Impaired K48-polyubiquitination downmodulates mouse norovirus propagation by Emmrich Wakeford, Elisabeth Werkmeister, Delphine Cayet, Sabine Poiret, Catherine Daniel, Jason Mackenzie, Jean-Claude Sirard, Frank Lafont, Ghaffar Muharram

“…Due to a lack of approved preventive or curative therapy options, intensive research effort is ongoing to better understand the pathogenesis mechanisms of noroviruses.MethodsIn this study, using the persistent murine norovirus S99 strain (MNoV_S99), we have investigated the role in the regulation of anti-noroviral responses of ubiquitination, a post-translational modification that covalently adds one or multiple ubiquitin molecules onto lysine residues of target proteins. …”
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Long-term outcome in people who use drugs successfully treated for hepatitis C infection with glecaprevir/pibrentasvir by Shana Yi, David Truong, Brian Conway

“…In the GRAND PLAN, we documented sustained virological response post-treatment Week12 (SVR12) in 108/117 (92.3 %) individuals (108/111 (mITT) or 97.3 % of those reaching the SVR12 timepoint) receiving an 8-week course of glecaprevir/pibrentasvir (G/P), with almost all using fentanyl and over half being unstably housed. …”
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Involvement of Nuclear Receptors PPAR-α, PPAR-γ, and the Transcription Factor Nrf2 in Cellular Protection Against Oxidative Stress Regulated by H₂S and Induced by Hypoxi... by Luz Ibarra-Lara, Araceli Sánchez-López, Leonardo del Valle-Mondragon, Elizabeth Soria-Castro, Gabriela Zarco-Olvera, Mariana Patlán, Verónica Guarner-Lans, Juan Carlos Torres-Narváez, Angélica Ruiz-Ramírez, Fernando Díaz de León-Sánchez, Víctor Hugo Oidor-Chan, Vicente Castrejón-Téllez

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Dietary Tithonia diversifolia improves hematology, antioxidant capacity, liver health, and disease resistance in hybrid of Oreochromis mossambicus × Oreochromis niloticus by Yuniel MÉNDEZ-MARTÍNEZ, Pedro D. MENDOZA-CARRANZA, Juan P. ORDÓÑEZ-IGLESIA, Veronica del C. SEGOVIA-MONTESDEOCA, Ana N. MORENO-VERA, Melanie A. CASANOVA-ERAZO, Mishel E. MÉNDEZ-SEGOVIA

“…At the end of the feeding trial, 18 fish from each group were given intraperitoneal injections with a pathogenic strain of Aeromonas hydrophila to test the protective efficacy of TD against bacterial infection for seven days (post-challenge period). The results after eight weeks revealed significant differences (P < 0.05), with an increase in haematological variables and antioxidant activity, low levels of transaminases and an adequate hepatic histological response in the TD-fed fish. …”
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First results of long-term follow-up of children in Russia after gene therapy for hereditary retinal dystrophies associated with biallelic mutations in the RPE65 gene by V. V. Neroev, L. A. Katargina, M. P. Kharlampidi, L. V. Kogoleva, I. V. Zolnikova, P. A. Ilyukhin, E. V. Denisova, S. V. Milash, N. A. Osipova, S. I. Kutsev, A. V. Polyakov, R. A. Zinchenko, V. V. Kadyshev, Yu. A. Bobrovskaya

“…The results of a one-year post VN treatment follow-up of Russian patients with RPE65-associated inherited retinal disease demonstrate stabilization and improvement of visual functions, which is especially important for otherwise incurable patients with a progressive course of the disease.…”
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Building research capacity to adapt and develop Patient-Reported outcome measures in low- and middle-income countries: results from a psychometrics workshop in Tanzania by Berivan Ece, Mrema Kilonzo, Sylvia Kaaya, Edith Tarimo, Candida Moshiro, Erasto Mbugi, Linda B. Mlunde, Lisa R. Hirschhorn, Claudia Hawkins, Emily H. Ho

“…Participants completed pre-workshop surveys on goals, experience, confidence, and knowledge, followed by a post-workshop survey to assess satisfaction (Level 1), knowledge changes (Level 2), and plans for use (Level 3), along with feedback. …”
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Drug tapering in animal research: current practices and challenges by Yatong Zhang, Yatong Zhang, Mengrui Chen, Mengrui Chen, Tongtong Jiang, Tongtong Jiang, Qianfang Fu, Qianfang Fu, Rong Ma, Rong Ma, Lianghui Nie, Lianghui Nie, Yuqiong You, Yuqiong You, Shuqi Gao, Shuqi Gao, Ping Rong, Ping Rong

