Comparative transcriptomics in B73-teosinte near-isogenic maize lines reveals key defense signaling and phytoalexins in response to Cercospora zeina infection by Xiaomeng Sun, Xiaomeng Sun, Ruiyu Zhang, Ruiyu Zhang, Zongping Wang, Zongping Wang, Haotian Zhang, Haotian Zhang, Hairun Wen, Hairun Wen, Junli Zhang, Naibin Yu, Naibin Yu, Zhe Wang, Zhe Wang, Huanhuan Tai, Huanhuan Tai, Qin Yang, Qin Yang

“…Here we conducted transcriptome analyses on leaves from a pair of B73-teosinte near-isogenic lines (NILs) with contrasting Qgls8 alleles infected with C. zeina at 0, 4, 8, and 12 hours post inoculation (hpi). A total of 1225 up-regulated genes (URGs) were identified in the resistant line Qgls8-R compared with the susceptible line Qgls8-S across the four time points. …”
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Perampanel for alleviation of secondary injury in traumatic brain injury (PEACE-TBI): a protocol for a phase-II multicentre randomised clinical trial by Ryota Tamura, Yuki Kuranari, Yukina Morimoto, Masahiro Toda, Tokunori Kanazawa, Makoto Inaba, Ryo Yamamoto, Koichiro Homma, Takahiro Shoji, Junichi Sasaki, Masayuki Shimizu, Masato Nakaya, Satoshi Terao, Ryota Sasao, Makoto Katayama, Koichi Ueno, Yumiko Oishi, Akiyoshi Nakamura, Yo Kikuo, Ryosuke Murakami, Sota Wakahara, Konosuke Ishikawa, Kenzo Kosugi, Tatsuro Ozaki

“…The antiepileptic drugs can be increased, changed or added as necessary if early post-traumatic seizures are observed. The primary outcome is favourable neurological outcome, defined as a Glasgow Outcome Scale Extended score of ≥5 at 90 days after the TBI diagnosis, which will then be compared between the groups through an intention-to-treat analysis.Ethics and dissemination The present study has been approved by the Certified Review Board of Keio at the principal institution (approval number: N20240004). …”
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Ornidazole-Induced Liver Injury: The Clinical Characterization of a Rare Adverse Reaction and Its Implications from a Multicenter Study by Ali Rıza Çalışkan, Ilker Turan, Sezgin Vatansever, Jasmin Weninger, Emine Türkmen Şamdancı, Ayşe Nur Akatli, Elvan Işık, Esra Durmazer, Ayşenur Arslan, Nilay Danış, Hüseyin Kaçmaz, Sedat Cicek, Osman Sağlam, Dilara Turan Gökçe, Derya Arı, Sevinç Tuğçe Güvenir, Serkan Yaraş, Cumali Efe, Meral Akdoğan Kayhan, Murat Harputluoğlu, Ali Canbay, Ulus Salih Akarca, Zeki Karasu, Ramazan Idilman, Fulya Günşar

“…Corticosteroids were used in 24.8% of cases (n = 25) and were associated with higher ANA positivity and a 20% (n = 5) relapse rate post-discontinuation. Recovery was achieved in 87.7% of cases (n = 88), while 7.9% of cases (n = 8) required liver transplantation and 4% (n = 4) died. …”
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Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation by Lifeng Gan, Lifeng Gan, Lifeng Gan, Peiyue Luo, Peiyue Luo, Peiyue Luo, Junrong Zou, Junrong Zou, Wei Li, Wei Li, Wei Li, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Yiran Lu, Liying Zheng, Biao Qian, Biao Qian

“…Long-stranded non-coding RNAs (lncRNAs), defined as non-coding RNAs exceeding 200 nucleotides in length, regulate various cellular processes by modulating gene expression at transcriptional, post-transcriptional, and epigenetic levels. Evidence suggests that lncRNAs can be regulated by HIF at the transcriptional level. …”
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Do bulls experience pain or stress during electroejaculation? Evidence from electroencephalography, behavioral, hormonal, and metabolite profiling by Ubedullah Kaka, Nurhusien Yimer Degu, Pavan Kumar, Abubakar Ahmed Abubakar, Yong-Meng Goh, Muhammad Waseem Aslam, Khaleeq Ur Rehman Bhutto, Muhammad Abdul Basit, Wasim S. M. Qadi, Norazlan Mohmad Misnan, Ahmed Mediani, Khor Kuan Hua

“…Results: EE induced significant increases (p < 0.05) in stress hormones at ejaculation, which gradually returned to baseline 20 min post-procedure. EEG metrics, such as MF and Ptot, significantly increased during EE (p < 0.05), indicating heightened cortical activity associated with nociception. …”
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El diagnóstico relacional colaborativo (II). Ampliando el diagnóstico relacional en la práctica del Trabajo Social by Josefa Cardona-Cardona, Maria Elena Cuartero-Castañer, José Francisco Campos-Vidal

