ACTivity as medicine In Oncology for Head and Neck (ACTIOHN): a feasibility study investigating a patient-centred approach to exercise for head and neck cancer patients by Joanne M. Patterson, Mary G. Cherry, Andrew Levy, Simon N. Rogers, Rachel C. Brooker, Valerie M. Bryant, Steven Lane, Michael M. Nugent, Ruth Price, Andrew G. Schache, Jennifer A. Kirton, Bridget Young, Debra Fisher, Adrian W. Midgely

“…ObjectiveTo determine the feasibility and acceptability of integrating a remote, personalised, collaborative, and flexible exercise programme into the head and neck cancer (HNC) care pathway.DesignA single arm mixed-methods feasibility study across two UK NHS hospitals.ProcedureEligible HNC patients (aged ≥ 16 years old, treated with curative intent and classified as low/medium risk according to an exercise risk stratification tool) were invited to participate between diagnosis and 8 weeks post-treatment. Patients treated with palliative intent and those identified as high risk on an exercise risk stratification tool were excluded. …”
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Differential Effects of Human Immunodeficiency Virus Nef Variants on Pulmonary Vascular Endothelial Cell Dysfunction by Amanda K. Garcia, Noelia C. Lujea, Javaria Baig, Eli Heath, Minh T. Nguyen, Mario Rodriguez, Preston Campbell, Isabel Castro Piedras, Edu Suarez Martinez, Sharilyn Almodovar

“…<b>Methods:</b> We utilized well-characterized Nef molecular constructs to examine their effects on cell adhesion molecule gene expression (<i>ICAM1</i>, <i>VCAM1</i>, and <i>SELE</i>), pro-apoptotic gene expression (<i>BAX</i>, <i>BAK</i>), and vasoconstrictive endothelin-1 (<i>EDN1</i>) gene expression in endothelial nitric oxide synthase (eNOS) nitric oxide and the production and secretion of pro-inflammatory cytokines over 24, 48, and 72 h post-transfections with Nef variants. <b>Results:</b> HIV Nef variants SF2, NA7, and PH-associated Fr17 and 3236 induced a significant increase in adhesion molecule gene expression of <i>ICAM1</i>, <i>VCAM1</i>, and <i>SELE</i>. …”
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CYTOMETRIC FEATURES OF THE CELLULAR COMPARTMENT OF THE IMMUNE SYSTEM OF PARTICIPANTS IN MODERN MILITARY CONFLICTS by S. L. Pashnin, E. V. Davydova, D. Sh. Altman, V. A. Zurochka, I. Yu. Zhuravlev, Ya. T. Zhakupova

“…A significant amount of knowledge has been accumulated about the mechanisms of immune-mediated reactions in the development of neuropsychiatric pathology, in particular post-traumatic stress disorder (PTSD). Activated T-regulatory cells play an important role in the development of neuroinflammation under stress.Purpose of the study: to study the indicators of the blood system, cytometric features of the cellular compartment of the immune system in participants in modern military conflicts with the presence of adaptation disorders associated with stress.Materials and methods. …”
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Substantia nigra related gene polymorphisms associated with antipsychotic-induced acute movement disorders: a genome-wide association study and multi-ancestry validation in schizop... by Zhe Lu, Yao-Yao Sun, Zhe-Wei Kang, Guo-Rui Zhao, Yu-Yanan Zhang, Jun-Yuan Sun, Rui Yuan, Wei-Hua Yue

“…Methods GWASs on AIMDs were conducted in 3 independent cohorts: a discovery cohort of 3067 patients (2016 subjects were reserved after quality control), a validation cohort of 277 patients, and a multi-ancestry validation cohort of 766 patients. Subsequent post-GWAS analyses included gene-based analyses, transcriptome-wide association studies (TWASs), and polygenic risk score (PRS) profiling. …”
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Adaptations to comprehensive abortion care during the COVID-19 pandemic: case studies of provision in Bolivia, Mali, Nepal, and the occupied Palestinian territory by Annik Mahalia Sorhaindo, Sarah Castle, Lola Flomen, Eva Lathrop, Shirine Mohagheghpour, Rasha Dabash, Francelle Kwankam Toedtli, Rebecca Wilkins, Laurence Läser, Patricia Titulaer, Ernest Nyamato, Mary Lea Dakouo, Ammal Awadallah, Raman Shrestha, Malena Morales, Ulrika Rehnström Loi

“…In the occupied Palestinian territory, the use of a hotline and social media expanded access to quick and reliable information, counselling, referrals, and post-abortion care. Adaptations to comprehensive abortion care service delivery to mitigate disruptions to services during the COVID-19 pandemic may continue to benefit service quality of care, access to care, routine monitoring, as well as inclusivity and communication in the longer term.…”
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Kinesiophobia and associated factors among patients after cardiac surgery under cardiopulmonary bypass: a cross-sectional study by Min You, Min You, Qianqian Mou, Qianqian Mou, Xiaotao Cao, Xiaotao Cao, Meng Luo, Meng Luo, Yi Song, Yi Song, Qingqing Li, Qingqing Li, Huiyun Hu, Huiyun Hu, Jianping Song

