A complex remodeling of cellular homeostasis distinguishes RSV/SARS-CoV-2 co-infected A549-hACE2 expressing cell lines by Claudia Vanetti, Irma Saulle, Valentina Artusa, Claudia Moscheni, Gioia Cappelletti, Silvia Zecchini, Sergio Strizzi, Micaela Garziano, Claudio Fenizia, Antonella Tosoni, Martina Broggiato, Pasquale Ogno, Manuela Nebuloni, Mario Clerici, Daria Trabattoni, Fiona Limanaqi, Mara Biasin

“…Viral replication was assessed at 72 hours post infection by droplet digital PCR, immunofluorescence, and transmission electron microscopy. …”
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Association between Early Resistive Index Measurement and Early Graft Function and Long-Term Graft Survival after Kidney Transplantation: an Evidence-based Clinical Review by Pande Made Wisnu Tirtayasa, Gede Wirya Kusuma Duarsa, Gerhard Reinaldi Situmorang, I Wayan Yudiana, Kadek Budi Santosa, Anak Agung Gde Oka, Arry Rodjani, Nur Rasyid

“…However, these studies were using RI measurement in the later stages post transplantation. The present study has conducted to identify the association between early RI measurement and early graft function represented as delayed graft function (DGF) and immediate graft function (IGF), as well as long-term graft survival. …”
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Targeting degradation of IKZF1 and IKZF3 through modulation of the E3 ligase substrates in the context of cellular therapies for multiple myeloma by David Kegyes, Anamaria Bancos, Adrian Bogdan Tigu, Ioana Rus, Delia Dima, Diana Cenariu, Madalina Nistor, Raluca Munteanu, Diana Gulei, Alina Tanase, Anca Colita, Anca Buzoianu, Cristina Iuga, Mihnea Zdrenghea, Evangelos Terpos, Stefan O. Ciurea, Aaron Ciechanover, Hermann Einsele, Ciprian Tomuleasa

“…In this paper, based on the literature presented at the Annual Meeting of the American Society of Hematology (ASH), the American Society of Clinical Oncology (ASCO), the International Myeloma Society (IMS), and the European Hematology Association (EHA) in the 2020–2025 timeframe, we explore the rationale and emerging evidence of combining CELMoDs with immunotherapies, and their use as a bridge to transplant or as post-ASCT maintenance therapy in MM.…”
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Quantification of liver fat fraction using T1-weighted mDixon MRI in young patients with ataxia telangiectasia undergoing whole-body MRI: an exploratory study by Soma Kumasaka, Rafal Panek, Renata Neves, Mohnish Suri, Sumit Jagani, Yuka Kumasaka, Yoshito Tsushima, Robert A. Dineen

“…Purpose To evaluate feasibility of T1-weighted two-point mDixon MRI for identification of liver steatosis in children with A–T and conduct exploratory analysis of relationships between MRI-quantified liver fat fraction and clinical and laboratory measures. Study type Post hoc analysis of prospectively collected research data. …”
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Diagnostic Value of F-FDG PET/CT Radiomics in Lymphoma: A Systematic Review and Meta-Analysis by Chaoying Liu MD, Jun Zhao PhD, Heng Zhang PhD, Xinye Ni PhD

“…The Fagan nomogram showed an absolute increase of 34% in the post-test probability following a positive test result. …”
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Activation of endogenous full-length utrophin by MyoAAV-UA as a therapeutic approach for Duchenne muscular dystrophy by Ruo Wu, Peng Li, Puhao Xiao, Shu Zhang, Xiaopeng Wang, Jie Liu, Wenjie Sun, Yue Chang, Xiuyi Ai, Lijiao Chen, Yan Zhuo, Jiaojian Wang, Zhengbo Wang, Shangang Li, Yuanyuan Li, Weizhi Ji, Wenting Guo, Shiwen Wu, Yongchang Chen

“…These benefits remain observable at six months post-treatment. In male nonhuman primates, systemic administration of MyoAAV-UA increases utrophin expression by twofold in skeletal muscle, with no significant side effects observed. …”
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Ectopic Mediastinal Thyroid: A Crossroad Between a Multi-Layered Endocrine Perspective and a Contemporary Approach in Thoracic Surgery by Claudiu Nistor, Mihai-Lucian Ciobica, Oana-Claudia Sima, Anca-Pati Cucu, Florina Vasilescu, Lucian-George Eftimie, Dana Terzea, Mihai Costachescu, Adrian Ciuche, Mara Carsote

