Nitroglycerin for treatment of retained placenta: A randomised, placebo-controlled, multicentre, double-blind trial in the UK. by Fiona C Denison, Kathryn F Carruthers, Jemma Hudson, Gladys McPherson, Gin Nie Chua, Mathilde Peace, Jane Brewin, Nina Hallowell, Graham Scotland, Julia Lawton, John Norrie, Jane E Norman, GOT-IT investigator team

“…The primary patient-sided outcomes were satisfaction with treatment and side-effect profile, assessed by questionnaires pre-discharge and 6 weeks post-delivery. Secondary clinical outcomes were measured at 5 and 15 minutes after study drug administration and prior to hospital discharge. …”
Get full text

Nonadherence to Diabetes Complications Screening in a Multiethnic Asian Population: Protocol for a Mixed Methods Prospective Study by Amudha Aravindhan, Eva Fenwick, Aurora Wing Dan Chan, Ryan Eyn Kidd Man, Wern Ee Tang, Ngiap Chuan Tan, Charumathi Sabanayagam, Junxing Chay, Lok Pui Ng, Wei Teen Wong, Wern Fern Soo, Shin Wei Lim, Ecosse L Lamoureux

“…Adherence and clinical data will be recorded at 16 months post enrollment. Additionally, selected participants and health care professionals will undergo qualitative interviews to elicit barriers or facilitators of adherence to rescreening. …”
Get full text

Percutaneous mechanical circulatory support for acute right heart failure: A practical approach by Mario Gramegna, Christophe Vandenbriele, Guido Tavazzi, Mir B. Basir, Caroline Bleakley, Mario Iannaccone, Daniel Kretzschmar, Francesco Maisano, Anna Mara Scandroglio, Benedikt Schrage, P. Christian Schultze, Gregory Serrao, Matthew Tomey, Richard Trimlett, Dirk Westermann, Matteo Montorfano, George Dangas, Susanna Price, Alaide Chieffo

“…Devices such as the Impella RP and dual‐lumen cannulas provide targeted haemodynamic support, with indications in various clinical scenarios, including acute myocardial infarction, post‐cardiac surgery, myocarditis, and after left ventricular assist device (LVAD) implantation. …”
Get full text

A China-Based exploration of surgical timing for polytrauma with a focus on fracture reconstruction by Chenning Ding, Mingwang Jia, Xing Han, Jiahui Zhang, Xin Zhao, Xiguang Sang

“…Given China’s healthcare context, this study will assess injury severity and perform definitive fracture reconstruction at specified post-trauma intervals. Postoperative infection rates, including wound infections, other complication incidences, hospital stay duration, treatment costs, and long-term outcomes will be observed and compared to identify the optimal timing for surgical intervention. …”
Get full text

Estratigrafía y deformación extensional en la región San Miguel de Allende-Querétaro, México by Susana Alicia Alaniz-Álvarez, Ángel Francisco Nieto-Samaniego, María Andrea Reyes-Zaragoza, Ma. Teresa Orozco-Esquivel, Ángel Catarino Ojeda-García, Luis F. Vassallo

“…El patrón de fallamiento generado durante los eventos post-eocénicos fue controlado por los límites de tres fronteras estructurales: la falla del Bajío, que separa la Mesa Central de la depresión homónima conocida como El Bajío; las fallas Ixtla y La Joya, que separan la Mesa Central de la Faja Volcánica Transmexicana (sistema de fallas NE-SW); y el sistema de fallas Taxco-San Miguel de Allende (NNW-SSE) que separa la Mesa Central de la Sierra Madre Oriental. …”
Get full text

Case Report: Successful transplantation of a living donor kidney with five renal arteries procured via laparoscopy and back-table vascular reconstruction using the recipient's inte... by Chenzhen Yu, Chenzhen Yu, Chenzhen Yu, Limin Zhang, Limin Zhang, Limin Zhang, Chunhui Lv, Chunhui Lv, Chunhui Lv, Sheng Chang, Sheng Chang, Sheng Chang, Gang Chen, Gang Chen, Gang Chen, Zhishui Chen, Zhishui Chen, Zhishui Chen, Weijie Zhang, Weijie Zhang, Weijie Zhang, Daqiang Zhao, Daqiang Zhao, Daqiang Zhao

“…Postoperative outcomes were excellent, with immediate graft function, no dialysis requirement, and stable renal function at 60 days post-transplant.ConclusionThis case demonstrates that retroperitoneoscopic LLDN for kidneys with five renal arteries is technically feasible and safe. …”
Get full text

