Multi-omics integration reveals the impact of mediterranean diet on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease by Zixuan Wang, Zixuan Wang, Ge Chen, Xutong Sun, Jia Xiao, Lingling Kong, Shunshun Jiang, Tingting Xu, Meijiao Wang, Meijiao Wang, Hong Zhao

“…ObjectiveTo investigate the effects of the Mediterranean diet (MD) on hepatic metabolism and gut microbiota in mice with metabolic dysfunction-associated steatotic liver disease (MASLD).MethodsC57BL/6 mice were fed a high-fat diet for 12 weeks to induce MASLD, with normal chow (NC)-fed mice as controls. Post-modeling, MASLD mice were randomized into three groups: HF (continued high-fat diet), HF-NC (switched to normal chow), and HF-MD (switched to MD). …”
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Regulating effect of empagliflozin plus liraglutide on glucose/lipid metabolism and serum levels of SFRP5， Irisin and tAPN in obese type 2 diabetics by Gao Rui-chao, Li Min, Jin Peng-ran, Liu Xuan, Feng Xue, Tan Zeng-huan

“…At pre-treatment and 3 months post-treatment， two groups were compared regarding the parameters of weight loss ［weight， waist circumference （WC）， body mass index （BMI）］， glucose metabolism ［glycated hemoglobin （HbA1c）， fasting blood glucose （FPG）， 2 h postprandial blood glucose （2 hPG）］， lipid metabolism ［low-density lipoprotein cholesterol （LDL-C）， high-density lipoprotein cholesterol （HDL-C）， triglycerides （TG）， total cholesterol （TC）］， insulin sensitivity ［homeostasis model islet β cell function index （HOMA-β）， homeostasis model insulin resistance index （HOMA-IR）］， serum levels of SFRP5， Irisin and tAPN and occurrences of adverse reactions.ResultsAfter 3-month treatment， body weight ［（74.93±2.68） <italic>vs</italic> （78.21±3.47） kg］， WC ［（90.40±2.17） <italic>vs</italic> （93.28±2.53） cm］ ，BMI ［（26.57±0.94） <italic>vs</italic> （27.94±1.06） kg/m²］ ，HbA1c ［（6.03±0.59）% <italic>vs</italic> （6.76±0.68）%］， FPG ［（6.24±0.73） <italic>vs</italic> （6.97±0.95） mmol/L］， 2 hPG ［（8.06±1.25） <italic>vs</italic> （8.83±1.50） mmol/L］， LDL-C ［（2.27±0.21） <italic>vs</italic> （2.58±0.27） mmol/L］， TG ［（1.83±0.34） <italic>vs</italic> （2.20±0.48） mmol/L］， TC ［（5.36±0.42） <italic>vs</italic> （5.92±0.53） mmol/L］ and HOMA-IR （2.35±0.24 <italic>vs</italic> 2.69±0.31） were lower in observation group than those in control group（<italic>P</italic>&lt;0.05）. …”
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Comparison of middle molecule removal with expanded hemodialysis versus haemodiafiltration among Chinese hemodialysis patients by Liangying Gan, Leyi Gu, Yongchun Ge, Hongli Lin, Yiwen Li, Fengling Chen, Wenge Li, Bihu Gao, Feng Ding, Xinzhou Zhang, Zhenwei Shi, Jiayao Ji, Qiang Yao, Brad Keller, Surupa Sarkar, Li Zuo

“…Background This study aimed to compare uremic toxin removal with expanded hemodialysis against post-dilution online haemodiafiltration therapy in Chinese patients with chronic kidney failure in a single treatment.Methods This randomized, controlled, open-label, parallel, multicenter trial enrolled prevalent patients on hemodialysis. …”
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Effectiveness of an online mindfulness based stress reduction intervention on psychological distress among patients with COVID19 after hospital discharge by Maryam Mozaffari, Manijeh Naderi, Hosein Zahednezhad, Fataneh Ghadirian

“…Cohen’s d was used to determine effect sizes. The post-test score of stress after the online MBSR training program for 4 weeks significantly decreased in the MBSR group to 12.59 ± 6.77 compared with the control group which had a score of 22.60 ± 10.82(p < 0.001). …”
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Design and testing of add-on prototypes for transport containers to improve the loading process for end-of-lay hens and catchers by Femke Delanglez, Anneleen Watteyn, Bart Ampe, Gunther Antonissen, Jan Detand, Wout Verroens, Frank Tuyttens

