The effect of antimicrobial stewardship interventions upon antimicrobial consumption and appropriateness in Vietnamese district hospitals: a cluster randomised trialResearch in con... by Jaslyn Doshi, Yen Pham Ngoc, Thu Thuy Ma, Linh Thuy Duong, Van Thi Thuy Pham, Van Giap Vu, Rodney James, Qingbin Li, Quy Trinh Van, Tu Son Nguyen, Thi Thu Trang Tran, Pham Minh Thu Vo, Van An Ngo, Huu Phuc Phan, Ngoc Canh Hoang, Justin Beardsley, Thu Anh Nguyen, Greg J. Fox

“…Findings: A total of 877 and 1220 antimicrobial prescriptions were reviewed in intervention hospitals, and 1277 and 1454 prescriptions in control hospitals at baseline and post-intervention. Inappropriate antimicrobial prescribing exceeded 60% in each hospital at baseline. …”
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Efficacy and cost-effectiveness of an ACT and compassion-based intervention for women with breast cancer: study protocol of two randomised controlled trials {1} by Inês A. Trindade, Andreia Soares, David Skvarc, Diogo Carreiras, Joana Pereira, Óscar Lourenço, Filipa Sampaio, Bruno de Sousa, Teresa C. Martins, Paula Boaventura, Joana Marta-Simões, Mind Project Team, Helena Moreira

“…Data will be collected at baseline, post-treatment and 6-month follow-up. The efficacy and cost-effectiveness of the two interventions will be assessed. …”
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Study of the mineralization potential of the intrusives around Valis (Tarom-Iran) by Mojtaba Bahajroy, Saeed Taki

“…According to the Rb/Sr, Zr/Hf, K/Rb ratios, the granite melts that form the aforementioned bodies are not extremely evolved and have not undergone post magmatic activity, which would lead to mineralization. …”
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POSTMODERNISM AS PRESENTIMENT IN THE THEORY OF “AUTHORIAL CINEMA” AND THE FILMS OF THE FRENCH “NEW WAVE” / ПОСТМОДЕРНИЗМ КАК ПРЕДЧУВСТВИЕ В ТЕОРИИ «АВТОРСКОГО КИНО» И ФИЛЬМАХ ФРА... by REIFMAN B.V. / РЕЙФМАН Б.В.

“…Almost simultaneously with an attack on the opposition between elite and mass culture undertaken by the founders of the Birmingham center for cultural studies and the Anglo-American “new left,” and over a decade before various variants of post-structuralism brought out their versions of the “death of the author,” Francois Truffaut, who was the first to have made use of the term “authorial cinema,” and other young cinema critics, who published their articles in the journal “Cahier du cinema,” got into an argument with this journal’s founder and editor-in-chief André Bazin, who defended the modernist, personalist-existentialist point of view about the cinema producer’s artistic activity. …”
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4D-CTA image and geometry dataset for kinematic analysis of abdominal aortic aneurysmsZenodo by Mostafa Jamshidian, Adam Wittek, Saeideh Sekhavat, Farah Alkhatib, Jens Carsten Ritter, Paul M. Parizel, Donatien Le Liepvre, Florian Bernard, Ludovic Minvielle, Antoine Fondanèche, Jane Polce, Christopher Wood, Karol Miller

“…The AAA geometries were extracted using an automated image processing pipeline comprising AI-based segmentation with PRAEVAorta software by NUREA (https://www.nurea-soft.com/), automated post-processing with the ISML-UWA in-house code (https://arxiv.org/abs/2403.07238), and surface model extraction using the freely available BioPARR (Biomechanics-based Prediction of Aneurysm Rupture Risk) (https://bioparr.mech.uwa.edu.au/) and 3D Slicer (https://www.slicer.org/) software packages [2,3]. …”
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An enigma of hypocalcaemia: unveiling the interaction between denosumab and intravenous iron when co-administered by Sabyasachi Roy, Anand Velusamy, Muhammed Russal Latheef

“…Avoiding close co-administration of denosumab and iron (separate by >4 weeks), preferring lower-risk iron (iron sucrose) and monitoring calcium, phosphate and magnesium levels for 4 weeks post-treatment are also recommended. Conclusion: Although no large trials specifically address this drug combination, the accumulating case series underscore a real safety signal.7…”
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Copper Pyrithione Induces Hepatopancreatic Apoptosis and Metabolic Disruption in <i>Litopenaeus vannamei</i>: Integrated Transcriptomic, Metabolomic, and Histopathological Analysis by Jieyu Guo, Yang Yang, Siying Yu, Cairui Jiang, Xianbin Su, Yongfeng Zou, Hui Guo

