Evaluating the role of quantitative pupillometry in chronic subdural hematoma: A pilot study by Lukas Klein, Christopher Beynon, Daniel Kühlwein, Sandro M. Krieg, Alexander Younsi, Pavlina Lenga

“…Pupillometry assessments were conducted prospectively using the automated NPi 200® Pupillometer and the Neurological Pupil Index (NPi) was measured pre- and post-operatively. Clinical and radiological parameters including the initial Glasgow Coma Scale (GSC) score, hematoma volume, residual cavity area (RCA), and the Evans index were obtained and all parameters were statistically compared. …”
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Fc-Elabela mitigates heart failure without liver and renal toxicity in mice by Huifen Zhou, Huifen Zhou, Da-Wei Gong, Ling Chen, Hui Chen, Quan Wang, Mustajab Ullah, Saleem Ahmad, Ishtiaq Jeelani, Qingbin Zhao, Qingbin Zhao

“…We found that Fc-ELA-21 significantly improved cardiac systolic dysfunction, mitigated pulmonary congestion, slowed down weight gain, activated vascular endothelial growth factor receptor 3 (VEGFR3) and APJ-mediated extracellular signal-regulated kinase (ERK) 1/2 signaling, and promoted endothelial cell proliferation in post-infarct mice. Moreover, the structure and function of the liver and kidney were normal in Fc-ELA-21-treated mice.ConclusionOur results demonstrate that Fc-ELA-21 improves systolic heart failure by activating VEGFR3 signaling and suggest a mechanism for cross-talk between the APJ receptor and VEGFR3 in myocardial infarction MI. …”
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Effects of a closed-loop mindfulness-based program for reducing stress in family caregivers of people with dementia: a study protocol of a randomized controlled trial by Patrick Pui Kin Kor, Kee Lee Chou, Alex Pak Lik Tsang, Winnie W. S. Mak, Julieta Galante, Rainbow Tin Hung Ho, Samuel Yeung Shan Wong, Daphne Sze Ki Cheung, Justina Yat Wa Liu, Steven H. Zarit

“…Evaluations will occur at baseline, post-intervention, and at a 6-month follow-up. The primary outcome will be perceived stress, while secondary outcomes will include depressive symptoms, peace of mind, caregiving burden, dyadic relationship quality, dispositional mindfulness, heart rate variability, and the care recipients’ neuropsychiatric symptoms. …”
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Effectiveness of Local Antibiotics for Infection Prevention in Primary Joint Arthroplasty: A Systematic Review and Meta-Analysis by Chia-Yu Lin, Chiung-Li Liu, Hon-Lok Lo, Shao-Yuan Hao, Wei-Hsuan Huang, Hsiu-Mei Chang, Tun-Chieh Chen

“…Smoking was identified as an important risk factor for post-operative infection. Further research, including more robust trials and cohort studies, is needed to confirm these findings. …”
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The efficacy comparison on femoral vein hemodynamics and morphology between two types of graduated elastic compression stockings among patients undergoing knee replacement: a singl... by Yaping Xu, Ruping Liu, Feiya Xu, Yibo Feng, Shuang Li, Dingyi Wang, Guohui Fan

“…Compressed ultrasound of the lower extremity was conducted before the operation (without GCS, as preoperative baseline) and within 24 hours post operation (postoperative baseline , with GCS, and with GCS + ankle pump). …”
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Systems biology-based assessment of immune responses to whole cell and acellular pertussis vaccines by Mariana Leguia, Antón Vila-Sanjurjo, Diana Juarez, Alejandra Garcia-Glaessner, Ana I. Gil, Mayita Alvarez, Rubelio Cornejo, Sami Cherikh, Casey E. Gelber, Johannes B. Goll, Leigh M. Howard, Natalia Jimenez-Truque, Kathryn M. Edwards, C. Buddy Creech, Claudio F. Lanata

“…We used RNA-Seq and ribosome profiling (RP) to identify transcriptional and translational signatures, respectively, in peripheral blood mononuclear cells (PBMCs) collected from 50 infant recipients of DTP or DTaP at two time-points (baseline (pre-vaccination at Day 1) and either Day 2 or 8 post-vaccination). We also used standard serologic methods to assess immunogenicity, and correlated these results with transcriptional and translational signatures. …”
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Complex pediatric neoplasms: The role of congenital cardiothoracic surgeryCentral MessagePerspective by Lindsay J. Nitsche, BS, Colleen E. Bontrager, BA, Paul J. Devlin, MD, Lea F. Surrey, MD, Jennifer E. Pogoriler, MD, PhD, Portia A. Kreiger, MD, Theodore W. Laetsch, MD, Frank Balis, MD, Alexander S. Fairman, MD, Peter Mattei, MD, Stephanie M. Fuller, MD, MS