“…El proceso de elaboración de esta evaluación compartida, a la que denominamos co-diagnóstico, considera criterios esenciales que se vinculan a una práctica del Trabajo Social post-estructural y a un posicionamiento centrado en el enfoque de las fortalezas. …”
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Survey of Piroplasmids in Wild Mammals, Unconventional Pets, and Ticks from Goiás State, Midwestern Brazil by Raphaela Bueno Mendes Bittencourt, Ana Cláudia Calchi, Lucianne Cardoso Neves, Nicolas Jalowitzki de Lima, Gabriel Cândido dos Santos, Ennya Rafaella Neves Cardoso, Warley Vieira de Freitas Paula, Luciana Batalha de Miranda Araújo, Jessica Rocha Gonçalves, Elisângela de Albuquerque Sobreira, Luiz Alfredo Martins Lopes Baptista, Hermes Ribeiro Luz, Marcos Rogério André, Filipe Dantas-Torres, Felipe da Silva Krawczak

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Use of an electrical stimulation-induced fatigue protocol to evaluate the myotropic effects of metabolic-active agents in <i>db/db</i> mice by V. A. Prikhodko, T. M. Matuzok, A. Yu. Grishina, V. E. Kovanskov, Yu. I. Sysoev, M. V. Titova, E. V. Popova, A. M. Nosov, D. Yu. Ivkin, S. V. Okovityi

“…Controlled ESIF of the muscle caused a 18.83–35.23 % (relative to baseline) decrease in CMAP amplitudes (p &lt; 0.01 for all groups) that was significantly smaller in the PVE, PJE, and maloben groups vs. control (p &lt; 0.05). The post-ESIF recovery period was associated with a 10.18–14.79 % increase in CMAP amplitudes that was significant in all groups except PGE (p &lt; 0.01 for control, PVE, and PJE; p &lt; 0.05 for maloben and metformin). …”
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Impact of distal or pylorus preserving gastrectomy on postoperative quality of life in T1 stage middle third gastric cancer patients by Hao Chen, Siqing Jing, Zhaoping Li, Lianlian Cao, Wenxian Guan, Xin Chen, Meng Wang

“…Secondary outcomes included intraoperative and postoperative conditions, incidence of complications, and changes in nutritional status at 6 and 12 months post-surgery. Compared to the DG group, the PPG group exhibited fewer lymph node dissections [20 (17, 26) vs. 25 (19.5, 32), Z = 2.013, P = 0.052], shorter distances from the upper resection margin [2.0 (1.3, 3.0) vs. 3.5 (2.5, 4.75), Z = 4.664, P = 0.0002], and shorter distances from the lower resection margin [2.0 (1.4, 3.0) vs. 4.5 (4.0, 5.5), Z = 6.691, P < 0.001]. …”
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Promoting smoking cessation and preventing relapse to tobacco use following a smoke-free mental health inpatient stay (SCEPTRE feasibility study): a multicentre randomised controll... by Simon Gilbody, Catherine Hewitt, John Britton, Lion Shahab, Tim Coleman, Elena Ratschen, Judith Watson, Alex Mitchell, Gregor Russell, Steve Parrott, Lesley Sinclair, Peter A Coventry, Paul Galdas, Michelle Horspool, Samantha Brady, Emily Shoesmith, Petal Petersen Williams, Lisa Huddlestone, Victoria Exley, Fraser Wiggins, Jodi Pervin, Moira Leahy, Claire Paul, Lesley Colley, Simon Hough

“…Data will be collected at baseline, 3 months and a second timepoint between 4 and 6 months post-randomisation. With 64 participants (32 in each group), the trial will allow a participation rate of 15% and completion rate of 80% to be estimated within a 95% CI of ±3% and ±10%, respectively. …”
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Induction of maturation gonads the Asian swamp eel Monopterus albus at different sizes with the hormones PMSG + antidopamine and hCG by Aan Aryanti Sandra, Agus Oman Sudrajat, Harton Arfah, Dinar Tri Soelistyowati

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Receptor activator of nuclear factor-kappa B ligand-derived microglia healing peptide 1-AcN inhibits osteoarthritis progression in mice by Yuji Fukuda, Munehisa Shimamura, Yuki Etani, Takaaki Noguchi, Takuya Kurihara, Atsushi Goshima, Taihei Miura, Makoto Hirao, Nagahiro Ochiai, Nan Ju, Atsushi Sugimoto, Takashi Kanamoto, Ken Nakata, Seiji Okada, Kosuke Ebina

“…Knee joints were harvested at 2, 4, and 8 weeks post-surgery. In vitro, the effects of MHP1-AcN were assessed on osteoclast differentiation, inflammatory cytokine expression, and M1/M2 macrophage polarization using mouse bone marrow-derived macrophages. …”
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Quality of Care and Outcomes of Inpatients with COPD: A Multi-Center Study in China by Wang F, Wang M, Chen X, Song A, Zeng H, Chen J, Wang L, Jiang W, Jiang M, Shi W, Li Y, Zhong H, Chen R, Liang Z

