Mpox virus: virology, molecular epidemiology, and global public health challenges by Siwei Chen, Siwei Chen, Ju Huang, Ju Huang, Junkai Chen, Junkai Chen, Fengqi Liu, Fengqi Liu, Shuqi Wang, Shuqi Wang, Na Wang, Na Wang, Ming Li, Ming Li, Ziyi Zhang, Ziyi Zhang, Congcong Huang, Congcong Huang, Weixing Du, Weixing Du, Long Liu, Long Liu, Zhixin Liu, Zhixin Liu

“…In addition, we highlight the mounting public health challenges, including vaccine inequity, immunity gaps in the post-smallpox era, surveillance limitations, healthcare system vulnerabilities, and stigma-related barriers to disease reporting and control. …”
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Transcranial direct current stimulation enhances the efficacy of wearable transcutaneous electrical nerve stimulation for mild knee osteoarthritis in the middle-aged person: a rand... by Chun-Ya Xia, Hao-Zhi Niu, Xin-Wen Zhang, Si-Yan Cai, Ying-Jie Fan, Tian-Pei Xie, Peng-Xia Dong, Xiao-Tong Zu, Ze-Lin Su, Xing-Sheng Lu, Yong-Gang Hao, Min Su

“…The combined protocol exhibited superiority over TENS monotherapy, with sustained benefits observed up to one-month post-intervention. Trial registration This research has been registered in chictr.org.cn (registration number: ChiCTR2200064735) on 15 October 2022, https://www.chictr.org.cn/showproj.html?…”
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AIIMS ICU Rehabilitation (AIR): development and description of intervention for home rehabilitation of chronically ill tracheostomized patients [version 4; peer review: 2 approved,... by Asha P. Shetty, Rashan Haniffa, Nanda Kumar P, Upendra Hansda, Mahalingam V, Alok Kumar Sahoo, Jayanta Kumar Mitra, Sujata Mahapatra, Kasturi Sanyal, P Bhaskar Rao, Guruprasad N, Itimayee Panda, Helen Eborral, Jagannath Sahoo, Nazir Lone, Swagata Tripathy, Abi Beane

“…Home visits on days 7 and 21 post-discharge assessed patient hygiene, nutrition, physiotherapy, and established contact with the nearest primary healthcare facility for the future. …”
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The impact of a lifestyle promotion program on anthropometric and clinical manifestations in adolescents with polycystic ovarian syndrome: a randomized controlled trial by Fatemeh Nahidi, Fahimeh Ramezani Tehrani, Delaram Ghodsi, Mahdi Jafari, Hamid Alavi Majd, Somayeh Abdolahian

“…No notable differences were observed in the nutritional status among all groups post-intervention. However, a significant increase in physical activity levels, measured in metabolic equivalent minutes per week (met/min/week), was recorded in both intervention groups (p < 0.05). …”
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Efecto de la pandemia de COVID-19 en la natalidad y salud neonatal del Hospital Español de México by Jimena Estandía-Espinosa, Daniel Ortiz-Morales, Ariane E. Weiser-Smeke, Lucía Escobedo-Berumen, Alejandra Márquez-Parra, Víctor M. Pacheco-Beltrán, Horacio Silva-Ramírez, Jorge Loría-Castellanos

“…Se aplicaron pruebas estad&#x00ED;sticas como Kolmogorov-Smirnov y Kruskal-Wallis para analizar variables cuantitativas, junto con la prueba post hoc de Bonferroni para identificar diferencias entre grupos. …”
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Contingent Analysis of Open Flap Debridement, Leukocyte-Rich Platelet-Rich Fibrin and Titanium Platelet-Rich Fibrin in the Treatment of Three-Walled Intra-Bony Defects in Chronic P... by Gowri Pendyala, Ameet Mani, Vinay Vadvadgi, Esha Thakare, Bharti Gupta

“…Evaluation of change in probing pocket depth, Gain in clinical attachment level was done at 9 Months, and defect fill and alveolar crestal bone resorption were evaluated at 6 and 9 Months after surgery by Analysis of Variance (ANOVA) with Post hoc Tukey’s test. Probing Pocket depth was measured from the gingival margin to the base of the pocket, Clinical attachment Level was measured from the cementoenamel junction of each tooth to the soft tissue base of the pocket by using a stent. …”
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Self-directed and prosocial wound care, snare removal, and hygiene behaviors amongst the Budongo chimpanzees by Elodie Freymann, Elodie Freymann, Elodie Freymann, Elodie Freymann, Catherine Hobaiter, Catherine Hobaiter, Michael Alan Huffman, Michael Alan Huffman, Harmonie Klein, Geresomu Muhumuza, Vernon Reynolds, Vernon Reynolds, Nora E. Slania, Nora E. Slania, Adrian Soldati, Adrian Soldati, Eguma Robert Yikii, Klaus Zuberbühler, Klaus Zuberbühler, Susana Carvalho, Susana Carvalho

