Pre-Exercise Ingestion of Hydrogen-Rich Cold Water Enhances Endurance Performance and Lactate Response in Heat by Mariem Khlifi, Nidhal Jebabli, Nejmeddine Ouerghi, Fatma Hilal Yagin, Ashit Kumar Dutta, Reem Alwhaibi, Anissa Bouassida

“…<i>Results:</i> Our results revealed a significant variation in dehydration, MAS, number of shuttle run repetitions, blood lactate, RPE, and FS (<i>p</i> = [0.001–0.036]); additionally, a significant group × time interaction was found for body temperature (<i>p</i> = 0.021). Post hoc tests revealed a significant change for MAS (HRCW: <i>p</i> < 0.001), number of shuttle run repetitions (HRCW: <i>p</i> < 0.001), dehydration (HRCW: <i>p</i>= 0.009; IEPC: <i>p</i> = 0.008), blood lactate (HRCW: <i>p</i> < 0.001; IEPC: <i>p</i> < 0.001), RPE (HRCW: <i>p</i> = 0.05; IEPC: <i>p</i> = 0.004), and FS (HRCW: <i>p</i> = 0.05; IEPC: <i>p</i> = 0.004), as well as a significant decrease in body temperature (IEPC: <i>p</i> < 0.001; HRCW: <i>p</i> = 0.028) compared to the control condition after the test. …”
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Significance of heterogenity in endothel-dependent vasodilatation occurrence in healthy individuals with or without coronary risk factors by Polovina Marija, Potpara Tatjana, Giga Vojislav, Ostojić Miodrag

“…True maximal FMD value was calculated as a percent change of the true maximal diameter from the baseline, and compared with FMD value calculated assuming that every participant reached maximal dilation at 60 seconds post cuff deflation (FMD60). Correlation of different RF with brachial artery temporal response was assessed. …”
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Methyl Indole-3-Acetate (MEIAA) mediated stem curvature and apical meristem necrosis in Ageratina adenophora: impacts on cell wall components, vascular system integrity, and key me... by Yanan Ruan, Xi Gao, Mehboob Hussain, Xiaoping Qin, Jingyi Ning, Dewei Yang, Tao Zhu, Deqiang Qin, Min Ye, Guoxing Wu

“…Results At 20 mM (optimized concentration), MEIAA induced dose-dependent stem curvature (1d post-treatment) and apical meristem necrosis (3d). …”
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Apobec-1 complementation factor regulates cell migration and apoptosis through Dickkopf1 by acting on its 3′ untranslated region in MCF7 cells by Xin Yan, Qianyin Li, Dongsheng Ni, Yajun Xie, Qingling He, Qianya Wan, Yamin Liu, Zhongshi Lyu, Zhaomin Mao, Qin Zhou

“…Previous researches mainly focused on its post-transcriptional cytidine to uridine RNA editing. …”
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Analysis of phosphomotifs coupled to phosphoproteome and interactome unveils potential human kinase substrate proteins in SARS-CoV-2 by Vineetha Shaji, Vineetha Shaji, Ahmad Rafi, Mukhtar Ahmed, Athira Perunelly Gopalakrishnan, Athira Perunelly Gopalakrishnan, Sowmya Soman, Amjesh Revikumar, Ganesh Prasad, Abhithaj Jayanandan, Rajesh Raju

“…Docking analysis showed MAP2K1 forms stronger, closer interactions with N protein compared to SRPK1, highlighting MAP2K1 as a potential host kinase for therapeutic targeting in SARS-CoV-2 infection.Discussion and ConclusionsThis study presents a framework for predicting human kinases of specific SARS-CoV-2 protein phosphosites by integrating kinase specificity, virus–host interactions, and post-translational modifications. MAP2K1 was identified as a key host kinase, showing stronger interactions than SRPK1, and is proposed as an antiviral drug target for repurposing in SARS-CoV-2 infections.…”
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Gender-affirming hormonal therapy induces a gender-concordant fecal metagenome transition in transgender individuals by Timur Liwinski, Matthias K. Auer, Johanna Schröder, Ina Pieknik, Christian Casar, Dorothee Schwinge, Lara Henze, Günter K. Stalla, Undine E. Lang, Alina von Klitzing, Peer Briken, Thomas Hildebrandt, Jeanne C. Desbuleux, Sarah V. Biedermann, Paul-Martin Holterhus, Corinna Bang, Christoph Schramm, Johannes Fuss