“…Conversely, family function and exercise self-efficacy mitigated kinesiophobia (P &lt; 0.05).ConclusionsKinesiophobia is highly prevalent and multifactorial in post-cardiopulmonary bypass patients. Healthcare providers should prioritize patients with the above risk profiles, while also establishing financial/emotional support systems, improving patient-family communication, optimizing acute pain management, implementing Enhanced Recovery After Cardiac Surgery protocols, and leveraging technology to design rehabilitation programs. …”
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Ultrasound-guided renal subcapsular transplantation of mesenchymal stem cells for treatment of acute kidney injury in a minipig model: safety and efficacy evaluation by Tuo Xiao, Yuhao Chen, Bo Jiang, Mengjie Huang, Yanjun Liang, Yue Xu, Xumin Zheng, Wenjuan Wang, Xiangmei Chen, Guangyan Cai

“…Results The method of pre-hydration at 4% of body weight, followed by post-cisplatin (3.8 mg/kg) hydration at 2% of body weight, successfully established a cisplatin-induced AKI minipig model with a survival time exceeding 28 days, closely mimicking the clinical characteristics of typical AKI patients. …”
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散装土榨花生油消费者KAP调查及信息干预效果评价KAP survey and evaluation of information intervention effect for consumers of bulk pressed peanut oil by 杨朝慧1,2， 何思蕾3， 邓俊锋3， 卢晓丹3， 何志妮3 YANG Zhaohui1,2, HE Silei3, DENG Junfeng3, LU Xiaodan3, HE Zhini3

“…The results showed that consumers initially exhibited low awareness (7.3%-42.5%), positive attitude rates (3.1%-30.6%), and positive behavioral intention rates (18.7%-52.3%). Post-information intervention, these metrics significantly increased to 24.8%-67.6%, 3.4%-51.0%, and 38.6%-60.0%, respectively. …”
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Imaging of human stem cell-derived dopamine grafts correlates with behavioural recovery and reveals microstructural brain changes by Stephen J. Paisey, Lucy R. Jones, David J. Harrison, Nicola J. Drummond, Olivia Z. Edwards, Maurice A. Canham, Victoria H. Roberton, Christopher Marshall, Greg Parker, Rachel Hills, Anne E. Rosser, Emma L. Lane, Stephen B. Dunnett, Tilo Kunath, Yaniv Assaf, Mariah J. Lelos

“…Tests of motor function and PET and MR imaging were conducted up to 6 months post-transplantation. Our data demonstrate that [18F]Fluorodopa imaging identified presynaptic DA synthesis from hfVM and hESC-derived dopaminergic grafts and [18F]Fallypride imaging confirmed occupancy and normalisation of D2/D3 receptor expression in the grafted hemisphere. …”
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Citizenship policies in the Baltic states and Ukraine by Zenonas Petrauskas

“…The article deals with the citizenship policies of several post-communist countries (mainly the Baltic states and Ukraine), especially in the context of their search for national identity and the approach undertaken in the constitutions and relevant laws of these countries in regard to the issues of citizenship. …”
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Health promotion in German kindergartens—design and methods of the exploratory, cluster-randomized, mixed methods KNEIPP–KITA Bavaria study by Miriam Ortiz, Christine Bernardi, Christine Welker, Lisa Boyer, Julia von Sommoggy, Julia von Sommoggy, Hansjoerg Baurecht, Hansjoerg Baurecht, Stephanie Roll, Tatjana Tissen-Diabaté, Anne Herrmann, Anne Herrmann, Anne Herrmann, Benno Brinkhaus

“…In addition, barriers and facilitators of the implementation are explored in a qualitative sub-study through semi-structured interviews conducted with kindergarten staff and parents in the Kneipp group at baseline and 14–16 months post-training. Data analyses will be carried out at both the individual and cluster level, with separate analyses for children, parents, and staff. …”
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LEO or LEO baby within enterprise overlapping stents combined with coil embolization treatment for ruptured vertebrobasilar artery dissecting aneurysms by Zengbao Wu, Minghui Zhou, Ali Abdi Maalim, Yang Han, Xiao Guo, Cao Chen, Ting Lei, Kai Shu, Mingxin Zhu

“…One patient (5.00%) required ventriculoperitoneal shunt placement. Immediate post-operation angiography revealed Raymond grade I, II, and III occlusions in 55.00%, 30.00%, and 15.00% of cases, respectively. …”
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Circulating genomic landscape following cyclin-dependent kinase 4/6 inhibitors exposure in HR + /HER2− metastatic breast cancer: a retrospective multi-institutional Consortium anal... by Letizia Pontolillo, Andrew A. Davis, Lorenzo Gerratana, Arielle J. Medford, Judy Wang, Eleonora Nicolo’, Katherine Clifton, Marko Velimirovic, Surbhi Warrior, Emily Podany, Eleni Andreopoulou, Mara Serena Serafini, Laura Munoz-Arcos, Elisabetta Molteni, Marla Lipsyc-Sharf, Caterina Gianni, Nadia Bayou, Charles S. Dai, Diana Giannarelli, Emilio Bria, Cynthia X. Ma, Aditya Bardia, Carolina Reduzzi, Massimo Cristofanilli

