Responsiveness of the mini-balance evaluation systems test, dynamic gait index, Berg balance scale, and performance-oriented mobility assessment in parkinson’s disease by Maryam Mehdizadeh, Seyed-Mohammad Fereshtehnejad, Merrill R. Landers, Parvaneh Taghavi Azar Sharabiani, Mohsen Shati, Seyede Salehe Mortazavi, Sayed Amir Hasan Habibi, Korosh Mansoori, Mahsa Meimandi, Zahra Nodehi, Zakieh Sadat Saberi, Ghorban Taghizadeh

“…Participants underwent baseline and post-intervention assessments using the Mini-BESTest, DGI, BBS, and POMA. …”
Get full text

Clinical insights into the role of bepridil in recurrence prevention after ablation of persistent atrial fibrillation by Moyuru Hirata, Koichi Nagashima, Ryuta Watanabe, Yuji Wakamatsu, Naoto Otsuka, Shu Hirata, Masanaru Sawada, Yuji Saito, Sayaka Kurokawa, Kenta Murotani, Yasuo Okumura

“…Among them, 162 received bepridil for 3 months post‐ablation (Bepridil group), while 70 received no antiarrhythmic drugs (No‐AADs group). …”
Get full text

Effectiveness, enjoyment, and meaningfulness of a virtual reality gait-based fall prevention exergame in community-dwelling healthy older adults: an interdisciplinary pilot study by Celina Ciemer, Celina Ciemer, Nadja Schott, Thomas Jürgen Klotzbier, Sabiha Ghellal

“…Over three weeks, the intervention group completed two 60-min sessions weekly. Baseline, mid-, and post-assessments included single- and dual-task gait (instrumented normal and tandem walks, counting task), lower limb strength and transitional movement (instrumented Five Times Sit-to-Stand test, 5xSTS), and static postural control (instrumented sway tests). …”
Get full text

Resilience in the shadows of loss: a hermeneutic phenomenological study of neonatal intensive care nurses’ coping after infant loss in Saudi Arabia by Nadia Bassuoni Elsharkawy, Osama Mohamed Elsayed Ramadan, Alaa Hussain Hafiz, Nouran Essam Katooa, Areej Abunar, Dena Marwan A. Attallah, Mashael Dewan, Majed Mowanes Alruwaili, Abeer Nuwayfi Alruwaili, Enas Mahrous Abdelaziz, Arab Qassim Alkhadam, Marwa Mohamed Ouda

“…Results Four thematic domains characterized NICU nurses’ experiences: (1) Emotional Processing of Loss (initial grief, disenfranchised professional grief, cultural-religious interpretations); (2) Adaptive Coping (faith-based practices, selective detachment, end-of-life ritualization, meaning-making through family support); (3) Resilience Development (career-stage evolution, professional identity integration, post-traumatic growth); and (4) Contextual Influences (institutional support disparities, multicultural team dynamics, resource constraints). …”
Get full text

Oregano-based feed additive reduces Salmonella enterica serovar Enteritidis colonization in young broilers by Christina L. Swaggerty, M. Dolores Cabrera, Santiago Sasia, Gabriel Cabrera, Kenneth J. Genovese, J. Allen Byrd, II, Michael H. Kogut, Rafael A. Cabrera

“…At 7-days-of-age, chicks were challenged via oral gavage (0.5 mL) with Salmonella enterica serovar Enteritidis (1 × 104-5 colony forming units [cfu]/chick). Fourteen-days post-challenge (dpc), 50 birds from each group were euthanized. …”
Get full text

Long-term clinical comparison of three different femoral stems in Total Hip Arthroplasty with femoral shortening in patients with high-riding hips by Kutalmis Albayrak, Yakup Alpay, Ozgur Ismail Turk, Muhammed Mert, Deniz Akbulut, Akif Albayrak

“…One-way ANOVA was used to compare continuous variables among groups, and post-hoc Tukey’s HSD test was applied for pairwise comparisons. …”
Get full text

Muscle fat content correlates with postoperative survival of viral-related cirrhosis patients after the TIPS: a retrospective study by Sai Li, Yong Li, Chunhui Zhou, Haiping Li, Yazhuo Zhao, Xiaoping Yi, Changyong Chen, Changli Peng, Tianming Wang, Fei Liu, Juxiong Xiao, Liangrong Shi

“…The aim of this study is to explore a comprehensive prognostic assessment model for evaluating the survival outcomes of patients post-TIPS.Materials and methods A total of 155 patients treated with TIPS were included in the study. …”
Get full text

