Influence of crouch angle on lower-extremity kinetic gait profile and walk distance in children with cerebral palsy: a cross-sectional study by Rajani Mullerpatan, Triveni Shetty, Sailakshmi Ganesan, Ashok Johari

“…Bonferroni adjustment was made for post-hoc analyses (p ≤ 0.01). Results Gait speed, cadence and 2-minute walk distance decreased from Group I to II to III(p ≤ 0.01). …”
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Usability, safety and tolerability of CUE1 vibrotactile device as promising therapeutic approach in orthostatic tremor by Viktoria Azoidou, Alexandra Zirra, Thomas Boyle, David Gallagher, Alastair John Noyce, Cristina Simonet

“…Compliance and tolerability were excellent (100 %), with only mild, transient skin irritation reported in two cases. Immediate post-intervention improvements were observed in TUG [-1.22 s (95 % CI: −2.03, −0.26), p = 0.020], tandem stance [+1.41 s (0.00, 6.13), p = 0.025], tandem walk [+0.50 steps (0.00, 2.50), p = 0.042], and heel raise hold [+1.62 s (1.00, 3.32), p = 0.020]. …”
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Transoral Incisionless Fundoplication for patients with Gastroesophageal Reflux Disease after Peroral Endoscopic Myotomy: a prospective cohort by Eduardo Guimarães Hourneaux de Moura, Matheus Ferreira de Carvalho, Victor Lira de Oliveira, Mateus Bond Boghossian, Antonio Afonso Miranda Neto, Eduardo Turiani Hourneaux de Moura, André Orsini Ardengh, Ary Nasi, Kenneth Chang, Mateus Pereira Funari

“…PATIENTS AND METHODS This was a pilot single-center prospective cohort study including ten patients with post-POEM GERD refractory to clinical management who underwent endoscopic treatment with the TIF procedure between February and November 2021. …”
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TM4SF1 overexpression in tumor-associated endothelial cells promotes microvascular invasion in hepatocellular carcinoma by Junwu Guo, Liangrui Chen, Binghua Dai, Chengjun Sui, Zhitao Dong, Keji Chen, Kecai Duan, Kunpeng Fang, Aijun Li, Kui Wang, Li Geng

“…BackgroundMicrovascular invasion (MVI) is linked to poor prognosis, early recurrence and post-surgical intrahepatic metastasis of hepatocellular carcinoma (HCC) but roles of tumor-associated endothelial cells (TECs) remain unclear. …”
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The effectiveness of e-learning in focused cardiac ultrasound training: a prospective controlled study by Johannes Ruppert, Rebecca Krüger, Sebastian Göbel, Susanna Wolfhard, Liv-Annebritt Lorenz, Andreas Michael Weimer, Roman Kloeckner, Elias Waezsada, Holger Buggenhagen, Julia Weinmann-Menke, Johannes Matthias Weimer

“…Materials and methods This prospective, controlled study assessed competency development among medical students attending a FOCUS workshop (study group) at two time points: T1 (pre-training) and T2 (post-training, after completing e-learning). The competence gain of the group was compared to a reference group (control group) of physicians who had also used the e-learning in preparation for a certified FOCUS workshop. …”
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Alpha-synuclein inclusions reduced by PIKfyve inhibition in Parkinson disease cell models by Sara Lucas-Del-Pozo, Giuseppe Uras, Federico Fierli, Veronica Lentini, Sofia Koletsi, Carlos Lazaro-Hernandez, Kai-Yin Chau, Derralynn A. Hughes, Anthony H.V. Schapira

“…Results: PIKfyve inhibition by YM201636 resulted in a lysosomal-dependant reduction of alpha-synuclein inclusions as early as 24 h post-treatment. YM201636 induced an increase in nuclear translocation of TFEB, and an increase in lysosomal markers LAMP1 and HEXA. …”
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RT-QuIC Reactivity in the Brain and Other Organs and Tissues in Early, Middle-early, Middle-late and Terminal Stages of Scrapie Agent 263K Intracerebral Infection in Hamsters by Donglin Liang, Chumou Liu, Kang Xiao, Yuan Wang, Donghua Zhou, Xiaoxi Jia, Yuezhang Wu, Xiaoping Dong, Qi Shi

