The effect of heat-sensitive moxibustion in the elderly with nocturia: protocol for a randomized controlled trial by Jinhua Geng, Jinhua Geng, Xintong Ma, Yihui Lin, Qiaoli Lin, Qiaoli Lin, Kaitian Wen, Kaitian Wen, Chunyan Ruan, Chunyan Ruan, Zunjiang Li, Zunjiang Li, Zhaofan Mo, Shuang Li, Banghan Ding, Banghan Ding, Na Liu, Na Liu

“…These assessments will be conducted at baseline, post-intervention and at the 2-month follow-up to comprehensively evaluate the effectiveness and safety of HSM.DiscussionIn this study, we aim to quantitatively analyse the therapeutic effect and safety of HSM on nocturia in the elderly, clarify the amount of moxibustion, the distribution pattern of heat-sensitized acupoints, the frequency of heat-sensitized acupoints, and the moxibustion sensation for the treatment of senile nocturia, which can bring insights into future clinical treatments.…”
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COP1 Deficiency in BRAF^V600E Melanomas Confers Resistance to Inhibitors of the MAPK Pathway by Ada Ndoja, Christopher M. Rose, Eva Lin, Rohit Reja, Jelena Petrovic, Sarah Kummerfeld, Andrew Blair, Helen Rizos, Zora Modrusan, Scott Martin, Donald S. Kirkpatrick, Amy Heidersbach, Tao Sun, Benjamin Haley, Ozge Karayel, Kim Newton, Vishva M. Dixit

“…These observations indicate that the post-translational regulation of ETV5 by CRL4^COP1/DET1 modulates transcriptional outputs in ERK-dependent cancers, and its inactivation contributes to therapeutic resistance.…”
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Unraveling progressive verbal memory deficits in Huntington’s disease: insights from the LASSI-L by Luis A. Sierra, Japleen Kaur, Samuel A. Frank, Samuel A. Frank, Mark A. Halko, Mark A. Halko, Rosie E. Curiel Cid, David A. Loewenstein, Jody Corey-Bloom, Simon Laganiere, Simon Laganiere

“…Group comparisons on the LASSI-L were assessed using multiple ANCOVAs adjusting for age, followed by post-hoc pairwise comparisons and a Bonferroni correction.ResultsSequential group differences for susceptibility to interference effects were observed on the LASSI-L. …”
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Exploring the roles of snoRNA-induced ribosome heterogeneity in equine osteoarthritis by Alzbeta Chabronova, Marie Walters, Sara Regårdh, Stine Jacobsen, Louise Bundgaard, James R. Anderson, Mandy J. Peffers

“…SnoRNAs are short non-coding RNAs that guide post-transcriptional modifications (PTMs) of ribosomal RNA (rRNA) nucleotides, which impact ribosome function and thus cellular protein expression programs. …”
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Epiregulon: Single-cell transcription factor activity inference to predict drug response and drivers of cell states by Tomasz Włodarczyk, Aaron Lun, Diana Wu, Minyi Shi, Xiaofen Ye, Shreya Menon, Shushan Toneyan, Kerstin Seidel, Liang Wang, Jenille Tan, Shang-Yang Chen, Timothy Keyes, Aleksander Chlebowski, Adrian Waddell, Wei Zhou, Yangmeng Wang, Qiuyue Yuan, Yu Guo, Liang-Fu Chen, Bence Daniel, Antonina Hafner, Meng He, Alejandro Chibly, Yuxin Liang, Zhana Duren, Ciara Metcalfe, Marc Hafner, Christian W. Siebel, M. Ryan Corces, Robert Yauch, Shiqi Xie, Xiaosai Yao

“…Gene regulatory networks (GRNs) can evaluate pharmacological agents and identify drivers of disease, but methods that rely solely on gene expression often neglect post-transcriptional modulation of TFs. We present Epiregulon, a method that constructs GRNs from single-cell ATAC-seq and RNA-seq data for accurate prediction of TF activity. …”
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HEMOSTATIC SYSTEM CONDITION AND HEART REMODELING IN PATIENTS WITH Q-WAVE MYOCARDIAL INFARCTION WITH ACUTE ANEURYSMS AND LEFT VENTRICLE THROMBUS by V. D. Syvolap, S. M. Kyselov

“…However, keeping in mind the pathogenetic features of myocardial defeat of the left ventricle (LV cavity dilation and thinning at the focus of myocardial infarction), which increase the risk of left ventricular aneurysm development and parietal thrombus formation, it is impossible to reduce significantly the risk of these serious complications development. Post-infarction left ventricular aneurysm, extremely unfavorable prognostic factor complicates the course of Q-wave myocardial infarction in 30% of cases. …”
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Changes in the ocular surface and meibomian glands following administration of 0.01 and 0.02% atropine by Xueyan Li, Yanying Zhu, Haiyan Xie, Yuexin Chen, Yukun Liu, Xiaochen Xu, Jing Wang

