Impact of the COVID-19 pandemic on antidepressant prescribing with a focus on people with learning disability and autism: an interrupted time series analysis in England using OpenS... by Ben Goldacre, David Evans, Orla Macdonald, Richard Croker, Rebecca Smith, Christopher Wood, Andrea Schaffer, Andrew Brown, Brian MacKenna, William Hulme, Chris Bates, Amir Mehrkar, Peter Inglesby, John Parry, Amelia Green, Helen Curtis, Alex Walker, Rose Higgins, Sebastian Bacon, Simon Davy, Tom Ward, Louis Fisher, Iain Dillingham, Milan Wiedemann, Lucy Bridges, Ben Butler-Cole, Colm Andrews, Christine Cunningham, Victoria Speed, Liam C Hart, Thomas O’Dwyer, Steve Maude

“…We did not find evidence that the pandemic was associated with a change in antidepressant prescribing trend in the general population (relative risk (RR) 1.00 (95% CI 0.97 to 1.02)), in those with autism (RR 0.99 (95% CI 0.97 to 1.01)) or in those with learning disability (RR 0.98 (95% CI 0.96 to 1.00)).New prescribing post restrictions was 13% and 12% below expected had COVID-19 not happened in both the general population and those with autism (RR 0.87 (95% CI 0.83 to 0.93), RR 0.88 (95% CI 0.83 to 0.92)), but not learning disability (RR 0.96 (95% CI 0.87 to 1.05)).Conclusions and implications In this England study, we did not see an impact of COVID-19 on overall antidepressant prescribing, although unique trends were noted, such as trends in new antidepressant prescriptions which increased in care homes over the pandemic and decreased in the general population and those with autism since recovery.…”
Get full text

Impacto del alargamiento de miembros inferiores con clavos telescópicos en la funcionalidad y calidad de vida de pacientes con acondroplasia by M. Galán-Olleros, J. Alonso-Hernández, C. Miranda-Gorozarri, J. García-Fernández, R.M. Egea-Gámez, Á. Palazón-Quevedo

“…Functionality (Lower Extremity Functional Scale, LEFS), self-esteem (Rosenberg Self-Esteem Scale), and HRQoL (Short Form-12, SF-12, and EuroQol VAS) were assessed preoperatively and at least two years post-surgery. Complications (Clavien-Dindo-Sink classification) and patient satisfaction were also recorded. …”
Get full text

Long-term alteration of heart rate variability following childhood maltreatment: Results of a general population study by Marian Stürmer, Johanna Klinger-König, Marcus Vollmer, Antoine Weihs, Stefan Frenzel, Marcus Dörr, Lars Kaderali, Stephan B. Felix, Beate Stubbe, Ralf Ewert, Henry Völzke, Hans J. Grabe, Elischa Krause

“…HRV was derived from 10-second electrocardiograms and 5-minute pre-sleep polysomnographic recordings. Post hoc analyses examined abuse and neglect. Results CM was associated with reduced HRV (logRMSSD: β = −0.20 [95%-CI: −0.28, −0.12], p = 1.2e−06), driven by neglect (β = −0.27 [−0.35, −0.18], p = 1.9e−09) rather than abuse (β = 0.01 [−0.12, 0.14], p = 1). …”
Get full text

Late anastomotic complication after laparoscopic surgery for clinical stage I low rectal cancers located within 5 cm of the anal verge: Sub‐analysis of the ultimate trial by Manabu Shimomura, Masanori Yoshimitsu, Yuichiro Tsukada, Hideki Ohdan, Jun Watanabe, Yosuke Fukunaga, Yasumitsu Hirano, Kazuhiro Sakamoto, Hiroki Hamamoto, Hisanaga Horie, Nobuhisa Matsuhashi, Yoshiaki Kuriu, Shuntaro Nagai, Madoka Hamada, Shinichi Yoshioka, Shinobu Ohnuma, Tamuro Hayama, Koki Otsuka, Yusuke Inoue, Kazuki Ueda, Yuji Toiyama, Satoshi Maruyama, Shigeki Yamaguchi, Keitaro Tanaka, Motoko Suzuki, Toshihiro Misumi, Takeshi Naitoh, Masahiko Watanabe, Masaaki Ito, Ultimate Trial Group

