Expanded analysis of vertebral endplate disruption and its impact on vertebral compression fracture risk by Khaled Dibs, Prasath Mageswaran, Raju Raval, Evan Thomas, Emile Gogineni, Jeff Pan, Brett Klamer, Ahmet Ayan, Eric Bourekas, Daniel Boulter, Nicholas Fetko, Eric Cochran, Vikram Chakravarthy, John McGregor, Esmerina Tili, Joshua Palmer, Natalie Peters, Russell Lonser, Ahmed Elguindy, Eugene Yap, Soheil Soghrati, William Marras, John Grecula, Arnab Chakravarti, James Elder, Dukagjin Blakaj

“…The 1-year cumulative incidence of VCF was evaluated by follow-up MRI and CT scans at 3-month intervals post-treatment. Based on multivariate analysis, a nomogram was created using four independent predictors: EP disruption, steroid use, SINS ≥ 7, and adverse histology. …”
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A proteogenomic analysis of cervical cancer reveals therapeutic and biological insights by Jing Yu, Xiuqi Gui, Yunhao Zou, Qian Liu, Zhicheng Yang, Jusheng An, Xuan Guo, Kaihua Wang, Jiaming Guo, Manni Huang, Shuhan Zhou, Jing Zuo, Yimin Chen, Lu Deng, Guangwen Yuan, Ning Li, Yan Song, Jia Jia, Jia Zeng, Yuxi Zhao, Xianming Liu, Xiaoxian Du, Yansheng Liu, Pei Wang, Bing Zhang, Li Ding, Ana I. Robles, Henry Rodriguez, Hu Zhou, Zhen Shao, Lingying Wu, Daming Gao

“…Proteomic stratification identifies three patient subgroups with distinct features in prognosis, genetic alterations, immune infiltration, and post-translational modification regulations. PRKCB is further identified as a potential radioresponse-related biomarker of CC patients. …”
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Machine learning-based prediction model for lung ischemia-reperfusion injury: insights from disulfidptosis-related genes by Yanpeng Zhang, Yanpeng Zhang, Yanpeng Zhang, Jingyang Sun, Jingyang Sun, Jingyang Sun, Yihan Lin, Yihan Lin, Yihan Lin, Rongxuan Jiang, Rongxuan Jiang, Rongxuan Jiang, Niuniu Dong, Niuniu Dong, Niuniu Dong, Huanhuan Dong, Huanhuan Dong, Huanhuan Dong, Peng Li, Peng Li, Peng Li, Jinteng Feng, Jinteng Feng, Jinteng Feng, Zijiang Zhu, Guangjian Zhang, Guangjian Zhang, Guangjian Zhang

“…The CIBERSORT method was used to assess the infiltration levels of immune cells in lung tissue samples post-transplant. Finally, cell line and animal experiments were carried out to validate the effectiveness and applicability of the model.ResultsA total of 14,592 hub differential-expressed genes were identified, showing significant changes in cold ischemia and reperfusion samples. …”
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Basic therapeutic approaches to the management of hematology/oncology patients with new coronavirus infection (COVID-19) by E. N. Misyurina, E. A. Baryakh, N. F. Frolova, O. N. Kotenko, Z. Yu. Mutovina, S. S. Andreev, T. N. Tolstykh, K. V. Yatskov, E. A. Karimova, A. B. Makeshova, O. A. Rukavitsyn, A. V. Misyurin, Yu. Yu. Polyakov, M. A. Mingalimov, T. S. Chudnova, D. E. Gagloeva, D. D. Ivanova, A. I. Koneva, O. L. Kochneva, E. N. Zotina, E. Yu. Grishina, L. T. Shimanovskaya, V. N. Yakimets, E. I. Zhelnova

“…Recently, antiviral drugs and monoclonal antibodies have become available for pre- or post-exposure prophylaxis, as well as for early treatment of COVID-19. …”
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Triamcinolone-loaded nanocarriers: a novel strategy to mitigate cognitive and emotional sequelae induced by traumatic brain injury via modulation of oxidative stress by Aída Marcotti, Aída Marcotti, Sofía De la Fuente, Sofía De la Fuente, María Lina Formica, María Lina Formica, Agustín Jorge Montivero, Agustín Jorge Montivero, Martina Ramires, Martina Ramires, Verónica Leonor Romero, Verónica Leonor Romero, María Florencia Constantin, María Florencia Constantin, María Jazmín Silvero, María Jazmín Silvero, María Cecilia Becerra, María Cecilia Becerra, Gastón Diego Calfa, Gastón Diego Calfa, Miriam Beatriz Virgolini, Miriam Beatriz Virgolini, Santiago Daniel Palma, Santiago Daniel Palma, Mariela Fernanda Pérez, Mariela Fernanda Pérez