A Review on Innovative Biotechnological Approaches for the Upcycling of Citrus Fruit Waste to Obtain Value-Added Bioproducts§ by Mahalingam Divyasakthi, Yerasala Charu Lekha Sarayu, Dilip Kumar Shanmugam, Guruviah Karthigadevi, Ramasamy Subbaiya, Natchimuthu Karmegam, J. Jessica Kaaviya, Woo Jin Chung, Soon Woong Chang, Balasubramani Ravindran, Kuan Shiong Khoo

Get full text

Changes of PGC-1α/TFAM signaling pathway and mitochondrial dysfunction of renal tubular epithelial cells during sepsis-associated acute kidney injury by Xiao Zhen-meng, Li Zhi-lian, Dong Wei, Zhang Meng-xi, Chen Yuan-han, Li Rui-zhao, Liang Xin-ling

“…Objective To explore the changes of signaling pathways of peroxisome proliferator-activated receptor γ coactivator 1α and mitochondrial transcription factor A and mitochondrial damage in renal tubular epithelial cells during sepsis-associated acute kidney injury（AKI）.Methods A murine model of septic AKI model was established after 8-10-week-old male C57 BL/6 mice received an intraperitoneal injection of lipopolysaccharide（LPS;10 mg/kg）.Serum levels of urea nitrogen, creatinine and kidney injury molecule 1 were measured at 24 h post-injection.Renal pathological damage was observed after periodic acid-Schiff（PAS）stain.Electron microscope was employed for observing the changes of mitochondrial morphology and count in proximal renal tubular epithelial cells.Western blot and real-time fluorescent quantitative polymerase chain reaction（PCR）were employed for detecting the mRNA/protein expression levels of LC3 II,p62,PGC-1α,TFAM and the ratio of mitochondrial DNA to nuclear DNA.In LPS-induced endotoxemia AKI model of renal tubular epithelial cell, PGC-1α and TFAM were measured by Western blot, RT-qPCR and immunofluorescence.MTT was utilized for detecting cell viability; mitochondrial membrane potential observed by JC-1;mitochondrial morphological change detected by MitoTracker and mitochondrial superoxide content assessed by Mito-SOX^TM.Results As compared with control group, blood urea nitrogen, serum creatinine and kidney injury molecule 1 spiked markedly in model group.And proximal renal tubular epithelial cells had mild vacuolar degeneration and a greater transcription of inflammation and oxidative stress factors such as IL-1β,IL-6 and HMGB1.Under electron microscope, mitochondria in proximal renal tubular epithelial cells in model group became obviously swollen and rounded with broken ridges and more autophagosomes and the expressions of autophagy marker proteins LC3 II and p62 were up-regulated in kidney tissue（P<0.05）and the mRNA/protein expressions of PGC-1α and TFAM declined markedly（P<0.05）.The ratio of mitochondrial DNA to nuclear DNA（mtDNA:nDNA）declined in renal cortex tissues of LPS-injected mice as compared with control mice（P<0.05）.In vitro LPS stimulation lowered HK-2 cell viability and boosted mitochondrial dysfunction.The protein expressions of PGC-1α and TFAM declined with the rising concentration of LPS in HK-2 cells（P<0.05）.Conclusion The signaling pathway of PGC-1α/TFAM may be a novel intervention target for septic AKI.…”
Get full text

Optimizing unsupervised feature engineering and classification pipelines for differentiated thyroid cancer recurrence prediction by Emmanuel Onah, Uche Jude Eze, Abdullahi Salahudeen Abdulraheem, Ugochukwu Gabriel Ezigbo, Kosisochi Chinwendu Amorha, Fidele Ntie-Kang

“…Accurate recurrence prediction is critical for guiding post-treatment strategies. This study aimed to enhance predictive performance by refining feature engineering and evaluating a diverse ensemble of machine learning models using the UCI DTC dataset. …”
Get full text

Pregnancy after breast cancer treatment in young patients by Young-Jin Lee, Tae-Kyung Yoo, Sae Byul Lee, Jisun Kim, Il-Yong Chung, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Seonok Kim, Hee Jeong Kim

“…The primary outcomes included post-treatment pregnancy rates, factors associated with subsequent pregnancy, timing of conception, pregnancy outcomes, and oncologic outcomes among those who conceived.ResultsThe median age was 32 years (interquartile range [IQR], 30–34 years). …”
Get full text