“…Abstract Background Although extensive research has been conducted on early anastomotic leakage (AL) after sphincter‐sparing surgery, the status of late anastomotic complications (post‐30 days) has received limited attention. These late complications significantly affect a patient's quality of life and often lead to permanent stoma creation. …”
Get full text

Urban greening for climate resilient and sustainable cities: grand challenges and opportunities by Prashant Kumar, Prashant Kumar, Prashant Kumar, Jeetendra Sahani, Karina Corada Perez, Ajit Ahlawat, Ajit Ahlawat, Maria de Fatima Andrade, Maria Athanassiadou, Shi-Jie Cao, Shi-Jie Cao, Lisa Collins, Sagnik Dey, Sagnik Dey, Silvana Di Sabatino, Christos H. Halios, Felicity Harris, Colin Horton, Luis Inostroza, Luis Inostroza, Laurence Jones, Laurence Jones, Thomas Rodding Kjeldsen, Ben McCallan, Ben McCallan, Aonghus McNabola, Aonghus McNabola, Rajeev Kumar Mishra, Sumit Kumar Mishra, Sumit Kumar Mishra, Sumit Kumar Mishra, Erick G. Sperandio Nascimento, Erick G. Sperandio Nascimento, Erick G. Sperandio Nascimento, Gwilym Owen, Khaiwal Ravindra, Neyval C. Reis, Veronica Soebarto, Jannis Wenk, Jannis Wenk, Hannah Sloan Wood, Runming Yao, Runming Yao, Runming Yao

Get full text

Prevalence of acquired resistance to antiretrovirals in children and adolescents living with HIV under clinical follow-up at the Roosevelt Hospital in Guatemala by S. Alonso, E. Salazar, N. Gálvez, J. Navas, C. Quintana, N. Orózco, L. Prieto, M.L. Navarro, S. Guillén, J.M. Gómez-Alba, C. Medina-Sánchez, J. Juarez, A. Holguín

“…Half received ART within the first month post-diagnosis. Seventy-nine (79.8%) harbored viruses with DRM: 61 (61.6%) to NRTIs, 70 (70.7%) to NNRTIs and 6 (6.3%) to PIs (major DRMs). …”
Get full text

Antibodies against integrin αvβ6 have high diagnostic accuracy for ulcerative colitis by Patrick Bez, Martina Scapolan, Davide Giuseppe Ribaldone, Gian Paolo Caviglia, Silvia Zago, Cristina Trucco, Simone Frara, Antonino Caruso, Marta Ascolani, Michele Campigotto, Stefano Benvenuti, Stefano Martelossi, Lara De Lucchi, Marta Favero, Francesco Cinetto, Francesco Cinetto, Elisabetta Faggin, Laura Ventura, Marcello Rattazzi, Marcello Rattazzi, Tilde Manetta, Giulio Mengozzi, Antonio Antico, Carla Felice, Carla Felice

“…The UC patients presented higher values of anti-integrin αvβ6 IgG compared to CD, IBS, and controls (Kruskal–Wallis test and post-hoc Holm’s correction: p < 0.001). The ROC of anti-integrin αvβ6 IgG performed optimally with an area under the curve of 0.93. …”
Get full text

Key experimental technologies and their development directions for the exploration and production of deep coalbed methane by Xia YAN, Fengyin XU, Xianyue XIONG, Feng WANG, Chunhu LI, Jiyuan ZHANG, Borui XU, Qianhui CHENG, Xiong HU, Xueguang ZHU, Wei LIANG, Pu YUAN, Yanqing FENG, Zhenji WEI