“…We also document self-directed hygiene behaviors including postcoital genital leaf wiping and post-defecation leaf wiping. For the first time in Budongo, we report the presence of prosocial wound care, adding to similar observations documented at other chimpanzee field sites. …”
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Ethylene‐Activated E3 Ubiquitin Ligase MdEAEL1 Promotes Apple Fruit Softening by Facilitating the Dissociation of Transcriptional Repressor Complexes by Tong Li, Li Liu, Guangxin Yang, Yingcong Cai, Yingda Wang, Bowen Sun, Le Sun, Weiting Liu, Aide Wang

“…This study elucidates the interplay between post‐translational modifications of a transcription factor and its epigenetic modification to regulate fruit softening, and highlights the complexity of ethylene‐induced softening.…”
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Hemodynamic correlates of fluctuations in neuronal excitability: A simultaneous Paired Associative Stimulation (PAS) and functional near infra-red spectroscopy (fNIRS) study by Zhengchen Cai, Giovanni Pellegrino, Amanda Spilkin, Edouard Delaire, Makoto Uji, Chifaou Abdallah, Jean-Marc Lina, Shirley Fecteau, Christophe Grova

“…The effect of PAS on excitability and hemodynamic activity showed a trend of positive correlation with MEP ratios (post-PAS/pre-PAS) linked to HbO and HbR ratios (r = 0.19, p = 0.29; r = 0.18, p = 0.30, respectively). …”
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Novel Adiposity Indices Are Associated With Poor Prognosis in Heart Failure With Preserved Ejection Fraction Without the Obesity Paradox by Shuai Zhang, Panpan Xu, Tianhao Wei, Changjiang Wei, Yanling Zhang, Huixia Lu, Cheng Zhang

“…Methods and Results This study is a post hoc analysis of data from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial. …”
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Perceived, objective, and applied numeracy among pregnant women engaged in home blood pressure monitoring in GhanaAJOG Global Reports at a Glance by Emma R. Lawrence, MD, Sanaya Irani, BS, Betty Nartey, MPH, Brittney Collins, BS, Elorm Segbedzi-Rich, MD, Andrea Pangori, MS, Titus K. Beyuo, MD, Cheryl A. Moyer, PhD, Jody R. Lori, PhD, Samuel A. Oppong, MD

“…After training, participants engaged in home blood pressure monitoring for 2 to 4 weeks. A post-monitoring survey evaluated confidence and experience interpreting blood pressure values, a validated numeracy scale, and interpretation of blood pressure monitor outputs—half with numbers only and half with both numbers and colors. …”
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Common Variant in Glycoprotein Ia Increases Long‐Term Adverse Events Risk After Coronary Artery Bypass Graft Surgery by Hanning Liu, Zhengxi Xu, Haiyong Gu, Wenke Li, Wen Chen, Cheng Sun, Kun Zhao, Xiao Teng, Heng Zhang, Lixin Jiang, Shengshou Hu, Zhou Zhou, Zhe Zheng

“…Patients who are GPIA rs1126643 T‐allele carriers have a higher major adverse cardiac or cerebrovascular events risk post‐CABG than those who are CC homozygotes (hazard ratio [HR]=1.29; P=0.022). …”
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Climate Change and Its Impacts on the Planting Regionalization of Potato in Gansu Province, China by Yulan Lu, Junying Han, Guang Li, Zhengang Yan, Lixia Dong, Zhigang Nie, Qiang Liu

“…The accumulated temperature above 10 °C showed a spatial pattern of high accumulated temperatures in the northwestern and southeastern regions and low accumulated temperatures in the remaining regions, while its tendency rate showed a decreasing trend from west to east and from north to south. (4) The impacts of climate change on potato planting in Gansu Province were mainly manifested as a decrease of 0.30 × 10⁶ hm² in the cultivated land area in the most suitable region for potato planting post-1998, while the suitable area diminished by 0.96 × 10⁶ hm², the sub-suitable area expanded by 0.47 × 10⁶ hm², and the plantable area increased by 0.79 × 10⁶ hm². …”
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Alterations in the intestinal fungal microbiome of patients with severe fever with thrombocytopenia syndrome by Meng-Yu Liu, Sheng-Fu He, Yu-Yao Li, Jiao-Jiao Shen, Jia-Jia Li, Ya-Sheng Li, Yan-Yan Liu, Ting Wu, Jia-Bin Li, Li-Fen Hu

“…Methods: Fecal samples were collected from 80 patients both during their hospitalization and post-discharge. Internal transcribed spacer (ITS) amplicon sequencing and fungal profiling of intestine were performed. …”
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Crocin promotes ferroptosis in gastric cancer via the Nrf2/GGTLC2 pathway by Nan Yan, Gaofu Li, Linglin Zhao, Qijing Guo, Jie Yang, Jianhong Liu, Wei Zhou, Yue Gao, Yue Gao, Yushuang Luo, Yushuang Luo

