Optimizing the Bioprocesses of Bacteriocin Production in <i>Lacticaseibacillus paracasei</i> HD1.7 by the “Acetate Switch”: Novel Insights into the Labor Division Between Energy Me... by Weige Yao, Rui Sun, Wen Zhang, Jie Kang, Zhenchao Wu, Liangyang Mao, Ying Yang, Shuo Li, Gang Song, Jingping Ge, Wenxiang Ping

“…After the “acetate switch”, the ATP content decreased and the QS genes for the post-regulation of bacteriocin were highly expressed, such as <i>rggs234</i> and <i>sigma70-1</i>/<i>70-2</i>. …”
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Sevoflurane reduces brain edema and improves blood-brain barrier by downregulating CaMKII to inhibit TMEM16A after cerebral ischemia injury both in vivo and in vitro by Jingbin Zhang, Yuhe Tian, Ruixue Wang, Xinlei Qin, Quntao Li, Ketao Ma, Junqiang Si, Dong Zhao, Yan Li, Jiangwen Yin

“…Sevoflurane was intervened through a combination of pre-treatment and post-treatment in entire process. TMEM16A overexpression and knockdown was performed by adeno-associated virus. …”
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Mitigation of chemotherapy-induced gut dysbiosis and diarrhea by supplementation with heat-killed Bacteroides fragilis by Xinwen Yan, Xinlong Lin, Jianhua Wu, Lijun Zheng, Yangyang Liu, Fang Wu, Ying Lin, Yishi Lu, Chongyang Huang, Binhai Shen, Hongbin Liu, Ruo Huang, Fengyi Hou, Qian Zhou, Mengyao Song, Ke Liu, Fangqing Zhu, Sheng Li, Yuqing Lin, Wei Wang, Ping Li, Wangjun Liao, Fachao Zhi

“…Results Analysis of paired fecal samples (pre- and post-chemotherapy) from 30 gastrointestinal cancer patients (n = 60) revealed chemotherapy-induced reduction of Bacteroides fragilis (B. f) via metagenomics sequencing, with baseline B. f relative abundance negatively correlating with CID severity (r =  − 0.93, p = 3.1e − 12). …”
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Clinical Frailty Scale and Charlson Comorbidity Index as predictors of hospitalization and mortality risk after kidney transplant failure by Rita Leal, Pedro Almiro e Castro, Rui Duarte, Ana Rita Silva, Maria Guedes Marques, Luís Rodrigues, Lídia Santos, Catarina Romãozinho, Helena Oliveira Sá, Arnaldo Figueiredo, Rui Alves

“…This study aimed to identify risk factors for hospitalization and mortality two years post-graft failure. Materials and methods: We conducted a retrospective cohort study of end-stage kidney disease patients who initiated hemodialysis following graft failure between January 2019 and December 2020. …”
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炎症标志物动态变化对急性缺血性卒中患者血管内治疗预后的影响 Effects of Dynamic Changes of Inflammatory Markers on Prognosis of Patients with Acute Ischemic Stroke Undergoing Endovascular Treatment... by 王辰涛，戴婧，李瑛姿，温宇昕，董理，刘春风，刘慧慧(WANG Chentao, DAI Jing, LI Yingzi, WEN Yuxin, DONG Li, LIU Chunfeng, LIU Huihui )

“…Based on the mRS score at 3 months post-EVT, patients were divided into two groups: the favorable prognosis group (mRS score 0-2 points) and the poor prognosis group (mRS score 3-6 points). …”
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Clinical Frailty Scale and Charlson Comorbidity Index as predictors of hospitalization and mortality risk after kidney transplant failure by Rita Leal, Pedro Almiro e Castro, Rui Duarte, Ana Rita Silva, Maria Guedes Marques, Luís Rodrigues, Lídia Santos, Catarina Romãozinho, Helena Oliveira Sá, Arnaldo Figueiredo, Rui Alves

“…This study aimed to identify risk factors for hospitalization and mortality two years post-graft failure. Materials and methods: We conducted a retrospective cohort study of end-stage kidney disease patients who initiated hemodialysis following graft failure between January 2019 and December 2020. …”
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Basic Molecular Biology, Metabolic and Immunological Mechanisms of Fecal Microbiota Transplantation by O. V. Goloshchapov, A. V. Beynarovich, A. B. Chukhlovin, R. V. Klementeva, A. A. Shcherbakov, E. A. Bakin, I. K. Golubovskaya, N. D. Ventslovayte, O. S. Yudintseva, M. V. Gorchakova, V. E. Karev, M. A. Kucher, M. A. Suvorova, E. V. Svetkina, G. G. Rodionov, V. V. Gostev, S. V. Sidorenko, I. S. Moiseev, A. D. Kulagin

