Recurrent gastric cancer sustaining a partial response after the nivolumab discontinuation because of immune-related adverse events: a case report by Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Takako Tanaka, Ken Sasaki, Masahiro Noda, Yoshiaki Kita, Shinichiro Mori, Yusuke Tsuruda, Hiroshi Kurahara, Takao Ohtsuka

“…Nevertheless, during adjuvant chemotherapy 1-year post-surgery, computed tomography (CT) revealed lymph node swelling in station no. 9. …”
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Effect of environmentally relevant concentrations of estrogens on the aggressive response of male zebrafish by Ying–Ying Zhang, Ying–Ying Zhang, Hong Tao, Hong Tao, Yan–Jun Shen, Yan–Jun Shen, Qi–Liang Chen, Qi–Liang Chen, Zhi–Hao Liu, Zhi–Hao Liu

“…In this study, adult male zebrafish were exposed to EE2-low (5.55 ng/L), EE2-high (11.1 ng/L), and Mix (4-NP, 62.2 ng/L; BPA, 250 ng/L; E1, 4.56 ng/L; E2, 5.53 ng/L; E3, 39.6 ng/L, with an estrogenic potency equal to EE2-low) for 60 days. Post-exposure assays (mirror test and dyadic interaction) revealed that Mix significantly reduced the frequency of approaching mirror, the attack mirror duration, and the frequency of chasing un-exposed fish, indicating a decrease in aggressive behaviour in Mix-fish. …”
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The Role of Emotions in the Persistence of Tensions and Conflicts in the Middle East (2011–2024) by Sayed Jalal Dehghani Firouzabadi, Fatemeh Damirchi

“…The findings suggest that emotions have exacerbated conflicts in the post-Arab Spring Middle East. Under these conditions, collective emotions and identities have not only played a central role in shaping domestic and foreign policies but have also emerged as significant obstacles to regional cooperation. …”
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Trends and projections of gallbladder and biliary tract cancer in China: a comprehensive analysis from 1990 to 2030 based on the Global Burden of Disease Study 2021 by Zhouwei Zhan, Bijuan Chen, Wenhao Teng, Rui Huang, Hanchen Zheng, Sijing Zhou, Jingjie Xu, Jiami Yu, Hui Lin, Xiaojie Wang, Zengqing Guo, Xiaoyan Lin

“…APC analysis highlighted increasing incidence among post-1950 birth cohorts and decreasing mortality in recent cohorts. …”
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Deubiquitylases MoUbp12 and MoUbp14 modulated by transcription factor MoMsn2 are critical for mitochondrial fusion/fission balance and infectious growth of the rice blast fungus by Xingyu Wang, Yuhan Xiao, Qi Li, Lele Xu, Yayuan Huang, Muxing Liu, Xinyu Liu, Zhengguang Zhang, Haifeng Zhang

“…Abstract Ubiquitination is a critical post-translational modification that regulates various cellular processes, including protein degradation and organelle dynamics. …”
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Evaluating the association of transient receptor potential cation channel subfamily A member 1 gene polymorphisms with pain sensitivity: results from an adaptive recall by genotype... by Aidan P. Nickerson, Laura J. Corbin, Nicholas J. Timpson, Megan Nott, Oliver Blanshard, Katie Foy, Fang Fang Quek, Christopher Geddie, Keith Phillips, Frances M.K. Williams, Anthony E. Pickering, James P. Dunham

“…The novel adaptive study design successfully balanced a 20% risk of incorrect interim assessment while optimising the power to observe sensory changes using small cohorts. Post-hoc simulation confirmed that the correct decision to terminate the study of a particular variant was performed in over 94% of permutations at our chosen interim point (N = 15).…”
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The Value of Cerebral Blood Volume Derived from Dynamic Susceptibility Contrast Perfusion MRI in Predicting IDH Mutation Status of Brain Gliomas—A Systematic Review and Meta-Analys... by José Pablo Martínez Barbero, Francisco Javier Pérez García, Paula María Jiménez Gutiérrez, Marta García Cerezo, David López Cornejo, Gonzalo Olivares Granados, José Manuel Benítez, Antonio Jesús Láinez Ramos-Bossini

“…However, heterogeneity in acquisition parameters and post-processing methods limits generalizability of results. …”
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HONORING WAR VETERANS AS A COMPONENT OF THE IMPLEMENTATION OF THE SOCIO-ECONOMIC FUNCTION OF THE STATE: ADMINISTRATIVE-LEGAL ASPECT by Liudmyla Sylenko, Serhii Sivkov, Denys Komarnytskyi