“…Furthermore, this study systematically analyzes the advances and challenges in experimental technologies for deep coals, involving the characterization of multi-scale pores and fractures, the assessment of absorption and gas-content properties, the mechanic characteristics and fracture propagation patterns of coals, and the dynamic patterns of fluid occurrence and production post-fracturing. ProspectsThis study posits seven development directions for deep CBM production and in-situ coal conversion experiments: (1) Clear, direct observation techniques for micropores (< 2 nm) in deep coal seams with ultra-low porosity and permeability, full-scale pore size splicing technology for multiscale pore structure characterized by abundant micropores, a few mesopores, and many macropores, and assessment techniques for pore-fracture connectivity. (2) Isothermal adsorption test technologies for raw coals considering the effects of deep coal seam wettability, fracturing fluid invasion, and high total dissolved solids (TDS) under high-temperature, high-pressure in-situ conditions; (3) Sealed coring devices and in-situ pressure-retaining coring technologies featuring high pressure retaining success rates, heat preservation rates, and traceable gas volume. (4) Nanoscience-based assessment technologies for gas and water occurrence in micropores in deep coal seams under high-temperature and high-pressure multi-field coupling, and experimental technologies for desorption, diffusion, and seepage across nano-micro-millimeter scales. (5) Techniques for developing and testing multifunctional mechanical experiment equipment applicable to in-situ conditions of deep coal seams featuring high stress, low modulus of elasticity, and high Poisson's ratio. (6) Experimental techniques for the purpose of enhancing CBM recovery of deep coal seams, including reservoir stimulation (microwaves, laser, and electric heating), stimulation for permeability enhancement (electromagnetic pulses, pulsed ultrasonic waves, and controlled shockwaves), displacement via CO2 injection, and mechanical pulsation with supercritical CO2. (7) Experimental techniques for in-situ coal conversion and utilization, including pyrolysis, underground coal gasification (UCG), geothermal utilization, and CO2 geological storage. …”
Get full text

Development and validation of a machine learning-based model to predict survival in patients with cirrhosis after transjugular intrahepatic portosystemic shuntResearch in context by Binlin Da, Huan Chen, Wei Wu, Wuhua Guo, Anru Zhou, Qin Yin, Jun Gao, Junhui Chen, Jiangqiang Xiao, Lei Wang, Ming Zhang, Yuzheng Zhuge, Feng Zhang

“…The RF model outperformed other scoring systems, such as the (Child-Turcotte-Pugh score) CTP, (model for end-stage liver disease) MELD, (sodium MELD) MELD-Na, (Freiburg index of post-TIPS survival) FIPS and (Albumin-Bilirubin) ALBI, showing the highest (area under the curve) AUC of 0.82 (95% CI: 0.72, 0.91) and 0.7 (95% CI: 0.60, 0.79) in predicting 1-year survival across the testing set and external validation cohort. …”
Get full text

Cortical thickness correlated with peripheral inflammatory cytokines in amyotrophic lateral sclerosis by Jing Yang, Jing Yang, Jing Yang, Wenyi Li, Wenyi Li, Wenyi Li, Mei Tian, Mei Tian, Mei Tian, Lei Zhang, Fengping Du, Fengping Du, Fengping Du, Xin Li, Xin Li, Xin Li, Qi Liu, Qi Liu, Qi Liu, Rui Li, Rui Li, Rui Li, Zhenzhong Li, Zhenzhong Li, Zhenzhong Li, Hui Dong, Hui Dong, Hui Dong, Yaling Liu, Yaling Liu, Yaling Liu

“…Twenty-six patients with ALS and 26 controls were studied using whole-cortex analysis, and post-hoc analyses were performed to examine the correlation between brain cortical thickness and ALSFRS-R or ΔFS scores.ResultsIL-4, IFN-α, IL-1β, and IL-2 levels were significantly correlated with ALSFRS-R scores, and the IL-2 level was significantly correlated with ΔFS scores. …”
Get full text

Hyperspectral abdominal laparoscopy with real-time quantitative tissue oxygenation imaging: a live porcine study by Oscar MacCormac, Oscar MacCormac, Conor C. Horgan, Conor C. Horgan, Dale Waterhouse, Dale Waterhouse, Philip Noonan, Philip Noonan, Mirek Janatka, Mirek Janatka, Richard Miles, Richard Miles, Jaco Jacobs, Cameron Dockerill, Cameron Dockerill, Théo Trotouin, Théo Trotouin, Alexis Schizas, Barbara Seeliger, Barbara Seeliger, Barbara Seeliger, Sebastien Ourselin, Sebastien Ourselin, Michael Ebner, Michael Ebner, Tom Vercauteren, Tom Vercauteren, Jonathan Shapey, Jonathan Shapey, Jonathan Shapey

