Effects of generative artificial intelligence (GenAI) patient simulation on perceived clinical competency among global nursing undergraduates: a cross-over randomised controlled tr... by Tai Chun John Fung, Siu Ling Chan, Choi Fung Mabel Lam, Chung Yan Lam, Christopher Chi Wai Cheng, Man Hin Lai, Cheuk Chun Joseph Ho, Siu Lun Au, Lok Yi Mak, Sophia Hu, Supapak Phetrasuwan, Jumpee Granger, Jung Min Yoon, Gulzar Malik, Clara Cabrera Moreno, Man Hei Patrick Kwok, Chia-Chin Lin

“…At T1, Group B (receiving GenAI) demonstrated significantly larger improvements in CCQ total score [47.68 (95% CI: 36.68, 58.68), p < 0.001] compared to Group A (receiving 360° VR) [24.95 (95% CI: 13.96, 35.95), p < 0.001], with significant between-group difference [16.59 (95% CI: 2.77, 30.41), p = 0.020]. At T2 (post-crossover), both groups maintained significant improvements. …”
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A comparative analysis of cardiopulmonary features in patients with systemic sclerosis and mixed connective tissue disease: results from SOPHIE registry by Mi Zhou, Mi Zhou, Bing-hua Wang, Ming-jiao Liao, Rui Yang, Jing Tan, Wen-jun Zhang, Chun-ka Wong, Chung-Wah Siu, Lixue Yin

“…Levels of SaO2 at pre-6MWD (96.55 ± 2.61 vs. 98.67 ± 2.05, p &lt; 0.001) and post-6MWD (95.73 ± 5.46 vs. 98.40 ± 2.73, p = 0.002) were markedly lower in MCTD patients compared to SSc patients. …”
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Use of sedative drugs in specialist palliative care (iSedPall): a multi-modal intervention pilot study protocol by Christoph Ostgathe, Claudia Bausewein, Eva Schildmann, Jeremias Bazata, Maria Heckel, Saskia Kauzner, Carsten Klein, Sabine H. Krauss, Alexander Kremling, Manuela Schneider, Andreas Seifert, Kerstin Ziegler, Christian Jäger, Jan Schildmann

“…Additionally, we will pilot the measurement of healthcare professionals´ confidence in using sedative drugs as an outcome indicator through a pre-post survey. Four specialist palliative care services will pilot the complex intervention for nine months. …”
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Human exposure to green spaces and monoterpenes: discovery and use of α-pinene metabolites as biomarkers by Zhengzhi Xie, Saurin R. Sutaria, Jin Y. Chen, Hong Gao, Daniel J. Conklin, Rachel J. Keith, Sanjay Srivastava, Pawel Lorkiewicz, Aruni Bhatnagar

“…Through a combination of pseudo-targeted and untargeted analyses, we discovered 22 α-pinene metabolites post-inhalation including nine novel structures, with two confirmed against synthetic standards. …”
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Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge (iRehab): a protocol for a randomised controlled assessor-... by Julie Bruce, Jason Madan, Martin Underwood, Roger Kenyon, Mariam Ratna, Ranjit Lall, Gavin D Perkins, Ella Terblanche, Kerry Raynes, Brenda O'Neill, Mandana Zanganeh, Rowena Williams, Danny McAuley, Paul Dark, Bronwen Connolly, Chen Ji, Judy Martina Bradley, Rachel Clarke, Jill Costley, Nigel D Hart, Penelope Firshman, Katherine Jones, Annette Henderson

“…The primary outcome is Health-related quality of life (HRQoL) at eight weeks post-randomisation measured using the EQ-5D-5L. Secondary outcomes are: HRQoL (six months), physical function, fatigue, illness perceptions anxiety and depression, healthcare resource use at eight weeks and six months and intervention acceptability. …”
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Arrhythmogenic right ventricular cardiomyopathy in recipients on heart transplant waiting list by M. A. Simonenko, P. A. Fedotov, A. A. Kostareva, Yu. V. Sazonova, K. N. Malikov, M. A. Bortsova, A. P. Polyakova, A. V. Berezina, I. A. Zemskov, T. M. Pervunina, L. B. Mitrofanova, G. V. Nikolaev, M. L. Gordeev, M. Yu. Sitnikova, M. A. Karpenko