“…Noting the symptoms, mediastinal anatomy, and size change, the MET was removed via a minimally invasive trans-cervical approach (eutopic gland preservation) with the help of a Cooper thymectomy retractor (which also allowed for a synchronous thymus mass resection). No post-operatory complications were registered, the thyroid function remained normal, and the mentioned symptoms were remitted. …”
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Enhancing laparoscopic surgery training: a comparative study of traditional models and automated error detection system by Yitian Luo, Jingjie Wang, Zongting Yan, Jingjing He, Liye Fu, Shenghan Wang, Ying Han, Yaoyu Fu, Xiandi Wang, Kang Li, Rong Yin, Dan Pu

“…Results Group A demonstrated a 24% reduction in errors post-AEDS (mean: 78.1 to 59.4, p < 0.001), outperforming Group B (mean: 67.4, p < 0.001). …”
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Dipeptidyl peptidase 4 inhibition sensitizes radiotherapy by promoting T cell infiltration by Yu Tian, Lingyi Kong, Yan Li, Zhiyun Liao, Xing Cai, Suke Deng, Xiao Yang, Bin Zhang, Yijun Wang, Zhanjie Zhang, Bian Wu, Lu Wen, Fang Huang, Yan Hu, Chao Wan, Yifei Liao, Yajie Sun, Kunyu Yang

“…Dipeptidyl peptidase 4 (DPP4) has been reported to inactivate chemokines via post-translational truncation. Single-cell sequencing revealed that dendritic cells (DCs) had a higher DPP4 expression among other cells in the TME and upregulated DPP4 expression after radiation. …”
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Thrombocytosis and bleeding in myeloproliferative neoplasms: exploring clinical diversity and risk of acquired von Willebrand syndrome—insights from a UK center by Giulia Simini, Andrew Innes, Saravanan Vinayagam, Golzar Mobayen, Nilanthi Karawitage, Simone Claudiani, Zain Odho, Mike Laffan, Deepa J. Arachchillage

“…Interestingly, we found moderate negative correlation between baseline VWF ristocetin/antigen and activated partial thromboplastin time (P = .02; r = −.37) and prothrombin time (P = .009, r = −.45), suggesting other potential coagulation imbalances associated with bleeding diathesis in MPNs. Post cytoreduction, there was a significant increase in mean VWF ristocetin/antigen ratio (P = .0009). …”
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A comparative bio-mechanical performance assessment of additively manufactured bone scaffolds using different beta Ti alloys and Gyroid based cellular structure by Mudassar Rehman, Yanen Wang, Kashif Ishfaq, Ray Tahir Mushtaq, Aqib Mashood Khan, Mohammed Alkahtani, Aamer Nazir, Maimoona Afzal

“…An exponential rise in demand for artificial implants has emphasized the need for novel biomaterials with good biocompatibility and mechanical properties comparable to human cortical and cancellous bone, to mitigate stress shielding and other post implantation challenges. This study investigated the processing performance of biomedical β-Ti alloys (Ti-12Ta-23Nb-24Zr, Ti-32Nb-25Zr) fabricated via Laser Powder Bed Fusion (L-PBF) under optimal working conditions. …”
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Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence by Lu Ding, Lu Ding, Meiling Zhang, Baochao Fan, Fuyuan Deng, Zhenyuan Li, Yixuan Han, Yifan Wu, Jingchun Zeng, Jingchun Zeng, Liming Lu

“…Glycine-serine-threonine and valine-leucine-isoleucine pathways were significant in diagnosing IS and AIS, and in differentiating ischemic and hemorrhagic strokes, as well as identifying post-stroke depression and cognitive impairment.ConclusionThis study confirms the potential diagnostic and prognostic value of changes in amino acids and lipids, as well as other metabolites and metabolic pathways, in IS. …”
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MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer by Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio

“…By performing a high‐throughput luciferase screening of 54 candidate miRNAs, we identified miR‐182‐3p as a specific and efficient post‐transcriptional regulator of TRF2. Ectopic expression of miR‐182‐3p drastically reduced TRF2 protein levels in a panel of telomerase‐ or alternative lengthening of telomeres (ALT)‐positive cancer cell lines. …”
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Dynamic changes of iron metabolism and the effectiveness of health education among apheresis donors in Guangzhou under the GLMM framework by CHEN Xiaowen, LI Fanhai, ZHONG Bi, LIU Guanghuan, CHEN Jinyan, WANG Hao, LI Shijie

