Identifying Clinical Measures Related to Falls in Ambulatory Patients with Spinal and Bulbar Muscular Atrophy by Joseph A. Shrader, Allison C. Niemic, Rafael Jiménez-Silva, Joshua G. Woolstenhulme, Galen O. Joe, Uma Jacobs, Ashwini Sansare, Angela Kokkinis, Kenneth Fischbeck, Chris Grunseich, Cris Zampieri

“…Results: We identified three clinical measures that help detect fall risk in people with SBMA. A post hoc receiver operating characteristic curve analysis helped identify cut scores for each test. …”
Get full text

Design of the OverCool study: Lung-conservative liquid ventilation for the induction of Ultra-Rapid Cooling after Cardiac Arrest (OverCool) by Renaud Tissier, Fabio Silvio Taccone, Lionel Lamhaut, Eric Vicaut, Fabrice Paublant, Jean-Damien Ricard, Alain Mercat, Alain Cariou

“…Secondary outcomes will include time to reach target temperature, vital status, systemic and pulmonary parameters and modified-Rankin Score at 28 days post- cardiac arrest. Conclusion: The OverCool study is a pilot study to validate performance and safety of ultra-rapid therapeutic hypothermia using total liquid ventilation for resuscitated cardiac arrest patients. …”
Get full text

Mosquito-borne alphaviruses in Zambia: Isolation and characterization of Eilat and Sindbis viruses by Chadwic De’Sean Mears, Koshiro Tabata, Takuma Ariizumi, Bernard M. Hang'ombe, Yongjin Qiu, Hayato Harima, Masahiro Kajihara, William W. Hall, Michihito Sasaki, Hirofumi Sawa, Yasuko Orba

“…EILV zmq19_M44 attained a saturating titer in C6/36 cells at 6–8-days post infection but was unable to replicate in mammalian cells. …”
Get full text

Comparative Study of Two Immunisation Protocols in Goats Using Thiol-Sepharose Chromatography-Enriched Extracts from Adult <i>Haemonchus contortus</i> Worms by Magnolia M. Conde-Felipe, José Adrián Molina, Antonio Ruiz, Otilia Ferrer, Mª Cristina Del Rio, Emma Carmelo, Juan R. Hernández-Fernaud, Francisco Rodríguez, José Manuel Molina

“…<b>Methods</b>: To evaluate the level of immunoprotection, animals were challenged with L3 of <i>H. contortus</i> two weeks after the last inoculation of the immunogen and humanely sacrificed at 8 weeks post-infection. Parasitological, biopathological, and serological parameters were monitored through the experiment. …”
Get full text

Noncommunicable disease risk factors and predictors of hypertension among Gurkha veterans in Nepal: a community-based cross-sectional study by Nilam Adhikari, Krishna Prasad Sapkota, Sagar Panthi, Rochana Acharya, Madhav Bhusal, Sangita Bhattarai, Gampo Dorji, Shyam Sundar Budhathoki, Dharanidhar Baral, Paras K. Pokharel

“…Abstract Background Nepal faces a rising burden of noncommunicable diseases (NCDs), yet Gurkha veterans—a population with distinct sociocultural backgrounds, occupational exposures, and post-service lifestyle transitions;remain largely overlooked in NCD research. …”
Get full text

Diminished immune cell adhesion in hypoimmune ICAM-1 knockout human pluripotent stem cells by Sayandeep Saha, W. John Haynes, Jiwon Seo, Natalia M. Del Rio, Elizabeth E. Young, Jue Zhang, Alexis M. Holm, Mireya Pimentel, Lauryn Flannagan, Liupei Huang, Wesley Blashka, Lydia Murphy, Merrick J. Scholz, Abigale Henrichs, Jayalaxmi Suresh Babu, John Steill, Jeremy Kratz, Ron Stewart, Timothy J. Kamp, Matthew E. Brown

“…We identify the adhesion molecule ICAM-1 as a hypoimmune target that plays multiple critical roles in both adaptive and innate immune responses post-transplantation. In our experiments, we find that ICAM-1 blocking or knockout in human pluripotent stem cell-derived cardiovascular therapies imparts significantly diminished binding of multiple immune cell types. …”
Get full text

