Engineering injectable bone/bioadhesive grafts delivery system with self-healing properties for bone regeneration by Qingzu Liu, Bin Zhu, Huikai Yang, Chongyang Liu, Yurong Chen, Xiaoyu Wu, Wangling Duan, Luyao Feng, Binhui Wang, Liang Shao, Jianpeng Gao, Yazhong Bu, Hongjian Liu, Keya Mao, Jianheng Liu

“…Additionally, bone defects are frequently associated with substantial bleeding, and bone graft system often fail to effectively seal and prevent leakage, increasing the post-operative complications. In this study, based on PEG active ester (Bi-PEG-SG) and gelatin, we developed a micro-scale calf bone granules/PEG-Gelatin bioadhesive grafts delivery system with self-healing properties, which not only possesses antioxidant properties but also demonstrates injectability, shape adaptability, adhesive capabilities and high bursting pressure. …”
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International society of liquid biopsy (ISLB) perspective on minimal requirements for ctDNA testing in solid tumors by Nicola Fusco, Konstantinos Venetis, Francesco Pepe, Omshree Shetty, Silvia Calabuig Farinas, Simon Heeke, Julia V. Burnier, Simon J. Patton, Ellen Heitzer, Giovanni Nigita, Paul Hofman, Maria Jose Serrano, Massimo Cristofanilli, Eloisa Jantus-Lewintre, David R. Gandara, Christian Rolfo, Umberto Malapelle

“…Ensuring reliable and reproducible ctDNA testing necessitates standardization across the pre-analytical, analytical, and post-analytical phases. Key considerations include appropriate blood collection, efficient cfDNA isolation and purification, thorough assay validation, and precise data interpretation. …”
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Multi‐omics analysis revealed biomarkers for coronary atherosclerosis: Occurrence and development by Mengxue He, Dongxue Wang, Yong‐Jiang Xu, Jiachen Shi, Aiyang Liu, Xiaoxi Zhao, Yunlai Gao, Yuan He, Yu Zhang, Ru‐Xing Wang, Yuanfa Liu

“…Results Multi‐omics analysis revealed that plasma metabolites exhibited the strongest correlation with CA severity, effectively distinguished different CA stages from healthy controls. Post hoc analysis confirmed the diagnostic model's robustness, with an AUC value higher than .933 (95% CI: .828–.984, sensitivity 93.75%, and specificity 80%). …”
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Factors Influencing Nerinetide Effect on Clinical Outcome in Patients Without Alteplase Treatment in the ESCAPE-NA1 Trial by Mayank Goyal, Bijoy K. Menon, Johanna Ospel, Mohammed Almekhlafi, Charlotte Zerna, Raul Nogueira, Ryan McTaggart, Andrew M. Demchuk, Alexandre Y. Poppe, Brian Buck, Kathy Heard, Manish Joshi, Diogo Haussen, Shawna Cutting, Shelagh B. Coutts, Daniel Roy, Jeremy L. Rempel, Thalia S. Field, Dar Dowlatshahi, Brian van Adel, Richard Swartz, Ruchir Shah, Eric Sauvageau, Volker Puetz, Frank L. Silver, Bruce Campbell, René Chapot, Michael Tymianski, Michael D. Hill, on Behalf of the ESCAPE-NA1 Investigators

“…We constructed two multivariable models using variables known prior to randomization and variables known immediately post-EVT procedure to provide adjusted estimates of effect. …”
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Risk of neuropsychiatric and related conditions associated with SARS-CoV-2 infection: a difference-in-differences analysis by Yiwen Lu, Jiayi Tong, Dazheng Zhang, Jiajie Chen, Lu Li, Yuqing Lei, Ting Zhou, Leyna V. Aragon, Michael J. Becich, Saul Blecker, Nathan J. Blum, Dimitri A. Christakis, Mady Hornig, Maxwell M. Hornig-Rohan, Ravi Jhaveri, W. Schuyler Jones, Amber Brown Keebler, Kelly Kelleher, Susan Kim, Abu Saleh Mohammad Mosa, Kathleen Pajer, Jonathan Platt, Hayden T. Schwenk, Bradley W. Taylor, Levon H. Utidjian, David A. Williams, Raghuram Prasad, Josephine Elia, Christopher B. Forrest, Yong Chen

“…Neuropsychiatric outcomes are examined 28 to 179 days post-infection or negative test between March 2020 and December 2022. …”
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Complicaciones de la administración intraósea de vancomicina en artroplastia total de cadera by W.F. Martínez, L. Camacho Terceros, F. Garbini, E.J. Bochatey, F.A. Lopreite