“…-- named anchor --> </a> <h5 class="section-title" id="d1447294e225">Methods:</h5> <p dir="auto" id="d1447294e227">Brain, skin and other organ specimens were collected at approximately 20, 40, 60 and 80 (terminal stage) days post-inoculation, and homogenates were prepared. …”
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Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair by Xingxiao Huang, Xingxiao Huang, Yan Ping, Yan Ping, Qiuli Sun, Qiuli Sun, Mingjun Yu, Mingjun Yu, Chao Yang, Xiao Liu, Long Wang, Jinyu Huang, Jinyu Huang

“…BackgroundPercutaneous coronary intervention (PCI) remains the primary treatment for coronary artery disease (CAD), yet post-procedural arterial injury triggers cellular change and pathological inflammation, leading to thrombosis and restenosis. …”
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Historical water environment changes in Chagan Lake (mid-19th to mid-20th century) inferred from sedimentary diatom records by Fengyang Sui, Fengyang Sui, Xinxin Du, Henglin Xiao, Henglin Xiao, Shuying Zang, Hongkuan Hui, Qi Lv, Yan Liu, Nannan Zhang, Yawen Fan

“…Sedimentological data further indicated accelerated sedimentation rates (0.34 cm·yr−1 pre-1950s vs. 1.31 cm·yr−1 post-1980s) and notable changes in grain-size characteristics, attributable to combined anthropogenic erosion, hydrological engineering, and climatic influences. …”
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Right atrial remodelling and prognosis in patients with severe atrial functional tricuspid regurgitation by Soongu Kwak, Dong‐Jae Han, Seung‐Pyo Lee, Ho Young Hwang, Hyung‐Kwan Kim, Yong‐Jin Kim, Kyung Hwan Kim, Jae Woong Choi, Jun‐Bean Park

“…In the surgical intervention group, four post‐surgical deaths (11.8%) occurred exclusively in patients with both high RA area and RV end‐diastolic area indices. …”
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Association of serum insulin-like growth factor-1 and adrenocorticotropic hormone therapeutic response in patients with infantile epileptic spasms syndrome by Ka-Na Lin, Ka-Na Lin, Feng Han, Ying-Yan Wang, Wei Zhao, Ji-Wen Wang, Hao Li, Hao Li, Yun-Qing Zhou, Yun-Qing Zhou

“…Within the hypsarrhythmia population, responders (n = 9) showed higher IGF-1, IGFBP-3 levels, and IGF-1/IGFBP-3 ratios than non-responders (n = 5) before ACTH treatment (p &lt; 0.05). Post-ACTH treatment, serum IGF-1 and IGFBP-3 levels increased in all patients, with greater elevation observed in responders.ConclusionOur findings demonstrate that serum IGF-1, IGFBP-3 levels, and their ratio correlate with both hypsarrhythmia severity and short-term ACTH response in IESS patients. …”
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The effect of aerobic exercise and crocin consumption on the gene expression of BDNF, TrkB, dopamine, and serotonin in the cerebral cortex of rats induced with methamphetamine by Soudabeh Nourolapour, Asieh Abbassi Daloii, Seyyed Javad Ziaolhagh, Alireza Barari

“…The data were analyzed by using one-way analysis of variance and Tukey's post hoc-test at the significance level of P≤0.05.   …”
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Zingerone Attenuates Cadmium-Induced Neuroinflammation, Oxidative Stress and Cognitive Deficit on the Prefrontal Cortex of Adult Wistar Rats by Oviosun A, Oviosun EC, Nto NJ, Memudu AE, Anyanwu EG

“…Data from this study was analysed using GraphPad Prism 10, and statistical difference between groups was determined using one-way ANOVA followed by Tukey’s post hoc test (p &lt; 0.05).Result and discussion: There was significant reduction in superoxide dismutase (SOD), catalase (CAT) and significant increase malondialdehyde (MDA) in the cadmium-only group; however, this effect was mitigated in Groups C–F that received zingerone treatment. …”
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Variability of bulb morpho-geometrical properties in onion (Allium cepa L.) germplasm collections, using digital imaging tools by Seong-Hoon Kim, Kanivalan Iwar, JiWon Han, Inchan Choi, Jaesu Lee, Kingsley Ochar

