Real world telehealth delivery of an evidence based self-management education program for people with epilepsy and cognitive comorbidity by Elaine T. Kiriakopoulos, Elaine T. Kiriakopoulos, Elaine T. Kiriakopoulos, Sarah J. Kaden, Lisa P. Sackett, Maureen T. Quigley, Trina Dawson, Laura DeMuro, Kathryn E. Giordano, Kathryn E. Giordano, Jessica DeNaples, Meredith E. Olenec, Stephanie Jennings, Ambereen Burhanuddin, Joanne Harris, Suzanne Lenz, Robert Ross-Shannon, Todd MacKenzie, Todd MacKenzie, Todd MacKenzie, Barbara Jobst, Barbara Jobst

“…This project examines the delivery of HOBSCOTCH outside of the research setting as it translates from science to service.MethodsPeople with epilepsy and subjective cognitive dysfunction (n = 205) enrolled in the HOBSCOTCH program over an 11-month period (3/11/24–2/12/25) and completed pre-and post-self-report assessments in which demographics, perceived cognition (Everyday Memory Questionnaire-Revised), quality of life (Quality of Life in Epilepsy-10), shared decision-making (CollaboRATE), and program satisfaction were measured.ResultsAfter completion of the 8-week HOBSCOTCH education program with a Cognitive Coach, participant quality of life and subjective cognition both significantly improved (p < 0.001). …”
Get full text

Randomised controlled trial of standard outpatient cardiac rehabilitation versus personalised cardiac rehabilitation for secondary prevention for all in need (SPAN) after type 1 my... by David Brieger, Tom Briffa, Julie Redfern, Derek P Chew, John Atherton, Jamie Rankin, Charley Budgeon, Andrew Maiorana, Anne Cordingley, Stephen Nicholls, Graham Hillis, Teagan Robinson, Tom Gilbert, Sam Lehman

“…This study aims to determine whether a programme of personalised cardiac rehabilitation achieves better completion rates compared with a routine outpatient rehabilitation model post-type 1 MI. A secondary aim is to determine any differences in rates of major adverse cardiovascular events at 12 months.Methods and analysis Secondary prevention for all in need (SPAN) is a prospective multisite single-blind comparative effectiveness randomised trial of personalised versus standard outpatient rehabilitation. …”
Get full text

Comparison of efficacy and safety between surgical and conservative treatments for hemorrhoids: a meta-analysis by Longfang Quan, Xuelian Bai, Fang Cheng, Jin Chen, Hangkun Ma, Pengfei Wang, Ling Yao, Shaosheng Bei, Xiaoqiang Jia

“…Conclusion Surgical treatments provide superior symptom relief, faster recovery, and lower recurrence but with some specific post-treatment complications, while conservative treatments are safer and less invasive but with provides slower symptom relief and higher recurrence rates. …”
Get full text

Umbilicoplastia: experiência com a técnica do minicírculo de pele Umbilicaplasty: experience with the skin mini-circle technique by José Carlos Daher, Alberto Benedik, César Augusto Daher Ceva Faria, Jefferson Di Lamartine Galdino Amaral, Jose Nava Rodrigues Neto, Ognev Meireles Cosac, Marcela Caetano Cammarota

“…RESULTS: The obtained results were considered satisfactory by the surgical team and the patients, without post operative problems that had require special care. …”
Get full text

Risk prediction model for waitlist mortality in patients with left ventricular assist devices by Anjan Tibrewala, MD, MS, Duc Thinh Pham, MD, Mo Hu, MS, Lucia C. Petito, PhD, Jonathan D. Rich, MD, Finn Gustafsson, MD, PhD, Theo M.M.H. de By, MBA, PhD, Kevin Veen, MD, PhD, Donald M. Lloyd-Jones, MD, ScM, Sanjiv J. Shah, MD

“…We considered 41 candidate predictors at 3 months post-implant. Univariate Fine-Gray models and 4 logistic regression techniques (logistic, LASSO, random forest, gradient boosting) were used to select variables for a final survival model using the Fine-Gray method. …”
Get full text

Struktur Mikroanatomi Hati dan Kadar Kolesterol Total Plasma Darah Tikus Putih Strain Wistar Pasca Suplementasi Minyak Lemuru dan Minyak Sawit by Ngudy Jaka Surasa, Nur Rahayu Utami, Wiwi Isnaeni

“…This study aimed to determine the micro-anatomy structure of liver and blood plasma total cholesterol level of white rats Wistar strain by post-oil supplementation of lemuru and palm oil. …”
Get full text