“…After health education, Hb levels remained unchanged, but SF increased compared to pre-intervention levels (mean difference: -18.571, P<0.05), though a declining trend persisted compared to baseline (mean difference from baseline to post-intervention: 23.068,P<0.05). [Conclusion] Female and number of donations are primary factors contributing to SF reduction in apheresis donors. …”
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Study on Susceptibility and Infection Characteristics of Dengue Virus in Cells Sourced from Different Tissues of Tree Shrews by LIU Xin, QI Mengdi, WANG Wenguang, HAN Yuanyuan, LU Meili, LI Na, DAI Jiejie, LU Caixia

“…C6/36, Vero, A549, and BHK-21 cells (commonly used for DENV propagation) were used as positive controls. Over 6 days post-infection, cellular cytopathic effects were monitored at 12-hour intervals using an inverted microscope, viral RNA loads in cell lysates were quantified by real-time fluorescent quantitative PCR to generate proliferation curves, and viral titers were determined by plaque assay. …”
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The Platelet Activation Signaling Pathway Regulated by Fibrinogen and Homo-Gamma-Linolenic Acid (C20:3)-Associated Lipid Metabolism Is Involved in the Maintenance of Early Pregnanc... by Miao Yu, Changzheng Du, Yabo Ma, Yuqin Ma, Pengfei Li, Xianguo Xie, Mengyuan Li, Xueyi Nie, Yueyang Liu, Yuxin Hou, Shenao Miao, Xingping Wang, Jinrui Xu, Yi Yang

“…To systematically investigate metabolic variations between early pregnancy and the estrous cycle and their relationship with pregnancy progression, this study utilized four-dimensional data-independent acquisition (4D-DIA) proteomics and liquid chromatography–tandem mass spectrometry (LC-MS/MS) metabolomics to analyze serum samples collected from Chinese native yellow cattle at day 0 and day 21 post-mating, combining bioinformatics analysis with experimental validation. …”
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Influence of colostrum supply on Salmonella spp. seroprevalence in piglet rearing and possibilities to increase colostrum production by optimised feeding by A. Schulte zu Sundern, C. Holling, K. Rohn, J. Schulte-Wülwer, A. Deermann, C. Visscher

“…The other half (n=184) received 1.25 kg of a test feed daily containing fibre rich cereals (barley, oats), a fibre component (soy husks) and potassium diformate in addition to the conventional feed until two days post-partum. Blood samples were taken from two light and two heavy piglets aged 2 d in each litter (n=1,469) and at the end of rearing (approximately nine weeks old; average body weight of 25 kg; n=588). …”
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Effects of integrating Feldenkrais method with dynamic neuromuscular stabilization exercises on clinical outcomes in older women with nonspecific chronic low back pain: A randomize... by Farzaneh Saki, Marziyeh Ziya

“…Assessments were conducted at baseline and post-intervention. Between-group differences were analyzed using analysis of covariance (ANCOVA) adjusted for baseline values, and paired t-tests were used to assess within-group changes (P≤0.05). …”
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Hypothermic Machine Perfusion Is Associated with Improved Short-Term Outcomes in Liver Transplantation: A Retrospective Cohort Study by Alexandru Grigorie Nastase, Alin Mihai Vasilescu, Ana Maria Trofin, Mihai Zabara, Ramona Cadar, Ciprian Vasiluta, Nutu Vlad, Bogdan Mihnea Ciuntu, Corina Lupascu Ursulescu, Cristina Muzica, Irina Girleanu, Iulian Buzincu, Florin Iftimie, Cristian Dumitru Lupascu

“…Results: HMP significantly reduced surgical (0% vs. 75.9%, <i>p</i> = 0.01) and biliary complications (0% vs. 34.4%, <i>p</i> = 0.004), improved hemodynamic stability post-reperfusion (∆MAP%: 1 vs. 21, <i>p</i> = 0.006), and achieved superior one-year survival rates (100% vs. 84.4%). …”
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LYSOZYME-INDUCED NEPHROPATHY IN CMML: A RARE BUT SIGNIFICANT COMPLICATION REQUIRING EARLY RECOGNITION AND INTERVENTION by Alfadil Haroon, Mohamed Kindawi, Ahmed S Alotaibi, Ali Debsan Alahmari, Hazzaa Alzahrani, Mansour Alfayez, syed Osman Ahmed

“…Unfortunately, he passed away 18-months post-diagnosis due to pneumonia and pulmonary hemorrhage. …”
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