Profiling disease experience in patients living with brain aneurysms by analyzing multimodal clinical data and quality of life measures by Sebastian R. Reder, Jochen Hardt, Marc A. Brockmann, Carolin Brockmann, Suam Kim, Melina Kawulycz, Marie Schulz, Sven Rainer Kantelhardt, Katja Petrowski, Sabine Fischbeck

“…Main disease profiles were identified: (1) those with increased LV post-rupture (high DW); (2) older individuals with stable aneurysms (low DW); (3) revealing a sex disparity in QoL despite similar vasospasm severity; and 4), focused on chronic pain and its impact on daily tasks. …”
Get full text

Optimizing Crystalline MoS₂ Growth on Technologically Relevant Platinum Substrates Using Ionized Jet Deposition: Interface Interactions and Structural Insights by Cristian Tomasi Cebotari, Christos Gatsios, Andrea Pedrielli, Lucia Nasi, Francesca Rossi, Andrea Chiappini, Riccardo Ceccato, Roberto Verucchi, Marco V. Nardi, Melanie Timpel

“…The results reveal that as-deposited MoS₂ films are initially amorphous and conform to the Pt substrate roughness, but crystalline growth is reached when the sample holder is sufficiently heated by the plasma. Further post-annealing at 270 °C enhances crystallinity and reduces sulfur-related defects. …”
Get full text

Clinical application analysis of a novel robotic system for total hysterectomy by Bingxin Han, Jun Wang, Jing Na, Shichao Han, Ya Li

“…Key indicators such as surgical duration, intraoperative blood loss, and time to first flatus post-surgery were observed. Additionally, the CUSUM method was employed to analyze the learning curve for the new robotic total hysterectomy. …”
Get full text

Cardiopulmonary responses to acute exogenous ketosis at rest, and during submaximal and maximal exercise by Christopher D. Crabtree, Justen Stoner, Alex Buga, Bradley Robinson, Drew Decker, Ashwini Chebbi, Xavier El‐Shazly, Emily Murphy, Aydan Jordan, Teryn Bedell, Madison L. Kackley, Tyler McClure, Yuchi Han, Orlando P. Simonetti, Jeff S. Volek

“…Participants began the V̇O2max test 120 min post‐beverage ingestion. At rest, capillary R‐βHB elevated rapidly after BO‐BD ingestion and continued to steadily increase to 2.4 mM prior to the maximal exercise test. …”
Get full text

PIN1-SUMO2/3 motif suppresses excessive RNF168 chromatin accumulation and ubiquitin signaling to promote IR resistance by Anoop S. Chauhan, Matthew J. W. Mackintosh, Joseph Cassar, Alexander J. Lanz, Mohammed Jamshad, Hannah L. Mackay, Alexander J. Garvin, Alexandra K. Walker, Satpal S. Jhujh, Teresa Carlomagno, Aneika C. Leney, Grant S. Stewart, Joanna R. Morris

“…Here, we reveal a cascade of post-translational modifications which act at three adjacent amino acids, threonine-208, proline-209 and lysine-210, to process RNF168 actively. …”
Get full text

Rotational coronary angiography in heart transplant recipients by S. A. Sakhovsky, E. A. Kalchenko, B. L. Mironkov

“…Given the grave condition of recipients in the early post-transplant period and annual angiographic studies, it is necessary to strive for reduction of radiation load on the body and reduction of dose of X-ray contrast agents used.Objective: to assess the possibilities of using rotational CAG in the activities of transplant centers.Materials and methods. …”
Get full text

Techno-Economic Evaluation of Carbon Capture and Storage for Combined Cycle Power Generation by Mujammil Asdhiyoga Rahmanta, Nur Cahyo, Ruly, Tiva Winahyu Dwi Hapsari, Eko Supriyanto, Meiri Triani

“…This study evaluates the he technological, financial, and ecological impacts of upgrading CCS technology on a Natural Gas Combined Cycle (NGCC) power generation with three blocks. Amine-based post-combustion capture technology is applied in this study. …”
Get full text

Rearrangement of Immunoglobulin Genes in Tumor Cells of Patients with Primary Mediastinal (Thymic) Large B-Cell Lymphoma by YaK Mangasarova, YuV Sidorova, AU Magomedova, BV Biderman, EE Nikulina, AB Sudarikov, AM Kovrigina, SK Kravchenko

