Economic evaluation of a lifestyle intervention for individuals with overweight or obesity suffering from chronic low back pain (the BO2WL trial): a protocol for a health economic... by Jo Nijs, Anneleen Malfliet, Ron Clijsen, Heiner Baur, Jan Taeymans, Peter Clarys, Alexander Philipp Schurz, Tom Deliens, Melanie Liechti, Matteo Vanroose, Wouter Van Bogaert, Nathanael Lutz

“…This protocol outlines the details of the economic evaluation of this trial.Methods and analysis The trial consists of a 14-week intervention followed by a 52-week post-intervention follow-up. Primary outcomes include direct and indirect costs, as well as quality-adjusted life years and pain intensity. …”
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Initial community response to a novel spatial repellent for malaria prevention in Busia County, Kenya by Sheila Muya Ekodir, Lucy Baker, Julius I. Odero, Jane Klein A. Ikapesi, Moureen Ekisa, Albert Casella, April Monroe, Anna Passaniti, Eric Ochomo, Steven A. Harvey

“…This analysis focuses on initial responses recorded one week and two months post-installation. The data were analysed using thematic coding, with researchers blinded to trial arm assignment. …”
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Preparation and Evaluation of Alpha-2-Macroglobulin Hydrogel for Drug Release Kinetics and Biocompatibility on Human Gingival Fibroblasts: An In-vitro Study by Poulami Chakraborty, ND Jayakumar, S Raghunandhakumar

“…Intergroup comparisons were performed using one-way ANOVA, followed by Tukey’s post hoc test for pairwise analysis. A p-value of ≤0.05 was considered statistically significant. …”
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Evaluating the Effect of Drug Provocation Tests on Anxiety and Hopelessness Levels by Gürgün Tuğçe Vural Solak, Kurtuluş Aksu, Melis Yağdıran, Fatma Dindar Çelik, Özgür Akkale, Onur Telli, Hatice Çelik Tuğlu, Nur Betül Baştuğ İnan, Özge Göktürk, Yavuz Karahan, Yavuzalp Solak

“…Demographic and clinical data, pre- and post-DPT scores, the status of using the medication provided after DPT, and the reason for not using it were analyzed. …”
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Achieving health-promotion practice in primary care using a multifaceted implementation strategy: a non-randomized parallel group study by Ylva Elisabet Nilsagård, Daniel Robert Smith, Fredrik Söderqvist, Emma Nilsing Strid, Lars Wallin

“…The effect increased during the active phase, with the intervention sites having on average 1.07 and 2.0 times the uptake rate of the control sites at 1 and 12 months, respectively; this effect was largely maintained during the 6-month post-intervention phase. A significant absolute effect, in terms of difference in predicted uptake per 1000 visits, was evident 7 months into the implementation phase. …”
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Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression by Aditya Singh, Mandakh Bekhbat, David R. Goldsmith, Ngoc-Anh Le, Evanthia C. Wommack, Zhihao Li, Ebrahim Haroon, Jennifer C. Felger

“…A composite score of lipid-related biomarkers (with increasing values reflecting higher concentrations) also precited anhedonia response (post-treatment minus baseline) to infliximab (r = −0.46, p < 0.05) but not placebo (r = 0.14, p = 0.56). …”
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A novel structural modeling magnitude and orientation radiomic descriptor for evaluating response to neoadjuvant therapy in rectal cancers via MRI by Charlems Alvarez-Jimenez, Jacob T. Antunes, Thomas DeSilvio, Zhouping Wei, Marwa Ismail, Joseph E. Willis, Emily Steinhagen, Andrei Purysko, David Liska, Smitha Krishnamurthi, Marka Crittenden, Michael Gough, Kristina Young, Anant Madabhushi, Eduardo Romero, Pallavi Tiwari, Satish E. Viswanath

“…Combined with traditional radiomic texture features, StODeO showed superior performance in distinguishing pathologic response groups of rectal cancer patients post-chemoradiation (hold-out validation AUC 0.77) as well as segregating composite response groups in a clinical trial of immune checkpoint inhibitors (external validation accuracy 0.71; NCT02688712). …”
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Intestinal inflammation disrupts energy metabolism in layer pullets: insights into energy partitioning and intestinal metabolomic profiling by Qiuyu Jiang, Bingjian Huang, Simiao Chen, Lihua Zhao, Zhibin Ban, Bingkun Zhang