“…Proposed ways of improving administrative and legal regulation aim to strengthen state support for veterans and their social integration, as well as strengthening national identity in conditions of martial law and post-war reconstruction. The subject of the article is the administrative and legal mechanisms for implementing the socio-economic functions of the state in conditions of a special period. …”
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Multiparity induces persistent myocardial structural, functional and transcriptomic remodelling in mice by Ruth R. Magaye, Bing H. Wang, Hongyi R. Liu, Shanae Bailey, Rithy Nuon, Sabrina Sutano, Michael Nyugen, Helen Kiriazis, Kyah Grigolon, Luchen Shan, William W. H. Ho, Fumihiko Takeuchi, Daniel G. Donner, David M. Kaye

“…Cardiac function was assessed by echocardiography together with transcriptomic analysis of the left ventricular myocardium. At 15 months post oestrous cycle disruption, MP mice continued to demonstrate a constellation of myocardial alterations including higher heart to tibial length ratio (P < 0.05), body weight (P < 0.01), and fat mass (P < 0.01) compared to NP mice. …”
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In Vivo Evaluation of the Anti-Skin-Ageing Bioactivity of a Recombinant Dual Humanised Collagen and Poly-L-Lactic Acid by Mingjie Tong, Xin Zhou, Jiongni Zhong, Dengjian Qu, Wei Chen, Chun Chen, Yiting Wang, Yaoping Liu, Shaochuan Li, Yuan Xiao, Ning Wang, Chaowan Guo, Qiuling Xie, Sheng Xiong

“…Early-stage intervention (30 days post-injection) markedly upregulated COL1A1 expression through the TGF-β/Smad3 pathway activation, outperforming poly-<span style="font-variant: small-caps;">l</span>-lactic acid (PLLA) in collagen deposition. …”
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The expression of renin-angiotensin system components in human carotid plaque by Kolaković Ana, Bundalo Maja, Đurić Tamara, Končar Igor, Stanković Aleksandra, Živković Maja

“…A two-way ANOVA followed by a post-hoc Tukey test was performed for the statistical analysis of results. …”
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Identification of potential prognostic biomarkers of thymoma with myasthenia gravis based on serum proteomics by Xiaoting Lin, Xiaoting Lin, Xiaoting Lin, Xiaoting Lin, Peng Liu, Peng Liu, Peng Liu, Peng Liu, Guoyan Qi, Guoyan Qi, Guoyan Qi, Guoyan Qi

“…Through proteomic analysis, we examined preoperative serum samples from patients with TMG to identify key prognostic proteins that could serve as a foundation for clinically predicting postoperative efficacy and guiding treatment selection.MethodAccording to the Clinical Research Guidelines of the Myasthenia Gravis Foundation of America (MGFA) for Post-Intervention Status (PIS), 20 patients with TMG were divided into an effective group (T1) [the PIS was minimal manifestation status (MMS) and above] and an ineffective group (T2) (the PIS did not reach MMS and above), with 10 cases each, and a healthy control group (C) with nine cases. …”
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Effect of Integrative Balance and Plyometric Training on Balance, Ankle Mobility, and Jump Performance in Youth Football Players: A Randomized Controlled Trial by Andrew Rinaldi Sinulingga, Kristaps Slaidiņš, Anastasija Salajeva, Agris Liepa, Inese Pontaga

“…No significant pre-to-post changes were observed in the CG, except for absolute and relative peak torque of DF by 10–19% (p = 0.01–0.02, d = 0.55–0.91), peak force DF in the dominant leg by 11% (p = 0.04, d = 0.71), and jump height by 5% (p = 0.008,d = 0.82). …”
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Successful implementation of a risk assessment and mitigation program to control bovine digital dermatitis at the herd-level by Jim Weber, Marina Hillen, Torsten Seuberlich, Andreas Fürmann, Corinne Gurtner, Jens Becker, Claudia Syring, Maria Welham Ruiters, Maher Alsaaod, Lina Mazurek, Gertraud Schüpbach, Adrian Steiner

