Genetic diversity, heritability, and estimated breeding values for growth of domesticated Asian seabass Lates calcarifer from Thailand by Sirikan Prasertlux, Atra Chaimongkol, Jutaporn Chaimongkol, Sirithorn Janpoom, Sureerat Tang, Puttawan Rongmung, Wanwipa Ittarat, Parichart Ninwichian, Putth Songsangjinda, Takashi Sakamoto, Bavornlak Khamnamtong, Panya Sae-Lim, Sirawut Klinbunga

“…Heritability and estimated breeding values (EBVs) for growth in G0 families were evaluated at 519 day post hatch (dph, mean body weight = 616.64 ± 266.80 g, N = 1655). …”
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Experience with Tixagevimab and Cilgavimab (Evusheld) in 86 rheumatic patients undergoing anti-B cell therapy with rituximab by T. V. Beketova, N. О. Levina, M. V. Dubinskaia, Yu. A. Uskova, I. V. Rozanova, V. V. Babak, M. F. Beketova, T. N. Krasnova

“…The presence of IRD is associated with a high risk of disease and severe course of COVID-19 during immunosuppressive treatment, primarily anti-B cell therapy with rituximab (RTX), and a low level of post-vaccination response in such patients. A new strategy for the prevention and treatment of COVID-19 are virus-neutralizing monoclonal antibodies to coronavirus; currently, combined long-acting monoclonal antibodies tixagevimab and cilgavimab (Evusheld) are registered for prevention in the world and the Russian Federation. . …”
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Engineering a 3D platform for testis bioengineering: generation and proteomic profiling of decellularized fish testicular scaffolds by Ivana Felipe Rosa, Ivana Felipe Rosa, Ivana Felipe Rosa, Beatriz Marques Souza, Lucas Benites Doretto, Lucas Benites Doretto, Maira da Silva Rodrigues, Caroline Nascimento Barquilha, Matheus Naia Fioretto, Luiz Marcos Frediani Portela, José Carlos Souza Vieira, Luis Antonio Justulin, Pedro de Magalhães Padilha, Changwei Shao, Changwei Shao, Rafael Henrique Nóbrega

“…Notably, critical ultrastructural features—such as the basal lamina, seminiferous tubules, and the D-periodic banding pattern of collagen fibrils—were retained post-decellularization. Proteomic analyses revealed enrichment of proteins associated with ECM organization, cell adhesion, and collagen biosynthesis, while proteins involved in glycolysis and metabolic pathways were downregulated. …”
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Clinical Evidence of Acupoint Stimulation for Primary Dysmenorrhea: A Systematic Review and Updated Meta-Analysis by Wang Y, Liu L, Wu X, Wu Y, Qin R, Wang M, Zhou B, Sun J, Song Y, Zhang M, Li M, Yu L

“…Compared with non-steroidal anti-inflammatory drugs (NSAIDs), acupoint stimulation showed both immediate effects (post-first-treatment SMD − 2.85, 95% CI − 4.06 to − 1.64) and sustained benefits (3 cycles SMD − 1.58, 95% CI − 2.43 to − 0.73; following 3 cycles SMD − 3.74, 95% CI − 5.57 to − 1.90), particularly with invasive techniques. …”
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Cardiovascular risks associated with adjuvant endocrine therapy in women with breast cancer: a population-based cohort study by Iokfai Cheang, Ying Gue, Mei-Zhen Wu, Jia-Yi Huang, Qing-Wen Ren, Ziqi Chen, Yi-Kei Tse, Hang-Long Li, Yap-Hang Chan, Hung-Fat Tse, Xinli Li, Gregory Y. H. Lip, Kai-Hang Yiu

“…Conclusion The study indicates that AIs are linked to a higher risk of cardiovascular events in post-menopausal patients compared to TMX. In younger patients, TMX’s protective effect on cardiovascular outcomes may be less pronounced. …”
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Peculiarity of Clinical Course of Childhood Hepatitis C Depending on the Viral Genotype by E. A. Leybman, L. I. Nikolaeva, E. I. Samokhvalov, K. K. Kyuregayn, O. V. Isaeva, G. V. Sapronov, T. V. Cherednechenko, A. G. Pisarev, A. E. Grishechkin, M. I. Michailov, V. F. Uchaikin

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Sex differences in discontinuations due to side effects of second-generation integrase strand transfer inhibitors: a systematic review and meta-analysisResearch in context by Zhou Fang, Tetiana Povshedna, Rowan Patterson, Erin Ready, Helene C.F. Cote, Melanie C.M. Murray, Elizabeth M. King