“…Methods Thirty-six transgender individuals (17 trans women, 19 trans men) provided pre- and post-GAHT stool samples. Shotgun metagenomic sequencing was used to assess the changes in gut microbiota structure and potential function following GAHT. …”
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INNOVATIVE TRANSFORMATIONS IN HIGHER EDUCATION SYSTEM OF AZERBAIJAN IN 2005/06 – 2022/23 ACADEMIC YEARS by Abasova Samira Huseyn qizi

“…The basis for the analysis was the statistical data of the State Statistics Committee of Azerbaijan, electronic pages and posts of the AGORA and Edu.az organizations on Facebook. …”
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Predicting neurodevelopmental outcomes from neonatal cortical microstructure: A conceptual replication study by Andrea Gondová, Sara Neumane, Yann Leprince, Jean-François Mangin, Tomoki Arichi, Jessica Dubois

“…We then aimed to extend the validation of the proposed predictive pipeline through the study of different cohorts (the largest one included 295 neonates, with gestational age between 29 and 42 week and post-menstrual age at MRI between 31 and 45 weeks). …”
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Comparative Analysis of Mineralogical Composition and Radioactivity Levels in Stone Samples from the Archaeological Site of <i>Halaesa</i> (Sicily, Italy) by Giuseppe Paladini, Paola Cardiano, Francesco Caridi, Lorenzo Pistorino, Domenico Majolino, Francesco Gregorio, Stefania Lanza, Gabriele Lando, Antonio Francesco Mottese, Marco Miano, Olivia Gómez-Laserna, Valentina Venuti

“…By examining the stone composition at both the elemental and molecular scales, with support from ion chromatography data, potential degradation patterns linked to post-depositional weathering and external decay agents were identified. …”
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Avortement au Maroc et virage au drame : femmes et professionnels de santé en parlent ! Une étude transversale mixte à Agadir by Sanae Elomrani, Bettina Utz, Vincent De Brouwere, Imane Kajjoune, Bouchra Assarag

“…Cette étude apporte une contribution à l’analyse du phénomène de l’avortement au Maroc et appelle à une action politique urgente sur plusieurs niveaux: l’accès aux programmes d’éducation sexuelle et à la contraception appropriée, l’élargissement des indications d’avortement préconisées dans le projet de loi, la mise en place des stratégies de lutte contre la stigmatisation de l’avortement par les professionnels de santé et l’accès à des soins post-avortement de haute qualité.…”
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Evaluación del predominio de variables geométricas en la frecuencia natural del sensor piezoeléctrico CTN-10- 3/92. // Geometric variables evaluation with influence in the natural... by R. Armas Cardona, F. Martínez Luzardo, J. García de la Figal Costales

“…The obtaining of 16 natural frequencies<br />variants of the load element with geometric changes was carried out through the modelation, analysis and post-processing<br />with the use of COSMOS/M. Details of CAD modelation of pieces, polyhedrons and generated parts, as well as the mesh<br />type and used element are incorporated in the work.…”
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3D comparative analysis of designed versus achieved maxillary teeth movements and influencing factors following first premolar extraction with invisalign: a new digital root model by Waseem S. Al-Gumaei, Reem Al-Attab, Hu Long, Wenli Lai, Fan Jian

“…The pretreatment, designed, and post-first series treatment teeth (crowns, roots, and bone) models were exported from ClinCheck® software (Align Technology). …”
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Anti-Toxoplasma gondii efficacy of beta, beta-dimethylacrylshikonin and isobutyrylshikonin in vitro and in vivo by Hai-Ting Guo, Lu Wang, Bintao Zhai, Shi-Chen Xie, Wen-Bin Zheng, Xing-Quan Zhu, Zhong-Yuan Li

“…Ultrastructural change in T. gondii tachyzoites post co-incubation in vitro was observed by electron microscopy. …”
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Comprehensive analysis of lactylation-related gene and immune microenvironment in atrial fibrillation by Yazhe Ma, Youcheng Wang, Yuanjia Ke, Yuanjia Ke, Yuanjia Ke, Qingyan Zhao, Qingyan Zhao, Qingyan Zhao, Jie Fan, Yang Chen