“…According to our results, causal variants in desmosome genes were determined in 1 from 4 patients and simultaneous presence of two unique genetic variants in the RKR2 gene were found in one. A special feature of post-HTx management was the development of agranulocytosis, which once again underlines the need for a personalized approach to the selection of the immunosuppressive therapy.…”
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The Temporal Trends of Mortality Due to Tuberculosis in Brazil: Tracing the Coronavirus Disease 2019 (COVID-19) Pandemic’s Effect Through a Bayesian Approach and Unmasking Disparit... by Reginaldo Bazon Vaz Tavares, Dulce Gomes, Thaís Zamboni Berra, Yan Mathias Alves, Antônio Carlos Vieira Ramos, Marcela Antunes Paschoal Popolin, André da Silva Abade, Nathalia Zini, Ariela Fehr Tártaro, Josilene Dália Alves, Fernanda Bruzadelli Paulino da Costa, Maria Eduarda Pagano Pelodan, Beatriz Fornaziero Vigato, Daniele de Moraes Pinheiro, Juliana Queiroz Rocha de Paiva, Clara Ferreira de Souza, Ricardo Alexandre Arcêncio

“…Females experienced a greater post-pandemic monthly increase (2.80%) in mortality than males (0.72%). …”
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A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID by Stefanie M. Bader, Dale J. Calleja, Shane M. Devine, Nathan W. Kuchel, Bernadine G. C. Lu, Xinyu Wu, Richard W. Birkinshaw, Reet Bhandari, Katie Loi, Rohan Volpe, Yelena Khakham, Amanda E. Au, Timothy R. Blackmore, Liana Mackiewicz, Merle Dayton, Jan Schaefer, Lena Scherer, Angus T. Stock, James P. Cooney, Kael Schoffer, Ana Maluenda, Elizabeth A. Kleeman, Kathryn C. Davidson, Cody C. Allison, Gregor Ebert, Gong Chen, Kasiram Katneni, Theresa A. Klemm, Ueli Nachbur, Smitha Rose Georgy, Peter E. Czabotar, Anthony J. Hannan, Tracy L. Putoczki, Maria Tanzer, Marc Pellegrini, Bernhard C. Lechtenberg, Susan A. Charman, Melissa J. Call, Jeffrey P. Mitchell, Kym N. Lowes, Guillaume Lessene, Marcel Doerflinger, David Komander

“…Whilst effective in the acute phase of a COVID infection, Paxlovid cannot be used by all patients, can lead to viral recurrence, and does not protect against post-acute sequelae of COVID-19 (PASC), commonly known as long COVID, an emerging significant health burden that remains poorly understood and untreated. …”
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Three security challenges for Lithuania by Paul A. Goble

“…In addition to striving to become part of the Western institutions, NATO and the EU, Lithuania should seek to improve its relations with Russia; second, although to the detriment of Baltic unity, Lithuania must develop as a regional actor, closely allied with Poland and the other Central European states; third, Lithuania must continue to expand its ties with the United States; fourth, Lithuania must recognize that in the post-cold war environment, NATO and the EU will not save Lithuania; fifth, Lithuania must get busy working on building the institutions of a civil society. …”
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Low‐Intensity Focused Ultrasound Ameliorates Cisplatin‐Induced Cognitive Impairment by Attenuating Hippocampal Neuroinflammation and Enhancing Synaptic Plasticity in Rats by Xiaowei Han, Hagiwara Akifumi, Pin Lv, Jiahuan Liu, Xiaowei Huang, Renyuan Liu, Xiaojing Long, Yang Liu, Jiangong Zhang, Guolin Ma, Bing Zhang

