Caffeine’s influence on vertical jump height: a real-life collegiate student-athlete approach by Zacharias Papadakis, Vassilios Panoutsakopoulos, Antonella Schwarz, Jose Antonio

“…Participants ingested 5 mg/kg caffeine or placebo, followed by SJ and CMJ testing on a force platform 60 minutes post-consumption. Three trials per jump type were retained to preserve intra-individual variance. …”
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Association between Early Resistive Index Measurement and Early Graft Function and Long-Term Graft Survival after Kidney Transplantation: an Evidence-based Clinical Review by Pande Made Wisnu Tirtayasa, Gede Wirya Kusuma Duarsa, Gerhard Reinaldi Situmorang, I Wayan Yudiana, Kadek Budi Santosa, Anak Agung Gde Oka, Arry Rodjani, Nur Rasyid

“…However, these studies were using RI measurement in the later stages post transplantation. The present study has conducted to identify the association between early RI measurement and early graft function represented as delayed graft function (DGF) and immediate graft function (IGF), as well as long-term graft survival. …”
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Targeting degradation of IKZF1 and IKZF3 through modulation of the E3 ligase substrates in the context of cellular therapies for multiple myeloma by David Kegyes, Anamaria Bancos, Adrian Bogdan Tigu, Ioana Rus, Delia Dima, Diana Cenariu, Madalina Nistor, Raluca Munteanu, Diana Gulei, Alina Tanase, Anca Colita, Anca Buzoianu, Cristina Iuga, Mihnea Zdrenghea, Evangelos Terpos, Stefan O. Ciurea, Aaron Ciechanover, Hermann Einsele, Ciprian Tomuleasa

“…In this paper, based on the literature presented at the Annual Meeting of the American Society of Hematology (ASH), the American Society of Clinical Oncology (ASCO), the International Myeloma Society (IMS), and the European Hematology Association (EHA) in the 2020–2025 timeframe, we explore the rationale and emerging evidence of combining CELMoDs with immunotherapies, and their use as a bridge to transplant or as post-ASCT maintenance therapy in MM.…”
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Diagnostic Value of F-FDG PET/CT Radiomics in Lymphoma: A Systematic Review and Meta-Analysis by Chaoying Liu MD, Jun Zhao PhD, Heng Zhang PhD, Xinye Ni PhD

“…The Fagan nomogram showed an absolute increase of 34% in the post-test probability following a positive test result. …”
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Activation of endogenous full-length utrophin by MyoAAV-UA as a therapeutic approach for Duchenne muscular dystrophy by Ruo Wu, Peng Li, Puhao Xiao, Shu Zhang, Xiaopeng Wang, Jie Liu, Wenjie Sun, Yue Chang, Xiuyi Ai, Lijiao Chen, Yan Zhuo, Jiaojian Wang, Zhengbo Wang, Shangang Li, Yuanyuan Li, Weizhi Ji, Wenting Guo, Shiwen Wu, Yongchang Chen

“…These benefits remain observable at six months post-treatment. In male nonhuman primates, systemic administration of MyoAAV-UA increases utrophin expression by twofold in skeletal muscle, with no significant side effects observed. …”
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Enhancing laparoscopic surgery training: a comparative study of traditional models and automated error detection system by Yitian Luo, Jingjie Wang, Zongting Yan, Jingjing He, Liye Fu, Shenghan Wang, Ying Han, Yaoyu Fu, Xiandi Wang, Kang Li, Rong Yin, Dan Pu

“…Results Group A demonstrated a 24% reduction in errors post-AEDS (mean: 78.1 to 59.4, p < 0.001), outperforming Group B (mean: 67.4, p < 0.001). …”
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A comparative bio-mechanical performance assessment of additively manufactured bone scaffolds using different beta Ti alloys and Gyroid based cellular structure by Mudassar Rehman, Yanen Wang, Kashif Ishfaq, Ray Tahir Mushtaq, Aqib Mashood Khan, Mohammed Alkahtani, Aamer Nazir, Maimoona Afzal