“…Due to early viral/bacterial colitis post-transplant associated with a multidrug-resistant strain of K. pneumoniae and herpes virus type 6, FMT was performed on days 46 and 47 after allo-HSCT. …”
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“Locality – Adaptation” Research of Hydropower Resettlement Communities in the Jinsha River Basin: A Case Study of Ludila Hydropower Station by Fang WANG, Zhuoqi LI, Haoyi XU, Jiaqi YAN

“…At the basin scale, the Patch-level Land Use Simulation Model (PLUS) is employed to analyze land use adaptation changes in the basin during two phases: 2005 –2010 (pre-resettlement period) and 2015 –2020 (post-resettlement period). At the settlement scale, the Mask Region-based Convolutional Neural Network (Mask R-CNN) deep learning model is utilized to identify architectural spatial features, categorizing three typical building types: traditional pitched-roof buildings, uniformly planned flat-roof buildings, and color steel plate-modified structures. …”
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Effect of Subthreshold Nanosecond Laser on Loss of OCT Outer Retinal Bands in Age-Related Macular Degeneration: A LEAD Study Report by Robyn H. Guymer, MBBS, PhD, Joseph P.M. Blair, PhD, Sandro De Zanet, PhD, Stefanos Apostolopoulos, PhD, Carlos Ciller, PhD, Zhichao Wu, BAppSc(Optom), PhD, S. Al-Qureshi, L. Busija, I. Constable, D. Louis, C. Harper, S. Wickremasinghe, P. Van Wijngaarden, L. Lim, S. Durkin, J. Runciman, J. Gihotra, J. Muecke, K. Haywood, C. Brko, J. Paley, M. Smith, C. Luscombe, R. Vincent, D. Lee, R.H. Guymer, C. Luu, Z. Wu, L.A.B. Hodgson, K. Brassington, E. Caruso, M. McGuinness, N. Tindill, K.Z. Aung, E. Baglin, P. Sharangan, C.A. Harper, S. Wickremasinghe, L. Lim, P. Van Wijngaarden, S. Sandhu, T. Nguyen, A. Cohn, D. Qatarneh, L. Robman, G. Makeyeva, R. Tan, S. Taori, K. Creese, M. Chen, D. Ong, S. No, R. Kandasamy, S.W. Lim, M. Okada, D. Cugley, R. O'Day, P. Keller, K. Lee, E. Alessandrello, J. Alessi-Calandro, M. Kolic, T. Wu, S. Griffin, J.J. Lek, W. Heriot, X. Fagan, R. McIntosh, C. Lowe, J. Boyle, O. Shanahan, F. Chen, I. McAllister, T. Isaacs, A. Shaw, C. Balarantnasingam, Y. Chen, W. Cunningham, R. Viljoen, K. Kennelly, R. Blum, S. Arunachalam, H. Razavi, M. Adams, H. Brown, J. Bryant, R. Cowles, S. Radtke, C. Barry, E. Wong, F. Shilton, A. Soloshenko, A. Jason, A. Lin, A. McSweeney, A. King, B. Shalan, D. Xie, H. Vu, I. Tang, K. Mather, M. Cuypers, M. Cheng, R. McKeone, T. Busby, R. Matthews, G. Lingham, J. Arnold, A. Luckie, D. Chan, J. Chang, T. Tan, L. Koh, H. Cass, R. Fitzsimons, T. Forsyth, A. Nguyen, V. Ghebrial, H. Ayson, A. Graham, M. Firibaldi, U. Chakravarthy, L. Kelly, K. Gillvray, M. Williams, G. Casalino, G. Mangoris, R. Das, T. Peto, L. Toth, M. Quinn, R. Denham, N.J. Lavery, G. Sterrett, V. Silvestri, G. Young, K. Graham, J. Keenan, L. Doyle, T. Douglas, D. Burns, P. Wright, L. Scullion

“…Purpose: To evaluate the effect of subthreshold nanosecond laser (SNL) treatment on the rate of loss of the OCT outer retinal bands in intermediate age-related macular degeneration (AMD). Design: Post hoc analysis of the Laser Intervention in the Early Stages of AMD (LEAD) study. …”
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Clinical trial and real-world evidence of circulating tumor DNA monitoring to predict recurrence in patients with resected colorectal cancer by H.T. Nguyen, V.-A. Nguyen Hoang, T.V. Nguyen, N.A.L. Trinh, T.H. Pham, D.N. Le, H.H. Ho, T.D. Nguyen, H.D. Nguyen, T.S.L. Thi, N. Nguyen, D.H. Tran, M.T. Le, T.C. Dinh, T.S. Nguyen, K.C.N. The, H. Mai, M.T. Chu, D.H. Pham, N.H.T. Phuc, D.N. Vinh, D.-N. Nguyen, X.-V. Nguyen, D.S. Nguyen, T.T.D. Thi, H. Giang, H.-N. Nguyen, L.N. Tu

