Immune checkpoint inhibitors plus debulking surgery for patients with metastatic renal cell carcinoma: clinical outcomes and immunological correlates of a prospective pilot trial by Sangeeta Goswami, Jianjun Gao, Sreyashi Basu, Daniel D. Shapiro, Jose A. Karam, Rebecca Slack Tidwell, Kamran Ahrar, Matthew T. Campbell, Yu Shen, Alexandro E. Trevino, Aaron T. Mayer, Alexsandra B. Espejo, Christian Seua, Marc D. Macaluso, Yulong Chen, Wenbin Liu, Zhong He, Shalini S. Yadav, Ying Wang, Priya Rao, Li Zhao, Jianhua Zhang, Sonali Jindal, Nizar M. Tannir, Andrew Futreal, Linghua Wang, Padmanee Sharma

“…Primary safety endpoint of this trial has been met, with 43 patients completing cytoreductive surgery, 36 patients undergoing post-ICT biopsy, and 25 patients without either procedure due to progressive disease or toxicities or withdrawal of consent (total N = 104). …”
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Case Report: Two-center case series of motor-sparing nerve blocks comprised of preservative-free midazolam–buprenorphine–clonidine–dexamethasone by Brian A. Williams, Brian A. Williams, Marsha E. Ritter, Marsha E. Ritter, Patrick J. Kennedy, Patrick J. Kennedy, Alissa M. Kmatz, Leath Abdullah, Rick L. Scanlan, Nicholas J. McNiffe, William M. Fowler, Michael S. Patzkowski, Michael S. Patzkowski

“…The presentation of these four cases is followed by an aggregate data summary (n = 305 cases) of analgesic duration (mean 30.5 h, 95% CI 28.5–32.5 h) and pre-/postintervention peak pain scores (pre: mean 7.8/10 [95% CI 7.5–8.0]; post: mean 6.3/10 [95% CI 6.0–6.6]) after the described four-drug nerve block intervention, derived from quality improvement data at one of the two contributing author centers.…”
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Craniectomia descompressiva para tratamento da hipertensão intracraniana traumática em crianças e adolescentes: análise de sete casos Decompressive craniectomy in children and adol... by Rodrigo Moreira Faleiro, Luiz Carlos Mendes Faleiro, Marcelo Magaldi Oliveira, Tiago Silva, Elisa Costa Caetano, Isabela Gomide, Cristina Carneiro Pita, Gustavo Lopes, Sebastião Gusmão

“…All patients had ICP monitored post operatively and the DC classified as ultra-early (<6h), early (6-12h) or late (>24h) according to the time of its application. …”
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The recurrence and multi-organ involvement of giant penile plexiform neurofibroma in an adult with neurofibromatosis type 1: a case report by Junhao Chu, Zhihui Zhang, Huisheng Yuan, Jiajun Kan, Zilong Wang, Muwen Wang

“…To alleviate right flank pain, percutaneous nephrostomy was performed, resulting in a reduction in serum creatinine to 90.80 µmol/L within three days post-procedure, with subsequent symptom relief. Owing to extensive tumor infiltration and financial limitations, the patient opted against radical surgery or systemic therapy. …”
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Exploring the standardization of human nasal antibody measurements by Xuanxuan Zhang, Yulong Fu, Si Chen, Guanxing Liu, Ying Wang, Qian He, Qian Wang, Na Li, Zhongfang Wang, Ling Chen, Junzhi Wang, Zhenglun Liang, Miao Xu, Qunying Mao

“…A collaborative study conducted by seven laboratories demonstrated that CS2 improved the harmonization of inter-laboratory variability (pre-standardization geometric coefficients of variance, 14–314%; post-standardization, 3–35%). Using CS2 ensured an accurate assessment of nasal antibodies. …”
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Evaluating the impact of acupuncture on perennial allergic rhinitis: A randomized placebo acupuncture control trial protocol by Chunxue Meng, Qianxi Na, Jing Zhang, Zijie Cai, Fei Wang, Qian Zhang, Shengfu Zhang, Hailong Zhao, Xuhong Tang, Ziye Chen, Qian Zhang, Bin Guo