“…Detailed records and documentation of complications during hospitalization and the first three months post-surgery were maintained. As a secondary outcome measure, the incidence of PJI was explored. …”
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Development and validation of an LDH-focused nomogram for the early prediction of heart failure in patients with acute ST-elevation myocardial infarction after percutaneous coronar... by Panting Wei, Jingjin Hou, Ruijiao Yu, Kun Na, Jiaqi He, Xiaojie Zhao, Ziqi Liu, Yan Xu, Yi Li, Chenghui Yan, Haibo Yu, Yaling Han

“…Results Patients with STEMI who developed HF within one year exhibited higher LDH levels within 24 hours post-PCI. A nomogram model was constructed that included alcohol drinking, left anterior descending artery involvement, and creatine kinase-MB, log N-terminal pro b-type natriuretic peptide, and LDH levels. …”
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Robust in vitro assay for analyzing the neutralization activity of serum specimens against hepatitis B virus by Ya-Li Zhang, Ying Gao, Jia-Li Cao, Jing-Hua Zhao, Tian-Ying Zhang, Chuan-Lai Yang, Hua-Long Xiong, Ying-Bin Wang, Shan-Hai Ou, Tong Cheng, Chang-Rong Chen, Quan Yuan, Ning-Shao Xia

“…In summary, the new cell-based assay provides a robust tool to analyse the anti-HBV NAT.Abbreviations: HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; Anti-HBs: Hepatitis B surface antibody; HBeAg: Hepatitis B e antigen; Anti-HBc: Hepatitis B core antibody; qAnti-HBs: quantitative hepatitis B surface antibody; qAnti-HBc: quantitative hepatitis B core antibody; qHBeAg: quantitative hepatitis B e antigen; NAT: neutralization activity; HBIG: hepatitis B immune globulin; NTCP: Na+-taurocholate cotransporting polypeptide; IRES: internal ribosome entry site; ccHBV: cell culture derived hepatitis B virus; GE/cell: genome equivalent per cell; MOI: multiplicity of infection; Dpi: day post infection; HepG2-TetOn: a HepG2-derived cell line that expresses the doxycycline-regulated transactivator; ROC: receiver operating characteristic curve; AUROC: area under receiver operating characteristic curve; LLOQ: the lower limits of quantification; MDF50: the maximum fold dilution required to produce ≥50% inhibition; IC50: half maximal inhibitory concentration…”
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Spatio-Temporal Characteristics and Driving Forces of Landscape Ecological Risks in Highly Urbanized Areas: A Case Study of Suzhou City by Lingyue LU, Dawei SHAO, Dianming WU

“…The research results can provide support for deepening the LER theoretical system at the optimal scale and high urbanization level, and offer scientific references for ecological risk management and control in similar city and post-urbanization areas.…”
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Long-lasting residual efficacy of a new indoor residual spraying product, VECTRON™ T500 (broflanilide), against pyrethroid-resistant malaria vectors and its acceptance in a communi... by Aristide Sawdetuo Hien, Koama Bayili, Samina Maiga, Welbeck Oumbouke, Jean Birba, Dieudonné Diloma Soma, Adissa Ya Ouattara, Delphine Ouissamien Karama, Marlize Coleman, Janneke Snetselaar, Graham Small, Shinya Niimi, Kawase Ayumi, Sidzabda Kompaoré, Katsutoshi Tsuchiya, Roch Kounbobr Dabiré, Abdoulaye Diabaté

“…Conclusions The residual efficacy of VECTRON™ T500 extended for 12 months post-spraying, effectively covering the full malaria transmission season while maintaining high mortality rates in pyrethroid-resistant malaria vectors. …”
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Recanalization and reperfusion in clinically-relevant porcine model of stroke by Błażej Nowak, Piotr Holak, Izabela Małysz-Cymborska, Alexandra Chovsepian, Yanina Dening, Jarosław Olszewski, Aleksandra Piecuch, Maria Jasieniak, Jakub Jasieniak, Arkadiusz Szterk, Maria Sady, Karolina Ferenc, Daniel Berchtold, Artur Jabłoński, Romuald Zabielski, Zdzisław Gajewski, Tim Magnus, Mirosław Janowski, Piotr Walczak, Andreas Meisel, Francisco Pan-Montojo, Francisco Pan-Montojo, Francisco Pan-Montojo, Dominika Gołubczyk