“…An exponential rise in demand for artificial implants has emphasized the need for novel biomaterials with good biocompatibility and mechanical properties comparable to human cortical and cancellous bone, to mitigate stress shielding and other post implantation challenges. This study investigated the processing performance of biomedical β-Ti alloys (Ti-12Ta-23Nb-24Zr, Ti-32Nb-25Zr) fabricated via Laser Powder Bed Fusion (L-PBF) under optimal working conditions. …”
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MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer by Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio

“…By performing a high‐throughput luciferase screening of 54 candidate miRNAs, we identified miR‐182‐3p as a specific and efficient post‐transcriptional regulator of TRF2. Ectopic expression of miR‐182‐3p drastically reduced TRF2 protein levels in a panel of telomerase‐ or alternative lengthening of telomeres (ALT)‐positive cancer cell lines. …”
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Dynamic changes of iron metabolism and the effectiveness of health education among apheresis donors in Guangzhou under the GLMM framework by CHEN Xiaowen, LI Fanhai, ZHONG Bi, LIU Guanghuan, CHEN Jinyan, WANG Hao, LI Shijie

“…After health education, Hb levels remained unchanged, but SF increased compared to pre-intervention levels (mean difference: -18.571, P<0.05), though a declining trend persisted compared to baseline (mean difference from baseline to post-intervention: 23.068,P<0.05). [Conclusion] Female and number of donations are primary factors contributing to SF reduction in apheresis donors. …”
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Study on Susceptibility and Infection Characteristics of Dengue Virus in Cells Sourced from Different Tissues of Tree Shrews by LIU Xin, QI Mengdi, WANG Wenguang, HAN Yuanyuan, LU Meili, LI Na, DAI Jiejie, LU Caixia

“…C6/36, Vero, A549, and BHK-21 cells (commonly used for DENV propagation) were used as positive controls. Over 6 days post-infection, cellular cytopathic effects were monitored at 12-hour intervals using an inverted microscope, viral RNA loads in cell lysates were quantified by real-time fluorescent quantitative PCR to generate proliferation curves, and viral titers were determined by plaque assay. …”
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Effects of integrating Feldenkrais method with dynamic neuromuscular stabilization exercises on clinical outcomes in older women with nonspecific chronic low back pain: A randomize... by Farzaneh Saki, Marziyeh Ziya

“…Assessments were conducted at baseline and post-intervention. Between-group differences were analyzed using analysis of covariance (ANCOVA) adjusted for baseline values, and paired t-tests were used to assess within-group changes (P≤0.05). …”
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Chronic lung tissue deposition of inhaled polyethylene microplastics may lead to fibrotic lesions by Wonkyun Jung, Mi-Jin Yang, Min-Sung Kang, Jin-Bae Kim, Kyung-Sik Yoon, Taekyung Yu, Cheolho Yoon, Hae Won Yang, Seong-Jin Choi, Eun-Jung Park

“…Given the expected increase in exposure to airborne microplastics, we here aimed to assess the acute and subchronic toxicity of inhaled polyethylene microplastics (PE-MPs). At 24 h post-exposure (0, 125, 250, and 500 μg/lung), PE-MPs were found within alveolar macrophages in the lungs of PE-MP-treated mice, along with an increase in the total number of pulmonary cells and higher pulmonary levels of LDH, CXCL-1, and CCL-2. …”
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Investigation of SiC MOSFET Structures for Surge Robustness in the Third Quadrant Under Various <inline-formula><tex-math notation="LaTeX">$V_{\text{GS}}$</tex-math></inline-formul... by Xinbin Zhan, Yanjing He, Xi Jiang, Hao Yuan, Qingwen Song, Xiaoyan Tang, Xiaowu Gong, Yuming Zhang

“…SiC JBSFET operates in a unipolar conduction mode prior to the surge current density threshold of 998.3 <inline-formula><tex-math notation="LaTeX">$\mathbf {A}/\mathbf {cm}^{\mathbf {2}}$</tex-math></inline-formula>, after which it transitions to a post-bipolar conduction mode, similar to SiC JBS diode. …”
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Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation by Man Yee Cheung, Chunmei Jiang, Imtiaz Ul Hassan, Hui Wang, Donghao Guo, Daniel Wuyang Dio, Huan Yan, Jianmin Sun, Xufeng Qi, Dongqing Cai, Wei Ge, Sheue-yann Cheng, Wai-Yee Chan, Hui Zhao