“…Onion bulb morphology, and geometrical properties, which are the physical and spatial dimensions and shape characteristics influence consumer and market demand, as well as suitability for processing and mechanizing post-harvest handling. Many previous studies employed manual tools such as Vernier calipers for measurement of onion bulb parameters, which is time-consuming. …”
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A multivariate cell-based liquid biopsy for lung nodule risk stratification: Analytical validation and early clinical evaluation by Jason D. Berndt, Fergal J. Duffy, Mark D. D'Ascenzo, Leslie R. Miller, Yijun Qi, G. Adam Whitney, Samuel A. Danziger, Anil Vachani, Pierre P. Massion, Stephen A. Deppen, Robert J. Lipshutz, John D. Aitchison, Jennifer J. Smith

“…Two models demonstrated discriminative ability in blind validation, one with AUC = 0.64 (95 % CI: 0.51–0.76). Post hoc integration with CT imaging features yielded a combined model with 90 % sensitivity, 64 % specificity, and 95 % negative predictive value at 25 % prevalence, suggesting clinical utility and surpassing performance of existing rule-out tests. …”
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Perbandingan Arsitektur Convolutional Neural Network Pada Klasifikasi Pneumonia, COVID-19, Lung Opacity, dan Normal Menggunakan Citra Sinar-X Thoraks by Agung Wahyu Setiawan

“…Therefore, it is necessary to classify Covid-19 and pneumonia not only during a pandemic but also post-pandemic. One of the methods is using chest X-ray images. …”
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Comparative child mental health and academic outcomes after primary school teachers deliver task-shifted mental health care in India by Priscilla Giri, Molly M. Lamb, Venessa C. Fuentes, Arpana Thapa, Surekha Bhattarai, Choden Dukpa, Catherine C. Shrestha, Setareh Ekhteraei, Juliana L. Vanderburg, Breanna Windsor, Abhishek K. Rauniyar, Karen Hampanda, Bradley N. Gaynes, Rinzi Lama, Michael Matergia, Christina M. Cruz

“…We conducted a pragmatic, mixed methods, post hoc analysis using data from 2019 of an open trial of Tealeaf running in parallel with the all-EUC first step of a stepped wedge cluster randomized controlled trial (SW-CRCT). …”
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Association between 45T/G Polymorphism of Adiponectin Gene and Coronary Artery Disease in an Iranian Population by Somaye Sabouri, Majid Ghayour Mobarhan, Mohsen Moohebati, Mitra Hassani, Jamal Kassaeian, Farnoosh Tatari, Fatemeh Mahmoodi-kordi, Habib A. Esmaeili, Shima Tavallaie, Roghayeh Paydar, Amirhossein Sahebkar, Shahireh Omidvar Tehrani, Gordon Ferns, Javad Behravan

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Promoting ferroptosis of keloid fibroblasts: a key mechanism underlying the efficacy of 5-aminolevulinic acid photodynamic therapy for keloids by Jiaying Zhang, Yahui Feng, Ning Zhang, Xiaoqing Wang, Dongmei Li, Dongmei Shi

“…ALA-PDT disrupted keloid fibroblasts ultrastructure, evidenced by mitochondrial swelling, autophagosome formation, and membrane blebbing, with a 3.2-fold increase in morphological changes post-treatment. The inhibitory effect of ALA-PDT on KFs mitochondrial dehydrogenase activity was ALA dose-dependent. …”
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Clinical manifestations and pathogenicity of Clade IIb monkeypox virus in rabbits by Chao Shang, Shaowen Shi, Qiwei Jiang, Xiaohan Wang, Xiaohong Yao, Wanzi Li, Gaojie Song, Yiquan Li, Yongyang Sun, Jinglei Hu, Cuiling Zhang, Yilong Zhu, Zirui Liu, Chaode Gu, Yan Liu, Wanyu Shi, Zongzheng Zhao, Xiao Li

“…Following intravenous MPXV injection, adult rabbits exhibited characteristic clinical manifestations, including widespread rash and fever, with viral replication in the skin, lungs, and testes, resulting in severe pathological damage by 6 days post-infection (dpi). Intradermal injection of MPXV into the dorsal skin of adult rabbits produced red lesions with central necrosis and hemorrhage accompanied by dense inflammatory infiltrates. …”
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