“…A regimen of 12 therapeutic sessions will be conducted across a 4-week interval.The primary outcome was the 3-month post-treatment recurrence rate, assessed using the Rhinitis Control Assessment Test (RCAT) score. …”
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Role of One Month Yoga Training on Arterial Stiffness in Young Adults with Familial Hypertension: A Prospective Interventional Study by Yashwanth Yellanki, Manjunatha R Aithala, Chandini Sheik, Amrit Podder, Madivalappa P Doddamani, Jyoti P Khodnapur

“…Anthropometric, physiological, as well as arterial stiffness parameters like pulse wave velocity and Arterial Stiffness Index (ASI), were recorded using Periscope preintervention at week zero and post-yoga intervention at week four. Statistical Package for the Social Sciences (Version 20.0) was used to analyse the data. …”
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The presidency of province and public instruction as a factors for expansion of the public space in the brazilian Empire / A presidência de província e a instrução pública como fat... by Vera Lúcia Nogueira, Dalvit Greiner de Paula

“…Unlike the former Spanish colonies, which gave rise to several republican states, in Brazil the monarchist regime was adopted, with a stable civil government, which centralized all decisions in the hands of the Emperor, including the appointment to the post of provincial president. The focus is on the work of Herculano Ferreira Penna (1811-1867), a politician who administered more provinces in the imperial state and in the attention he conferred on public education in the provinces where he passed. …”
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Real-world effectiveness of goserelin 10.8-mg compared to goserelin 3.6-mg in premenopausal and perimenopausal Chinese patients with hormone receptor positive breast cancer: a coho... by Yongsheng Wang, Xi Wang, Jiong Wu, Hong Liu, Jiuda Zhao, Jian Huang, Jianxia Liu, Youling Gong, Hao Wang, Huaqing Yang, Guorong Zou, Quchang Ouyang, Guoqin Jiang, Huijuan Liu, Sujie Ni, Binghe Xu, Jinming Yu

“…Results: From 1st January, 2015 to 15th December, 2023, 15,629 patients from 16 hospitals nationwide were screened, with 1,060 eligible patients included in the full analysis set (3.6-mg group: 678; 10.8-mg group: 382). Post-PSM, the primary endpoint was analyzed in 590 patients (295 in each group). …”
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Passive dehydration alters raw bioimpedance parameters: generic vs. individualized phase angle and estimated characteristic frequency by David H. Fukuda, Modesto A. Lebron, Kworweinski Lafontant, Gavin N. Van Staden, Adam J. Wells, Jeffrey R. Stout

“…Reliability for PhA@Fc and Fc was determined from two BIA assessments separated by at least 72 h.Results A PhA type × dehydration interaction was found where both PhA@Fc and PhA@50 kHz significantly increased (p = 0.006; Δ: +1.41°); however, Holm post-hoc adjustments yielded no differences between them before (p = 0.336) or after (p = 0.053) the sauna intervention. …”
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Cardiac MRI study of adverse events in patients treated with immune checkpoint inhibitors: a prospective cohort study of cardiac adverse events by Antonio Di Muzio, Alessandro Marchese, Lorenzo Monti, Cristina Panico, Marinos Kallikourdis, Gianluigi Condorelli, Armando Santoro, Matteo Simonelli, Angelo Dipasquale, Pasquale Persico, Laura Giordano, Giovanna Finocchiaro, Agnese Losurdo, Matteo Perrino, Marco Francone, Chiara Catalano, Simone Serio, Federica Catapano, Stefano Figliozzi, Carla D’Andrea, Marco Cremonesi, Maria Chiara Tronconi, Enrico Lugli