“…In the real-world data analysis, post-operative ctDNA remained the only significant prognostic biomarker for DFS (HR = 44.2, 95% CI 9.2-212.0, P < 0.0001). …”
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Evaluation of the feasibility and effectiveness of trauma-focused cognitive behavioural therapy for children and youth in Ukraine during the war by Elisa Pfeiffer, Maike Garbade, Renée Beer, Anette Birgersson, Natalie Cabrera, Judith A. Cohen, Esther Deblinger, Rafaela Gjini, Veronica Kirsch, Zlatina Kostova, Michael Larsson, Anthony Mannarino, Gavin Moffitt, Marja Onsjö, Tale Ostensjo, Anna Vikgren, Hanna Weyler, Vitalii Klymchuk, Cedric Sachser

“…The patients (age 3–21, 37% male) reported significant improvement in symptoms of PTSD at the end of treatment with large pre-post effect sizes for DSM-5 PTSD (d selfreport = 2.36; d caregiverreport = 2.27), ICD-11 PTSD (d selfreport = 1.97; d caregiverreport = 1.77), ICD-11 CPTSD (d selfreport = 2.04; d caregiverreport = 1.99), and DSM-5 pre-school PTSD (dcaregiverreport = 3.14). …”
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Understanding Onset, Dynamic Transitions, and Associated Inequality Risk Factors for Adverse Posttraumatic Neuropsychiatric Sequelae After Trauma Exposure by Chiyoung Lee, Stacey L. House, Francesca L. Beaudoin, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey Jr, Phyllis L. Hendry, Sophia Sheikh, Brittany E. Punches, Robert A. Swor, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Claire Pearson, David A. Peak, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Paulina Sergot, Leon D. Sanchez, Steven E. Bruce, John F. Sheridan, Steven E. Harte, Karestan C. Koenen, Ronald C. Kessler, Samuel A. McLean, Qing Yang, Xinming An

“…Objective Several gaps remain in the understanding of the onset, dynamic transitions, and associated risk factors of adverse posttraumatic neuropsychiatric sequelae (APNS) in the acute post‐trauma window. Based on serial assessments of symptoms from a large cohort study, we identified homogeneous statuses across multiple APNS symptom domains and investigated the dynamic transitions among these statuses during the first 2 months after trauma exposure. …”
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Clinical application value of intracavitary PRP infusion combined with IVF-FET in patients with chronic endometritis by ZHANG Xiaotong, HAO Xiaoyuan, FANG Rui, HU Shuyao, MA Linkun, ZHAO Yaqi, HAN Wei

“…[Conclusion] Intrauterine autologous PRP perfusion in CE patients enhances pregnancy and live birth rates, improves pregnancy outcomes post-FET, and demonstrates superior efficacy in endometrial repair and receptivity with two PRP perfusions compared to a single perfusion. …”
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Unhealthy family functioning is strongly associated with warfighter brain health following traumatic brain injury in United States service members and veterans by Tracey A. Brickell, Tracey A. Brickell, Tracey A. Brickell, Tracey A. Brickell, Louis M. French, Louis M. French, Louis M. French, Brian J. Ivins, Brian J. Ivins, Sara M. Lippa, Sara M. Lippa, Megan M. Wright, Megan M. Wright, Megan M. Wright, Samantha M. Baschenis, Samantha M. Baschenis, Samantha M. Baschenis, Jamie K. Sullivan, Jamie K. Sullivan, Jamie K. Sullivan, Lars D. Hungerford, Lars D. Hungerford, Rael T. Lange, Rael T. Lange, Rael T. Lange, Rael T. Lange

“…Participants completed 10 HRQOL measures from the TBI-QOL and Neuro-QOL, and the Family Assessment Device-General Functioning subscale (FAD-GF) 2-or-more years post-injury. Using the FAD-GF, the NIC, MTBI, and STBI participants were divided into six subgroups: Group 1 = NIC Healthy Family Functioning (HFF) (n = 34); Group 2 = NIC Unhealthy Family Functioning (UnHFF) (n = 28); Group 3 = MTBI HFF (n = 88); Group 4 = MTBI UnHFF (n = 101); Group 5 = STBI HFF (n = 58); and Group 6 = STBI UnHFF (n = 50).ResultsParticipants with UnHFF had a significant and meaningfully higher number of clinically elevated HRQOL scores compared to those with HFF in the MTBI (p &lt; 0.001, ηp2=0.07) and STBI (p = 0.001, ηp2=0.10) groups, but not in the NIC group (p = 0.107, ηp2=0.04). …”
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Circulating immunoregulatory B cell and autoreactive antibody profiles predict lack of toxicity to anti-PD-1 checkpoint inhibitor treatment in advanced melanoma by Akshay Patel, Yin Wu, Sophie Papa, Sean Whittaker, Ashley Di Meo, Ioannis Prassas, Katie E Lacy, Eleftherios P Diamandis, Sophia N Karagiannis, Thomas J Tull, Sophia Tsoka, Dhruva Biswas, Jitesh Chauhan, Katie Stoker, Zena N Willsmore, Lucy Booth, Amanda Fitzpartick, Matthaios Kapiris, Esperanza Perucha, Gary W Middleton