“…While intra-operative overt ischaemia can be perceived with the naked eye, timely recognition of borderline perfusion can prevent post-operative ischaemic complications, which is particularly relevant for colorectal anastomoses. …”
Get full text

Restoration of NOX4 signalling reverses endothelial colony-forming cell angiogenic dysfunction associated with experimental and clinical diabetes by Karla M. O’Neill, Kevin S. Edgar, Shun Hay Pun, David C. Campbell, Tinrui Toh, Xin N. Wong, Bianca Botezatu, Jyoti Kandel, Una McCoy, Jennifer Nicell, Catherine McClintock, Kiran J. McLoughlin, Yuxin Wu, Vinuthna Vani Madishetti, Arya Moez, Mohammed Alsaggaf, Eleanor K. Gill, Rawan A. Abudalo, Christina L. O’Neill, Edoardo Pedrini, Jasenka Guduric-Fuchs, Coy Brunssen, Henning Morawietz, Philip D. Dunne, Chris J. Watson, Reinhold J. Medina, David J. Grieve

“…Statistical significance was determined using one-way ANOVA with Bonferroni post-host testing or paired/unpaired Student’s t-test, as appropriate. …”
Get full text

Carer administration of as-needed subcutaneous medication for breakthrough symptoms in people dying at home: the CARiAD feasibility RCT by Zoë Hoare, Clare Wilkinson, Dyfrig A Hughes, Anthony Byrne, Annmarie Nelson, Julia Hiscock, Bee Wee, Marlise Poolman, Annie Hendry, Stella Wright, Paul Perkins, Anne Parkinson, Emily Holmes, Liz Reymond, Betty Foster, Julie O’Connor, Penney Lewis, Nia Goulden, Rossella Roberts, Sian Roberts

“…Strict risk assessment criteria needed to be met before the approach, including a known history of substance abuse or carer ability to be trained to competency.Intervention Intervention-group carers received training by local nurses using a manualised training package.Primary outcome measures Quantitative data were collected at baseline and 6–8 weeks post-bereavement and via carer diaries. Interviews with carers and healthcare professionals explored attitudes to, experiences of and preferences for giving subcutaneous medication and experience of trial processes. …”
Get full text

Long-term functioning status of COVID-19 survivors: a prospective observational evaluation of a cohort of patients surviving hospitalisation by Linamara Rizzo Battistella, Felipe Fregni, Marta Imamura, Vinicius Delgado Ramos, Lucas Ramos De Pretto, Simon K H A A Van Cauwenbergh, Sabrina Saemy Tome Uchiyama, Denise Matheus, Flavia Kuhn, Ana Alice Amaral de Oliveira, Gabriella Souza Naves, Aline Rossetti Mirisola, Fernando de Quadros Ribeiro, Andre Tadeu Sugawara, Mauricio Cantarino, Rafael Andrade Santos Antunes Cavalca, Vanessa Pagano, Melina Valentim Marques, Elizabeth Mendes da Silva, Alessandra Pereira Gomes

“…It analyses participants' sociodemographic background, COVID-19 clinical manifestations, and clinical and functional evaluations.Setting Tertiary-level university hospital in São Paulo, Brazil.Participants Study participants are COVID-19 survivors admitted to hospital care for at least 24 hours to treat acute SARS-CoV-2 infection.Outcome measures Epworth Sleepiness Scale, EuroQoL-5 Dimensions-5 Levels, Functional Assessment of Chronic Illness Therapy–Fatigue, Functional Independence Measure, Functional Oral Intake Scale, Handgrip Strength, Insomnia Severity Index, Medical Research Council (MRC) Dyspnea Scale, MRC sum score, Modified Borg Dyspnea Scale, pain Visual Analogue Scale, Post-COVID-19 Functional Status, Timed Up and Go, WHO Disability Assessment Schedule 2.0, 1-Minute Sit to Stand Test.Results Many participants required invasive mechanical ventilation (41.57%, 333 of 801). …”
Get full text