“…Immune infiltration plays a crucial role in AF pathogenesis, yet its mechanisms remain unclear. Lactylation, a novel post-translational modification, has been implicated in immune regulation, but its association with AF remains unexplored. …”
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Redox regulation and dynamic control of brain-selective kinases BRSK1/2 in the AMPK family through cysteine-based mechanisms by George N Bendzunas, Dominic P Byrne, Safal Shrestha, Leonard A Daly, Sally O Oswald, Samiksha Katiyar, Aarya Venkat, Wayland Yeung, Claire E Eyers, Patrick A Eyers, Natarajan Kannan

“…In eukaryotes, protein kinase signaling is regulated by a diverse array of post-translational modifications, including phosphorylation of Ser/Thr residues and oxidation of cysteine (Cys) residues. …”
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Does syndesmotic fixation technique impact complication rates and functional outcomes measured by PROMIS scores following operative repair of ankle fractures? by Steven M. Hadley, Rachel Bergman, John J. Peabody, Sarah J. Westvold, Ryan Filler, Muhammad Mutawakkil, Milap Patel, Anish R. Kadakia

“…Open fractures, pilons, and neuropathies were excluded. 252 had syndesmotic injury identified via intraoperative fluoroscopy. 159/252 who had minimum one-year radiographic follow-up were included for complications analysis. These 159 were sent post-operative PROMIS CATs. 68/159 consented and were included for final analysis of PROMIS. …”
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Preclinical and clinical evaluation of [64Cu]Cu-PSMA-Q PET/CT for prostate cancer detection and its comparison with [18F]FDG imaging by Fei Chen, Hao Zhang, Yousheng Zhan, Xiaohong Huang, Zongxi He, Daiyuan Ma, Tielong Tang, Suping Li

“…Small -animal PET/CT imaging revealed peak tumor uptake at 4 h post-injection in LNCaP C4-2B tumor xenografts. In clinical evaluations, [64Cu]Cu-PSMA-Q PET/CT detected more lesions than [18F]FDG, with significantly higher SUVmax, SUVmean, and tumor-to-background ratios. …”
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Effects of combined training on quality of life in individuals with overweight-related type 2 diabetes: a pilot study of correlations with metabolic, inflammatory and thermogenic m... by Ivan Luiz Padilha Bonfante, Daniela Bastos Vieira, Marcelo Oliveira Batista, William Ciriaco Barbosa, Renata Garbellini Duft, Keryma Chaves da Silva Mateus, Ana Paula Boito Ramkrapes, Liliane Ribeiro Vasconcelos, Milena Monfort-Pires, Celso Darío Ramos, Licio Augusto Velloso, Mara Patricia Traina Chacon-Mikahil, Cláudia Regina Cavaglieri

“…The CT consisted of strength training followed by aerobic training three times/week for 16 weeks. Pre- and post-intervention assessments included QoL perception, clinical variables, serum biochemical markers, and brown adipose tissue (BAT) activity.Results The CTG showed improvement in the perception of general QoL (20.0%) and in the physical (12.7%) and social (10.1%) domains. …”
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Left ventricular global longitudinal strain and diagnostic yield of genetic testing in hypertrophic cardiomyopathy in a multicenter registry analysis by Viktoria Santner, Viktoria Höller, Maria Ungericht, Nora Schwegel, David Zach, Heidelis Tichy, Gert Waltl, Richard Belciug, Markus Wallner, Johannes Gollmer, Ewald Kolesnik, Peter P. Rainer, Dirk von Lewinski, Klemens Ablasser, Sabine Rudnik-Schöneborn, Gerhard Pölzl, Ellen Heitzer, Andreas Zirlik, Nicolas Verheyen

“…Echocardiographic parameters were measured in post-processing analysis by a blinded investigator. …”
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In Parkinson’s disease, dual-tasking reduces gait smoothness during the straight-walking and turning-while-walking phases of the Timed Up and Go test by Antonio Caronni, Maurizio Amadei, Lorenzo Diana, Gaia Sangalli, Stefano Scarano, Laura Perucca, Viviana Rota, Nadia Bolognini

“…ANOVA was used for hypothesis testing and estimated marginal means for post-hoc tests and effect sizes (ES). Results In straight-walking and turning, cognitive and motor dual tasks decreased gait speed (ES range = [0.476, 1.379]; p < 0.01) and increased the step number (ES = [0.402, 0.927]; p < 0.05). …”
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