“…One month later the stroke was confirmed through follow-up MRI scans and post-mortem histological and immunohistochemical analyses.ResultsWe successfully induced stroke with an average lesion size based on ADC at 8.18 ± 4.98 cm3, ranging from 3.27 to 17.33 cm3. …”
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Alpha‐Ketoisocaproate Attenuates Muscle Atrophy in Cancer Cachexia Models by Pooreum Lim, Sang Woo Woo, Jihye Han, Young Lim Lee, Jin Ju Lim, Yeong Hoon Kang, Ji Wook Moon, Jeong Min Nam, Jeong Hyeon Kim, Donghun Kim, Jae Ho Shim, Hyeon Soo Kim

“…Grip strength was measured weekly, and mice were sacrificed 4 weeks post‐injection for muscle collection. C2C12 myotubes were treated with conditioned media (CM) derived from C26 or 4T1 cells. …”
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Early and Extensive Ultraviolet through Near Infrared Observations of the Intermediate-luminosity Type Iax Supernovae 2024pxl by W. B. Hoogendam, C. Ashall, D. O. Jones, B. J. Shappee, M. A. Tucker, M. E. Huber, K. Auchettl, D. D. Desai, A. Do, J. T. Hinkle, M. Y. Kong, S. Romagnoli, J. Shi, A. Syncatto, C. D. Kilpatrick

“…We find a tentative correlation between the H -band break Co ii velocity ∼20 days post-peak and absolute magnitude, with more luminous SNe Iax showing faster Co ii velocities. …”
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Mycotoxin binder for immune and intestinal histopathology ameliorations against Newcastle disease in vaccinated broilers [version 3; peer review: 1 approved, 3 approved with reserv... by Hery Purnobasuki, Erma Safitri, Sri Hidanah, Mitsuhiro Takagi, Goo Jang, Siti Darodjah Rasad, Martia Rani Tacharina, Jola Rahmahani, Sri Mulyati, Chairul Anwar Nidom, Mohammad Anam Al Arif, Muhammad Thohawi Elziyad Purnama, Eka Pramyrtha Hestianah, Maulida Ilma Sadida, Merisa Wahyu Erdhina, Suzanita Utama, Tita Damayanti Lestari

“…Nonetheless, during the post-vaccination phase, production may be negatively impacted by mycotoxin contamination in feed. …”
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[Translated article] An Update on EBV-related Cutaneous Lymphoproliferative Disorders: a Systematic Review by S. García-González, L. Prieto-Torres, M. García-García

“…B-cell EBV+ LPD include primary cutaneous lymphomas such as EBV-Mucocutaneous Ulcer, as well as systemic lymphomas affecting the skin at diagnosis that may present such as lymphomatoid granulomatosis (LG), EBV diffuse large B cell lymphoma, NOS, plasmablastic lymphoma (PBL), extracavitary primary effusion lymphoma (EC-PEL) EBV+, EBV-positive polymorphic B cell LPD, and post-transplant lymphoproliferative disorders (PTLD). …”
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Human growth and development across time and space by Michael Hermanussen, Christiane Scheffler, Jana Fritsch, Piotr Fedurek, Joanna Nieczuja-Dwojacka, Maria Kaczmarek, Sylvia Kirchengast, Dominik Hagmann, Birgit Bühler, Katarzyna Górka, Sylwia Bartkowiak, Başak Koca Özer, Esin Köksal Babacan, Kübra Baran, Martin Musalek, Takashi Satake, Roshan Peiris, Toshie Hirohara, Komei Hattori, Natalia Nowak-Szczepanska, Anna Apanasewicz-Grzegorczyk, Aleksandra Gomula, Slawomir Koziel

“…Secular trends in body height and trends in the distribution of body weight and body mass index were discussed both in view of concurrent trends in economic variables, health, nutrition, and education, and, in view of more recent evidence of body height, as a social signal. Post-war periods of political instability associated with visions of future independence and prosperity favor upward body height trends independent of the economic and almost independent of the nutritional situation. …”
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MicroRNA Signatures in Endometrial Receptivity—Unlocking Their Role in Embryo Implantation and IVF Success: A Systematic Review by Charalampos Voros, Antonia Varthaliti, Diamantis Athanasiou, Despoina Mavrogianni, Kyriakos Bananis, Antonia Athanasiou, Aikaterini Athanasiou, Anthi-Maria Papahliou, Constantinos G. Zografos, Panagiota Kondili, Maria Anastasia Daskalaki, Dimitris Mazis Kourakos, Dimitrios Vaitsis, Marianna Theodora, Panagiotis Antsaklis, Dimitrios Loutradis, Georgios Daskalakis