“…Animals received NT, conventional triamcinolone, or empty LNCs, 15 minutes and 24 hours post-injury. They were sacrificed 24 hours, 1 or 7 days later for biochemical analysis of AOPP, MDA, and antioxidant enzymes (catalase and superoxide dismutase) activity in the hippocampus, prefrontal, and motor cortices. …”
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Specialty choices among UK medical students: certainty, confidence and key influences—a national survey (FAST Study) by Jessica Lo, Anna Collins, Sophie West, Daniel MaGee, Sara Ali, Tomas Ferreira, Anson Wong, Kavyesh Vivek, Freya F Semple, Benjamin French, Riya Patel, Guilherme Movio, Andreas Stavrinou, Tushar Rakhecha, Alexander M Collins, Oliver Feng, Maeve K Mulchrone, Heather A Lewis, Sara Kidher, Erin Fitzsimons-West, Meghna Sreekumar, Olivia King, Malvi Shah, Samantha Burley, Basma R Khan, Vaishvi Dalal, Safa Razzaq, Hugo Bernie, Luke Dcaccia, Olivia Rowe, Ananya Jain, Arthur Handscomb, Sudhanvita Arun, Alfaiya Hashmi, Hannah Layton-Joyce, Matilda Gardener, Emily R Finbow, Sakshi Roy, Bilal Qureshi, Khyatee Shah, Mia Mäntylä, Momina Iqbal, Katie Appleton, Yasmin Owadally, Amelia Dickson, Jack M Read, Chiamaka Anthony-Okeke, Rida Khan, Shama Maliha, Catherine L Otoibhi, Sophie Kidd, Muhammed Asif, Tawfique Rizwan, Aleksandra Dunin-Borkowska, James Brawn, Ayeza Akhtar, Medha Pillaai, Sakshi Garg, Ria Bhatt Ben Sweeney, Cameron Thurlow, Alyssa Weissman, Chloe Milton, Samuel Foxcroft, James A Cairn, Leah Njenje, Daniel C Chalk, Jessica Sinyor, Ryan White, Krishnika Vetrivel, Muhammad Hamza Shah, Emily Bolton, Amelia Fortescue, Ella Plumb, Megan Fallows, Ioan Valnarov-Boulter, Hsuan-Tung Kuo, Aryan A Sagdeo, Bethany McDermott, Michael Y Luo, Sharon Yuen Shan Ho, Lubana Hemayet, Dora Pascoe, Leya Luhar, Rakeem Khalid Basith, Mayisha Samiha, Molly Doyle, Flora E MacInnes, Yasmin Al-Rawi, Manuel Giardino, Maisha Hayat, Anjali Cyril, Rivya Mathews, Ashleigh Stirling, Adam Mohamed Capdevila, Zulaikha Bibi, Mackenzie F Garlick, Lily Chadwick, Fariha Hasan, Zoe Mary Constantinou, Beray Berkay, Joseph Nicholson, Louis R Dowland, Tan Jit Yih, Dev Ranka, Kajoke M S Avolonto, Elliot Skittrall, Madison Gill, Humaira Khanom, Jonathan Craven, Harini Elankhumaren, Hannah Glover-Adams, Ishagit Kaur, Maia C Letts, Hesham Zalghana, Urja Ashish Mhatre, Nikita Sanctis, Sundaramoorthy Balasubramanian, Saimathusan Sivakandarajah, Sourab Chand Surana, Rosemary M Davis, Daria Maria Bageac, Ibrahem Al-Obaidi, Subham Roy, Mohammed Suhaib Amin, Tessa Yau, Pakhi Goel, Abderrahmane El Guernaoui, David Gringras, Soo Sun Chong, Aaliyah J Bax, Rachelle Thevathas, Ajwa Fayaz, Pranjil Pokharel Vera Onongaya, Phoebe Hatrick, Rhiannon Tanner, India R Barrons, Louis Naraine, Artemis Prevot, Muaawiyah Shaheen, Farah Ahmed, Mathumetha Rubaratnam, Harsh Sai Modalavalasa, Sushmhitah Sandanatavan, Anhukrisha Karthikeyan, Saarah Saanan Khan, Gregory A Rowland, Alexa McCloskey, Nidhi Sachidananda, Lydia Melaku, Vyom Patel, Iliyah Shahbeik, Jui Kanetkar, Hannah Bolton, Timo L Kuerten, Emily Carver, Mairi C Docherty, Nabilah Ali, Shereen Ahmad, Shiksha Guru, Anushka Pujari, Khadijah Khan, Sewa A Badejo, Ellena K Briggs, Raghad A F Sallama, Emma Marsh, Brandon S H Low, Laura A E Munn, Ahamed Hafeezul Nashith Ahamed Rizwaan, Carys M. Francis, Ali Hamed Mahmood Al-Nakeeb, Michael E. Bryan, Sydney LA Barnes, Tommy Wai Kei LI