“…In paired blood samples pretreatment and post-treatment, these humoral immune response profiles were monitored and correlated with the onset of toxicity.Results We found increased circulating IL-10+ (Interleukin-10+) plasmablasts and double-negative (DN) B cell frequencies, higher PD-L1 (programmed death ligand 1), TGFβ (Transforming Growth Factorβ) and CD95 expression by B cells, alongside higher IgG4 and IgE serum levels in patients with stage III/IV melanoma. …”
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Seismic Performance Analysis of Energy Dissipation Building with Non-preload Variable Friction Inerter Under Extremely Rare Earthquake by ZHAO Guifeng, LIU Wei, MA Yuhong, KONG Sihua, CHEN Jiachuan, CHEN Zhaosheng

“…A Bouc‒Wen elastoplastic model was employed in the SDOF system with a yield strength of 24 kN and post-elastic stiffness of 200 kN/m. The SDOF system with and without the proposed NVFI was considered and denoted as SDOF‒NVFI and SDOF, respectively. …”
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Understanding patient pathways to Mother and Baby Units: a longitudinal retrospective service evaluation in the UK by Nikolina Jovanović, Žan Lep, Giles Berrisford, Aysegul Dirik, Julia Barber, Bukola Kelani, Olivia Protti

“…Most patients were in the post partum period, admitted for the first time through emergency, informal and complex pathways. …”
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CRYOGENESIS AND GEODYNAMICS OF ICING VALLEYS by V. R. Alekseyev

“…Five stages of cryogenic channelling are distinguished: I – pre-glacial development, II – transgression, III – stabilization, IV – regression, and V – post-glacial development. Each stage is characterised by a specific glaciohydrological regime of runoff channels and their specific shapes, sizes and spatial patterns.The channel network is subject to the maximum transformation in aufeis development stages III and IV, when the transit flow channel is split into several shallow-water branches, producing a complicated plan pattern of the terrain. …”
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Long noncoding RNA LINC00339 promotes osteoporosis development via modulating of regulator CDC42 by binding PARP1 by Dong-Li Zhu, Yan Zhang, Xiao-Yu Zhang, Zi-Han Qiu, Ke Li, Xiao-Rong Zhou, Zhen-Zhen He, Xiao-Feng Chen, Shan-Shan Dong, Wen Tian, Ya-Kang Wang, Tie-Lin Yang, Bo Yang, Yan Guo

“…Notably, integrated transcriptomic and rescue experiments revealed that LINC00339 and PARP1 coregulate CDC42 expression through post-transcriptional regulatory mechanisms. Conclusions: The identification of the LINC00339-PARP1-CDC42 regulatory axis elucidates a novel molecular mechanism contributing to osteoporosis pathogenesis. …”
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Development and validation of a prediction model for early recurrence in upper tract urothelial carcinoma treated with radical nephroureterectomy by Yi-Ju Chou, Hao-Lun Luo, Hung-Jen Wang, Steven K. Huang, Yu-Che Hsieh, Wen-Jeng Wu, Ching-Chia Li, Han-Yu Weng, Ta-Yao Tai, Chao-Hsiang Chang, Hsi-Chin Wu, Po-Hung Lin, Jacob See-Tong Pang, Chung-Hsin Chen, Jian-Hua Hong, Jen-Shu Tseng, Marcelo Chen, I-Hsuan Alan Chen, Chia-Cheng Yu, Pi-Che Chen, Ian-Seng Cheong, Chung-You Tsai, Pai-Yu Cheng, Yuan-Hong Jiang, Yu-Khun Lee, Shian-Shiang Wang, Chuan-Shu Chen, Thomas Y. Hsueh, Wei-Chieh Chen, Chia-Chang Wu, Yung-Tai Chen, Wei-Yu Lin, Richard Chen-Yu Wu, Chi-Wen Lo, Marco Moschini, Francesco Soria, Ekaterina Laukhtina, Tamás Fazekas, Marcin Chlosta, Jeremy Yuen-Chun Teoh, Shahrokh F. Shariat, Yao-Chou Tsai

“…Results Early recurrence time point in localized UTUC was determined at 9 months post-surgery, with patients experiencing early recurrence exhibiting worse overall and cancer specific survival. …”
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