“…Among them, 14.3% underwent post-bronchodilator spirometry. Documentation of exacerbation history and symptom scores was found in 16.8% and 1.2% of medical records, respectively. …”
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Physical and insecticidal durability of PermaNet® 3.0 and Olyset® plus piperonyl butoxide-synergist insecticide-treated nets in Sierra Leone: results of durability monitoring from... by Raymond Kiprop Sudoi, Keith Esch, Frederick Yamba, Laurent Iyikirenga, Charlene Youssef, Prince Nallo, Isabel Swamidoss, Carla Mapp, Dennis Marke, Samuel Juana Smith, Ronald Carshon-Marsh, Musa Sillah-Kanu, Dave Schnabel, Jacky Raharinjatovo, Jenny Carlson, Rebecca Levine, Evelyne Alyko, Ramlat Jose, Tony Hughes, Djenam Jacob, Yemane Yihdego, Kevin Opondo, Stephen Poyer

“…PermaNet® 3.0 ITNs displayed 13% 24-h mortality against pyrethroid-resistant mosquitoes on roof panels, with a 46% reduction in PBO content 34 months post-distribution. Olyset® Plus ITNs had 3% f24-hour mortality against pyrethroid-resistant mosquitoes, with a 77% reduction in PBO content. …”
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ARTS AND MACHINE CIVILIZATION INTERNATIONAL SCIENTIFIC CONFERENCE / МЕЖДУНАРОДНАЯ НАУЧНАЯ КОНФЕРЕНЦИЯ «ИСКУССТВО И МАШИННАЯ ЦИВИЛИЗАЦИЯ»... by DUKOV YEVGENY V. / ДУКОВ Е.В., EVALLYO VIOLETTA D. / ЭВАЛЛЬЕ В.Д.

“…The purpose of the conference was to comprehend the artistic practices in the era of machine civilization, get acquainted with current hypotheses, publish new facts and discuss modern terminologies (law of spontaneity, law of semantic uncertainty, algorithmic apophenia, post-opera, artificial life and new vitality). Along with the study of new challenges, old issues were raised, which became in demand in the machine civilization: originals and copies of artworks, the boundaries of conventionality and overcoming distrust in new media, narratives and poetics in serious and entertaining screen genres. …”
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Dynamic-covalent hybrid hydrogels with cartilaginous immune microenvironment temporally regulating meniscus regeneration by Zhanyu Chang, Xinyue Ran, Yaru Chu, Bohui Li, Zhenlin Fan, Genke Li, Dan Li, Wenjie Ren, Yujie Hua, Guangdong Zhou

“…Furthermore, CIME is successfully created by the introduction of a temporally on-demand regulatory system: naproxen anti-inflammatory drugs are preferentially released to regulate M1/M2 macrophage polarization through PI3K/Akt/mTOR signaling pathway at early stage, while TGFβ3/CTGF growth factors are on-demand released to promote fibrochondrogenic differentiation of stem cells in the post-regulatory microenvironment at later stage. …”
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An Experimental Study on the Effect of Thermally Oxidised Ti-6Al-4V Substrate on the Surface Characteristics and Composition of Hydroxyapatite Coatings Produced by Modified Cold Ga... by Norarney Ahmad, Norehan Mokhtar, Siti Noor Fazliah Mohd Noor, Hussain Zuhailawati, Suzianti Iskandar Vijaya

“…Statistical analysis was performed using the Kruskal-Wallis test for group comparisons, followed by post-hoc Mann-Whitney U tests. A p-value of less than 0.05 was considered statistically significant. …”
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Molecular Cloning and Expression Characteristics of otx2 and eya1 During the Early Development of Seriola aureovittata by Yan JIANG, Xin LIU, Yongjiang XU, Aijun CUI, Bin WANG, Xinfu LIU, Xuezhou LIU, Zhiyong XUE

“…At the larval and juvenile stages, the expression of otx2 and eya1 could be detected, with high expression levels at the early stage, during which the expression level of otx2 was first upregulated and then downregulated; the expression level at 3–25 dph (days post-hatching) was significantly higher than those at 1 dph and 30–60 dph, with the highest level reached at 20 dph (P < 0.05). …”
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Neurologic symptoms following COVID-19 in Lima, Peru: a prospective longitudinal observational study by Hanalise V. Huff, Hanalise V. Huff, Carla Villanueva-Colina, Monica M. Diaz, Sofia Tovar, Andrea Davila Luna, Tianxia Wu, Davidson H. Hamer, Davidson H. Hamer, Davidson H. Hamer, Igor J. Koralnik, Tom Solomon, Tom Solomon, Miguela A. Caniza, Patricia J. Garcia

“…Pre-existing anxiety was associated with post-COVID-19 hearing changes, muscular pain, numbness and weakness and pre-existing depression with neck stiffness and numbness. …”
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Preemptive analgesia regimen modulates hippocampal c-fos expression in a rat postoperative uterine pain model by Saima Mumtaz, PhD Anatomy, Najma Baseer, PhD Anatomy, Syed H. Habib, PhD Physiology, Noman U. Wazir, PhD Anatomy

“…Pain was assessed with a subjective pain scale (Abdominal Pain Assessment, APA) at 2, 4, 6, 9, and 24 h post-surgery. Expression of c-fos in hippocampal tissue, including the dentate gyrus, CA1, and CA3 regions, was detected immunohistochemically. …”
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