“…Only 23.1% of students felt confident about securing a specialty training post, with confidence higher among males (OR 1.36, 95% CI 1.21 to 1.52, p<0.0001) and privately educated students (OR 1.18, CI 1.03 to 1.35, p=0.02). …”
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DFO-loaded PDA nanoparticles facilitated 3D stem cell spheroids for diabetic wound repair by normalizing the pathological microenvironment by Tong Luo, Peijun Zhu, Shuai Li, Maolin Qin, Zeyu Fang, Fangfang Wu, Qian Wu, Suhong Lu, Yinhe Zhang, Yuli Chen, Junhua Zhou, Daqing Chen, Liangliang Yang, Hongyu Zhang

“…Despite the high therapeutic potential of 3D stem cell spheroids, owing to their structural and functional advantages, the complex microenvironment encountered post-transplantation significantly diminishes their survival and efficacy. …”
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Clinical Outcomes and Health Care Utilization in Patients with Advanced Chronic Kidney Disease not on Dialysis After the Onset of the COVID-19 Pandemic in Ontario, Canada by Carol Wang, Yuguang Kang, Stephanie N. Dixon, Nivethika Jeyakumar, K. Scott Brimble, Amit X. Garg, Peter G. Blake, Therese A. Stukel, Matthew J. Oliver, Ahmed Al-Jaishi, Kristin K. Clemens, Longdi Fu, Jane Ip, Susan McKenzie, Louise Moist, Amber O. Molnar, Flory Muanda-Tsobo, Marian Reich, Pavel Roshanov, Samuel A. Silver, Ronald Wald, Matthew A. Weir, Kevin Yau, Ann Young, Kyla L. Naylor

“…Poisson generalized estimating equations were used to predict post-COVID-19 patient outcomes and health utilization based on pre-COVID trends, estimating relative changes between the observed and expected outcomes. …”
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Global Feature Focusing and Information Enhancement Network for Occluded Pedestrian Detection by ZHENG Kaikui, JI Kangyou, LI Jun, LI Qiming

“…Existing methods, including post-processing optimization, specific model based improvements, and body part feature based methods, have limitations such as inaccurate handling of heavily occluded positive samples, high computational complexity, and susceptible to background noise. …”
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Comparison of cerebrospinal fluid biomarkers in patients with severe COVID-19 neurological outcomes and Alzheimer’s disease by Fernanda G.Q. Barros-Aragão, Thaís L. Pinheiro, Talita P. Pinto, Bart Vanderborgh, Nathane B.S. Rezende, Guilherme B. de Freitas, Gabriel R. de Freitas, Fernando A. Bozza, Andrea S. Souza, Erika C. Rodrigues, Carlos O. Brandão, Paulo Mattos, Felipe K. Sudo, Fernanda F. Tovar-Moll, Fernanda G. De Felice