“…Metabolomic analysis identified numerous significantly different metabolites (SDMs) at both 3 and 48 h post-exposure, with most SDMs associated with energy metabolism, fatty acid metabolism, and related pathways. …”
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Quantitative electroencephalography characteristics in delirium with various etiologies: A multicenter study by Julia van der A, Robert Fleischmann, Annerose Mengel, Lisette Vernooij, Cornelis Stam, Sophie Leroy, Pauline Schneider, Johannes Ehler, Arjen Slooter, Edwin van Dellen

“…Etiology-based delirium subtypes included post-stroke, medical and postoperative delirium diagnosed by staff physicians based on the Diagnostic and Statistical Manual of Mental Disorders-IV or 5 criteria. …”
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Sensitive detection of minimal residual disease and immunotherapy targets by multi-modal bone marrow analysis in high-risk neuroblastoma – a multi-center study by Nina U. Gelineau, Eva Bozsaky, Lieke M. J. van Zogchel, Fikret Rifatbegovic, Daria Lazic, Andrea Ziegler, Ahmad Javadi, Lily Zappeij-Kannegieter, Ulrike Pötschger, Marta Fiocco, Peter F. Ambros, Inge M. Ambros, Bernd Bodenmiller, Ellen C. van der Schoot, Ruth Ladenstein, Marie Bernkopf, Godelieve A. M. Tytgat, Sabine Taschner-Mandl

“…RT-qPCR-MES, despite lower sensitivity, identified 37 additional cases and showed delayed clearance of MES markers post-chemotherapy, with increases prior to relapse. …”
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Difference-making factors for successful implementation of a multicomponent colorectal cancer screening program in rural clinics (SMARTER CRC) by Amanda F. Petrik, Brittany Badicke, Melinda M. Davis, Melinda M. Davis, Melinda M. Davis, Edward J. Miech, Jennifer Coury, Erin S. Kenzie, Erin S. Kenzie, Jennifer L. Schneider, Robert Durr, Anna C. Edelmann, Anders Herreid-O’Neill, Emily Myers, Gloria D. Coronado

“…Factors included in the analysis were collected through qualitative interviews, practice facilitation notes, and project datasets.ResultsA total of 14 intervention clinics were included in our analysis. Post-intervention, overall clinic-level screening rates for CRC ranged from 12.6 to 22.0%, while FIT completion rates among patients who were mailed a kit ranged from 12.3 to 41.7%. …”
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UFMylation of NLRP3 Prevents Its Autophagic Degradation and Facilitates Inflammasome Activation by Jiongjie Jing, Fan Yang, Ke Wang, Mintian Cui, Ni Kong, Shixi Wang, Xiaoyue Qiao, Fanyu Kong, Dongyang Zhao, Jinlu Ji, Lunxian Tang, Jiaxin Gao, Yu‐Sheng Cong, Deqiang Ding, Kun Chen

“…Aberrant activation of NLRP3 inflammasome is closely related to various inflammatory diseases. Post‐translational modifications are critical for NLRP3 inflammasome regulation. …”
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Impact of antihypertensive drug classes on cardiovascular outcomes: insights from the STEP study by Xinyi Peng, Michael Hecht Olsen, Manan Pareek, Jingjing Bai, Yang Liu, Qirui Song, Jun Cai

“…The HRs for ARBs per-unit increase in relative time remained consistently lower than those of CCBs across the primary outcome, MACE, and stroke (all P < 0.05). Conclusions This post hoc analysis suggested that ARBs and CCBs might be more favourable for composite cardiovascular outcomes than diuretics and beta-blockers. …”
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SARS-CoV-2 outbreak in lions, tigers, and hyenas at Denver Zoo by Emily N. Gallichotte, Laura Bashor, Katelyn Erbeck, Lara Croft, Katelyn Stache, Jessica Long, Sue VandeWoude, James C. Johnson, Kristy L. Pabilonia, Gregory D. Ebel

“…Infectious virus was correlated with high levels of vRNA and was more likely to be detected earlier during infection. Four months post-infection, all tested animals generated robust neutralizing antibody titers. …”
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Effect of mild posterior capsule opacification on visual outcomes in trifocal diffractive pseudophakic eyes: A multicenter prospective study by Limei Zhang, Runhan Shi, Xuanzhu Chen, Xuefen Gu, Jiying Shen, Aijun Wang, Shuang Ni, Lei Cai, Haike Guo, Jin Yang

“…However, in patients with PCO grade 1 (mild), post-capsulotomy UNVA, DLI, medium and high spatial frequency CS under photopic condition and VF-14 scores were significantly improved compared with pre-capsulotomy values (all P ​< ​0.05). …”
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Moderate-intensity training has a better effect on growth factors than high-intensity training in rats by Laily Mita Andriana, Adi Pranoto, Greta Ahmad Bukhori, Joseph Kenoly Nugroho, Irmantara Subagio, Nining Widyah Kusnanik, Bayu Agung Pramono, Dany Pramuno Putra, Muhamad Fauzi Antoni, Bekir Erhan Orhan

