Implementation of a value-based approach for older people who have suffered an acute myocardial infarction: study protocol by Denis Juraga, Tomislav Rukavina, Tomislav Rukavina, Mihaela Marinović Glavić, Lovorka Bilajac, Lovorka Bilajac, Lovorka Bilajac, Aleksandar Racz, Esmee L. S. Bally, Oscar Zanutto, Tamara Alhambra-Borrás, Maite Ferrando, Alen Subotić, Hein Raat, Vanja Vasiljev

“…Patients older than 65 years who have suffered a myocardial infarction will be divided into control and intervention groups within a pre-post-controlled design research study. Members of the intervention group will be provided with a personalized plan developed by healthcare professionals and based on the results from the baseline questionnaire.DiscussionTwo ValueCare digital solution components will be developed: a mobile application for the participants and a web platform for the professionals, researchers, and informal caregivers. …”
Get full text

Impact of plant pathogens on potato rhizosphere enzymes and microbial dynamics by Gaihuan Xu, Gaihuan Xu, Linmei Deng, Jian Dao, Wenping Wang, Chunjiang Liu, Yanli Yang, Jing Zhao, Xia Liu

“…For instance, under S. scabies stress, urease (URE) activity increased significantly at the full flowering and post-flowering stages, while catalase (CAT) activity decreased significantly during the seedling and full flowering stages. …”
Get full text

Dynamic Pollen–Stigma Coordination in <i>Dendrobium</i> Hybridization: A Strategy to Maximize Fruit Set and Hybrid Seed Viability by Qian Wu, Yanbing Qian, Ao Guan, Yan Yue, Zongyan Li, Bruce Dunn, Jianwei Yang, Shuangshuang Yi, Yi Liao, Junmei Yin

“…Results identified a critical synchronization window: pollen viability peaked at 1–3 days post anthesis (DPA) or during the mid-anthesis phase, while stigmas exhibited maximal receptivity when secretory activity and antioxidant enzyme levels significantly increased. …”
Get full text

Perception, Trust, and Motivation in Consumer Behavior for Organic Food Acquisition: An Exploratory Study by Elena Moroșan, Violeta Popovici, Ioana Andreea Popescu, Adriana Daraban, Oana Karampelas, Liviu Marian Matac, Monica Licu, Andreea Rusu, Larisa-Marina-Elisabeth Chirigiu, Sinziana Opriţescu, Elena Iuliana Ionita, Alina Saulean, Maria Nitescu

“…This work investigates the sociodemographic factors, knowledge, trust, and motivations involved in organic food acquisition behavior. (2) Methods: An online survey via Google Forms platform, with 316 respondents, was conducted from 1 March to 31 May 2024. (3) Results: Our findings show that suitably informed people with high educational levels (academic and post-college) report significant satisfaction with organic food consumption (<i>p</i> < 0.05). …”
Get full text

Dual role of Eisenia fetida and its excreta in boosting tomato biomass and defense against Botrytis cinerea by Maryan Chelkha, Rubén Blanco-Pérez, Jorge Dueñas-Hernani, Ignacio Vicente-Díez, Victoria Pastor, Raquel Campos-Herrera

“…Gene expression of defense markers was assessed at 24 and 48 h post-inoculation (hpi), while physiological parameters and disease severity were evaluated at 72 hpi. …”
Get full text

Unveiling the hidden threat: prevalence of Enterocytozoon bieneusi and other intestinal parasitic infections among organ transplant recipients in Southern Iran by Mohammad Hossein Motazedian, Leila Morabi, Shahrokh Ezzatzadegan Jahromi, Mojtaba Shafiekhani, Saeed Shahabi, Hamed Nikoupour Dailami, Siavash Gholami, Bahador Sarkari

“…The subjects of the study were 150 organ transplant recipients (kidney, liver, intestine, simultaneous pancreas and kidney [SPK]) who were at least two months post-transplantation. Stool samples were collected from each participant, and demographics along with clinical features were recorded. …”
Get full text

MicroRNAs as regulators of NLRP3 inflammasome activation in herpes simplex virus type 2 infection by Debashree Dass, Debashree Dass, Anwesha Banerjee, Ashwini More, Anupam Mukherjee, Anupam Mukherjee, Anupam Mukherjee, Anupam Mukherjee

“…Luciferase assays confirmed that miR-141 directly targets NLRP3, while miR-211 regulates CASP1, validating their roles as post-transcriptional repressors of inflammasome components.DiscussionThese findings establish miR-141 and miR-211 as critical modulators of HSV-2-induced inflammasome activation, highlighting a novel miRNA-based regulatory mechanism. …”
Get full text