“…Results: Case 1: 16 × 15.5 × 11 cm right chest synovial sarcoma in a male patient status post–neoadjuvant chemoradiation. Imaging revealed invasion of the right-sided subclavian vein, subclavian artery, phrenic nerve, and vagus nerve. …”
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ANALYSIS OF APOPTOSIS FACTORS IN PATIENTS WITH PREINVASIVE AND INVASIVE CERVICAL CANCER by P. I. Kovchur, E. V. Bachidze, O. V. Kurmyshkina, T. O. Volkova

“…This article assesses the disturbance degree of apoptotic program in patients with preinvasive and invasive cervical cancer by investigating the expression level of genes of caspases-3, -6, -8 и -9 in mononuclear cells of periphery blood and in tumor tissue on the two regulating levels – on mRNA level (transcriptional) and proteolytic activity (post transcriptional). 75 patients with stage III of cervical intraepithelial neoplasias (CIN) III  (middle age of 32,9 ± 7,4),45 patients with stage IA (31,3 ± 6,0), 21 – with stage II (43,6 ± 13,2), 15 – with stage III–IV (46,9 ± 11,1) have been examined. …”
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Effects of lifestyle intervention by a nurse-led app on the prevention of symptoms in postpartum women: a randomized controlled trial by Yulian Liang, Shiying Wang, Jie Tao, Zheng Yao, Yongzi Yao, Jinguo Zhai

“…Clinicians can enhance the use of mHealth in their work by providing mHealth education to mothers to compensate for the lack of traditional care in the post-discharge phase. However, due to the limitations of this single-center study with a small sample size, future multicenter studies with long-term follow-up are needed to further explore the broader applicability and sustainability of this intervention. …”
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The Effects of Artificial Intelligence Supported Flipped Classroom Applications on Learning Experience, Perception, and Artificial Intelligence Literacy in Higher Education by Mehmet Yavuz, Şener Balat, Bünyami Kayalı

“…Quantitative findings revealed a statistically significant improvement in students’ AI literacy levels from pre-test to post-test. Qualitative analyses indicated that AI-supported flipped classroom practices positively influenced students’ motivation, interest in the course, and personalized learning experiences. …”
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Inoculation with Pseudomonas spp. in Solanum lycopersicum increases yield and fruit quality under nutrient shortage conditions by Patricia Torres-Solórzano, Homero Reyes-De la Cruz, Josué Altamirano-Hernández, Lourdes Macías-Rodríguez, Jesús Campos-García, Alfonso Luna-Cruz

“…All isolates demonstrated rhizosphere persistence for 30 days post-root inoculation. Conclusions The results position Pseudomonas spp. isolates C13, C14, C15, P. fluorescens C30, and P. putida ACJ14 as sustainable PGPR alternatives enabling 50% reduction of nitrogen, phosphorus, and calcium fertilization in greenhouse tomatoes. …”
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Outcomes of BTD vs. BCD as initial treatment of renal amyloid light-chain amyloidosis: a retrospective cohort study in China by Sheng Li, Weiting He, Hok-him Yau, Jianteng Xie, Yaxi Zhu, Xiaojie Chen, Shaogui Zhang, Yifan Zhang, Pengjun Liao, Hui Liu, Liwen Li, Liye Zhong, Wenjian Wang

“…There was no significant difference of renal and cardiac response between groups. However, post-treatment proteinuria levels after treatment were significantly lower in the BTD group compared to those in the BCD group (747 mg/24h vs. 2928 mg/24h, p = 0.048).Conclusions Compared to BCD regimen for renal AL amyloidosis, initial treatment with BTD regimen demonstrated similar rates of hematologic CR but showed superior reduction in proteinuria, reduced cumulative dose of bortezomib and faster time-to-response.…”
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Safety and immunogenicity of an mRNA-1273 vaccine booster in adolescents by Amparo L. Figueroa, Kashif Ali, Gary Berman, Wenqin Xu, Weiping Deng, Bethany Girard, Anne Yeakey, Karen Slobod, Jacqueline Miller, Rituparna Das, Frances Priddy