Études comportementales pour la conservation du singe laineux de Poeppig (Lagothrix l. poeppigii) by Justine Philippon

“…Le but sera ici de savoir si le traumatisme lié à la capture et à la séparation subite du groupe natal produit des effets comparables à ceux du choc post-traumatique observés chez l’homme et les chimpanzés. …”
Get full text

Soft Tissue Augmentation by Electrospun Membranes embedded With Nano-Hydroxyapatite: Histologic and Volumetric Analyses by Yu Zhu, Zuohui Xiao, Yingxin Gu, Qiang Zhi, Zhuoli Huang, Yijie Zhang, Chunan Zhang, Shichong Qiao

“…The animals were sacrificed at 12 weeks post-surgery and received volumetric analyses. Histological examinations at the meantime were carried out at five different depths below the crest (0, 1.5, 2.5, 3.5 and 5.5 mm). …”
Get full text

Assessment and Enhancement of Coastal Community Resilience Strategies: A Case Study of Wuyuan Bay in Xiamen by Xu Mengjie, Liu Xingzhao, Xie Huili, Zhang Yang, Dai Hongxia, Zhou Yanhai, Huang Faming

“…Compared with traditional disaster prevention models, the synergistic mechanism between resilience theory and community risk management not only provides a theoretical framework for urban complex risk prevention, but also demonstrates dynamic adaptive advantages in pre-disaster prevention, disaster response, and post-disaster recovery. Accordingly, this study integrated the resilience community theory with the sponge city concept, selecting 25 storm surge-prone bay communities in the Xiamen Wuyuan Bay Area as samples to establish a community resilience evaluation framework encompassing exposure, vulnerability, adaptability, and spatial connectivity. …”
Get full text

Short-Term Hormonal Changes Following Microdissection Testicular Sperm Extraction among Men with Non-Obstructive Azoospermia: Findings from a Large Longitudinal Prospective Multice... by Fausto Negri, Edoardo Pozzi, Christian Corsini, Massimiliano Raffo, Federico Belladelli, Alessandro Bertini, Francesco Cattafi, Eugenio Ventimiglia, Rayan Matloob, Antonino Saccà, Luca Boeri, Alessia d’Arma, Francesco Montorsi, Andrea Salonia

“…Preoperative serum hormone levels (total testosterone [tT], luteinizing hormone [LH], follicle-stimulating hormone [FSH], and 17β-estradiol) were collected, with repeat measurements at 3-month post-surgery. We divided the cohort into two groups using a tT cut-off value of 3 ng/mL: 1) men who kept eugonadal status; and, 2) men who were initially eugonadal but became testosterone deficient (TD) after surgery. …”

Computational Analysis Method for Multi-subject Behavior in Public Spaces Based on Targeted Computer Vision Tracking by Chao YAN, Siyan LIU, Shanshu HE, Leiqing XU

“…The computational analysis method based on congestion degree, static usage rate, and dynamic usage rate systematically reveals adult − child interaction dynamics, and the cross-comparative analysis using visualized heatmaps uncovers the effects of spatial features on multi-subject interaction behaviors.ConclusionThe computational analysis method for multi-subject behavior supports spatial behavioral research involving interactions of various crowd categories and is applicable to post-occupancy evaluations and design optimization in complex public spaces. …”
Get full text

Effect of inhibition of reactivated alcohol-associated memories with propranolol on alcohol craving by Shuai Yu, Peng-Jiao Xu, Le Shi, Xiao-Yang Zhang, Chuan-Sheng Wang, Fang Wu, Xiao Li, Ping Cui, Rui-Ling Zhang, Lin Lu, Ya-hui Xu

“…Repeated measures analysis of variance was used to compare the craving degree and independent samples t-tests were used for comparing demographic characteristics, scale scores between alcohol-dependent patient groups, and pre-post differences in heart rate, systolic blood pressure, and diastolic blood pressure at each experimental phase. …”
Get full text