Perception of Lemborexant Effectiveness as Assessed by the Patient Global Impression–Insomnia Questionnaire by Drake CL, Yardley J, Pinner K, Moline M, Malhotra M

“…PGI-I results were analyzed post hoc in relation to patient-reported (subjective) sleep-onset latency (sSOL) and total-sleep-time (sTST).Results: At 6 months: 67.3% (LEM5) and 68.8% (LEM10) of subjects reported positive effects of medication helping them sleep versus 45.0% (both p< 0.0001) with PBO. …”
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Robot-assisted adrenalectomy: Step-by-step technique and surgical outcomes at a high-volume robotic center by Federico Piramide, Carlo Andrea Bravi, Marco Paciotti, Luca Sarchi, Luigi Nocera, Adele Piro, Maria Peraire Lores, Eleonora Balestrazzi, Angelo Mottaran, Rui Farinha, Hubert Nicolas, Pieter De Backer, Frederiek D'hondt, Peter Schatteman, Ruben De Groote, Geert De Naeyer, Alexandre Mottrie

“…Demographic, intra- and post-operative, and pathological data were retrieved from our prospectively maintained institutional database. …”
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Myocardial native T1 and extracellular volume measurements at 5T: Feasibility study and initial experience by Yubo Guo, Lu Lin, Keting Xu, Shihai Zhao, Gan Sun, Yuyan Chen, Ke Xue, Yuxin Yang, Shuo Chen, Yan Zhang, Yanjie Zhu, Yining Wang

“…T1 mapping was acquired using a motion-corrected modified Look–Locker inversion recovery sequence [5(3)3 scheme for pre-contrast, (4(1)3(1)2) scheme for post-contrast] in three short-axis planes (base, middle, and apex). …”
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Time Zero for Net Zero: A Coal Mine Baseline for Decarbonising Heat by Alison A. Monaghan, Luke Bateson, Adrian J. Boyce, Neil M. Burnside, Rebecca Chambers, Julia R. de Rezende, Eilidh Dunnet, Paul A. Everett, Stuart M. V. Gilfillan, Muhammad S. Jibrin, Gareth Johnson, Richard Luckett, Donald John MacAllister, Alan M. MacDonald, John W. Moreau, Laura Newsome, Alessandro Novellino, Barbara Palumbo-Roe, Ryan Pereira, Douglas Smith, Mike J. Spence, Vanessa Starcher, Helen Taylor-Curran, Christopher H. Vane, Thomas Wagner, David B. Walls

“…Time zero soil chemistry, ground gas, surface water and groundwater characterisation, together with ground motion and seismic monitoring, document ongoing seasonal and temporal variability that can be considered typical of a post-industrial, urban environment underlain by abandoned, flooded coal mine workings. …”
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A retrospective analysis of outcomes and complications of living- and deceased-donor split-liver transplantation in Johannesburg, South Africa by R Crawford, J Loveland, P Gaylard, J Fabian, K Kinandu, B Bobat, A Mahomed, D Parbhoo, M Beretta, S Berkenfeld, S Rambarran, F van der Schyff, L Brannigan, B Strobele

“…There were no significant differences between the DDSLTs and LDLTs in respect of pre- or post-discharge intervention, in-hospital mortality, length of stay, and recipient or graft survival within both the paediatric and adult groups. …”
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The effects of dance intervention on clinical symptoms and cognitive deficits in hospitalized patients with chronic schizophrenia: a randomized controlled trial by Gujing Li, Hui He, Kexin Gao, Yuanyuan Yu, Yayun Liu, Tianhuan Li, Ping Xi, Frank Pollick, Jing Lu, Lixue Yin, Dezhong Yao, Mingjun Duan, Li Mi, Cheng Luo

“…Results The PANSS total scores (P < 0.01**), PANSS negative scores (p < 0.001**), NOISE score (p < 0.001**), MCCB cognitive scores, and physiological indicators were significantly changed after the intervention in both groups compared with baseline. Post-hoc analysis revealed notable improvements in the specific cognitive subscales, including the Continuous Operation Test-identical pairs (CPT-IP, p = 0.026*), Hopkins Verbal Learning Test-Revised (HVLT-R, p = 0.019*) and the physiological indicators Cystatin C (CYS-C, p = 0.037*) in the dance intervention group. …”
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Prognostic implication of sarcopenia diagnosed by updated Asian Working Group for Sarcopenia criteria in older patients with heart failure: Utility and limitation by Satoshi Katano, Kotaro Yamano, Toshiyuki Yano, Ryo Numazawa, Ryohei Nagaoka, Suguru Honma, Yusuke Fujisawa, Yasuhiro Miki, Yuhei Takamura, Hayato Kunihara, Hiroya Fujisaki, Hidemichi Kouzu, Katsuhiko Ohori, Masaki Katayose, Akiyoshi Hashimoto, Masato Furuhashi