Targeted inhibition of macrophage STING signaling alleviates inflammatory injury and ventricular remodeling in acute myocardial infarction by Huan Yao, Qingman He, Shujun Wei, Li Xiang, Yuanyuan Luo, Cong Huang, Weiwei Liu, Chuan Zheng, Xueping Li, Yongxiang Gao

“…These findings establish the mtDNA–STING axis in macrophages as a critical driver of post-AMI inflammation and identify pharmacological STING inhibition with PTS as a promising therapeutic strategy. …”
Get full text

Exploring the publication gap in pediatric randomized clinical trials: completed vs. uncompleted pediatric clinical trials by Katerina Nebeska, Katerina Nebeska, Lenka Souckova, Lenka Souckova, Lenka Souckova, Lenka Souckova, Radka Stepanova, Regina Demlova, Regina Demlova

“…Of 908 completed RCTs, 58.48% posted results in registries, while 70% had results published in peer-reviewed journals. …”
Get full text

Effect of a structured Orem’s self-care model nursing intervention on sleep quality and academic self-efficacy in nursing students by Mir Amirhossein Seyednazari, Kourosh Amini, Farhad Ramezani-Badr, Abdolah Khorami Markani

“…Methods This quasi-experimental study employed a pre-test and post-test control group design to evaluate the intervention’s effects. …”
Get full text

Toll-like Receptor 9 Mediates Epstein–Barr Virus-Aggravated Inflammation in a Mouse Model of Inflammatory Bowel Disease by Hassan F. Nour Eddine, Aya M. Kassem, Zahraa Salhab, Nour Sherri, Karen Moghabghab, Zahraa Mohsen, Georges Naim, Sally Mahmoud, Abdo Jurjus, Jana G. Hashash, Elias A. Rahal

“…<b>Methods</b>: Three days post colitis induction, EBV particles were intra-rectally injected into female C57BL/6J mice, followed by the intra-peritoneal administration of TLR9 inhibitor. …”
Get full text

High-vacuum laser treatments enhance strength, ductility and fatigue limit of additively manufactured stainless steel by Juan Guillermo Santos Macías, Kewei Chen, Alexandre Tanguy, Nathalie Isac, Maxime Vallet, Louis Cornet, Vincent Michel, Manas Vijay Upadhyay

“…Post-process laser scanning under high vacuum is proposed as a non-isothermal heat treatment to simultaneously refine the intragranular microstructure near the surface and reduce surface roughness, while preventing oxidation, to enhance the mechanical response of an alloy. …”
Get full text

Effects of Blighia sapida arils oil consumption on hemoglobin, serum proteins, and some vital organs in Wistar rats by Aklesso Nabede, Haziz Sina, Tiatou Souho, Mamatchi Mélila, Batcha Ouadja, Hafiz A. Salami, Sylvestre A. Assogba, Adolphe Adjanohoun, Lamine Baba-Moussa, Kou'santa Amouzou

Get full text

Survivorship in robotic total knee arthroplasty compared with conventional total knee arthroplasty: A systematic review and meta-analysis by Jiawei Chen, Ryan Wai Keong Loke, Katelyn Kaye-Ling Lim, Barry Wei Loong Tan

“…Secondary outcomes included associated complications, post-operative pain scores, and functional outcomes. …”
Get full text

Chlorinated biscoumarins inhibit chikungunya virus replication in cell-based and animal models by Chidinma Nelson Orji, Naphat Loeanurit, Van-Can Pham, Thi-Hong-Truc Phan, Kowit Hengphasatporn, Yasuteru Shigeta, Altri Diana Putri, Laura Sandra Lello, Andres Merits, Noppadol Wacharachaisurapol, Wanna Eiamart, Supeecha Wittayalertpanya, Tanatorn Khotavivattana, Warinthorn Chavasiri, Siwaporn Boonyasuppayakorn

“…Time-of-addition and replicon assays suggested that both compounds act at a post-entry step, likely inhibiting viral RNA replication. …”
Get full text

Application of granular and ozone-biological activated carbon treatments for the mitigation of organic chemical peaking events in potable water schemes by George William Kajjumba, Ceonie M.M. Washington, Aarthi Mohan, Zita L.T. Yu, Larry Schimmoller, Jesus Gonzalez, R. Scott Summers, Eric R.V. Dickenson

“…These preliminary results suggest GAC post-RO can mitigate haloalkane and ether-like VOC peaks, although real-world monitoring and long-term pilot testing are needed. …”
Get full text