“…Primary objectives included safety and inference of effectiveness by establishing noninferiority of neutralizing antibody (nAb) responses after the booster compared with the nAb post-primary series of mRNA-1273 among young adults in COVE (NCT04470427). …”
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A specifically designed multi-biotic reduces uremic toxin generation and improves kidney function by Alice Beau, Jane Natividad, Berengère Benoit, Philippe Delerive, Stéphane Duboux, Yuan Feng, Marie Jammes, Cecile Barnel, Giuseppina Sequino, Claudie Pinteur, Griet Glorieux, Denis Fouque, Hubert Vidal, Laetitia Koppe

“…Using an ex vivo Simulator of the Human Intestinal Microbial Ecosystem (SHIME) colonized with fecal samples from eight CKD patients or nine healthy volunteers, a higher bacterial generation of p-cresol and indoles post-amino acid enrichment, as well lower basal butyrate levels, in the feces of CKD patients were found. …”
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Chronic Obstructive Pulmonary Disease and Metabolic Syndrome: A Maltese Study on Biomarkers and Clinical Implications by Gauci J, Gauci Pullicino S, Caruana E, Petroni Magri V, Formosa MM, Fenech AG, Fava S, Montefort S, Fsadni P

“…The American Heart Association (AHA) and National Heart, Lung, and Blood Institute (NHLBI) criteria were used to diagnose MetS. A post-bronchodilator FEV1/FVC ratio of less than 0.7 was necessary to diagnose COPD, as recommended by Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines.Results: The study group consisted of 24 subjects diagnosed with both MetS and COPD. …”
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Impact of thermocycling on surface roughness, microhardness and optical properties of three different lithium disilicate ceramics by Ahmad M. Al-Thobity, Abdulkareem M. AlOtaibi, Abdulrahman E. Alhumaidan, Ahmed A. Aldossary, Intisar Ahmad Siddiqui, Mohamed Ahmed Helal, Abdulmohsen Alsalman

“…Data of surface roughness, color parameters, and microhardness were obtained using an optical profiler, a spectrophotometer, and a Vickers hardness tester, respectively. One-way ANOVA, a post-hoc Tukey’s test, and a paired sample t-test were implemented for statistical analysis (p ≤ 0.05). …”
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Aerobic Exercise Ameliorates Alzheimer’s Disease-Like Pathology by Regulating Hepatic Phagocytosis of Aβ by Qing Wang, Feng-Rui Hu, Xing-Chun Gou, Shan Wang, Nai-Chun Ji

“…Data were analyzed using one-way ANOVA with Tukey’s post hoc test, and p < 0.05 was deemed statistically significant. …”
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Lung recruitment maneuver improves right and left ventricular function in patients with acute respiratory distress syndrome by Alexis Lambour, Yoann Zerbib, Pablo Mercado, Loay Kontar, Bertrand De Cagny, Julien Maizel, Michel Slama, Clément Brault

“…This study aimed to evaluate the direct impact of LRM on cardiac function in patients with moderate-to-severe acute respiratory distress syndrome (ARDS). Methods This post-hoc analysis included 34 patients with moderate-to-severe ARDS from two prospective cohort studies. …”
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The intersection between circulatory microRNAs and biomarkers of neurodegeneration by Amber Yaqub, Rima Mustafa, M. Arfan Ikram, Mohsen Ghanbari

“…Finally, we performed a post-hoc in-silico analysis to study the common miRNAs between all four biomarkers, their potential target genes and their link to dementia. …”
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Imaging the lifecycle of Microsporidia sp. MB in Anopheles coluzzii from western Burkina Faso reveals octosporogony by Ewan R. S. Parry, Roland Pevsner, Beth C. Poulton, Deepak-Kumar Purusothaman, Abdelhakeem I. Adam, Sare Issiaka, Thomas H. Ant, Stephanie M. Rainey, Etienne Bilgo, Abdoulaye Diabaté, Steven P. Sinkins

“…Sporogony was identified for the first time in a proportion of developing oocytes and in embryos post-oviposition. Microsporidian spore characteristics were subsequently confirmed with electron microscopy. …”
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