“…The primary endpoint was all-cause mortality at three years post-discharge. Results: Of 534 patients, 42%, 57%, and 44% were diagnosed with sarcopenia according to AWGS 2014, AWGS 2019H, AWGS 2019B, respectively. …”
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Comparative transcriptomics in B73-teosinte near-isogenic maize lines reveals key defense signaling and phytoalexins in response to Cercospora zeina infection by Xiaomeng Sun, Xiaomeng Sun, Ruiyu Zhang, Ruiyu Zhang, Zongping Wang, Zongping Wang, Haotian Zhang, Haotian Zhang, Hairun Wen, Hairun Wen, Junli Zhang, Naibin Yu, Naibin Yu, Zhe Wang, Zhe Wang, Huanhuan Tai, Huanhuan Tai, Qin Yang, Qin Yang

“…Here we conducted transcriptome analyses on leaves from a pair of B73-teosinte near-isogenic lines (NILs) with contrasting Qgls8 alleles infected with C. zeina at 0, 4, 8, and 12 hours post inoculation (hpi). A total of 1225 up-regulated genes (URGs) were identified in the resistant line Qgls8-R compared with the susceptible line Qgls8-S across the four time points. …”
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Perampanel for alleviation of secondary injury in traumatic brain injury (PEACE-TBI): a protocol for a phase-II multicentre randomised clinical trial by Ryota Tamura, Yuki Kuranari, Yukina Morimoto, Masahiro Toda, Tokunori Kanazawa, Makoto Inaba, Ryo Yamamoto, Koichiro Homma, Takahiro Shoji, Junichi Sasaki, Masayuki Shimizu, Masato Nakaya, Satoshi Terao, Ryota Sasao, Makoto Katayama, Koichi Ueno, Yumiko Oishi, Akiyoshi Nakamura, Yo Kikuo, Ryosuke Murakami, Sota Wakahara, Konosuke Ishikawa, Kenzo Kosugi, Tatsuro Ozaki

“…The antiepileptic drugs can be increased, changed or added as necessary if early post-traumatic seizures are observed. The primary outcome is favourable neurological outcome, defined as a Glasgow Outcome Scale Extended score of ≥5 at 90 days after the TBI diagnosis, which will then be compared between the groups through an intention-to-treat analysis.Ethics and dissemination The present study has been approved by the Certified Review Board of Keio at the principal institution (approval number: N20240004). …”
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Patient centered outcomes in stroke: utility-weighted modified Rankin Scale results in a community-based study by Carlos Delfino, Gabriel Cavada, Lorena Hoffmeister, Pablo Lavados, Pablo Lavados, Paula Muñoz Venturelli, Paula Muñoz Venturelli, Paula Muñoz Venturelli

“…Key determinants of health-related quality of life in post-stroke patients included age, prior disability, and stroke severity. …”
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Enhanced fibrotic potential of COL1A1hiNR4A1low fibroblasts in ischemic heart revealed by transcriptional dynamics heterogeneity analysis at both bulk and single-cell levels by Cheng Luo, Cheng Luo, Cheng Luo, Baoping Tan, Luoxiang Chu, Liqiang Chen, Xinglong Zhong, Yangyang Jiang, Yuluan Yan, Fanrui Mo, Hong Wang, Fan Yang, Fan Yang

“…The effectiveness and robustness of the gene-derived diagnostic tool were validated using two independent IHD cohorts.Subsequently, we validated the signature genes using a rat post-myocardial infarction heart failure model.ResultsWe conducted an analysis on high-quality snRNA-seq data obtained from 3 IHD and 4 cardiac sarcoidosis heart samples, resulting in the identification of 16 FB clusters. …”
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Ornidazole-Induced Liver Injury: The Clinical Characterization of a Rare Adverse Reaction and Its Implications from a Multicenter Study by Ali Rıza Çalışkan, Ilker Turan, Sezgin Vatansever, Jasmin Weninger, Emine Türkmen Şamdancı, Ayşe Nur Akatli, Elvan Işık, Esra Durmazer, Ayşenur Arslan, Nilay Danış, Hüseyin Kaçmaz, Sedat Cicek, Osman Sağlam, Dilara Turan Gökçe, Derya Arı, Sevinç Tuğçe Güvenir, Serkan Yaraş, Cumali Efe, Meral Akdoğan Kayhan, Murat Harputluoğlu, Ali Canbay, Ulus Salih Akarca, Zeki Karasu, Ramazan Idilman, Fulya Günşar

“…Corticosteroids were used in 24.8% of cases (n = 25) and were associated with higher ANA positivity and a 20% (n = 5) relapse rate post-discontinuation. Recovery was achieved in 87.7% of cases (n = 88), while 7.9% of cases (n = 8) required liver transplantation and 4% (n = 4) died. …”
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Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation by Lifeng Gan, Lifeng Gan, Lifeng Gan, Peiyue Luo, Peiyue Luo, Peiyue Luo, Junrong Zou, Junrong Zou, Wei Li, Wei Li, Wei Li, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Yiran Lu, Liying Zheng, Biao Qian, Biao Qian