“…Considering that inflammation may persist post-COVID, our findings urge the assessment of possible AD-related biomarker changes in COVID-19 survivors with lingering symptoms.…”
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Fusion of SARS-CoV-2 neutralizing LCB1 peptide with Bacillus amyloliquefaciens RNase improves antiviral efficacy by Nikita N. Kostin, Tatyana V. Bobik, Elena V. Konovalova, Milita V. Kocharovskaya, Maria A. Simonova, Natalia Yu Rushkevich, Yuliana A. Mokrushina, George A. Skryabin, Roman S. Kalinin, Sergey I. Kovalchuk, Rustam H. Ziganshin, Leonid A. Kaluzhskiy, Oksana V. Gnedenko, Evgeniy O. Yablokov, Alexis S. Ivanov, Aleksandr S. Chernov, Vitaly A. Kazakov, Oksana N. Khokhlova, Arkady N. Murashev, Senlian Hong, Elena I. Shramova, Alexey A. Schulga, Ekaterina N. Lyukmanova, Mikhail P. Kirpichnikov, Ivan V. Smirnov, Alexey A. Belogurov, Yuri P. Rubtsov, Alexey V. Stepanov, Hongkai Zhang, Alexander G. Gabibov, Sergey M. Deyev

“…LCB1-ABD-Bn exhibits good tolerability at doses below 10 mg/kg and provides protection of SARS-CoV-2-infected CAG-hACE2 animals in 24-hour post-infection intraperitoneal treatment. Cryo-EM reveals the LCB1-ABD-Bn’s tight interaction with S protein RBD domains, highlighting its potential as a promising drug candidate against SARS-CoV-2.…”
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Evolution of antibiotic prescription in Primary Health Care according to the indicators of the Spanish Action Plan on Antibiotic Resistance (PRAN) by Carlos Marcilla Vázquez, Juan Ríos Laorden, Ángeles Lloret Callejo, Francisco Tejada Cifuentes, María José Tirado Peláez, Ignacio Párraga-Martínez

“…Pre-pandemic data (2014-2019) was 19.32 DID and 13.92 DOT, being reduced during the two years of the pandemic (2020-2021) to 8.30 DID and 6.05 DOT and subsequently increased to 18.05 DID and 12.40 DOT in post-pandemic years (2022-2023). An improvement in the adequacy of antibiotic prescription was observed after the COVID-19 pandemic, with a reduction of the consumption of amoxicillin-clavulanate and a greater consumption of penicillin and amoxicillin during pre-pandemic and pandemic years (p < 0.05). …”
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Mechanistic insights into JSS1_004-mediated antagonism of the DndBCDE-FGH restriction system and engineering applications by Yu He, Susu Jiang, Fang Wang, Junwu Bi, Siting Li, Fuliang Yin, Shi Chen, Chao Chen, Lianrong Wang

“…Upon host invasion, the early gene transcriptional fragment of JSS1 facilitated the rapid expression of JSS1_004, with a N-terminal kinase domain that mediated phosphorylation of serine, threonine, and tyrosine residues within the DndFGH defense complex. This post-translational modification induced conformational changes in the complex, effectively neutralizing its restriction activity against phage propagation. …”
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Transcription factor ELF4 in physiology and diseases: Molecular roles and clinical implications by Dian Hu, Zerui Zhang, Yijun Wang, Siwen Li, Jiaqian Zhang, Zhangfan Wu, Mengyu Sun, Junqing Jiang, Danfei Liu, Xiaoyu Ji, Shuai Wang, Yufei Wang, Xiangyuan Luo, Wenjie Huang, Limin Xia

“…This review provides an in-depth overview of the molecular structure and post-translational modifications of ELF4. It also summarizes the hallmarks of ELF4 in physiology and diseases, with a particular focus on its significance in oncology. …”
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The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke by Tingbo Li, Ling Yang, Jiaqi Tu, Yufan Hao, Zhu Zhu, Yingjie Xiong, Qingzhu Gao, Lili Zhou, Guanglei Xie, Dongdong Zhang, Xuzhao Li, Yuxiao Jin, Yiyi Zhang, Bingrui Zhao, Nan Li, Xi Wang, Jie-Min Jia