“…However, a comprehensive understanding of TH and its receptors, thyroid hormone receptors (TRs), orchestrating with other regulatory processes for heart regeneration, such as the hypoxia signaling pathway and post-injury metabolic switches, remains elusive. …”
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Acute suicidal ideation in context: highlighting sentiment-based markers through the diary entries of a clinically depressed sample by Damien Lekkas, Amanda C. Collins, Michael V. Heinz, Tess Z Griffin, Arvind Pillai, Subigya K. Nepal, Daniel M. Mackin, Andrew T. Campbell, Nicholas C. Jacobson

“…Entry results were grouped based on phase trajectory type, and the Kruskal-Wallis test was employed with post-hoc multiple hypothesis correction to statistically compare SEANCE features between all group pairs. …”
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Dexmedetomidine protects against N-Nitrosodiethylamine induced acute hepatic damage by modulating autophagy and apoptosis through SIRT1 by Ruixin Wu, Sailan Tang, Aoxue Xu, Qi Xue, Shuwen He, Qizhi Liao, Chanjuan Chen, Dachen Zhou, Xianwen Hu, Nianliang Zhang, Gang Li, Ye Zhang, Chunxia Huang

“…Histopathological changes, inflammatory and oxidative responses were assessed 24 h post-DEN exposure. The roles of autophagy and SIRT1 were further examined using hepatocyte-specific SIRT1 knockout mice (SIRT1f/fALBcre+/−). …”
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Randomised trial of assessing diagnostic yield in transbronchial biopsy with a guide sheath by Hao-Chun Chang, Yao-Wen Kuo, Ching-Kai Lin, Lih-Chyun Chang, You-Yi Chen, Ching-Yao Yang, Jung-Yien Chien, Chia-Lin Hsu, Tzu-Hsiu Tsai, Chao-Chi Ho, Jin-Yuan Shih, Chong-Jen Yu

“…The histopathology, cytology and microbiology yield rates, as well as procedure time and post-procedure adverse events, of the two groups were compared. …”
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Effects of rapid maxillary expansion and functional orthodontic treatment in children with sleep disordered breathing: a systematic review by Magdalena Piełunowicz, Jacek Kotuła, Krzysztof Kotuła, Mieszko Więckiewicz, Joanna Lis, Beata Kawala, Anna Ewa Kuc, Michał Sarul

“…The study design was defined in the PICO format—Population (P): non-syndromic prepubertal and adolescent patients requiring orthodontic treatment, who additionally have coexisting sleep disorders; Intervention (I): Orthodontic treatment of malocclusion with differentiated appliances; Comparison (C): evaluation of Apnea Hypopnea Index (AHI) and sleep questionnaires pre and post treatment; Outcome (O): effect of orthodontic treatment on sleep quality. …”
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Neutrophil- and Endothelial Cell-Derived Extracellular Microvesicles Are Promising Putative Biomarkers for Breast Cancer Diagnosis by Thayse Batista Moreira, Marina Malheiros Araújo Silvestrini, Ana Luiza de Freitas Magalhães Gomes, Kerstin Kapp Rangel, Álvaro Percínio Costa, Matheus Souza Gomes, Laurence Rodrigues do Amaral, Olindo Assis Martins-Filho, Paulo Guilherme de Oliveira Salles, Letícia Conceição Braga, Andréa Teixeira-Carvalho

“…In addition, the MVs of BC patients were analyzed before treatment and 6, 12, and 24 months post-treatment. Machine learning approaches were employed to determine the performance of MVs to identify BC and to propose BC classifier algorithms. …”
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Rationale and protocol of the LEAD 2.0 study: a randomized controlled trial assessing the feasibility of a virtually delivered 6-month exercise and nutrition intervention in older... by Bobby Neudorf, Noah Koblinsky, Krista Power, Malcom Binns, Alexandra J. Fiocco, Shlomit Rotenberg, Susan Marzolini, Paul Oh, Jane Thornton, Fatim Ajwani, Kylie Sullivan, Stéphanie Chevalier, Caryl Russell, Guylaine Ferland, Nicole D. Anderson, Laura E. Middleton

“…Assessments will be performed virtually at baseline, 6 months (post-intervention), and 12 months. Feasibility will be measured by recruitment rate, adherence, and retention. …”
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