“…The outcomes of tapering were classified into drug discontinuation, low-dose maintenance, and drug substitution, with all studies reporting the effects post-tapering.ConclusionThe methods of drug tapering in animal studies are influenced by multiple factors, including disease characteristics, treatment duration, animal tolerance, and specific goals. …”
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Key geological and engineering technologies and research directions for shale gas exploration and development in western Hubei Province, China by Guangyou Zhu, Jineng Jin, Qilin Xiao, Lei Wang, Guanglong Sheng, Jun Tang, Jianghui Meng, Zhiyuan Lu, Can Chen

“…For seismic data interpretation, pre-stack elastic inversion and azimuthal anisotropy inversion can be employed as core techniques, overcoming the limitation of individual post-stack attributes in typically detecting only major faults. …”
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Are Urethral Pressure Profile Measurements Effective in Diagnosing Urodynamic Stress Incontinence in Women Presenting with Stress or Mixed Urinary Incontinence? Results from a Cros... by Konstantinos Pantazis, Themistoklis Mikos, Sofia Tsiapakidou, Iakovos Theodoulidis, Stamatios Petousis, Konstantinos Dinas, Antonio Schiattarella, Antonio Simone Laganà, Apostolos P. Athanasiadis

“…However, the women in Group 2 had a significantly lower MUCP, FUL, and post-void residual after pressure flow compared to the women in Group 1 (<i>p</i> = 0.038, 0.003, and 0.04, respectively, upon Student’s <i>t</i> test for independent parameters). …”
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Involvement of ionomic metabolism of both the cerebrospinal fluid and the spinal cord in the analgesic efficacy of matrine in rats by Jin-Lu Huang, Chen-Yue Tang, Yao Fu, Li-Li Wan, Jie Li, Xi-Peng Sun, Jia-Lu Hu, Yue-Yi Zhang, Li-Ying Qu, Miao-Jia Fu, Yuan-Yuan Zhang, Le Ma, Cheng Guo, Jiu-Geng Chen

“…Matrine also dose-dependently yielded analgesia against formalin-induced biphasic pain, with an onset at around 10 min post-injection and a duration of 100 min. The ED50 and Emax values were 19.01 mg/kg and 71.86% for phase I and 40.30 mg/kg and 81.51% for phase II, respectively. …”
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Ethnicity and Power in the Soviet Union by Andrzej Wierzbicki

“…Another group of scientists, including those from post-Soviet states (e.g., Žambyl Artykbaev, Otar Džanelidze, and Georgij Siamašvili) as well as western scholars (e.g., Rogers Brubaker) concede that positive processes such as the allotment of territory to republics and other territorial units, the constitution of authority and administrative apparatus, and the formation of the elites once characterised the ethnic history of the USSR. …”
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The characterization of uterine calcium transport and metabolism during eggshell calcification of hens laying high or low breaking strength eggshell by Ying-ying Yang, Dong Dai, Hai-jun Zhang, Shu-geng Wu, Guang-hai Qi, Jing Wang

“…Laying hens were sampled at 1 h, 7 h (the initiation stage of eggshell calcification), and 17 h (the growth stage of eggshell calcification) post-oviposition (PO). The LS group showed a decreased thickness, weight and weight ratio of eggshells, accompanied with ultrastructural deterioration and total Ca reduction. …”
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Benralizumab Outcomes in Patients with Severe Eosinophilic Asthma Treated in Real-Life Settings: Results of the BREEZE Study in 5 Countries From Central Eastern Europe and Baltics by Mihaltan F, Csoma Z, Pauk N, Irás B, Baukienė J, Teodorescu G, Malakauskas K, Staevska M

“…., 1117, Budapest, Hungary, Tel +36 1883 6500, Email Bela.Iras@AstraZeneca.comPurpose: To describe real-world clinical characteristics, treatment patterns and outcomes of severe eosinophilic asthma (SEA) patients initiated on benralizumab after treatment authorization in Central Eastern Europe and Baltic Area.Patients and Methods: BREEZE was a retrospective, medical chart review with a pre-post design conducted in 42 clinical centers from Bulgaria, Czech Republic, Hungary, Lithuania and Romania. …”
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Multisession transcranial direct current stimulation and aerobic exercise synergistically improve food craving symptoms, impulsivity, and cognitive flexibility in women with overwe... by Sahar Malek Khataei, Ehsan Amiri, Daniel Gomes da Silva Machado