“…Long-stranded non-coding RNAs (lncRNAs), defined as non-coding RNAs exceeding 200 nucleotides in length, regulate various cellular processes by modulating gene expression at transcriptional, post-transcriptional, and epigenetic levels. Evidence suggests that lncRNAs can be regulated by HIF at the transcriptional level. …”
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Do bulls experience pain or stress during electroejaculation? Evidence from electroencephalography, behavioral, hormonal, and metabolite profiling by Ubedullah Kaka, Nurhusien Yimer Degu, Pavan Kumar, Abubakar Ahmed Abubakar, Yong-Meng Goh, Muhammad Waseem Aslam, Khaleeq Ur Rehman Bhutto, Muhammad Abdul Basit, Wasim S. M. Qadi, Norazlan Mohmad Misnan, Ahmed Mediani, Khor Kuan Hua

“…Results: EE induced significant increases (p < 0.05) in stress hormones at ejaculation, which gradually returned to baseline 20 min post-procedure. EEG metrics, such as MF and Ptot, significantly increased during EE (p < 0.05), indicating heightened cortical activity associated with nociception. …”
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TERAPIA GÊNICA NO TRATAMENTO DA HEMOFILIA A: UMA REVISÃO SISTEMÁTICA by ACS Mendes, LCM Henriques, DL Almeida, VEA Jesus, RM Camelo, J Alvares-Teodoro

“…Todos os estudos iniciais com valoctocogene roxaparvoveque tiveram análises post-hoc, com descrição de dados de eficácia e segurança por até 6 anos após a TG. …”
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El diagnóstico relacional colaborativo (II). Ampliando el diagnóstico relacional en la práctica del Trabajo Social by Josefa Cardona-Cardona, Maria Elena Cuartero-Castañer, José Francisco Campos-Vidal

“…El proceso de elaboración de esta evaluación compartida, a la que denominamos co-diagnóstico, considera criterios esenciales que se vinculan a una práctica del Trabajo Social post-estructural y a un posicionamiento centrado en el enfoque de las fortalezas. …”
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Survey of Piroplasmids in Wild Mammals, Unconventional Pets, and Ticks from Goiás State, Midwestern Brazil by Raphaela Bueno Mendes Bittencourt, Ana Cláudia Calchi, Lucianne Cardoso Neves, Nicolas Jalowitzki de Lima, Gabriel Cândido dos Santos, Ennya Rafaella Neves Cardoso, Warley Vieira de Freitas Paula, Luciana Batalha de Miranda Araújo, Jessica Rocha Gonçalves, Elisângela de Albuquerque Sobreira, Luiz Alfredo Martins Lopes Baptista, Hermes Ribeiro Luz, Marcos Rogério André, Filipe Dantas-Torres, Felipe da Silva Krawczak

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Efficacy of danhong injection adjuvant therapy in patients with acute ischemic stroke: a real-world, multicenter, retrospective study by Danping Pan, Haitong Wan, Haitong Wan, Yu He, Jiehong Yang, Yilei Guo, Li Yu, Feihu Zhang, Guoqing Zheng, Bin Xu, Yaohong Song, Mingjun Zhao, Xiangzhe Liu, Jianhe Liu, Gang Sun, Yaming Lin

“…Secondary outcomes included the proportions of patients with post-treatment NIHSS scores ≤4 or ≤1, the mRS score, the proportion of patients achieving mRS ≤1, and the incidence of in-hospital complications (IHC).ResultsA total of 3,560 patients were enrolled, including 1,425 in the DHI group, and 2,135 in the Non-DHI group, with 1,415 matched pairs identified via PSM. …”
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Use of an electrical stimulation-induced fatigue protocol to evaluate the myotropic effects of metabolic-active agents in <i>db/db</i> mice by V. A. Prikhodko, T. M. Matuzok, A. Yu. Grishina, V. E. Kovanskov, Yu. I. Sysoev, M. V. Titova, E. V. Popova, A. M. Nosov, D. Yu. Ivkin, S. V. Okovityi

“…Controlled ESIF of the muscle caused a 18.83–35.23 % (relative to baseline) decrease in CMAP amplitudes (p &lt; 0.01 for all groups) that was significantly smaller in the PVE, PJE, and maloben groups vs. control (p &lt; 0.05). The post-ESIF recovery period was associated with a 10.18–14.79 % increase in CMAP amplitudes that was significant in all groups except PGE (p &lt; 0.01 for control, PVE, and PJE; p &lt; 0.05 for maloben and metformin). …”
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Estimation of Genetic Parameters for Carcass and Meat Quality Traits Using Genomic Information in Yorkshire Pigs by Yangxun Zheng, Fuping Ma, Xitong Zhao, Yanling Liu, Quan Zou, Huatao Liu, Shujuan Li, Zipeng Zhang, Sen Yang, Kai Xing, Chuduan Wang, Xiangdong Ding

“…Meat quality traits also displayed medium to high heritability, expect for pH value measured within one hour post-slaughter (h² = 0.12). Drip loss indicators had higher genetic correlations with pH (r = mean −0.73) than with meat color indicators (r = mean 0.22). …”
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