‘Super Rehab’: can we achieve coronary artery disease regression? A feasibility study protocol by David Murphy, Charalambos Antoniades, John Graby, Fiona Gillison, Amardeep Dastidar, Dylan Thompson, Theresa Smith, Oliver Peacock, Ali Khavandi, Hugh McLeod, Jonathan Carl Luis Rodrigues

“…However, many patients with coexistent cardiovascular risk factors, particularly those with metabolic syndrome (MetS), remain at heightened risk of future MACE despite current management.Cardiac rehabilitation is offered to patients post-revascularisation, however, there is no definitive evidence demonstrating its benefit in a primary prevention setting. …”
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Variation in Arterial CO2 is a Stronger Determinant of Brain Tissue Oxygenation Than its Synchronous Value in Critically Ill Patients With Acute Brain Injury by Joanie Martineau, MD, MSc, Francis Bernard, MD, Alexandrine Gagnon, MD, Virginie Williams, PhD, Sabrina Araujo de Franca, BSN, David Williamson, BPharm, PhD, Yiorgos Alexandros Cavayas, MD, Msc

“…DESIGN:. We performed a post hoc analysis of a prospective cohort study collecting arterial blood gas (ABG) values alongside synchronous neuromonitoring variables. …”
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Advanced 4-chamber echocardiography techniques enable clinically matched precise characterization of heart disease progression in mice by Ege Kacira, Mariam F. Oueis, Nawal H. Tamimi, Sarah L. Sturgill, Xianyao Xu, Thomas J. Hund, Mark T. Ziolo, Yuchi Han, Isabelle Deschênes, Ji-dong Fu

“…Results: Here we show that LAX-BP echocardiography demonstrates volumetric accuracy comparable to cardiac magnetic resonance (CMR) and detects significant LV functional decline within the first week post-TAC–changes that are not clearly captured by M-mode imaging. …”
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The enhanced integration of proven techniques to quantify the uncertainty of forecasting extreme flood events based on numerical weather prediction models by Mitra Tanhapour, Jaber Soltani, Hadi Shakibian, Bahram Malekmohammadi, Kamila Hlavcova, Silvia Kohnova, Peter Valent

“…A Multi-Model Ensemble (MME) system was developed using the Group Method of Data Handling (GMDH) and Weighted Average-Weighted Least Square Regression (WA-WLSR) models to post-process raw precipitation forecasts. We thereupon proposed an approach that combined the Hydrologiska Byråns Vattenbalansavdelning (HBV) hydrological model with the Long-Short Term Memory (LSTM) network (HBV-LSTM model) to enhance flood forecasting. …”
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Surgical effect and prognostic factors of myasthenia gravis with thymomas by Wenxin Tian, Xiao Li, Hongfeng Tong, Wenhan Weng, Fan Yang, Guanchao Jiang, Jun Wang

“…A total of 162 patients were evaluated for post intervention MG status. A total of 55 patients achieved complete stable remission; the overall effective rate was 84.5%. …”
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Implikasi terhadap Status Kepemilikan Hak atas Tanah dalam Transformasi UMKM Menjadi Perseroan Terbatas Perorangan by Dewinta Sukma Wijaya, Diyan Isnaeni

“…This study, through a normative juridical approach, reveals a regulatory gap that may affect the operational continuity of MSMEs post-conversion. Compared to previous literature that generally emphasizes administrative ease, this study highlights the often-overlooked implications of asset restructuring, particularly in land governance. …”
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Effects on choroid after repeated low-level red-light therapy in preclinical and clinical myopic children: a randomized controlled trial by Hongyu Wei, Sahil Thakur, Qin Zhu, Yanrong Zhou, Xuejun Cao, Shuyuan Xiao, Qin Chen, Min Hu, Hua Zhong

“…Improvements on choriocapillaris blood flow were evident at 3 months post-RLRL, yet these changes were not sustained and did not correlate with longer-term choroidal thickening. …”
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Ginkgo ketone ester tablets for the treatment of cognitive impairment associated with chemotherapy for breast cancer - a prospective cohort study by Jiajing Chen, Lixin Chen, Kexin Jiang, Dandan Wang, Chunyu Wu, Yuenong Qin, Sheng Liu