“…PurposeTo investigate the changes in the ocular surface and meibomian glands following the administration of 0.01 and 0.02% atropine.SettingThe Second Affiliated Hospital of Anhui Medical University, Anhui, China.MethodsIn this randomized controlled study, the 0.01% group (18 patients, 36 eyes) and the 0.02% group (15 patients, 30 eyes) underwent assessments using the Ocular Surface Disease Index (OSDI), Visual Analogue scale (VAS), tear meniscus height (TMH), first noninvasive tear film breakup time (fNIBUT), and average noninvasive tear film breakup time (avNIBUT) at baseline (before administration) and at 1, 3, 6, and 12 months post-treatment. The meibomian glands of both the upper (U) and lower (L) eyelids were evaluated using Meibomian Gland Bio-image Analyzer, measuring parameters such as average gland diameter (avGD), average gland length (avGL), average gland area (avGA), deformation coefficient (DC), and gland visibility score (VS).ResultsThere were no statistically significant differences in any of the parameters within the 0.01% group (all p > 0.05). …”
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Faecal microbiota transplantation to decolonize vancomycin-resistant Enterococcus: A pilot study to evaluate safety and clinical outcome by Shu-Min Lin, Puo-Hsien Le, Chyi-Liang Chen, Yuan-Ming Yeh, Hsien-Li Liao, Cheng-Hsun Chiu

“…In responders, the abundance of genera within the phylum Firmicutes (Bacillota), including Anaerostipes, Blautia, Faecalibacterium, and Ruminococcus, and the genus Collinsella within the phylum Actinobacteriota increased steadily through 180 days post-FMT. Conclusions: FMT may leverage bacterial strain competition to facilitate decolonization of drug-resistant organisms, with successful VRE decolonization potentially linked to increased abundance of phyla Firmicutes and Actinobacteriota over 6 months.…”
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The role of probiotic supplementation in reducing Helicobacter pylori recurrence after classic quadruple therapy by Jie Zhao, Jieyun Chen, Yanqing Wang, Chen Zhu, Chenjing Xia, Wei Yang

“…The primary outcome was H. pylori recurrence within 12 months post-treatment, confirmed by 13C-urea breath test. …”
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A SARS-CoV-2 variant with the 12-bp deletion at E gene by Yi-Sheng Sun, Fang Xu, Qi An, Chen Chen, Zhang-Nv Yang, Hang-Jing Lu, Jian-Cai Chen, Ping-Ping Yao, Jian-Min Jiang, Han-Ping Zhu

“…An inactivated vaccine made from the F8 strain could trigger high levels of the IgG titer and neutralizing antibody titer, which could last for at least 6 weeks and were significantly higher than those from the 8X strain at 1 and 3 weeks post vaccination, respectively. In conclusion, we reported that both the E gene mutant and wild-type SARS-CoV-2 strains were isolated from the same clinical sample by plaque purification. …”
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Supporting Muslim undergraduate medical students through medical school: lessons from a novel, student-led case-based learning intervention by Zain Mohammed, Zain Mohammed, Hafsah Ba, Linta Nasim, Emily Roisin Reid

“…Data were gathered to assess the effectiveness of the teaching innovation against its aims in the following formats: (1) in-session participant feedback, (2) transcriptions of the in-session discussions which demonstrated participant learning gain, and (3) notes from the post-session facilitator team reflections. These data were thematically analyzed using Braun and Clarke's six-point framework, with individuals coding the data individually and collectively across three meetings to refine and agree upon the themes.ResultsFive key themes of insights emerged from the data: Staff and Student cultural literacy relating to Islam, Facilities and Environment, Curriculum, Policy and Processes, Islamophobia and discrimination. …”
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Representasi identitas dan fashion pria metrosexual di sosial media Instagram Vidi Aldiano by Aisha Alya

“…The research method is based on the theory of symotics to reveal the meanings embedded in Vidi Aldiano's lifestyle and appearance through his Instagram posts. Metrosexual culture, which reflects men's attention to modern appearance and lifestyle, is an interesting phenomenon to remember. …”
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Mitochondrial homeostasis restoring peptide-drug conjugates with ROS-responsive NO releasing ability for targeted therapy of myocardial infarction by Zhaoyang Lu, Quanyou Chai, Wenbin Dai, Bo Yu, Qingbo Lv, Fuyu Qiu, Jing Gao, Juhong Zhang, Xiaohua Shen, Shengyu Chen, Zhida Shen, Min Shang, Wenbin Zhang, Guosheng Fu, Qiao Jin, Yanbo Zhao, Fan Jia