“…Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a malignant tumor with large atypical lymphoid cells expressing post-germinal differentiation markers. Rearrangements of immunoglobulin genes in PMBCL are revealed in 30–65 % of cases. …”
Get full text

RETRACTED ARTICLE: Tamoxifen suppresses brain metastasis of estrogen receptor-deficient breast cancer by skewing microglia polarization and enhancing their immune functions by Shih-Ying Wu, Sambad Sharma, Kerui Wu, Abhishek Tyagi, Dan Zhao, Ravindra Pramod Deshpande, Kounosuke Watabe

“…For clinical validation study, brain metastasis specimens from pre- and post-menopause breast cancer patients were examined for microglia polarization by immunohistochemistry. …”
Get full text

SARS-CoV-2 (MA10) Infection Aggravates Cerebrovascular Pathology in Endothelial Nitric Oxide Synthase-Deficient Mice by Saifudeen Ismael, Meenakshi Umar, Blake Ouvrier, Gregory Hall, McKenzie Cummins, Arjun Sapkota, Grant Talkington, Amanda Louise White, Richard Milner, Damir B. Khismatullin, Gregory Bix

“…Mice were evaluated for weight loss, viral load, and markers of inflammation and senescence 3 days post-infection. eNOS^+/− mice showed more weight loss (~15%) compared to WT mice (~5%) and increased inflammatory markers (<i>Ccl2</i>, <i>Cxcl9</i>, <i>Cxcl10</i>, <i>IL-1β</i>, and <i>IL-6</i>) and senescence markers (p53 and p21). …”
Get full text

Sugammadex versus neostigmine on postoperative adverse respiratory events in elderly patients undergoing lung resection: study protocol for a randomized controlled trial by Yuxin Wang, Xiang Li, Huimin Deng, Di Feng, Liuyuan Zhao, Feihong Lin, Tian Jin, Sheng Wang, Xin Lv, Juan Wei

“…The primary outcome is a composite of AREs occurring in the post-anaesthesia care unit (PACU). Secondary outcomes include time from neuromuscular to extubation, the composite of ARE and rescue measures, PACU length of stay, postoperative pulmonary and extra-pulmonary complications, unplanned intensive care unit (ICU) admission, chest drainage tube duration, hospital length of stay, and mortality. …”
Get full text

Ultra-endurance race performance and muscle mass as predictors of cognitive capacity by Deina Vilite, Diana Lismane, Jelena Raudeniece, Jelena Raudeniece, Linda Laizane, Linda Laizane, Gita Gersone, Gita Gersone, Ilze Barone, Ilze Barone, Ilze Justamente, Ilze Justamente, Kristiana Kovtuna, Kristiana Kovtuna, Bart Roelands, Bart Roelands, Bart Roelands, Maksims Zolovs, Maksims Zolovs, Maksims Zolovs, Dace Reihmane, Dace Reihmane

“…341 km over 18 h, with cognitive function assessed using a three-stage Stroop Test before, immediately after, and 24 h post-race. For each stage, results from the three time points were combined and analyzed using regression analyses to examine their relationship with various anthropometric, metabolic, and performance-related parameters.ResultsHigher average race speed was associated with improved simple reaction time, while longer race duration predicted better performance in more cognitively demanding tasks, such as inhibitory control. …”
Get full text

The Surrealism of Men’s Rights Discourses on Sexual Assault Allegations: A Feminist Reading of Kafka’s The Trial by Meg Danielle Lonergan

“… Being a feminist in the contemporary Canadian context, post-Ghomeshi, can lead to existential crises. In this paper I investigate this relationship of feminist activism and reality, men’s rights activism (MRA) and surrealism, and the Absurd via the work of surrealist novelist Franz Kafka. …”
Get full text

The value of microvascular obstruction according to contrast-enhanced cardiac magnetic resonance imaging in assessing the prognosis of patients with acute ST-segment elevation myoc... by M. A. Terenicheva, R. M. Shakhnovich, O. V. Stukalova, D. V. Pevzner, I. S. Yavelov, Yu. O. Shalaginova, S. K. Ternovoy

“…MVOs was associated with post-infarction LV aneurysm. An increase in MVO size correlated with a decrease in LVEF and an increase in LVEDV both in the acute period and one year after MI.…”
Get full text