“…BackgroundChemotherapy-related cognitive impairment (CRCI) affects up to 75% of breast cancer patients during treatment, with 35% experiencing persistent post-treatment deficits. Current interventions show limited efficacy, creating urgent need for targeted therapies. …”
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Retrospective Analysis of Prognostic Factors and Pregnancy Outcomes in Patients with Moderate-to-Severe Intrauterine Adhesions Following Hysteroscopic Adhesiolysis and Modified Int... by Peng Q, Cao CX, Chen YN, Liu WC, Zhao RK, Jiang QJ, Zhou Q

“…A comprehensive follow-up period of 2 years post-stent removal was instituted.Results: The occurrence of adhesion recurrence increased progressively, demonstrating a recurrence rate of 11.54% at hysteroscopic reevaluation administrated in 3 months after surgery and surging to 32.69% during the 2-year follow-up period. …”
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Predicting IDH and 1p/19q molecular status of gliomas with multi-b values DWI by Shanshan Zhao, Peipei Wang, Eryuan Gao, Mengzhu Wang, Guang Yang, Shouhui Niu, Mengjiao Pan, Kai Zhao, Jingliang Cheng, Xiaoyue Ma

“…Multi-b-value DWI images were post-processed to generate parametric maps based on the mono-exponential (Mono), the intravoxel incoherent motion (IVIM), the stretched exponential model (SEM) and the continuous-time random walk (CTRW) models. …”
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Spatial Distribution of Cadmium in Avocado-Cultivated Soils of Peru: Influence of Parent Material, Exchangeable Cations, and Trace Elements by Richard Solórzano, Rigel Llerena, Sharon Mejía, Juancarlos Cruz, Kenyi Quispe

“…For data analysis, we applied (1) univariate statistics (skewness, kurtosis); (2) multivariate methods such as Spearman correlations and principal component analysis (PCA); (3) spatial modeling using the Geodetector tool; and (4) non-parametric testing (Kruskal–Wallis test with Dunn’s post hoc test). Our results indicated (1) the presence of hotspots with Cd concentrations exceeding 3 mg·kg⁻¹, displaying a leptokurtic distribution (skewness = 7.3); (2) dominant accumulation mechanisms involving co-adsorption and cation competition (Na⁺, Ca²⁺), as well as geogenic co-accumulation with Zn and Pb; and (3) significantly higher Cd concentrations in Leptosols derived from Cretaceous intermediate igneous rocks (diorites/tonalites), averaging 1.33 mg kg⁻¹ compared to 0.20 mg·kg⁻¹ in alluvial soils (<i>p</i> < 0.0001). …”
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Association between vitamin D receptor gene polymorphisms and athletic performance in Chinese male youth soccer players by Shidong Yang, Wei Zhang, Meng Jia, Haichun Chen

“…One-way analysis of variance and Bonferroni’s post hoc test were implemented to analyze the differences in parameters among groups, and statistical significance was set at p ≤ 0.05. …”
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Computer vision applications for the detection or analysis of tuberculosis using digitised human lung tissue images - a systematic review by Kapongo D. Lumamba, Gordon Wells, Delon Naicker, Threnesan Naidoo, Adrie J. C. Steyn, Mandlenkosi Gwetu

“…Conclusion The literature indicates that post 1950s, TB was predominantly studied using animal models even though no animal model reflects the full spectrum of human pulmonary TB disease and does not reproducibly transmit Mtb infection to other animals (Hunter, 2011). …”
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Evaluating the multitargeted potency of Pixuvri against cell cycle regulation proteins in cervical cancer by Mohammed Ali Alshehri, Hadil Alahdal, Akram Ahmed Aloqbi, Afnan Mohammed Shakoori, Ghadir Sindi, Rehab M. Bagadood, Nida Alsaffar, Mohammad Ahmad Alobaidy, Noof Abdulrahman Alrabiah, Md Khursheed, Abeer Al Tuwaijri, Abeer Al Tuwaijri