“…The CTP-PBA-ISN efficiently inhibited myocardial apoptosis, improved myocardial function, and ameliorated adverse cardiac remodeling post-MI in mice by relief of oxidative stress, promotion of angiogenesis and restoration of mitochondrial homeostasis and function. …”
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Thoracic dysfunction in whiplash associated disorders: A systematic review. by Nicola R Heneghan, Richard Smith, Isaak Tyros, Deborah Falla, Alison Rushton

“…Results were reported in the context of overall quality and were presented for measures of pain or dysfunction and presented, where possible, according to WAD severity and time point post injury. Key findings include: 1) high prevalence of thoracic pain (>60%); higher for those with more severe presentations and in the acute stage, 2) low prevalence of chest pain (<22%), 3) evidence of thoracic outlet syndrome, with some association to and involvement of the brachial plexus, 4) muscle dysfunction in the form of heightened activity of the sternocleidomastoid or delayed onset of action of the serratus anterior, 5) high prevalence of myofascial pain and trigger points in the scalene muscles, sternocleidomastoid and mid/lower fibres of trapezius muscle (48-65%), and 6) inconclusive evidence of altered thoracic posture or mobility.…”
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Effect of β-casein A2 cow milk supplementation on physical growth, inflammation, growth-related hormones, and nutritional biomarkers in stunted children by Revi Gama Hatta Novika, Atriany Nilam Sari, Siti Nurhidayati, Rufidah Maulina, Luluk Fajria Maulida, Nurul Jannatul Wahidah, Muhana Fawwazy Ilyas, Lanjar Sumarno, Sigit Prastowo, Cecilia M. Jevitt

“…The outcome assessments were physical growth (body weight and height), inflammation (tumor necrosis factor-alpha [TNF-α] and cortisol levels), and biological markers related to growth and nutrition (insulin-like growth factor-1 [IGF-1], growth hormone [GH], and transferrin) that were measured during pre-, mid (week 6)-, and post (week 12)-intervention periods. Results This study included 30 study participants. …”
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The effect of eight weeks of high-intensity interval swimming training on the expression of liver RBP4 protein, serum hs-CRP and insulin resistance in rats with Non-Alcoholic Steat... by Mohammad Amin Delavari, Elham Shahabpour, Alireza Jowhari

“…One-way ANOVA test was used to determine between-group differences and Bonferroni's post-hoc test was used to identify which mean differences were statistically significant.Results: There was a significant increase of RBP4 in the control-NASH group compared to the healthy control (P=0.004) and a non-significant decrease in RBP4 (P=0.762) and insulin resistance (P=0.14) in exercise-NASH compared to the control-NASH. …”
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Identification of lactic acid bacteria from lemea's to lower blood sugar levels in mice's diabetes mellitus by Yenni Okfrianti, Catur Herison, Fahrurrozi Fahrurrozi, Budianto Budianto, Anggi Okticah, Miliza Mayang Sari

“…Materials and Methods: This study used a pre-test, post-test, control group design for its experimental methodology. …”
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Effects of human urine application on soil physicochemical properties, microbial communities, and enzymatic activities by Guangquan Yu, Qian Wang, Qian Wang, Xiangqun Zheng, Xiangqun Zheng, Bo Yang, Bo Yang, Chunxue Zhang, Chunxue Zhang, Guowei Zhang, Xiaocheng Wei, Xiaocheng Wei

“…However, the absence of long-term field trials underlines the necessity for comprehensive evaluations of HU’s impact on soil fertility and crop health, and careful attention must be paid to potential environmental safety risks post-HU application.…”
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Mindfulness and Traditional Training: A 16 – Week Study on Their Combined Effect on Shooting Accuracy and Anxiety in Football Players by Yuvaraj Dharmalingam, Manobala Vijayan, Nithya Govind, Ramajayam Munusamy, Ketheeswaran Kumarasamy, Dibakar Debnath, Premkumar Govindhan

“…Background and Purpose This study explores the combined impact of traditional training and post-training mindfulness on shooting accuracy and anxiety among football players. …”
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Silibinin protects the ischemic brain in mice by exerting anti-apoptotic effects via the EGFR/ERK pathway by Linlin Li, Wenyan Shang, Yuexia Ma, Cong Zhang, Xiangjian Zhang

“…These effects were accompanied by up-regulation of p-EGFR/EGFR, p-ERK/ERK, and Bcl-2, as well as down-regulation of Bax and cleaved-Caspase3 in ischemic brain tissue post-stroke, while inhibiting EGFR activation attenuated or reversed the anti-apoptotic effects of silibinin. …”
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