“…Studies in pregnancy, post-partum, pediatrics, co-infections (e.g., TB), and monotherapy were excluded. …”
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Un broche de cinturón tardoantiguo de la cueva de Lazaldai (Zuia, Álava/Araba) by José Ángel Hierro Gárate, Enrique Gutiérrez Cuenca, Leticia Tobalina Pulido, Diego Garate Maidagan, Iñaki Intxaurbe Alberdi, Antonio Torres Riesgo, Sergio Salazar Cañarte

“…This f ind contributes to our understanding of regional identity construction and the circulation of objects and ideas in post-Roman western Europe.…”
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Breaking prolonged sitting with high-intensity interval training to improve cognitive and brain health in middle-aged and older adults: a protocol for the pilot feasibility HIIT2SI... by Charles Hillman, Talha Syed, Dominika M Pindus, Tomasz S Ligeza, Jin Kuang, Scott Paluska, Joseph So, Miroslaw Wyczesany, Jesus Sarol, Flor B Quiroz, Ramiya Shanmugam, Maciej Kos, Naiman Khan, Art Kramer

“…The primary outcomes include the feasibility (recruitment and retention rates, percentage of valid electroencephalogram data), acceptability of time commitment, HIIT bouts and neurocognitive assessments, fidelity (the intensity of HIIT breaks, percentage of time spent sitting) and the amplitude and the latency of the P3b component of event-related brain potentials measured during the modified Eriksen flanker task at pretests, after the first and the third PA bout and at post-test. General linear mixed-effects models will be used to test the effects of the intervention on the P3b component.Ethics and dissemination The Institutional Review Board at the University of Illinois Urbana-Champaign provided the ethical approval for the study. …”
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Glucose metabolism in heterozygous familial hypercholesterolemia with a founder effect and a high diabetes prevalence: a cross-sectional study by Ana María González-Lleó, Yeray Brito-Casillas, Virginia Martín-Santana, Yaiza Gil-Quintana, Antonio Tugores, Roberto Scicali, Marta Riaño, Luisa Hernández-Baraza, Roberto Jiménez-Monzón, Josefa Girona, Francesco Di Giacomo Barbagallo, Luis Masana, Mauro Boronat, Ana M. Wägner, Rosa M. Sánchez-Hernández

“…Compared with HeFH-It patients, HeFH-GC individuals had higher fasting glucose levels (99 vs. 92.5 mg/dL; p = 0.004) and lower 120-min post-OGTT glucose levels (115 vs. 136.5 mg/dL; p = 0.001). …”
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Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis by Chun Zhang, Xiuxing Liu, Chenyang Gu, Yuhan Su, Jianjie Lv, Yidan Liu, Yuehan Gao, Hui Chen, Nanwei Xu, Jing Xiao, Zhuping Xu, Wenru Su

“…Our further studies showed that targeted inhibition of HDACs effectively alleviated EAU, restored its Th17/Treg balance, and reduced inflammatory gene expression, especially in CD4+ T cells. Post-HDACs inhibition, Treg proportions increased with enhanced immunomodulatory effects. …”
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Comprehensive genomic and transcriptomic analyses reveal prognostic stratification for esophageal squamous cell carcinoma by Jian Gao, Qiming Wang, Fangqiu Fu, Yue Zhao, Teng Yang, Xiangze Li, Yihua Sun, Hong Hu, Longfei Ma, Longsheng Miao, Xiaoyang Luo, Ting Ye, Yiliang Zhang, Yang Zhang, Ziling Huang, Hang Li, Longlong Shao, Midie Xu, Kuaile Zhao, Shiyue Zhang, Mou Zhang, Jun Wang, Chong Dai, Xiaoxiao Shang, Tingyi An, Yawei Zhang, Jiaqing Xiang, Zhiwei Cao, Bin Li, Haiquan Chen

“…In contrast, activation of the epithelial-keratinization (EpK) pathway was strongly linked to favorable prognosis and lower post-chemotherapy recurrence rates. Independent validation supported S100A8 + S100A9 complex as a key marker of EpK pathway. …”
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Remote Ischemic Preconditioning Prevents Acute Kidney Injury Following Coronary Angiography by Oladipupo Olafiranye, MD, MS, Adam C. Straub, PhD, Yingze Zhang, PhD, Rahul Chaudhary, MD, MBA, Megan P. Miller, BS, Kathan Trivedi, MD, Lawrence Hoang, MD, Oussama Khalifa, MD, Adetola Ladejobi, MD, MPH, Floyd W. Thoma, BS, Ning Feng, MD, PhD, Aref Rahman, MD, John A. Kellum, MD