“…In this study, we screened Selleckchem approved library against cervical cancer proteins that regulate the cell cycle, particularly during mitosis and cell division (PDBIDs: 2VFX, 2WVI, 3KND, 4N14) using HTVS, SP, and XP docking followed by MMGBSA post-processing. Pixuvri (Pixantrone Maleate) emerged as the top candidate with docking scores of -5.234 to -9.218 kcal/mol and MMGBSA scores of -39.22 to -53.87 kcal/mol. …”
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A phase 4, open-label, multicenter study of the safety and efficacy of agalsidase beta in Chinese patients with Fabry disease by Hong Ren, Wei Zhang, Yan Ouyang, Junhong Guo, Hong Xu, Jie Ma, Xiaoping Luo, Xiaoxia Pan, Yun Yuan, Wei Zhang, Qian Shen, Bin Li, Qiqi Feng, Shi Liu, Nan Chen

“…The endpoints of efficacy included changes in plasma globotriaosylceramide (GL-3), globotriaosylsphingosine (Lyso-GL-3), symptoms and estimated glomerular filtration rate (eGFR) from baseline to week 48. A post-hoc subgroup analysis was conducted by age group (< 30 years and ≥ 30 years) and in patients with or without COVID-19 infection. …”
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Recurrent hyponatremia due to syndrome of inappropriate antidiuresis after traumatic brain injury: two case reports by Iulia Petria, Iulia Petria, Rita Indirli, Rita Indirli, Beatrice Mantovani, Valeria Lanzi, Valeria Lanzi, Giovanna Mantovani, Giovanna Mantovani, Emanuele Ferrante

“…Consistently, olanzapine-related hyponatremia could be ruled out and post-traumatic SIAD confirmed.Case 2A 37-year-old man experienced TBI with diffuse axonal injury falling during a mountain trip. …”
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Heart transplantation in patients undergoing extracorporeal cardiopulmonary resuscitation in in‑hospital cardiac arrest by V. N. Poptsov, E. A. Spirina, A. K. Solodovnikova, A. S. Epremyan, A. A. Kuznetsova, A. S. Ignatkina, G. B. Glinkin, S. A. Budagaev

“…The cause of death (n = 4; 15.3%) in the early post-HT period was irreversible multiple organ dysfunction.Conclusion. …”
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Plasma longitudinal metabolic changes with acute maximal aerobic exercise and one-hour recovery by William A. Fountain, Stefano Donega, Nirad Banskota, Ruin Moaddel, Mona Patel, Linda Zukley, Sarah Church, Katie Bustin, Josephine M. Egan, Josephine M. Egan, Jeremy Walston, Luigi Ferrucci

“…This study examined metabolic changes during each person’s peak aerobic exercise and one-hour post-exercise recovery in 29 Baltimore Longitudinal Study of Aging (BLSA) participants.MethodsBlood samples were collected at baseline, and at 3-min intervals during both incremental exercise on a treadmill until exhaustion and during recovery. …”
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From Breathlessness to Better Living: Transforming COPD Care with Home-Based Pulmonary Rehabilitation by Abins Thozhuthinkal Kasim, Ravi Gaur, Nitesh Manohar Gonnade, Nagma Sheenam, Chinchu Kolakkanni, Sarankumar Ganesan, Adharshna Thangamalai Kannan

“…Methods A prospective, single-arm pre–post interventional study was conducted among 62 COPD patients at All India Institute of Medical Sciences, Jodhpur. …”
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Therapeutic effects of Jing Si herbal tea for chronic obstructive pulmonary disease: a comprehensive investigation from clinical to basic research by Chou-Chin Lan, Chou-Chin Lan, Po-Chun Hsieh, Kuo-Liang Huang, Kuo-Liang Huang, Mei-Chen Yang, Mei-Chen Yang, Guan-Ting Liu, Chan-Yen Kuo, I.-Shiang Tzeng, Yao-Kuang Wu, Yao-Kuang Wu

“…Cellular studies on lipopolysaccharide (LPS)-stimulated A549 cells demonstrated that JSHT effectively reduced the release of DAMPs such as HMGB1, FPR1, and extracellular ATP, and decreased the expression of inflammatory markers including pMAPK, pJNK, NF-kB, and cCaspase 3, and pro-inflammatory cytokines like IL-1, IL-6, IL-8, and TNF-α post-LPS induction.ConclusionJSHT improved the HRQL in patients with COPD, both in stable and exacerbated states. …”
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