“…The data were analyzed by using one way-ANOVA and Tukey’s HSD post hoc test with significant levels of 5%. Results: We observed GH levels in CON (4.30 ± 0.29) pg/mL, MIT (4.55 ± 0.17) pg/mL, HIT (4.09 ± 0.28) pg/mL and (p < 0.001). …”
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Venous Sinus Stenting Using a Ledge‐Reducing Catheter, 0.088‐in. Catheter‐Extender With an External Single Point of Control: Technique and Multicenter Clinical Experience by Oded Goren, Fabio Settecase, George Luh, Tareq Kass‐Hout, Rami Morsi, Coleman O. Martin, Ahmad K. Almekkawi, Nicholas A. Telischak, Matthew D. Alexander, Michael G. Abraham, Sivani Lingam, Ramesh Grandhi, M. Shazam Hussain, Tudor G. Jovin, Priyank Khandelwal, Thanh T. Nguyen, Piers Klein, Joey D. English, Mohamad K. Abdalkader

“…Median stenosis decreased from 80% (interquartile range 75–87) to 0% (interquartile range 0–0) post stenting (P<0.001). There were no Monopoint‐related complications. compared with the operators’ typical VSS catheter setup/technique, MS was rated “better” in 93% and “slightly better” in 6%; operators cited ease of crossing the stenosis, improved trackability and support, as well as lack of stent‐catheter length incompatibilities. …”
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H2S-mediated protein S-sulfhydration modulates infectivity and autophagy in the rice blast fungus by Hong Hu, Mengyuan Qin, Jiening Zhang, Jintao Jiang, Zhiqin Su, Lun Guan, Zhiguang Qu, Caiyun Liu, Xuan Cai, Zhiyong Ren, Yuhang Duan, Deyao Zhang, Hao Liu, Lu Zheng, Junbin Huang, Xiao-Lin Chen

“…Abstract Hydrogen sulfide (H2S) regulates cellular activities in plants and mammals through S-sulfhydration, a post-translational modification of proteins. The role of H2S and its molecular targets in fungi, however, remains unclear. …”
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Comparison of the proteomic landscape in experimental ischemia reperfusion with versus without ischemic preconditioning by Yalda Kakaei, Shafaat Hussain, Ahmed Elmahdy, Evelin Berger, Aaron Shekka Espinosa, Valentyna Sevastianova, Zahra Sheybani, Amin Al-Awar, Mana Kalani, Sandeep Jha, Ermir Zulfaj, Amirali Nejat, Abhishek Jha, Tetiana Pylova, Maryna Krasnikova, Erik Axel Andersson, Vagner Ramon Rodrigues Silva, Elmir Omerovic, Björn Redfors

“…Myocardial samples were collected at early (T1) and 4-hour post-reperfusion (T2) time points for proteomic analysis. …”
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Exploring the psychological landscape of thyroid nodules: resilience, anxiety, and ultrasound correlations by Jing Wang, Lixia Wang, Daidi Zhang, Daidi Zhang, Guoqing Chen, Guoqing Chen, Qinfang Zhang, Qinfang Zhang, Haiyan Chen, Jiamao Cheng

“…Psychological assessments employed the Hamilton Anxiety Rating Scale (HAMA) and Connor-Davidson Resilience Scale (CD-RISC) within 48 h post-examination. Advanced statistical analyses included: (1) Multivariate regression modeling accounting for demographic confounders. (2) Spearman/Kendall correlation matrices. (3) Ordinal logistic regression for malignancy risk stratification.ResultsPsychological assessments revealed that TN+ patients exhibited elevated resilience (CD-RISC total: 64.04 ± 14.166 vs. 60.61 ± 15.074; p = 0.025) but paradoxically higher anxiety levels (HAMA total: 32.51 ± 8.516 vs. 30.67 ± 8.667; p = 0.005), demonstrating a negative correlation between resilience and anxiety severity (r = −0.259, p &lt; 0.001). …”
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Development and validation of a prognostic model to predict relapse in adults with remitted depression in primary care: secondary analysis of pooled individual participant data fro... by Simon Gilbody, Dean McMillan, Bob Phillips, Kym I E Snell, Richard D Riley, David A Richards, Jaime Delgadillo, Shehzad Ali, Chris Salisbury, Lewis W Paton, Lucinda Archer, Peter A Coventry, Stephen Pilling, Andrew S Moriarty, Joshua E J Buckman, Nick Meader, Carolyn A Chew Graham

“…Relationship status warrants further research to explore its role as a prognostic factor for relapse.Clinical implications Until we can accurately stratify patients according to risk of relapse, a universal approach to relapse prevention may be most beneficial, either during acute-phase treatment or post remission. Where possible, this could be guided by the presence or absence of known prognostic factors (eg, residual depressive symptoms) and targeted towards these.Trial registration number NCT04666662.…”
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