“…Follow-up measurements for FC and CF were also conducted one month post-intervention. Results FC was lower in the a-tDCS + AE group compared to Sham + AE and Control groups in Phase 1 (Cohen’s d = 1.4 and 1.9, respectively). …”
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Evaluation of potential mechanisms for skeletal muscle mass recovery early after left ventricular assist device implantation by Didjana Celkupa, BS, Benjamin A. Sweigart, MA, Joronia Chery, BA, Alex Coston, MD, Laura Telfer, BS MS, Matthew Lawrence, BS, Michael S. Kiernan, MD MS, Gregory S. Couper, MD, Masashi Kawabori, MD, Nathan LeBrasseur, PhD MS, Edward Saltzman, MD, Amanda R. Vest, MBBS MPH

“…Dual X-ray absorptiometry (DXA) measured ALM at baseline and at 3- and 6-months post-LVAD implantation (n = 22 with ALM at baseline and 3 months). …”
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Genome-scale mRNA and miRNA transcriptomic insights into the regulatory mechanism of cucumber corolla opening by Xiao-fei SONG, Dan-feng GE, Yang XIE, Xiao-li LI, Cheng-zhen SUN, Hao-nan CUI, Xue-yun ZHU, Ren-yi LIU, Li-ying YAN

“…This integrated study on the transcriptional and post-transcriptional profiles can provide insights into the molecular regulatory mechanism underlying corolla opening in the cucumber.…”
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Plasma levels of the neuron damage markers brain-derived tau and glial fibrillary acidic protein in Lyme neuroborreliosis: A longitudinal study by Mathilde Ørbæk, Fernando Gonzalez-Ortiz, Rosa M.M. Gynthersen, Åse Bengaard Andersen, Kubra Tan, Ulf Andreasson, Kaj Blennow, Helene Mens, Henrik Zetterberg, Anne-Mette Lebech

“…Methods: A retrospective longitudinal cohort study including plasma collected at diagnosis and approximately three- and six-months post diagnosis from adult NB patients enrolled at the Department of Infectious Diseases, Rigshospitalet between 2018 and 2020.BD-tau concentrations were measured in-house using the Single Molecule Array (Simoa) HD-X platform, while GFAP concentrations were assessed on the same platform utilizing the GFAP Discovery Kit. …”
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Pregnancy and infant outcomes among HIV-infected women taking long-term ART with and without tenofovir in the DART trial. by Diana M Gibb, Hilda Kizito, Elizabeth C Russell, Ennie Chidziva, Eva Zalwango, Ruth Nalumenya, Moira Spyer, Dinah Tumukunde, Kusum Nathoo, Paula Munderi, Hope Kyomugisha, James Hakim, Heiner Grosskurth, Charles F Gilks, A Sarah Walker, Phillipa Musoke, DART trial team

“…<h4>Conclusions</h4>Overall 1-year 5% infant mortality was similar to the 2%-4% post-neonatal mortality observed in this region. …”
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Maternal nitrate supplementation improves offspring cardiometabolic outcomes in obese pregnancies by Kristi M. Crowe-White, Katelyn E. Senkus, Janie C. DiNatale, Arlin B. Blood, Taiming Liu, Meijuan Zhang, Khondoker Adeba Ferdous, Rebecca Bloch, Han-A Park

“…NFD (n = 4), HFD (n = 3), and HFDN (n = 4) maintained their respective diets, yet all weanling pups were transitioned to NFD at post-natal day 21 (P21). Body composition was assessed by bioimpedance spectroscopy along with assessment of body weight (BW), and abdominal circumference as well as brown adipose tissue (BAT) and white adipose tissue (WAT) mass. …”
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Global trends and interdisciplinary insights in Tai Chi research: a bibliometric analysis (2004–2024) by Bei Li, Xiwei Zhu, Xiwei Zhu, Xiwei Zhu, Haoli Zhang, Su Zhang, Yanwei Li, Shuxi Wu, Shuxi Wu, Shuxi Wu, Jie Han, Jie Han, Jie Han

“…Disciplinary distribution was analyzed using Web of Science subject categories, and visualized through VOSviewer’s clustering algorithm.ResultsFrom 2004 to 2023, the number of research papers related to Tai Chi showed an overall upward trend, with a 12.3% average annual growth rate post-2012. China contributed 68.5% of publications (n = 645/941), followed by the United States (15.2%, n = 143). …”
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