“…However, disease progression is inevitable and unveiling resistance mechanisms is crucial to guide post-CDK4/6i therapeutic strategies. In this study, we retrospectively analyzed a real-world, multi-institutional cohort of patients with HR + /HER2- MBC characterized by circulating tumor DNA (ctDNA) through next-generation sequencing (NGS) before starting second-line treatment. …”
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Comparison of Dexmedetomidine-bupivacaine Combination versus Bupivacaine Alone for Scalp Block in Attenuating the Haemodynamic Response to Skull Pin Placement during Neurosurgical... by Emin Jimmy, Arpana Kedlaya, Nayanthara Joachim

“…Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), and Mean Arterial Pressure (MAP) were recorded at baseline and at 1, 3, 5, 10 and 15 minutes post scalp block. Haemodynamic changes were analysed using the unpaired Student’s t-test in both groups. …”
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Confirming the Presence of Neurapraxia and Its Potential for Immediate Reversal by Novel Diagnostic and Therapeutic Ultrasound-Guided Hydrodissection Using 5% Dextrose in Water Wit... by Ho Won Lee, Jihyo Hwang, Chanwool Park, Minjae Lee, Yonghyun Yoon, Yeui-Seok Seo, Hyemi Yu, Rowook Park, Jaehyun Shim, Junhyuk Ann, Daniel Chiung-Jui Su, Teinny Suryadi, Keneath Dean Reeves, King Hei Stanley Lam

“…Under real-time guidance, 50 mL D5W (no local anesthetic) was injected to hydrodissect the radial nerve. Immediate post-procedure assessment showed restored wrist extension (medical research council (MRC) grade 4+). …”
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Synthesis MFI Zeolites Using Alternative Silica Source for CO₂ Capture by Clenildo de Longe, Aryandson da Silva, Anne Beatriz Figueira Câmara, Francisco Gustavo Hayala Silveira Pinto, Lindiane Bieseki, Luciene Santos de Carvalho, Sibele Berenice Castellã Pergher

“…These changes are attributed to human action, which is responsible for the emission of polluting gases, mainly through the burning of fossil fuels, deforestation, and industrial processes that are responsible for the greenhouse effect. Post-combustion CO₂ capture using solid adsorbents is a technology that is currently gaining prominence as an alternative and viable form of capture to other industrial processes used. …”
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Association of Pulmonary Hypertension With Outcomes in Kidney Transplant Recipients by Isabel G. Scalia, Juan M. Farina, Milagros Pereyra Pietri, Nima Baba Ali, Mohammed Tiseer Abbas, Kamal Awad, Ahmed K. Mahmoud, Niloofar Javadi, Nadera N. Bismee, Samy Riad, Hani Wadei, Byron Smith, D. Eric Steidley, Timothy Barry, Robert L. Scott, Yeoungjee Cho, David W. Johnson, Chadi Ayoub, Reza Arsanjani, Girish Mour

“…Conclusion: Pretransplant PHTN classified by echocardiographic RVSP was independently and incrementally associated with an increased risk of mortality and allograft failure post-KTx. In pretransplant work up, this may allow for identification of a high-risk cohort that could benefit from further evaluation, early intervention, and closer surveillance in the posttransplant period.…”
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Impact of fermentation and drying on the bioactive compounds and physicochemical properties of four cacao genotypes in Northwestern Peru by Luz Quispe-Sanchez, Ives Yoplac, Manuel Alejandro Ix-Balam, Grobert A. Guadalupe, Manuel Oliva-Cruz, Denny Cortez, Jorge R. Díaz-Valderrama, Segundo G. Chavez

“…Overall, genotype and post-harvest processing conditions strongly influence cocoa bioactive compound stability.…”
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Sodium butyrate attenuates skin wound-induced secondary intestinal barrier impairment in turbot, Scophthalmus maximus L. by Zhichu Chen, Jintao Pan, Guijuan Yu, Dong Huang, Wenbing Zhang, Qinghui Ai, Kangsen Mai, M. Ángeles Esteban, Yanjiao Zhang

“…Analyses were conducted at the end of the feeding trial, 1st day, and 7th day post-wounding (dpw). The skin wounds induced proliferative enteritis, evidenced by the profound infiltration of admixed leukocytes in the lamina propria, the increased pro-inflammatory cytokine gene expressions, and the dysregulated tight junction protein expressions. …”
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Short-Term Effects of a Snack Including Fruit Juice Enriched with Vitamin D3, n-3 Fatty Acids, and Probiotics on Energy Intake and Satiety in Normal-Weight and Overweight Individua... by Christina Athanasaki, Nikolaos Zacharodimos, Sofia Tsitsou, Dionysia-Lydia Bothou, Stamatia Vitsou-Anastasiou, Olga S. Papadopoulou, Emilia Papakonstantinou

“…Additionally, the overweight individuals had a lower total energy intake at the meal and a lower energy intake 24 h post intervention day, as well as lower protein and fat intakes, compared to the normal-weight individuals. …”
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