“…Deciphering the mechanism by which E-pericytes coordinate post-stroke recovery may reveal a novel therapeutic opportunity.…”
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How well do coverage surveys and programmatically reported mass drug administration coverage match? Results from 214 mass drug administration campaigns in 15 countries, 2008–2017 by Karsor Kollie, Nebiyu Negussu, Scott D Nash, Donal Bisanzio, Fiona M Fleming, Pamela S Mbabazi, Richard Reithinger, Kathryn L Zoerhoff, Katherine Gass, John Kraemer, Brian B Fuller, Lynsey Blair, Roland Bougma, Aboulaye Meite, Bizuayehu Gashaw, Nana-Kwadwo Biritwum, Jean Frantz Lemoine, Helena Ullyartha Pangaribuan, Eksi Wijayanti, Clara Fabienne Rasoamanamihaja, Lazarus Juziwelo, Square Mkwanda, Pradip Rimal, Issa Gnandou, Bocar Diop, Ameyo Monique Dorkenoo, Rachel Bronzan, Edridah Muheki Tukahebwa, Fatima Kabole, Violetta Yevstigneyeva, Lauren Courtney, Joseph Koroma, Egide Endayishimye, Margaret C Baker

“…Surveyed treatment coverage came from post-MDA community-based coverage evaluation surveys, which were conducted as per standardised WHO recommended methodology.Results Coverage estimates using routine reporting and surveys gave the same result in terms of whether the minimum coverage threshold was reached in 72% of the MDAs surveyed in the Africa region and in 52% in the Asia region. …”
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Integrated Multiomics Analyses of the Molecular Landscape of Sarcopenia in Alcohol‐Related Liver Disease by Nicole Welch, Pugazhendhi Kannan, Saurabh Mishra, Annette Bellar, Vandana Agrawal, Grahame Kidd, Emily Benson, Ryan Musich, Raya Tabbalat, Ling Li, J. Mark Brown, Belinda Willard, Karyn A. Esser, Laura E. Nagy, Srinivasan Dasarathy

“…Conclusions An integrated multiomics approach, combined with experimental validation, identifies HIF1α stabilization and accelerated post‐mitotic senescence as novel mechanisms of sarcopenia in ALD. …”
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microRNA-1 regulates metabolic flexibility by programming adult skeletal muscle pyruvate metabolism by Ahmed Ismaeel, Bailey D. Peck, McLane M. Montgomery, Benjamin I. Burke, Jensen Goh, Abigail B. Franco, Qin Xia, Katarzyna Goljanek-Whysall, Brian McDonagh, Jared M. McLendon, Pieter J. Koopmans, Daniel Jacko, Kirill Schaaf, Wilhelm Bloch, Sebastian Gehlert, Kevin A. Murach, Kelsey H. Fisher–Wellman, Ryan L. Boudreau, Yuan Wen, John J. McCarthy

“…Conclusions: These data identify a novel post-transcriptional mechanism of whole-body metabolism regulation mediated by a tissue-specific miRNA.…”
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The geoarchaeology, chronology and environment of Lusakert-1, a Late Middle Palaeolithic rockshelter (Kotayk Province, Armenia) by Keith N. Wilkinson, Ethel Allué, Simon J. Armitage, Adam van Arsdale, Guy Bar-Oz, Alex Brittingham, Boris Gasparyan, Jayson Gill, Philip Glauberman, Thomas F.G. Higham, Ellery Frahm, Tanner Kovach, Vasilija Lukich, Carolina Mallol, Yannick Raczynski-Henk, Iván Rey Rodríguez, Jennifer E. Sherriff, Aayush Srivastava, Lior Weissbrod, Reuven Yeshurun, Daniel S. Adler

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Protocol for a cluster randomised trial evaluating a multifaceted intervention starting preconceptionally—Early Interventions to Support Trajectories for Healthy Life in India (EIN... by Mary Barker, Janis Baird, K S Joseph, Cindy-Lee Dennis, Zulfiqar A Bhutta, Prakesh S Shah, Saumyadipta Pyne, Nalini Singhal, Murali Krishna, Prabhat Jha, Harshpal Singh Sachdev, Kalyanaraman Kumaran, Caroline H D Fall, Stephanie Atkinson, Stephen Lye, Stephen G Matthews, Daniel Sellen, Ghattu V Krishnaveni, Kumar Gavali Suryanarayana, Manohar Prabhu Prasad, Antonisamy Belavendra, Ramaswamy Balasubramaniam, Robert H J Bandsma, Giriraj Ratan Chandak, Elena M Comelli, Sandra T Davidge, Geoffrey L Hammond, Sadhana R Joshi, Kang Lee, Patrick McGowan, Pablo Nepomnaschy, Vivek Padvetnaya, Sirazul Ameen Sahariah, Jacquetta Trasler, Chittaranjan S Yajnik, Marie-Claude Martin, Nusrat Husain

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