary Sihlangu, Julie-Anne Coombs, Thoko Malaba, Josaphat Byamugisha, Alieu Amara, Joshua Gini, Laura Else, Christie Heiburg, Eva Maria Hodel, Helen Reynolds, Ushma Mehta, Pauline Byakika-Kibwika, Andrew Hill, Landon Myer, Mohammed Lamorde, Saye Khoo

“…<h4>Methods and findings</h4>In DolPHIN-1, HIV-infected treatment-naïve pregnant women (28-36 weeks of gestation, age 26 (19-42), weight 67kg (45-119), all Black African) in Uganda and South Africa were randomised 1:1 to dolutegravir (DTG) or efavirenz (EFV)-containing ART until 2 weeks post-partum (2wPP), between 9th March 2017 and 16th January 2018, with follow-up until six months postpartum. …”
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Comparative efficacy and safety of nitinol vs. novel fully biodegradable occluders for transcatheter patent foramen ovale closure in migraine treatment: a retrospective cohort stud... by Rui-lin Li, Jing-juan Huang, Jie Ming, Ying Hao, Wei Wen, Yun-li Shen, Li Lin, Lin-xiang Lu

“…Secondary outcomes included the incidence of safety-related events and the rate of residual right-to-left shunt.ResultsBoth the nitinol group and biodegradable groups showed significant reductions in MIDAS scores post-procedure with no significant difference in migraine relief between groups (P = 0.644, Kaplan-Meier analysis). …”
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Construction and multidimensional effect evaluation of a mindfulness-based second victim intervention support programme for intensive care unit nurses: a case–control study by Xiaolei Chen, Aiyan Du, Mei Yu, Cen Zhang, Xuefen Zhu, Yan Cao, Linghong Hua, Xiaodong Cao

“…Specifically, the PSQI score in the experimental group decreased from 12.94 ± 2.03 at baseline to 9.32 ± 2.13 post-intervention, whereas the control group’s score only decreased from 12.76 ± 2.21 to 10.72 ± 1.99. …”
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Self-injurious behavior in Greek adolescents: the role of mental health problems and COVID-19 trauma by Georgios Giannakopoulos, Foivos Zaravinos-Tsakos, Efrosyni Pilafa, Andre Sourander, Gerasimos Kolaitis

“…Participants completed the Strengths and Difficulties Questionnaire (SDQ) to assess emotional symptoms, conduct problems, hyperactivity, and peer difficulties, and the Children’s Revised Impact of Event Scale-8 (CRIES-8) to evaluate post-traumatic stress symptoms. SIB was assessed via self-report, and specific COVID-19–related experiences (e.g., quarantine, hospitalization) were recorded alongside measures of suicidal ideation and suicide attempts. …”
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U–Pb dating on calcite paleosol nodules: first absolute age constraints on the Miocene continental succession of the Paris Basin by V. Monchal, R. Rateau, K. Drost, C. Gagnaison, B. Mennecart, R. Toullec, K. Torremans, D. Chew

“…Recent progress in carbonate U–Pb dating can improve correlations between continental successions by providing absolute age constraints on carbonate deposition and/or on syn- to post-depositional processes such as pedogenesis.</p> <p>In this study, we analysed pedogenic calcite nodules within a continental Miocene succession in the southwestern Paris Basin (the important paleontological site at Mauvières quarry, France). …”
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Transient gray matter decline during antarctic isolation: Roles of sleep, exercise, and cognition by David Roalf, Mathias Basner, Joanne C. Beer, Russell T. Shinohara, Kosha Ruparel, Tyler M. Moore, David F. Dinges, Alexander C. Stahn, Jad Nasrini, Emanuel Hermosillo, Adrian J. Ecker, Karthik Prabhakaran, Mustafa M. Almuqbel, Michael G. Smith, Christopher W. Jones, Bernd Johannes, Darius A. Gerlach, Beth Healey, Floris P. van den Berg, Hanns-Christian Gunga, Tracy R. Melzer, Bruce V. Taylor, Ruben C. Gur

“…This study assessed brain structure changes in 25 crewmembers who spent 12 months at Concordia, with MRI scans conducted before, immediately after, and five months post-mission. The study included 25 controls scanned over a similar interval and 4 “flying phantom” individuals who were scanned at all sites. …”
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Cross-lineage 5-methylcytosine methylome profiling reveals methylated divergence among Toxoplasma gondii tachyzoites of the three major clonal lineages by Xiao-Nan Zheng, Hong-Yu Song, Hany M. Elsheikha, Chen-Ran Tian, Xing Tian, Qing Liu, Wen-Bin Zheng, Xing-Quan Zhu

“…Among the emerging layers of gene regulation, 5-methylcytosine (m5C) has emerged as a pivotal post-transcriptional modification in eukaryotes. …”
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Exploring the impact and mechanisms of behavioral activation on sleep disorders in colorectal cancer: a randomized controlled trial by Anlong Li, Runze Huang, Han Ge, Dajie Liu, Shaochun Liu, Yingxue Jia, Jiaying Chai, Xinyi Zheng, Lijun Liu, Chen Gan, Jian Xu, Ling Cheng, Mingjun Zhang, Huaidong Cheng

“…Assessments of quality of life, sleep disturbances, psychological distress, activation, avoidance, and physical activity levels were conducted at baseline (T0), four weeks later (T1), and post-intervention (T2). Generalized estimating equation (GEE) analysis was used to evaluate the intervention’s impact and potential mediating effects. …”
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