“…The product of urinary tissue inhibitor of metalloproteinase-2 and insulin-like growth factor-binding protein-7, 2 markers of AKI, significantly increased at 48 hours post-angiography compared to pre-angiography level (0.51 vs 0.89; P = 0.004) in the sham-RIPC but not in the RIPC group (0.39 vs 0.68; P = 0.091). …”
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Myostatin Levels in SMA Following Disease‐Modifying Treatments: A Multi‐Center Study by Fiorella Piemonte, Sara Petrillo, Anna Capasso, Giorgia Coratti, Adele D'Amico, Michela Catteruccia, Maria Carmela Pera, Concetta Palermo, Marika Pane, Emanuela Abiusi, Gianpaolo Cicala, Marianna Villa, Chiara Bravetti, Chiara Arpaia, Agnese Novelli, Salvatore Falqui, Stefania Fiori, Giulia Napoli, Silvia Baroni, Francesco Danilo Tiziano, Enrico Bertini, Giacomo Comi, Stefania Corti, Eugenio Mercuri

“…The longitudinal cohort included 46 treatment‐naive patients assessed at baseline and 12 months post‐treatment. Myostatin levels were measured using ELISA. …”
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Construction and Evaluation of a Rat Model of Abnormal Uterine Bleeding by LIAN Hui, JIANG Yanling, LIU Jia, ZHANG Yuli, XIE Wei, XUE Xiaoou, LI Jian

“…Uterine bleeding was recorded during the 48-hour observation period post-modeling. Serum and uterine tissue samples were collected from the model group at 0, 12, 24, 36, and 48 h after mifepristone administration, while the normal control group was sampled at 36 h. …”
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Magnolia officinalis enhanced immune responses and the resistance to Vibrio harveyi infection in pearl gentian groupers by Yilin Zhang, Yilin Zhang, Yuhao Li, Yuhao Li, Xinlan Xu, Xinlan Xu, Luxi Xu, Luxi Xu, Weifu Li, Weifu Li, Zhen Gan, Zhen Gan, Yishan Lu, Yishan Lu

“…After being challenged with V. harveyi ZJ0603 at 28 days post-injection, the survival rate (SR) of groupers were 50.0, 60.0, 73.3, and 66.7% in MO groups at different concentrations, respectively, indicating that MO administration could improve the resistance to V. harveyi infection in groupers. …”
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Transcranial direct current stimulation over the temporal-parietal junction yields no lexical-semantic effects in logopenic primary progressive aphasia: a double-blind sham-control... by Marc Teichmann, Clara Sanches, Angelina Bourbon, Dennis Q. Truong, Marom Bikson, Antoni Valero-Cabré

“…Computational modeling was used to characterize predicted cortical tDCS current distribution.Comparisons of post/pre-tDCS results did not show language improvement in any task. …”
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Adjuvant melatonin therapy during exercise prescription in breast cancer survivors on physical and anthropometric parameters, quality of life, and hormonal response. A randomized c... by Ana M. Celorrio San Miguel, Luis M. Cacharro, Gema Santamaría, Manuel Garrosa, Manuel Garrosa, Marta Celorrio San Miguel, Enrique Roche, Enrique Roche, Enrique Roche, Enrique Roche, Evelina Garrosa, Diego Fernández-Lázaro, Diego Fernández-Lázaro, Diego Fernández-Lázaro

“…Our findings suggest no clear effect of melatonin in post-treatment for BCS in the mentioned parameters. …”
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The Impact of Whole Body Vibration on Muscle Tone, and Sensory Motor Function in Children with Spastic Diplegic Cerebral Palsy by Hussein HM, Dakheel N, Alshammari HZM, Alshammari AA, Gabr AM, El-Shamy SM, SD S, A RH, Dewir IM, Mohamed AR, Ibrahim AA

“…However, there were limited studies involving the effect of WBV on the tone and function of diplegic CP; we aimed to investigate the effect of WBV on muscle tone, function, and sensorimotor function in children with CP.Patients and Methods: This is a single-blind randomized controlled clinical trial involving 54 spastic diplegic CP child recruited from local rehabilitation centers in the Ha’il region of Saudi Arabia, they were randomly divided into the WBV group (n = 28 with mean age of 9.47± 1.92), which received standard physical therapy and WBV therapy, and the control group (n = 26 with mean age of 9.73± 1.62) they received standard physical therapy three time per week for four weeks; Muscle tone, function, strength and Sensory motor integration were evaluated pre and post interventions.Results: At baseline, the two groups had no significant differences. …”
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Efficacy and safety of flupentixol-melitracen in patients with refractory chronic cough: a randomised, double-blinded, placebo-controlled clinical trialResearch in context by Qiang Chen, Mengru Zhang, Li Zhang, Alimire Aierken, Ran Dong, Xianghuai Xu, Li Yu, Kefang Lai, Zhongmin Qiu

“…The safety set (SS) was used for safety analysis and included all patients who took at least one dose of treatment and had post-dose safety records. The FAS and SS were equivalent in this study. …”
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