“…Neuroimaging revealed significant differences in diffusion tensor imaging metrics of specific brain regions pre‐ and post‐LIFUS. Moreover, neuropathology showed higher dendritic spine density, less myelin loss, fewer apoptotic cells, more synapses, and less mitochondrial autophagy after LIFUS treatment. …”
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Stress hyperglycemia ratio as a biomarker for early mortality risk stratification in cardiovascular disease: a propensity-matched analysis by Mingxing Lei, Yan Li, Longcan Cheng, Nan Tang, Jie Song, Mi Song, QingQing Su, Mingxuan Liu, Shihui Fu, Feng Lin, Yuan Gao

“…., OASIS AUC: +0.034 for in-hospital, P < 0.001), though benefits diminished post-PSM (e.g., OASIS: +0.012 for in-hospital, P = 0.009). …”
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Indobufen versus aspirin after percutaneous coronary intervention in elderly patients with acute coronary syndrome by Wenbo Dai, Guanyu Mu, Jiayi Ren, Sutao Hu, Rongxin Guo, Tian-shu Gu, Jingjin Che, Xianghong Ma, Tong Liu, Xue Wu, Jing-Kun Zhang, Gary Tse, Yajie Wang, Jian-Mei Zhou, Seung-Woon Rha, Kangyin Chen

“…Purpose This study aims to assess the safety and efficacy of Indobufen as an alternative to aspirin when used in combination with clopidogrel in elderly ACS patients post-PCI. Methods This is a single-center, retrospective study employing propensity score matching. …”
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Case report: Endolymphatic sac tumor with blurred vision by Ke Yuan, Weijian Luo, Weijian Luo, Weijian Luo, Weijian Luo, Jia Chen, Jia Chen, Jia Chen, Jia Chen, Quanzhou Peng, Quanzhou Peng, Quanzhou Peng, Xiaoguang Tong, Xiaoguang Tong, Xiaoguang Tong, Xiaoguang Tong, Xiaoguang Tong, Jiliang Hu, Jiliang Hu, Jiliang Hu, Jiliang Hu

“…Complete surgical resection is the treatment of choice, and any remaining tumor remnants can be managed with adjuvant radiotherapy post-surgery, necessitating long-term follow-up to monitor any developments.…”
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RETRACTED ARTICLE: Target receptor identification and subsequent treatment of resected brain tumors with encapsulated and engineered allogeneic stem cells by Deepak Bhere, Sung Hugh Choi, Pim van de Donk, David Hope, Kiki Gortzak, Amina Kunnummal, Jasneet Khalsa, Esther Revai Lechtich, Clemens Reinshagen, Victoria Leon, Nabil Nissar, Wenya Linda Bi, Cheng Feng, Hongbin Li, Yu Shrike Zhang, Steven H. Liang, Neil Vasdev, Walid Ibn Essayed, Pablo Valdes Quevedo, Alexandra Golby, Naima Banouni, Anna Palagina, Reza Abdi, Brian Fury, Stelios Smirnakis, Alarice Lowe, Brock Reeve, Arthur Hiller, E. Antonio Chiocca, Glenn Prestwich, Hiroaki Wakimoto, Gerhard Bauer, Khalid Shah

“…Activation of the kill switch enhances the efficacy of MSCBif and results in their elimination post-tumor treatment which can be tracked by positron emission tomography (PET) imaging. …”
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Long COVID Symptoms and Five Dimensions of HRQoL: A Retrospective Regional Study of Patients Recovered from COVID-19 Infection in Saudi Arabia by Almoliky MA, Alsaif B, Saleh KA, Alkubati SA, Hassan SUN, Algahtani FD, Aldhmadi BKM, Assaggaf HM, Alzain MA