Development and characterization of a fully humanized ACE2 mouse model by Chunyu Ge, Amr R. Salem, Amany Elsharkawy, Janhavi Natekar, Anchala Guglani, Jaser Doja, Osarume Ogala, Gavin Wang, Susan H. Griffin, Orazio J. Slivano, Robin Shoemaker, Benard O. Ogola, Christopher F. Basler, Ajay Kumar, W. Bart Bryant, Mukesh Kumar, Joseph M. Miano

“…Intranasal infection of K18 mice with the beta variant of SARS-CoV-2 resulted in high viral replication and inflammation of the lung and brain, weight loss, and compassionate euthanasia five days post-infection (PI). Similarly infected hACE2 mice displayed viral replication and inflammation in the lung (but not in brain), sustained weight, and 100% survival up to 12 days PI, with clear evidence of acquired immunity. …”
Get full text

Patient-centered outcomes on preparing for and undergoing gender-affirming phalloplasty: a qualitative, descriptive study by Daphna Harel, Asa Radix, Rachel Bluebond-Langner, Tenny R Zhang, Carolyn A Berry, Nnenaya Mmonu, Elijah Castle, Lee Zhao, Clarissa Ospina-Norvell, Mark Fendrick

“…The objective of this study is to elucidate transgender and non-binary patient perspectives on gender-affirming phalloplasty/metoidioplasty via structured focus groups and determine convergent themes as the first step towards the development of a GGAS patient-reported outcome measure.Design We conducted a systematic qualitative study using a thematic content analysis of four focus groups from April 2021 to April 2022 comprising 8 patients undergoing phalloplasty/metoidioplasty and 10 patients post-phalloplasty/metoidioplasty. Focus groups were hosted virtually and recorded and transcribed. …”
Get full text

Assessing the Holistic Impact of Accreditation Standards on Healthcare Professionals at a Tertiary Care Setting in India: A Cross-sectional Study by R Diwakar, Meera Premanand, K Bincy, Kaveri Palanisamy, M Manoharan

“…Multivariate regression analysis indicated that nurses (p-value=0.009), pharmacists (p-value <0.001), and those with less than five years of experience (p-value=0.001) were significantly associated with variations in perceptions of service quality, while health administrators (p-value=0.046, p-value=0.034) were significant for service quality and adaptability post-accreditation. Challenges such as time constraints and excessive workload hindered implementation. …”
Get full text

Systemic IGF-1 administration prevents traumatic brain injury induced gut permeability, dysmorphia, dysbiosis, and the increased number of immature dentate granule cells by Lavanya Venkatasamy, Jaclyn Iannucci, Aleksandr Pereverzev, Jonathan Hoar, Emily Huber, Angel Ifegbo, Reagan Dominy, Yumna El-Hakim, Kathiresh Kumar Mani, Alan Dabney, Rachel Pilla, Farida Sohrabji, Lee A. Shapiro

“…Because GI dysfunction has been linked to hippocampal dysfunction, we also examined proliferation and immature granule cells in the hippocampal dentate gyrus. 10-week-old male rats were treated with an intraperitoneal (i.p.) dose of IGF-1 at 4 and 24 h after lateral fluid percussion injury (FPI). At 3- and 35-days post-injury (DPI), gut permeability, gut dysmorphia, the fecal microbiome, and the hippocampus were assessed. …”
Get full text

Structured Training in Robotic Abdominal Wall Surgery: A Systematic Review of Educational Models, Methodologies, Existing Gaps and Unmet Needs by Francesco Brucchi, Francesco Brucchi, Francesco Brucchi, Annabelle De Troyer, Alice Gori, Alice Gori, Gianlorenzo Dionigi, Gianlorenzo Dionigi, Eva Vanderstraeten, Alexander Mottrie, Isabelle Van Herzeele, Isabelle Van Herzeele, Niki Rashidian, Niki Rashidian, Filip Muysoms

“…Reported costs ranged from €40 for silicone models to €600 for porcine models; one study demonstrated $1,207 in cost savings per case post-training.ConclusionCurrent training models for robotic-assisted abdominal wall surgery are heterogeneous in design, assessment methods, and cost. …”
Get full text

Kidney Dysfunction and Pathology in the Setting of Hemophagocytic Lymphohistiocytosis by Miroslav Sekulic, Ibrahim Batal, Satoru Kudose, Dominick Santoriello, M. Barry Stokes, Belinda Jim, Hans-Peter Marti, Øystein Eikrem, Jai Radhakrishnan, Vivette D. D’Agati, Glen S. Markowitz