“…Parameters (filling duration, number of escapes, number of body part entrapments, restlessness, and loading inefficiency in container) were scored during the catch, supplemented by a post-loading catcher survey, and at the slaughterhouse (loading damage prevalence, number of dead-on-arrivals). …”
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Predictive demographic and clinical features for the development of dysthyroid optic neuropathy in a multi-ethnic TED population: a retrospective cohort study by Malik Moledina, Vickie Lee, Ahmed Alnahrawy, Ourania Fydanaki, Nicole George, Nour Hubby, Daisy Metcalf, Natalie Man, Gabriella Guevara, Claire Feeney, Rashmi Akshikar, Rajni Jain, Ahmad Aziz, Vassiliki Bravis, Karim Meeran

“…Consecutive patients aged over 18 years old with a minimum of 6 months follow-up post-diagnosis of TED were included. We compared those patients with DON and those without (no-DON) to determine which factors were more prevalent in patients with DON. …”
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The Association of Lipoprotein(a) and Stroke Recurrence: A Systematic Review and Meta-Analysis by Lina Palaiodimou, Konstantinos Melanis, Maria-Ioanna Stefanou, Aikaterini Theodorou, Sotirios Giannopoulos, Vaia Lambadiari, Diana Aguiar de Sousa, Simona Sacco, Mira Katan, Gerasimos Siasos, Georgios Tsivgoulis

“…Results A total of 12 studies, including one RCT post hoc analysis and 11 observational studies, comprising 17,903 patients (mean age 63 years, 38% female), were included. …”
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Burden and Outcomes of Severe Lower Respiratory Tract Infections with Unknown Etiology: A Retrospective Observational Study on Epidemiological Trends Over an 8-Year Period (2016–20... by Giovanni Scaglione, Marta Canuti, Martina Offer, Valentina Breschi, Antonio Piralla, Fausto Baldanti, Gabriele Del Castillo, Francesco Scovenna, Sabrina Buoro, Federica Morani, Danilo Cereda, Alessandra Bandera, Andrea Gori, Marta Colaneri

“…Hospitalizations with unknown etiology were more common in minors (42,190 episodes, 57.6% of total in < 18 years) and elderly (358,534 episodes, 56.2% of total in > 75 years), especially during warm seasons. Post-pandemic years saw increased bacterial and viral hospitalizations alongside a reduced proportion of those without an unknown etiology. …”
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A Novel Analysis via Micro-CT Imaging Indicates That Chemically Modified Tetracycline-3 (CMT-3) Inhibits Tooth Relapse after Orthodontic Movement: A Pilot Experimental Study by Giovanni Modesto Vieira, Denise Pinheiro Falcao, Sormani Bento Fernandes de Queiroz, Valthierre Nunes de Lima, Ricardo Bentes de Azevedo, Valdenize Tiziane, Heitor Moreno, Rivadavio Amorim

“…The difference was statistically significant between the groups as to recurrence (p=0.048), and the post hoc test identified the value of p=0.007 between the control group and the CMT-3 group. …”
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Identification of amino acid residues in polymerase PB2 responsible for differential replication and pathogenicity of avian influenza virus H5N1 isolated from human and cattle in T... by Mahmoud Bayoumi, Ramya S. Barre, Ruby A. Escobedo, Vinay Shivanna, Nathanial Jackson, Chengjin Ye, Adolfo García-Sastre, Ahmed Mostafa, Luis Martinez-Sobrido

“…These findings indicate that HPAIV H5N1 of cattle origin has post-transmission amino acid changes that increase viral replication in human cells and pathogenicity in mice.…”
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Effects of different game-based physical activity programs on body composition in Chinese preschool children by Sha Qu, Yueyu Feng, Wenjing Song, Zihao Wang, Zan Gao, Xing Zhao

“…Body composition was assessed pre- and post-intervention using bioelectrical impedance analysis (BIA), while dietary intake was evaluated through 24-h dietary recalls. …”
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Cone-Beam Computed Tomography analysis of prevalence of Nasal Septum Deviation and its relationship with the presence of Middle Concha Bullosa by Sergio Lucio Pereira de Castro Lopes, Mari Eli Leonelli de Moraes, Luiz Roberto Coutinho Manhães Junior, Thiago de Oliveira Gamba, Isadora Luana Flores, Carolina Fernandes de Faria, Afonso Celso Assis

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Recurrence Prediction by Multi-Omics in the Patient with Colorectal Peritoneal Metastases After Cytoreductive Surgery: A Prospective Biomarker Study by Chen C, Gong Z, Zhang Z, Gu H, Zhu A, Peng D, Li B, Wang J, Hu Y, Wang D, Sun L