“…After the calorimetry, intestinal tissues were collected post-euthanasia from one bird per replicate for morphological and mucosal metabolomic analysis. …”
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A Brief Report on a Systematic Review of Real-World Effectiveness Studies of ICS/LAMA/LABA for Treatment of Adults with Asthma in the US by Stephen G. Noorduyn, Kejsi Begaj, Amber Martin, Sergio Forero-Schwanhaeuser, Kassandra Schaible, Alison Moore, Rosirene Paczkowski

“…The proportion of patients with ≥ 1 rescue OCS dispensing decreased with TIO 1.25 mcg + ICS + LABA MITT, with greatest reductions for MITT ± leukotriene receptor antagonist (pre-treatment: 68.4%, post treatment: 54.2%). Mean number of OCS dispensings/patient/year significantly decreased (29%, p < 0.001) following FF/UMEC/VI 100/62.5/25 mcg SITT initiation. …”
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Development of a toxin-selective immunotracer for in vivo detection of Clostridioides difficile infection by immunoPET by Mario González-Arjona, Lorena Cussó, Luis Alcalá, María Isabel González, Alexandra de Francisco, María Jesús Fernández-Aceñero, Dag Sehlin, Stina Syvänen, Emilio Bouza, Patricia Muñoz, Manuel Desco, Beatriz Salinas

“…Results The monoclonal antibody bezlotoxumab, was radiolabeled with [125I]I for in vitro characterization and with [89Zr]Zr for in vivo PET imaging, resulting in high radiochemical yields (75.36 ± 4.11% for [125I]I and 71.58 ± 8.19% for [89Zr]Zr) and purities (> 99.99% in both cases), with stable binding properties. PET/CT imaging 48 h post-infection in an animal model of CDI (C57BL/6 mice and ribotype 027 strain) demonstrated specific accumulation of [89Zr]Zr-DFO-Beztxab in the colon and cecum of infected mice, thus making it possible to distinguish CDI from dysbiosis without specific C. difficile infection and healthy controls. …”
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Disruption of reproductive and thyroid endocrine systems in zebrafish following early life and whole life cycle exposure to low-dose norgestrel by Shuyan Mai, Weicai Hu, Yan-Qiu Liang, Zhongdian Dong, Chang-Gui Pan, Zhiyun Liu, Runting Ouyang, Yangjie Zeng, Zhong Lin, Liping Hou

“…In this study, zebrafish embryos were exposed to low NGT concentrations (9 and 66 ng/L) for 90 days post-fertilization (dpf), covering embryonic-juvenile (0–30 dpf) and juvenile-adult stages (31–90 dpf, with/without continuous exposure to NGT). …”
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Student Perceptions and Effectiveness of Video-Based Flipped Classroom for Improving Medical Physiology Teaching at AUSOM by Kottath Veetil P, Kollukkad Mani M, Arja SB, Paramban S, Kattambally PA, Fatteh R, Arja SB

“…Hundred short instructional videos were created and integrated into 65 Physiology sessions. Pre- and post-implementation surveys assessed students’ perceptions and the effectiveness of VBFC. …”
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Neuroprotective effects of creatine supplementation in mild TBI management among contact sport athletes: A scoping review by John E. Giraldo, Diego A. Bonilla, Luis F. Bedoya, Katherine F. Hoyos, Santiago G. Velasquéz, Mayra M. Márquez, Jorge L. Petro

“…Studies that did not report metabolic or neurocognitive outcomes were excluded.Results A total of 52 studies were found, four studies met all the inclusion criteria two of the four studies focused on animal models, and two on contact sport athletes; in animal models (rats and mice), creatine supplementation significantly reduced lactate accumulation and post-injury tissue damage, indicating a potential neuroprotective effect. …”
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Prebiotic, probiotic and marine algae suplementation in juvenile tilapia diet by Maria José T. Ranzani-Paiva, Danielle de Carla Dias, Raissa Bertoncello Cavalcante, Guilherme Telli, Eliana Oshiro, Carlos Massatoshi Ishikawa, Maria Letizia Petesse, Miguel Frederico Fernandez-Alarcon, Mariene Miyoko Natori, Miguel Angel Moriñigo, Silvana Tapia, Said Ben Hamed, Leonardo Tachibana