Disproportionality Analysis of the Five Most Widespread Neurological Effects of COVID-19 Vaccines from 2021 to 2023: Insights from EudraVigilance by Arturo Gómez López de las Huertas, Stefan Stewart, Mikel Urroz Elizalde, Javier Guijarro-Eguinoa, Enrique Seco-Meseguer, Elena Diago-Sempere, María Jiménez González, Antonio J. Carcas-Sansuan, Alberto M. Borobia Pérez, Elena Ramírez

“…<b>Background/Objectives:</b> Post-market surveillance of COVID-19 vaccines is vital. …”
Get full text

Shexiang Tongxin Dripping Pills regulates SOD/TNF-α/IL-6 pathway to inhibit inflammation and oxidative stress to improve myocardial ischemia-reperfusion injury in mice by Wanying Du, Wanying Du, Chenguang Zhai, Chenguang Zhai, Huijie Zhang, Huijie Zhang, Jun Ren, Jun Ren, Xiaoyang Chen, Xiaoyang Chen, Xuejing Sun, Xuejing Sun, Chun Li, Chun Li, Wei Wang, Wei Wang, Yijun Chen, Yijun Chen, Yijun Chen

“…Cardiac function assessments showed STDP improved both contractility and diastolic function post-MIRI and reduced arrhythmia incidence.DiscussionSTDP ameliorates MIRI in mice by inhibiting inflammatory responses and oxidative stress, primarily through modulation of the SOD/TNF-α/IL-6 pathway. …”
Get full text

PO24 | Emicizumab prophylaxis and bleeding outcomes: a single center clinical experience

“…During EP, 14/29 (48.3%) pts never experienced a bleeding episode. 11 non-inhibitor pts experienced 19 mild-moderate bleeds: 17 traumatic and 2 spontaneous hematuria (same pt), all managed with rFVIII therapy. 4 PwI experienced a total of 5 mild-moderate bleeds: 4 traumatic (managed with rFVIIa) and 1 small spontaneous hematoma. Comparing pre-vs-post emicizumab ABR and AJBR, we observed a reduction by 63.78% (p=0.0114) and 56.52% (p=0.17) in the non-inhibitor group and a reduction by 96.17% (p=0.0079) and 98.57% (p=0.0476) in PwI. …”
Get full text

Hybrid-J shape needle in ultrasound-guided looped thread carpal tunnel release: a cadaveric study on safety and efficacy by Lin Jiasen, Li Yuxiang, Jiang Liang, Long Yi, Li Honglve, Wang Yongbo, Geng Weikuan, Deng Xinghao, Zhang Congda, Yang Rui, Hou Jingyi

“…Intraoperative structural damage such as nerve, blood vessel and tendon were assessed by blinded observer and anatomist. Post-procedural dissection confirmed transverse carpal ligament (TCL) transection completeness. …”
Get full text

„Ahol a kincsed, ott lesz a szíved is.” A materializmus konstruktumának vizsgálata, valamint a Materiális Értékek Skála magyar adaptációja by Andrea FERENCZI, Szabolcs TAKÁCS, Zsuzsanna KÖVI, Veronika MÉSZÁROS

“…Lastly, their content reflects post-material values that trigger socially desirable processes in the respondent that encourage consent. …”
Get full text

Abstract 107: Endovascular Therapy for Tandem Vertebral and Basilar Artery Occlusion in a Patient with Low NIHSS by Vikalpa Dammavalam, Sayedatun Nessa, Michael Guido, Jingxin Wang, David Fiorella

“…NIHSS remained 1 for ataxia throughout admission, although exam also revealed mild unsteady gait requiring home physical therapy and a walker on discharge. Post‐stroke mRS was 1 on discharge; 3‐month mRS is pending. …”
Get full text

Objective gait analysis using Kinect v2® for the prognosis of walking during the acute phase of rehabilitation after proximal femoral fracture surgery by Kohki Matsubara, Kohki Matsubara, Gen Kuroyanagi, Gen Kuroyanagi, Atsushi Imamura, Atsushi Imamura, Yuichiro Mizuno, Shintaro Tsukada, Ruido Ida, Haruhiko Tokuda, Haruhiko Tokuda, Hideki Murakami, Hideki Okamoto, Yoshino Ueki

“…ObjectiveWhile factors affecting gait post-surgery for proximal femoral fracture (PFF) have been studied, the prognostic value of objective gait analysis during acute postoperative rehabilitation remains unclear. …”
Get full text