“…ICI treatment was associated with a significant left ventricular ejection function (LVEF) reduction pre-ICI versus post-ICI treatment (60.1±8% to 58.1±8%, p=0.002, paired t-test) and more than 3% LVEF loss in a substantial proportion of patients (18; 32%). …”
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Burst steroid therapy and quality of life in patients with acute heart failure: Insights from the CORTAHF trial by Matteo Pagnesi, Gad Cotter, Beth A. Davison, Yonathan Freund, Adriaan A. Voors, Christopher Edwards, Maria Novosadova, Koji Takagi, Hamlet Hayrapetyan, Andranik Mshetsyan, Mayranush Drambyan, Alain Cohen‐Solal, Jozine M. terMaaten, Jan Biegus, Piotr Ponikowski, Gerasimos Filippatos, Ovidiu Chioncel, Malha Sadoune, Tabassome Simon, Douglas L. Mann, Alexandre Mebazaa, Marco Metra

“…Abstract Aims Patients hospitalized with acute heart failure (AHF) treated with a 7 day prednisone course in the CORTAHF pilot trial had a greater improvement in health‐related quality of life (QoL) at Day 7 in both the overall population and in patients with baseline interleukin 6 > 13 pg/mL. This post‐hoc analysis examines the specific QoL domains and the relationship between clinical signs of congestion and QoL. …”
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Transient colonization by Priestia megaterium B1L5 alters the structure of the rhizosphere microbiome towards potential plant beneficial bacterial groups in apple plantlets by Fatma M. Mahmoud, Holger Edelmann, Yang Si, Lea Endrejat, Karin Pritsch, Caroline Gutjahr, Armin Ehrenreich, Traud Winkelmann, Jana Barbro Winkler, Jörg‑Peter Schnitzler, Michael Schloter

“…Results P. megaterium B1L5 successfully colonized apple roots in both soils 6 days post-inoculation (dpi), but was not detectable at 33 dpi. …”
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The effects of TiO2 nanotubes on bond strength and radiopacity of a self-adhesive resin cement in self-curing mode by Leandro Edgar Pacheco, Ana Paula Rodrigues Magalhães, Carla Muller Ramos-Tonello, Ligia Saraiva Bueno, Orisson Ponce Gomes, Lucas José Azevedo Silva, Adilson Yoshio Furuse, Paulo Noronha Lisboa-Filho, Carmem Silva Costa Pfeifer, Ana Flavia Sanches Borges, Paulo Afonso Silveira Francisconi

“…KEYWORDS Bond strength; Dental cements; Fiber post; Nanotubes; Radiopacity; Titanium. …”
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Divide-and-conquer strategy with engineered ossification center organoids for rapid bone healing through developmental cell recruitment by Xianzhu Zhang, Wei Jiang, Xinyu Wu, Chang Xie, Yi Zhang, Liying Li, Yuqing Gu, Zihao Hu, Xinrang Zhai, Renjie Liang, Tao Zhang, Wei Sun, Jinchun Ye, Wei Wei, Xiaozhao Wang, Yi Hong, Shufang Zhang, Youzhi Cai, Xiaohui Zou, Yihe Hu, Hongwei Ouyang

“…Particularly noteworthy is the specific expansion of Krt8+ SSCs concomitant with the simultaneous reduction of Has1+ migratory fibroblasts (MFs) post-OCO implantation. Furthermore, cross-species comparisons employing machine learning reveal high resemblance of the relative Krt8+ SSCs/Has1+ MFs composition in bone regeneration with that in public data from developmental bone tissues. …”
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Tuned Generalised <i>k</i>-<i>ω</i> (GEKO) Turbulence Model Parameters for Predicting Transitional Flow Through Stenosis Geometries of Various Degrees by Jake Emmerling, Sara Vahaji, David A. V. Morton, Svetlana Stevanovic, David F. Fletcher, Kiao Inthavong