“…., Ltd, Guangzhou, Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Da Wang, Department of Colorectal Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, People’s Republic of China, Tel +86-571-87784720, Email wangda0618@zju.edu.cn Lifeng Sun, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, People’s Republic of China, Tel +86-571-87783586, Email sunlifeng@zju.edu.cnBackground: Colorectal cancer with peritoneal metastases (CRCPM) exhibits high recurrence post-cytoreductive surgery (CRS). This study evaluated tumor tissue biomarkers and combined circulating tumor DNA (ctDNA) and methylation analysis via ultra-deep next-generation sequencing (NGS) for recurrence prediction.Methods: CRCPM patients undergoing surgery were enrolled (n=21). …”
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Different Patterns of Oral Mucositis and Microbiota Injury After Total Body Irradiation- Versus Chemotherapy-Based Myeloablative Allogeneic Hematopoietic Cell Transplantation by Maryam Ebadi, MD, Hakan Gem, PhD, DDS, Gale Sebastian, DDS, Rania Abasaeed, DDS, Michele Lloid, RDH, Yolanda D. Tseng, MD, Omar Y. Mian, MD, PhD, Samuel Minot, PhD, David R. Dean, DDS, Armin Rashidi, MD, PhD

“…Although the cohorts were similar in plaque microbiota composition at baseline, they became significantly different at all post- hematopoietic cell transplantation timepoints. …”
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Effects of endurance exercise and dietary protein intake on osteokine, bone turnover, and inflammatory markers in endurance runners: A narrative review by Sofia Valente Ferreira, Silar Gardy, Tyler A. Churchward-Venne, Andrea R. Josse, Jenna C. Gibbs

“…Adequate dietary protein ingestion habitually and pre-, during, and post-exercise may attenuate bone resportion and pro-inflammatory markers in endurance athletes.…”
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The Effect of Multidimensional Sexual Education-Counseling on Sexual Knowledge and Attitudes of Couples Preparing for Marriage by Soghra Khani, Armin Firouzi, Mahmood Moosazadeh, Seyyed Hossein Hosseini Karnami, Zahra karimian, Fatemeh Seyri

“…Online questionnaires were completed before the intervention, immediately after, and three months post-intervention. Data analysis was performed using SPSS version 25. …”
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Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury by Sarah Mantash, Soulaimane Aboulouard, Hassan Dakik, Yanis Zirem, Lydia Ziane-Chaouche, Ali Nehme, Khalil Mallah, Marya El-Kurdi, Naify Ramadan, Isabelle Fournier, Kazem Zibara, Firas Kobeissy, Michel Salzet

“…We assessed motor and cognitive outcomes at 2-, 7-, and 30-days post-injury to explore functional impairments associated with observed molecular changes. …”
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Integration of mRNA and miRNA Analysis Reveals the Regulation of Salt Stress Response in Rapeseed (<i>Brassica napus</i> L.) by Yaqian Liu, Danni Li, Yutong Qiao, Niannian Fan, Ruolin Gong, Hua Zhong, Yunfei Zhang, Linfen Lei, Jihong Hu, Jungang Dong

“…These results provide novel insights into the post-transcriptional regulation of salt tolerance in <i>B. napus</i>, offering potential targets for genetic improvement.…”
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Association of myeloid-derived suppressor cells with hematopoietic recovery after high-dose chemotherapy in multiple myeloma by V. S. Anmut, T. V. Tyrinova, E. V. Batorov, T. A. Aristova, S. A. Sizikova, G. Yu. Ushakova, V. V. Denisova, E. R. Chernykh

“…Thus, the obtained results indicate the association of a higher number of M-MDSCs with a shorter duration of leukopenia after high-dose chemotherapy with autologous stem cell transplantation and indicate a positive role of M-MDSCs in hematopoietic recovery in the early post-transplant period in patients with MM.…”
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Mosquito- and tick-borne orthoflaviviruses cross an in vitro endothelial-astrocyte barrier by Felix Schweitzer, Felix Schweitzer, Lara-Jasmin Schröder, Lara-Jasmin Schröder, Alina Friedrichs, Alina Friedrichs, Viktoria Gudi, Thomas Skripuletz, Imke Steffen, Imke Steffen, Martin Palus, Martin Palus, Daniel Růžek, Daniel Růžek, Daniel Růžek, Albert Osterhaus, Albert Osterhaus, Chittappen Kandiyil Prajeeth

“…Nevertheless, virus replication did not affect the barrier function of endothelial cells as demonstrated by sustained TEER and absence of leakage of high molecular weight dextran molecules through the endothelial barrier even at several hours post infection.DiscussionOur findings indicate that orthoflaviviruses can infect the endothelial cells, replicate within them without affecting the cells and its barrier function. …”
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