Is a wound drain needed routinely after anterior cervical discectomy and fusion? by Jude Geldart, BSc (Hons), MBChB, Katie Mathieson, MBChB (c), Sayan Biswas, MBChB (Hons), MRes (Dist), Ella Snowdon, BSc (Hons), MBChB, Ved Sarkar, BSc (c), Callum Tetlow, BSc, K. Joshi George, MBBS, MD, FRCS (Neurosurgery), FEBNS, FISS

“…Conclusions: Our study found no significant differences in the incidence of POHs or SSIs between post-ACDF patients with drains and those without, nor was there any difference in postoperative length of stay between the groups. …”
Get full text

Antiviral Activity of Double-Stranded Ribonucleic Acid and Interferon Alpha Composition in the Model of Experimental Influenza Infection of Mice by S. G. Gamaley, М. O. Skarnovich, E. V. Makarevich, О. Yu. Mazurkov, L. N. Shishkina, О. S. Ivanova, G. M. Levagina, Е. D. Danilenko

“…The study compositions were intranasally administered 3 hours before infection with influenza virus, as well as 1 and 3 days post infection. The doses of active components in the administered compositions were as follows: for dsRNA — 2.5 mg/kg, for IFN-alpha-2b — 500 IU/kg, 2500 IU/kg, or 5000 IU/kg. …”
Get full text

Prognostic factors for stent restenosis in patients with coronary artery disease undergoing percutaneous coronary intervention by M. А. Meshkova, I. A. Starodubtseva, A. A. Pashkova

“…In CAD patients 1-2 months post-PCI for ACS, restenosis development is associated with longer CAD duration, CKD stage 3A, use of BMS, and elevated Lp(a) levels >30 mg/dL, irrespective of achieving the target LDL-C level <1.4 mmol/L. …”
Get full text

Current status of nurses’ public health emergency response capacity for emerging infectious disease: a cross-sectional study by Qin Qiu, Qin Qiu, Yuntong Liu, Fanping Meng, Fanping Meng, Xinhua Wang, Chunxiang Su

“…ObjectivesThis study aimed to assess the current status of nurses’ public health emergency response capacity for emerging infectious diseases (EIDs) in tertiary hospitals in Beijing, explore the deficiencies of nurses’ emergency response capacity, and analyze the influencing factors in the post-epidemic era.MethodsA convenience sampling method was utilized to recruit registered nurses in 3 tertiary hospitals in Beijing from 27 August and 2 September 2024. …”
Get full text

Pharmacokinetics and Safety with Bioequivalence of Isosorbide Mononitrate Sustained-Release Tablets in Chinese Healthy Volunteers: Bioequivalence Study by Wu B, Wang W, Zhang Q, Yu G, Lin J, Zhang T, Ye L, Wang K, Zhang W, Wu X

“…Serial blood samples were collected over 36 hours post-dose (Days 1 and 6). The plasma concentrations of isosorbide mononitrate were measured using a high-performance liquid chromatography-tandem mass spectrometry method, and pharmacokinetic parameters were determined using noncompartmental methods.Results: Fifty-six healthy subjects were enrolled. …”
Get full text

Digitising the on-call medical team's patient list system: a QIP by Fahad-Bin Zahid

“…Feedback was collected after each cycle to address challenges and refine functionality, including: • Removal of unnecessary columns • Removal of the ‘low-priority’ category (eg, falls, social issues), because such patients were delayed for extended periods, raising clinical safety concerns; • Improved navigation by fixing headers and introducing alternate row colouring to support dyslexic users1–3; • Enhanced visibility for same-day emergency care department (SDEC) and patients who were post-take; • Created a video guide for staff and clarified the log-in process; • Created a secure folder for archived spreadsheets to improve data storage; • Developed an automatic timestamp for when details were entered.Efficiency gains: • Reduced handover times by 13.5 min (on average) per handover; • 73% of registrars reported improved workflow efficiency; • Features, such as live updates and centralised tracking, minimised information loss and streamlined referral management.Environmental impact: • Eliminated 100% of official paper-based referral list, aligning with NHS sustainability goalsUser satisfaction: • 91% of registrars preferred the electronic system. • 73% rated the system 8–10 for usabilityEquality impact: • The project had no adverse effects on any protected characteristic groups. …”
Get full text