“…The effect of four GEKO parameters (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>C</mi><mrow><mi>S</mi><mi>E</mi><mi>P</mi></mrow></msub></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>C</mi><mrow><mi>N</mi><mi>W</mi></mrow></msub></semantics></math></inline-formula>, <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>C</mi><mrow><mi>J</mi><mi>E</mi><mi>T</mi></mrow></msub></semantics></math></inline-formula> and <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>C</mi><mrow><mi>M</mi><mi>I</mi><mi>X</mi></mrow></msub></semantics></math></inline-formula>) on flow in the post-stenotic region was investigated by simulating a wide range of parameter values. …”
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Biological use influences the impact of inflammation on risk of major adverse cardiovascular events in rheumatoid arthritis by George Athanasios Karpouzas, Anne Grete Semb, Ellen-Margrethe Hauge, Dionicio Angel Galarza-Delgado, Miguel A González-Gay, Solbritt Rantapää-Dahlqvist, Petros P Sfikakis, Virginia Pascual-Ramos, Irazú Contreras-Yáñez, Carol Hitchon, Durga Prasanna Misra, Iris J Colunga-Pedraza, Alfonso Corrales, George Kitas, Linda Tsang, Hani El-Gabalawy, José Ramón Azpiri-lópez, Sarah R Ormseth, Patrick Dessein, Piet Leonardus Cornelis Maria van Riel

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Associations between nighttime or weekend deliveries and adverse maternal, birth, and neonatal outcomes: secondary analysis of the MANGO study in western Kenya by Maneet K. Virk, Jenine Shafi, Pooja Maheria, Garoma Basha, Harold E. Kooreman, John Humphrey, James G. Carlucci, Audrey Chepkemoi, Caitlin Bernard, Megan S. McHenry, Beverly Musick, Caroline Kerich, Winnie Matelong, Constantin T. Yiannoutsos, Wycliffe Kosgei, Julia Songok, Kara Wools-Kaloustian, Edwin Were, Rena C. Patel

“…No association was found between nighttime/weekend delivery and neonatal death. In post-hoc analyses, weekend deliveries were associated with reduced risk of emergency Caesarean deliveries, preterm birth, and low birth weight. …”
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Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice by Dilpreet Kour, Dilpreet Kour, Parul Khajuria, Parul Khajuria, Kuhu Sharma, Kuhu Sharma, Alpa Sharma, Alpa Sharma, Ankita Sharma, Ankita Sharma, Syed Mudassir Ali, Priya Wazir, P. Ramajayan, P. Ramajayan, Sanghapal D. Sawant, Sanghapal D. Sawant, Sanghapal D. Sawant, Utpal Nandi, Utpal Nandi, Zabeer Ahmed, Zabeer Ahmed, Ajay Kumar, Ajay Kumar

“…Data from all in vitro and in vivo experiments were analyzed by using one-way ANOVA and post-hoc Bonferroni tests.ResultsIn-vitro analyses in astrocytes demonstrated that IBC at 5 and 10 μM concentrations induce AMPK phosphorylation through CAMKK2, promoting autophagy and inhibiting the NLRP3 inflammasome in primary astrocytes. …”
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LRRK2-mutant microglia and neuromelanin synergize to drive dopaminergic neurodegeneration in an iPSC-based Parkinson’s disease model by Lucas Blasco-Agell, Meritxell Pons-Espinal, Veronica Testa, Gerard Roch, Jara Montero-Muñoz, Irene Fernandez-Carasa, Valentina Baruffi, Marta Gonzalez-Sepulveda, Yvonne Richaud-Patin, Senda Jimenez, Thais Cuadros, Joana M. Cladera-Sastre, Joan Compte, Zoe Manglano-Artuñedo, Salvador Ventura, Manel Juan, Eduardo Tolosa, Angel Raya, Miquel Vila, Antonella Consiglio

“…When exposed to NM-containing particles, but not α-synuclein fibrils, LRRK2 hMG trigger DAn degeneration, in a process that is prevented by pre-treatment with the immunomodulatory drug ivermectin. Finally, post-mortem analysis of midbrain tissue of LRRK2-PD patients show increased microglia activation around NM-containing neurons, confirming our in vitro findings. …”
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