“…Considering the results of the histopathological examination, of 16S metagenomic sequencing and of the Fluorescence in situ hybridization as indicators for healing, 6/7 (85.7%) selected lesions were cured 2 months post completion of treatment. The results of this study show that the described BDD control measures can markedly reduce the within-herd prevalence of BDD. …”
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Advanced quantification pipeline reveals new spatial and temporal tumor characteristics in preclinical multiple myeloma by Zhixin Sun, Jacqueline M. Godbe, Alexander Zheleznyak, Brad Manion, Junhao Hu, Julie L. Prior, Kathleen Duncan, Ulugbek S. Kamilov, Monica Shokeen

“…A marked increase in tumor uptake was observed by day 18 post-implantation, with significant SUVmean increases in the spine (p = 0.012), left/right femurs (p = 0.007/0.006), pelvis and pelvic joints (p = 0.018), and sacrum (p = 0.02). …”
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Neuro-Cells Mitigate Amyloid Plaque Formation and Behavioral Deficits in the APPswe/PS1dE9 Model of Alzheimer Disease While Also Reducing IL-6 Production in Human Monocytes by Johannes de Munter, Kirill Chaprov, Ekkehard Lang, Kseniia Sitdikova, Erik Ch. Wolters, Evgeniy Svirin, Aliya Kassenova, Andrey Tsoy, Boris W. Kramer, Sholpan Askarova, Careen A. Schroeter, Daniel C. Anthony, Tatyana Strekalova

“…Twelve-month-old APPswe/PS1dE9 mice or their wild-type littermates were injected with NC or vehicle into the cisterna magna. Five to six weeks post-injection, cognitive, locomotor, and emotional behaviors were assessed. …”
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T cell receptor-like antibody specifically targets and eliminates cells infected with cytomegalovirus by Dabing Chen, Caidong Hu, Yunda Hong, Jingjing Xu, Jiaqi Sun, Jinhua Ren, Yangtao Wu, Ningshao Xia, Quan Yuan, Jianda Hu, Ting Yang

“…These findings highlight the potential of TCR-like antibodies in treating CMV infections, supporting a promising novel therapeutic strategy for managing post-transplant CMV complications.…”
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Early statin use might reduce the hemorrhagic transformation among acute ischemic stroke patients with recanalization therapy: a retrospective cohort study by Boyan Pan, Jiaying Lan, Xiaojun Li, Haoxuan Chen, Luankun Weng, Haoyou Xu, Yuanqi Zhao, Min Zhao

“…Secondary outcomes included in-hospital mortality, favorable clinical outcomes (mRS 0–2) at discharge, and neurological improvement 7 ± 2 days post-stroke (defined as a reduction of ≥4 points in NIHSS from baseline).ResultsA total of 266 AIS patients were analyzed, with 164 (61.7%) receiving statins within 24 h (24 h-statins group). …”
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IL-33/ST2 Pathway and Classical Cytokines in End-Stage Heart Failure Patients Submitted to Left Ventricular Assist Device Support: A Paradoxic Role for Inflammatory Mediators? by C. Caselli, A. D'Amico, R. Ragusa, R. Caruso, T. Prescimone, M. Cabiati, S. Nonini, P. Marraccini, S. Del Ry, M. G. Trivella, O. Parodi, D. Giannessi

“…IL-33, ST2, and conventional cytokines (IL-6, IL-8, and TNF-α) were determined in cardiac biopsies and plasma of 22 patients submitted to LVAD implantation (pre-LVAD) and compared with (1) control stable chronic HF patients on medical therapy at the moment of heart transplantation without prior circulatory support (HT); (2) patients supported by LVAD at the moment of LVAD weaning (post-LVAD). Results. Cardiac expression of ST2/IL-33 and cytokines was lower in the pre-LVAD than in the HT group. …”
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An analytical, mathematical annuloplasty ring curvature model for planning of valve-in-ring transcatheter mitral valve replacementCentral MessagePerspective by Matthew H. Park, MS, Mateo Marin-Cuartas, MD, Mark Sellke, PhD, Pearly K. Pandya, MS, Yuanjia Zhu, MD, PhD, Robert J. Wilkerson, BS, David M. Holzhey, MD, PhD, Michael A. Borger, MD, PhD, Y. Joseph Woo, MD

“…Evaluated semi-rigid and rigid rings showed little to no difference between pre- and post-dilation states. Annuloflex rings (flexible band) showed a postdilation variance reduction of 32.83% (P < .001) followed by an increase after 10 minutes of relaxation that was still reduced by 19.62% relative to the initial state (P < .001). …”
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