Activation of notch signaling pathway is a potential mechanism for mucin2 reduction and intestinal mucosal barrier dysfunction in high-altitude hypoxia by Ruhan Jia, Ying Han, Qinfang Zhu, Jingxuan Zhang, Huan Zhang, Maojia Ka, Yi Ma, Mohammed Gamah, Wei Zhang

“…Elevated serum DAO, D-La, and inflammatory markers indicated severe intestinal damage. DBZ treatment post-DSS and hypoxia significantly reduced these symptoms. …”
Get full text

Abstract 180: A Prospective, Single‐Center Study Appraising Aneurysm Embolization using the Balt Optima™ Coil System (APPLY Study) by Hunter J. King, Nicole Mercado, Siamak Bonabi, Antik Patel, Zeyad Khokhar, Nikil Swamy, Asif Taqi

“…Methods This study was an investigator‐initiated, prospective, real‐world, single‐center, post‐market study conducted in Thousand Oaks, California. …”
Get full text

The “House of Cards” of Political Reality / КАРТОЧНЫЙ ДОМИК ПОЛИТИЧЕСКОЙ РЕАЛЬНОСТИ by CHERNENKO JULIA A. / ЧЕРНЕНКО ЮЛИЯ АЛЕКСАНДРОВНА

“…This kind of approach gives the author the ability to show how the screen realities and storytelling can have impact on current political reality in the era of “mediatization of everything” and “post-truth politics”. The following narrative analysis of female figures in the aforementioned television serials related to politics makes it possible to observe a strong embedment of feminist issues in the American screen culture. …”
Get full text

Implementing heart failure disease management in primary care: a mixed-methods analysis of the IMPACT-B study by Gijs Van Pottelbergh, Bert Vaes, Miek Smeets, Stefan Janssens, Willem Raat, Marie Van de Putte

“…The programme resulted in increased awareness and registration of HF in primary care, increased self-management of patients and improved follow-up after discharge, although these results should be interpreted cautiously given the uncontrolled pre-post study design.Trial registration Trial registration NCT04334447 (clinicaltrials.gov).…”
Get full text

Impact of genetic risk and lifestyles on cardiovascular disease-free and total life expectancy: a cohort study by Dong Sun, Qiufen Sun, Yinqi Ding, Canqing Yu, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Iona Y. Millwood, Robin G. Walters, Huaidong Du, Jun Zhang, Dan Schmidt, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv, the China Kadoorie Biobank Collaborative Group

“…Results Genetic risk was more strongly associated with CVD onset than post-CVD mortality. As a result, the increase in LE without CVD associated with low genetic risk (4.9 years (95% CI 4.3–5.5) for women and 4.4 years (3.6–5.1) for men) was greater than the increase in total LE (2.9 years (1.8–3.8) for women and 2.6 years (1.5–3.5) for men) when compared to high genetic risk. …”
Get full text

Factors Associated with Absolute Neutrophil Count Dynamics and Docetaxel-Adryamicin-Cyclophosphamide (TAC) Chemotherapy Induced Neutropenia During Extended Filgrastim Administratio... by Ami Ashariati, Ugroseno Yudho Bintoro, Merlyna Savitri, Muhammad Noor Diansyah, Putu Niken Ayu Amrita, Pradana Zaky Romadhon, Andi Yasmin Wijaya, Winona May Hendrata, Steven Sheng Looi, Ahmad Amin Mahmudin

“…The entire patients received 5μg/kg/day filgrastim by subcutaneous injection 24 hours post-chemotherapy. ANC was monitored daily and filgrastim administration was stopped when ANC reached >10000/mm3 or 14 days of administration. …”
Get full text

Effectiveness of combining psychological prevention interventions with interventions that address the social determinants of mental health in low- and middle-income countries: a sy... by Crick Lund, Katherine Sorsdahl, Marianna Purgato, Corrado Barbui, Nagendra Luitel, Mark Jordans, Emily Garman, Rakesh Singh, Emiliano Albanese, Eleonora Prina, Beatrice Bano, Daniela Trujillo, Maria Cecilia Dedios Sanguineti

“…Combined interventions were effective in reducing the incidence of depression and post-traumatic stress disorders at postintervention compared with control conditions for adults (risk ratio (RR) 0.82, 95% CI 0.73 to 0.93) and children (RR 0.70, 95% CI 0.49 to 0.99). …”
Get full text