Real-World Treatment Efficacy and Safety Profile of Sofosbuvir- and Velpatasvir-Based HCV Treatment in South Korea: Multicenter Prospective Study by Jae Hyun Yoon, Chang Hun Lee, Hoon Gil Jo, Ju-Yeon Cho, Jin Dong Kim, Jin Won Kim, Ga Ram You, Sung Bum Cho, Sung Kyu Choi

“…The primary endpoint was a sustained virological response at 12 weeks post-treatment (SVR12). Results: Among 101 patients treated with SOF/VEL, the mean age was 64.71 years, and 40.9% were male. …”
Get full text

A novel glycogene-related signature for prognostic prediction and immune microenvironment assessment in kidney renal clear cell carcinoma by Xuyan Zhao, Hanxiao Cui, Mingjing Zhou, Xueting Ren, Zihao Li, Peinan Liu, Danni Zhao, Shuai Lin, Huafeng Kang

“…Glycosylation is a key post-translational modification that is essential in cancer progression. …”
Get full text

Epidemiological Situation on Cholera in the Russian Federation in 2023 and Forecast for 2024 by A. Yu. Popova, A. K. Noskov, E. B. Ezhlova, V. D. Kruglikov, E. V. Monakhova, O. S. Chemisova, A. A. Lopatin, S. M. Ivanova, O. A. Podoynitsyna, A. S. Vodop’yanov, D. A. Levchenko, I. V. Savina

“…It was established that the toxigenic strains isolated from patients belonged to the currently dominant in the world “post-Haitian” group, including in India and Bangladesh, with the genotype ctxB7 tcpACIRS rtxA4a VSP-IIΔ0495-0512. …”
Get full text

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures by Alexandra M. Lish, Nancy Ashour, Richard V. Pearse, II, Paige C. Galle, Gwendolyn A. Orme, Sarah E. Heuer, Courtney R. Benoit, Kellianne D. Alexander, Elyssa F.L. Grogan, Gizem Terzioglu, Allegra Scarpa, Andrew M. Stern, Nicholas Seyfried, Vilas Menon, Tracy L. Young-Pearse

“…This model leverages cryopreserved cells, enabling co-cultures within 20 days post-thaw. Comparing monocultures and tricultures, we demonstrate how cell-cell interactions shape transcriptional and functional states across all three cell types. …”
Get full text

Functional Imaging of Liver Cancer (FLIC): Study protocol of a phase 2 trial of 18F-DCFPyL PET/CT imaging for patients with hepatocellular carcinoma. by Esther Mena, Joanna Shih, Joon-Yong Chung, Jennifer Jones, Atoosa Rabiee, Cecilia Monge, Baris Turkbey, Liza Lindenberg, Kilian E Salerno, Michael Kassin, Brad Wood, Jonathan Hernandez, Roberto Maass-Moreno, Babak Saboury, Neha Jakhete, Jason K Molitoris, Keith R Unger, Peter L Choyke, Freddy E Escorcia

“…Participants with histopathologic confirmation of HCC and a positive baseline 18F-DCFPyL-PET/CT will undergo a post-treatment 18F-DCFPyL-PET/CT during the first routine follow-up, typically within 4-8 weeks. …”
Get full text

A comparative study in the functional outcomes after conventional Deltopectoral approach vs. anterior deltoid split approach for fixation of proximal humerus fractures by Shradha A. Kulkarni, MS Orthopaedics, DNB Orthopaedics, Mansoor Malnas, Postgraduate Student-MS Orthopaedics (final year- 3rd year), Karan Bhanushali, MS Othopaedics, DNB Orthopaedics, Parag K. Munshi, MS Orthopedics, Dorth, DNB, MchOrth, FRCS (Gen Surg), FRCS (Orth)

Get full text

PRE-SURGERY STATUS AND IN-HOSPITAL COMPLICATIONS OF CORONARY BYPASS GRAFTING IN PREDIABETES AND TYPE 2 DIABETES PATIENTS by A. N. Sumin, N. A. Bezdenezhnykh, A. V. Bezdenezhnykh, A. V. Osokina, A. A. Kuzmina, О. V. Gruzdeva, О. L. Barbarash

“…Totally, 708 consecutive patients included, post coronary bypass grafting (CBG) in 2011-2012 in the SRI CICVS. …”
Get full text

Research of subpopulation CD3+ CD4- CD8- double-negative T lymphocytes in kidney transplant recipients by S. V. Zybleva, S. L. Zyblev

“…A kidney graft dysfunction in the late post-transplant period is characterized by a decrease in the blood level of CD3+CD4- CD8- T lymphocytes.Authors declare no conflict of interest.…”
Get full text