“…Pathway enrichment analysis was performed on differentially expressed genes post-crocin treatment. Lentiviral vectors were used to knockdown and overexpress GGTLC2, exploring its role in GC progression and crocin’s therapeutic effects. …”
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Modeling and regulation of water exchange between the oxbow lake and the middle Yangtze River by Xiaoguang Liu, Shiming Yao, Zhongwu Jin, Bing Ding, Lican Ge, Shuo Guan, Weijie Wang

“…Seasonal and interannual variations in water exchange intensity were quantified across three critical intervals: flood preparation (Interval I), peak fish migration (Interval II), and post-flood recession (Interval III). Findings revealed reduced water exchange during Interval II negatively impacted small fish populations, challenging species such as the Yangtze finless porpoise. …”
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High-intensity non-invasive ventilation during exercise-training versus without in people with very severe COPD and chronic hypercapnic respiratory failure: a randomised controlled... by Klaus Kenn, Rainer Gloeckl, Daniela Leitl, Tessa Schneeberger, Inga Jarosch, Wolfgang Hitzl, Clancy John Dennis, Carl-Peter Criée, Andreas Rembert Koczulla, Antje Stegemann, Maximilian Leidinger, Ursula Schoenheit-Kenn

“…Primary outcome was change in cycle endurance time (ΔCETtime), while secondary outcomes were dyspnoea at isotime during the cycle endurance test and during ET-sessions and for the HI-NIV group, post-trial preferred exercising method.Results Twenty-six participants (forced expiratory volume in 1 s 22±7%pred, PaCO251±7 mm Hg) completed the trial (HI-NIV: n=13, ET: IPAP 26±3/EPAP 6±1 cm H2O; control n=13). …”
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Neoadjuvant in situ vaccination with cowpea mosaic virus as a novel therapy against canine inflammatory mammary cancer by Daniel Alonso-Miguel, Guillermo Valdivia, Diego Guerrera, Maria Dolores Perez-Alenza, Stanislav Pantelyushin, Angela Alonso-Diez, Veronique Beiss, Steven Fiering, Nicole F Steinmetz, Maria Suarez-Redondo, Johannes vom Berg, Laura Peña, Hugo Arias-Pulido

“…In the TME, higher neutrophilic infiltration and MPO expression, lower tumor Ki-67 PI, increase in CD3+ lymphocytes, decrease in FoxP3+/CD3+ ratio (p&lt;0.04 for all comparisons), and no changes in CC-3+ immunostainings were observed in post-treatment tumor tissues when compared with pretreatment tumor samples. eCPMV-treated IMC patients had a statistically significant (p=0.033) improved overall survival than patients treated with medical therapy.Conclusions Neoadjuvant in situ eCPMV immunotherapy demonstrated anti-tumor efficacy and improved survival in IMC patients without systemic adverse effects. eCPMV-induced changes in immune cells point to neutrophils as a driver of immune response. …”
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Machine learning suggests polygenic risk for cognitive dysfunction in amyotrophic lateral sclerosis by Katerina Placek, Michael Benatar, Joanne Wuu, Evadnie Rampersaud, Laura Hennessy, Vivianna M Van Deerlin, Murray Grossman, David J Irwin, Lauren Elman, Leo McCluskey, Colin Quinn, Volkan Granit, Jeffrey M Statland, Ted M Burns, John Ravits, Andrea Swenson, Jon Katz, Erik P Pioro, Carlayne Jackson, James Caress, Yuen So, Samuel Maiser, David Walk, Edward B Lee, John Q Trojanowski, Philip Cook, James Gee, Jin Sha, Adam C Naj, Rosa Rademakers, The CReATe Consortium, Wenan Chen, Gang Wu, J Paul Taylor, Corey T McMillan

“…We demonstrate that a polygenic risk score derived using sCCA relates to longitudinal cognitive decline in the same cohort and also to in vivo cortical thinning in the orbital frontal cortex, anterior cingulate cortex, lateral temporal cortex, premotor cortex, and hippocampus (N = 90) as well as post‐mortem motor cortical neuronal loss (N = 87) in independent ALS cohorts from the University of Pennsylvania Integrated Neurodegenerative Disease Biobank. …”
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Plasma microRNA signatures of aging and their links to health outcomes and mortality: findings from a population-based cohort study by Lieke M. Kuiper, Michelle M. J. Mens, Julia W. Wu, Jaap Goudsmit, Yuan Ma, Liming Liang, Albert Hofman, Trudy Voortman, M. Arfan Ikram, Jeroen G. J. van Rooij, Joyce B. J. van Meurs, Mohsen Ghanbari

“…Abstract Background MicroRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally and show differential expression in various tissues with aging phenotypes. …”
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