“…For the challenge experiment, the fish were fed for 21 days, infected via intraperitoneal injection with A. hydrophila (1 x 106 UFC·mL-1), and the mortality rate was registered for 15 days post-infection. Results indicated the capacity of probiotic to remain in the gut for 63 days, and it was inhibited neither by autochthonous microbiota nor by prebiotics used. …”
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Subtypes I and II of <i>Ulva prolifera</i> O.F. Müller: Dominant Green Tide Species in the Southern Yellow Sea and Their Responses to Natural Light and Temperature Conditions by Shuang Zhao, Jinlin Liu, Zhangyi Xia, Jingyi Sun, Jianheng Zhang, Peimin He

“…Pre-co-culture photosynthetic profiling demonstrated Subtype I’s superior quantum efficiency (α = 0.077 vs. 0.045) with marked differences in regulated energy dissipation (YNPQ) and non-photochemical quenching (NPQ). Post-co-culture physiological adaptation was evident in Subtype II, showing significant elevation of non-regulated energy dissipation quantum yield (YNO) and eventual surpassing of maximum electron transport rate (ETRmax) compared to Subtype I. …”
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Differential Effects of Electroconvulsive Therapy on Patients with Schizophrenia Versus Depressive Disorder: Clinical Distinction Between Antipsychotic and Antidepressant Effects o... by Naho Nakayama, Tatsuo Nakahara, Hideyuki Iwanaga, Manabu Hashimoto, Takako Mitsudo, Yoshiomi Imamura, Hiroko Kunitake, Yoshito Mizoguchi, Takefumi Ueno

“…We aimed to compare pre- and post-ECT treatment outcomes between patients with SCZ and a combined group of patients with MDD and BD (MDD+BD) to assess the distinction between the antipsychotic and antidepressant effects of ECT. …”
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Single-cell analysis of dup15q syndrome reveals developmental and postnatal molecular changes in autism by Yonatan Perez, Dmitry Velmeshev, Li Wang, Matthew L. White, Clara Siebert, Jennifer Baltazar, Guolong Zuo, Juan Andrés Moriano, Songcang Chen, David M. Steffen, Natalia Garcia Dutton, Shaohui Wang, Brittney Wick, Maximilian Haeussler, Stormy Chamberlain, Arturo Alvarez-Buylla, Arnold Kriegstein

“…Using single-cell and single-nucleus RNA sequencing of cortical organoids from dup15q patient-derived iPSCs and post-mortem brain samples, we identify increased glycolysis, disrupted layer-specific marker expression, and aberrant morphology in deep-layer neurons during fetal-stage organoid development. …”
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Transcriptomic analysis reveals long non-coding RNA involved in the key metabolic pathway in response to Botrytis cinerea in kiwifruit by Yijia Ma, Tianjing Zeng, Zhexin Li, Dengwei Jue, Yuan Sui, Xu Wang, Hongpan Zhong, Jiaqi Yang

“…Results Our study aimed to identify lncRNAs induced by B. cinerea infection in ‘Hongyang’ kiwifruit at 0 to 3 days post-inoculation (dpi) through high-throughput sequencing. …”
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A randomized controlled trial to test the efficacy of trans-tympanic injections of a sodium thiosulfate gel to prevent cisplatin-induced ototoxicity in patients with head and neck... by Viannique Rolland, François Meyer, Matthieu J. Guitton, Richard Bussières, Daniel Philippon, Isabelle Bairati, Mathieu Leclerc, Mathieu Côté

“…On the day before the beginning of CCR, eligible and consenting patients were randomized to receive a trans-tympanic injection of the gel either in the left ear or in the right ear. A final post-treatment complete audiometric evaluation was scheduled to be performed 1 month after the end of CCR by audiologists kept blind to the ear assignment. …”
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Understanding Safety in Online Mental Health Forums: Realist Evaluation by Paul Marshall, Neil Caton, Zoe Glossop, Steven Jones, Rachel Meacock, Paul Rayson, Heather Robinson, Fiona Lobban

“…ResultsSurvey responses revealed that over half of the participants felt safe to post because of online anonymity (n=202, 40.1% agreed and n=97, 19.2% strongly agreed), while a minority reported encountering distressing forum posts (n=95, 18.8% agreed and n=18, 3.6% strongly agreed) and expressed concern that talking about mental health online could make them feel worse (n=113, 22.4% agreed and n=17, 3.4% strongly agreed). …”
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