“…MicroRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) have emerged as important post-transcriptional regulators of endometrial function, although their diagnostic and molecular functions are poorly understood. …”
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Social and clinical vulnerability in stroke and STEMI management during the COVID-19 pandemic: a registry-based study by Jérome Berge, Gaultier Marnat, Emmanuel Ellie, Igor Sibon, Basile Ondze, Ludovic Lucas, Xavier Combes, Catherine Pradeau, Pierre Coste, Jean-Luc Banos, Nicolas Delarche, François Rouanet, Pierre Fournier, Patricia Bernady, David Higue, Julie Péron, Stephanie Bannier, Virginie Heydel, Nathalie Goulois, Francois Orcival, Stephanie Vandentorren, Jean-Louis Leymarie, Bernard Karsenty, Emilie Lesaine, Sandrine Domecq, Laura Cetran, Sahal Miganeh-Hadi, Floriane Sevin, Stéphanie Demasles, Régis Hubrecht, Florence Francis, Florence Saillour, Jean Faucheux, Elena Leca Radu, Gaëlle Seignolles, Cécile Chazalon, Maria Dan, Laurent Wong-So, Miquel Martinez, Claire Nocon, Véronique Hostyn, Jérémy Papin, Philippe Bordier, Philippe Casenave, Laurent Maillard, Isabelle Argacha, Eliane Tidahy, Lucie Ferraton, Yousra Mostefai, Djoumana Bakpa, Christine Bartou, Catherine Goze-Dupuy, Hélène Lavocat, Frédéric Senis, Virginie Delonglee, Didier Darraillans, Tarak Mokni, Bertrand Bataille, Jean Lorendeau, Anncy Eclancher, Bruno Trogoff, Véronique Chartroule, Philippe Touchard, Hervé Leyral, Fogue Ngounou, Catherine Scouarnec, Bertrand Tahon, Emmanuel Py, Sorina Bidian, Jean Fabre, Nidhal Cherhabil, Leila Baha, Pierre-Arnaud Fort, Vincent Maisonnave, Luc Verhoeven, Paul Claveries, Emma Ansart, Brice Lefevre, Marie-Pierre Liepa, Marc Lacrouts, Jean-Baptiste Coustere, Philippe Jarnier, Nicolas Marque, Jean-Marie Perron, Akil Hassan, Francois Casteigt, Bernard Larnaudie, Guillaume Laplace

“…Associations between social (deprivation index) and clinical (age >65 years, neurocardiovascular history) vulnerabilities and care management times were analysed using multivariate linear mixed models, with an interaction on the time period (pre-wave, per-wave and post-first COVID-19 wave).Results The first medical contact procedure time was longer for elderly (p<0.001) and ‘very socially disadvantaged’ (p=0.003) STEMI patients, with no interaction regarding the COVID-19 period (age, p=0.54; neurocardiovascular history, p=0.70; deprivation, p=0.64). …”
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Effects of multi-site non-invasive brain stimulation on cognitive impairment after stroke: a systematic review and meta-analysis by Heling Wang, Di Zhang, Xu Wang, Qixin Ding, Shenhong Ma, Qiaohua Han, Yuefang Li, Tianshu Li, Ying Li, Wanyue Li, Weisheng Zhuang, Weisheng Zhuang

“…ObjectivePost-stroke cognitive impairment (PSCI) is one of the core symptoms following a stroke, which severely affects the prognosis of patients. …”
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Spinal Instability Neoplastic Score as a Predictor of Vertebral Fracture in Patients Undergoing Radiation Therapy for Spinal Metastases: A Single-Institution Study by Patrick Doyle, MS, Sarah Caplan, MS, Neil Klinger, MD, Kee-Young Shin, MS, Michael Groff, MD, Maeve Dillon-Martin, BS, Thomas Johnson, MS, Heejoo Kang, BS, Teresia Perkins, BS, Claire Novack, BS, Alexander Spektor, MD, Mai Anh Huynh, MD, PhD, Ellen Kim, MPH, Shyam Tanguturi, MD, Cara Richards, MSPAS, PA-C, Wenxin (Vincent) Xu, MD, David Kozono, MD, PhD, Ron Alkalay, PhD, David Hackney, MD, Tracy Balboni, MD, MPH

“…Results: A total of 187 patients who were treated to 361 vertebral levels underwent post-RT follow-up. Average follow-up time for patients on study was 9.4 months (range, 0.2-38.8 months). …”
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