“…Autopsy patients had a median terminal admission of 1 month, and 33% of the biopsied patients died (ranging from 0.3–5 months post-biopsy). Variable pathologies were identified, including acute tubular injury (ATI, 43%), lupus nephritis (LN, 23%), collapsing glomerulopathy (17%), thrombotic microangiopathy (TMA, 17%), and cortical necrosis (10%). …”
Get full text

Vaginal microbiota changes of persistent human papillomavirus infection after cervical conization by Lingyun Liang, Lingyun Liang, Cailing Ma, Cailing Ma, Yan Li, Yilidana Mijiti, Lipeng Zhang, Yanjia Liu

“…Anaerobic bacteria and biofilm formation may play a significant role in the persistence of HPV infection post-surgery, and the role of Gardnerella in the vaginal flora under an HPV-infected state warrants further study.…”
Get full text

Retrospective analysis of open reduction and locking plate fixation in three and four part proximal humeral fractures with efficacy and complications by Haiqiang Ma, Jianbin Sun, Xu Ma, Zhipeng Yang, Huanhuan Sun, Donghui Cao, Liangguo Si, Peijie Zhao, Zewen Qiao

“…At the final follow-up (i.e., 12 months post-operation), the postoperative clinical efficacy was evaluated by comparing the Constant-Murley score, Disabilities of the Arm, Shoulder and Hand (DASH) score, Visual Analog Scale (VAS) score, and range of motion (ROM) of the shoulder joint between the affected side and the unaffected side. …”
Get full text

Statin use during intensive care unit stay is associated with improved clinical outcomes in critically ill patients with sepsis: a cohort study by Caifeng Li, Ke Zhao, Qian Ren, Lin Chen, Ying Zhang, Guolin Wang, Keliang Xie

“…Propensity score matching generated balanced cohorts with 6070 patients in each group. Post-PSM analysis revealed significantly lower 28-day all-cause mortality in the statin group (14.3% [870/6070]) compared to the no statin group (23.4% [1421/6070]). …”
Get full text

Predictive value of subacromial motion metrics for the effectiveness of ultrasound-guided dual-target injection: a longitudinal follow-up cohort trial by Wei-Ting Wu, Che-Yu Lin, Yi-Chung Shu, Lan-Rong Chen, Levent Özçakar, Ke-Vin Chang

“…Clinical assessments and static/dynamic ultrasound were performed at baseline and 4 weeks post-procedure. Minimal vertical acromiohumeral distance (mVAHD) was measured by tracing the humeral greater tuberosity against the acromion. …”
Get full text

Effect of fasting on cardiovascular risk factors among healthy adult Muslims attending primary care, Kano, Northern Nigeria by Zainab Abdulkadir, Yakubu Omeiza Sule, Abdurrahman Shuaibu, Abubakar Mohammed Abiso, Fatima Mohammed Damagum, Abdulkareem A. Yusuff, Abdullahi Ibrahim Haruna, Ishaq Inuwa Gombe, Zakari Muhammed Abdullahi, Mohammed Adamu Askira, Imana Sadiq

“…Method The study was pre/post-test single arm intervention conducted at the staff clinic of Family Medicine department, AKTH, and Northwest, Nigeria. …”
Get full text

Clinical features of respiratory syncytial virus and influenza infections in hospitalized adults across three Italian regions by Tommaso Bigoni, Franco Alfano, Marta Vicentini, Maria João Fonseca, Elisa Turriani, Elisa Vian, Micaela Romagnoli, Massimiliano Beccaria, Luca Pontalto, Michele Schincaglia, Federico Baraldi, Alberto Papi

“…Of these, 9 (3.7% of the total included patients or 25.0% of those with any infection) tested positive for the influenza virus, 5 (55.6%) of whom developed acute respiratory failure, with one dying by 3 months post-discharge. A further 3 patients (1.2% of the total included patients or 8.3% of those with any infection) tested positive for RSV. …”
Get full text

Development and external validation of a dynamic nomogram for predicting the risk of functional outcome after 90 days in patients with acute intracerebral hemorrhage by Shaojie Li, Hongjian Li, Jiani Chen, Baofang Wu, Jiayin Wang, Chaocan Hong, Changhu Yan, Weizhi Qiu, Yasong Li, Hongzhi Gao

“…In this study, adverse outcomes were defined as a Modified Rankin Scale (mRS) score of 3–6 at 90 days post-ICH onset, as assessed during follow-up. Later, least absolute shrinkage and selection operator (LASSO) regression and multifactorial logistic regression were used to screen the variables and construct a nomogram. …”
Get full text