“…Multiple regression analysis showed that marital status (p=0.05), irregular exercise (p&lt; 0.01), duration of hospitalization (p&lt; 0.01), and oxygen therapy (p&lt; 0.05) were the independent background factors affecting HRQoL post-COVID-19. Among the long-COVID-19 symptoms, fatigue (p=0.05), persistent cough (p=0.001), dyspnea (p=0.02), and sexual dysfunction (p&lt; 0.001) were the independent factors that impacted the HRQoL after controlling for background variables.Conclusion: The study has significant implications for Saudi Arabia’s Health Sector Transformation Program that could achieve its goals of human centric care and patient satisfaction though addressing the negative impacts of specific long-COVID symptoms such as fatigue, persistent cough, dyspnea and sexual dysfunction and improving the HRQoL in domains of pain/discomfort and anxiety/depression.Keywords: pandemic, healthcare, fatigue, pain, discomfort, anxiety, sexual dysfunction…”
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The impact of passive ultrasonic irrigation on the bond strength of two different self-etch adhesives to human pulp chamber dentine: a laboratory investigation by Mohammed Turky, Jukka Matinlinna, Monika Lukomska-Szymanska, Venkateshbabu Nagendrababu, Paul M. H. Dummer, Ahmad Abdel Hamid Elheeny, Nermin Alsayed Mahmoud

“…Statistical analysis was conducted using one-way ANOVA and Tukey’s post hoc tests to compare irrigation regimens for each adhesive technique independently, while failure modes of each adhesive system were represented as the frequency for each irrigation method. …”
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Fermented strawberry pomace enhances carcass characteristics and meat quality by regulating plasma biochemical indices and antioxidant capacity in aged laying hens by Wei Lan, Wei Lan, Wei Lan, Ting Chen, Ting Chen, Binghua Qin, Binghua Qin, Md. Abul Kalam Azad, Md. Abul Kalam Azad, Zhihua Li, Yadong Cui, Yadong Cui, Xiangfeng Kong, Xiangfeng Kong, Xiangfeng Kong

“…FSP supplementation at 0.25–1% reduced breast muscle pH at 48 h post-slaughter, as well as 48 h drip loss. An elevation in leg muscle a* values (p &lt; 0.05) was observed in both 0.25 and 0.5% FSP groups compared with the control group, while L* value was higher (p &lt; 0.05) in the 0.25% FSP group compared to the 0.5% FSP group. …”
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Exploratory study of the effect of DHA supplementation on blood fatty acids and inflammatory markers in children with MIS-C by Elvira Verduci, Elvira Verduci, Patrizia Risè, Giulia Fiore, Giulia Fiore, Sara Vizzuso, Alice Bonomi, Dario Dilillo, Laura Fiori, Elisabetta Di Profio, Valeria Calcaterra, Savina Mannarino, Elena Zoia, Enza D’Auria, Angelo Sala, Gianvincenzo Zuccotti, Gianvincenzo Zuccotti

“…Blood samples were collected at hospital discharge (T0), and at 3 (T1) and 6 months (T2) post-discharge using dried blood spots for fatty acid analysis by gas chromatography. …”
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Exosomal miR-202-5p derived from iPSC-MSCs protects against myocardial infarction through inhibition of cardiomyocyte pyroptosis by Jiaqi Chen, Xiaoting Liang, Qian Han, Haiwei He, Xinran Huang, Ying Shen, Jie Qiu, Fang Lin, Cong Mai, Ziqi Li, Kexin Ma, Bei Hu, Xin Li, Yuelin Zhang

“…Cardiac function was assessed four weeks post-injection. Myocardial pyroptosis was evaluated using TUNEL staining and measurement of associated factors. …”
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Association of peripheral monocytic myeloid-derived suppressor cells with molecular subtypes in single-center endometrial cancer patients receiving carboplatin + paclitaxel/aveluma... by C. D’Alterio, G. Rea, M. Napolitano, E. Coppola, A. Spina, D. Russo, R. Azzaro, C. Mignogna, G. Scognamiglio, D. Califano, L. Arenare, C. Schettino, C. Pisano, S. C. Cecere, M. Di Napoli, A. Passarelli, F. Perrone, S. Pignata, S. Scala

“…Moreover, in a subgroup of patients, primary tumors were highly infiltrated by M-MDSCs in MSS as compared to MSI-high ECs. A post hoc analysis displayed higher frequency of M-MDSCs (p = 0.020) and lower frequency of CD4+ (p < 0.005) at pretreatment in EC patients as compared to healthy donors. …”
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