Primary aldosteronism diagnosis in the intensive care unit: resistant alkalosis and hypokalemia during severe sepsis with hyperlactatemia: a case report by Yug Garg, Madhumati S. Vaishnav, Reshma Harsha, Nidhi Garg, Siddhartha Dinesha, Leena Lekkala, Thummala Kamala, Kavitha Muniraj, Sathyanarayana Srikanta, Samatvam Endocrinology Diabetes Collaborative Group

“…Patient improved with supportive care and was discharged on day 10 with reinstituted antihypertensive medications. Post-hospitalization, endocrine evaluation confirmed primary aldosteronism with plasma renin activity 0.62 ng/mL/hour, serum aldosterone 43.2 ng/dL (1.20 nmol/L), and aldosterone–renin ratio 69.7. …”
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Listening effort and stress in tinnitus: a multidimensional approach by Giovanna Giliberto, Maria Itati Palacio, Giulia Cartocci, Emiliano Fernandez-Villalba, Dario Rossi, Nieves Minguez, Maria Botia, Maria Botia, Jose Domingo Cubillana, Jose Joaquin Ceron, Jose Joaquin Ceron, Fabio Babiloni, Maria Trinidad Herrero

“…Salivary amylase increased post-task (p = 0.016), electrodermal activity differed between the initial and final quiet phases (p < 0.001), and heart rate varied according to noise levels (p = 0.008). …”
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Measurement of Intratumor Heterogeneity and Its Changing Pattern to Predict Response and Recurrence Risk After Neoadjuvant Chemotherapy in Breast Cancer by Mingxi Zhu, Qiong Wu, Xiaochuan Geng, Huaying Xie, Yan Wang, Ziping Wu, Yanping Lin, Liheng Zhou, Shuguang Xu, Yumei Ye, Wenjin Yin, Jia Hua, Jingsong Lu, Yaohui Wang

“…Patients with increased heterogeneity exhibited a higher risk of recurrence approaching two years post-surgery, particularly within the non-pCR population. …”
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Determination of the optimal ejaculate concentration of a buffalo bull for successful semen cryopreservation by Krishna Bansal, Krishna Bansal, Dinesh Jhamb, Usha Yadav, Usha Yadav, Mamta Meel, Mamta Meel, Akanksha Gupta, Akanksha Gupta, Renu Bala, Meenakshi Virmani, Meeti Punetha, Dharmendra Kumar, Pradeep Kumar

“…The second objective was to evaluate the post-thaw sperm quality of ejaculates that initially met the criteria for cryopreservation. …”
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Inhibition of Mitochondrial Dynamics by Mitochondrial Division Inhibitor-1 Suppresses Cell Migration and Metastatic Markers in Colorectal Cancer HCT116 Cells by Mehmood T, Nasir Q, Younis I, Muanprasat C

“…Moreover, Mdivi.1 decreased dynamin-related protein-1 (Drp1) and phosphorylated-Drp1 expression and increased mitofusin-2 (Mfn2) expression in a concentration-dependent manner at 48 and 72 h post-treatment. Notably, Mdivi.1 induced inhibition of translocation of Drp1 from the cytosol to the outer mitochondrial membrane. …”
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MicroRNA-15a-5p mediates abdominal aortic aneurysm progression and serves as a potential diagnostic and prognostic circulating biomarker by Greg Winski, Ekaterina Chernogubova, Albert Busch, Suzanne M. Eken, Hong Jin, Moritz Lindquist Liljeqvist, Tooba Khan, Alexandra Bäcklund, Valentina Paloschi, Joy Roy, Rebecka Hultgren, Christine Brostjan, Gert J. de Borst, Joost P. G. Sluijter, Nadja Sachs, Hans-Henning Eckstein, Reinier A. Boon, Joshua M. Spin, Philip S. Tsao, Folkert W. Asselbergs, Lars Maegdefessel

“…Abstract Background MicroRNAs are post transcriptional modulators of gene expression. …”
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Supplementation of live yeast (Saccharomyces cerevisiae) as natural feed additives on growth performance, meat quality and physiological status of broiler chickens by Maruf Hossain, Amio Kante Das, Kanan Talukder, Md Momotaj Hossen, Kanon Das, Chondhon Bormon, Mansur Ahmed, Mohammad Al Mamun, Mohammad Abujar Shuva, Mahmoud Azzam, Shad Mahfuz

“…At 42 days of age, the broilers fed diets containing live yeast had a lower 7-day drip loss, a lower cooking loss, and a higher breast muscle pH at 45 min post-mortem (P < 0.05) than the control group. Supplementing with live yeast also decreased serum triglycerides, total cholesterol, and heterophil/lymphocyte ratio (P < 0.05). …”
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Efficacy of sacubitril/valsartan on improving clinical symptoms in patients with acute myocardial infarction complicated with heart failure: a retrospective study by Guiping Wang, Ruolin Zhang, Xuyang Li, Shuping Zuo, Boheng Zhang, Yanan Zhao, Suya Sun, Juanjuan Zhang, Xiaokun Liu

“…Follow-up assessments were conducted 1 year post-discharge to evaluate NT-proBNP levels, and symptom progression. …”
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The Risk of Developing Tinnitus and Air Pollution Exposure by Po-Yu Lai, Chang-Yin Lee, Kuang-Hsi Chang, Yu-Kang Chang, Yi-Chao Hsu, Ing-Ming Chiu, Stella Chin-Shaw Tsai, Der-Yang Cho, Cheng-Li Lin, Tsung-Hsing Lin, Wu-Lung Chuang

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Evaluation of the efficiency and safety of combined therapy with a symptomatic sustained-release drug and hyaluronic acid versus monotherapy with hyaluronic acid in patients with... by K. A. Berdyugin, I. V. Kadyntsev, O. V. Berdyugina, E. A. Taskina, N. G. Kashevarova

“…Searching for new treatment methods and regimens for OA is relevant.Objective: to evaluate the efficiency and safety of therapy with a symptomatic sustained-release drug (Alflutop) in combination with intra-articular hyaluronic acid (HA) injection versus monotherapy with HA in patients with knee OA in routine clinical practice.Patients and methods. A post-registration open-labeled prospective comparative randomized study was conducted to assess the results of treatment in 76 patients (31 men and 45 women; mean age, 49.3±8.5 years; body mass index, 28.4±0.8 kg/m2 ) in two clinical centers in Yekaterinburg and Perm. …”
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Protein lactylation of citrate synthase promotes the AKI-CKD transition by activating the NLRP3 inflammasome by Fang Yu, Yan Meng, Xiaoyue Wang, Jia Chen, Junling He, Xiangling Yi, Yani He, Kehong Chen

“…Notably, the rate-limiting enzyme citrate synthase (CS) exhibits significantly elevated lactylation levels post-AKI induction, and K370 was the most significant lysine residue. …”
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Trichinella spiralis adult excretory-secretory antigen promotes peripheral regulatory T cell differentiation and attenuates experimental colitis via TGF-β-like mechanisms by Xi-Meng Sun, Ze-Ni Luo, Wei Wang, Chun-Yue Hao, Zhi-Ang Li, Saeed El-Ashram, Xin-Ping Zhu

“…Foxp3eGFP mice subsequently received intraperitoneal injections of TsAES (20 µg/mouse) biweekly for a total of three doses. On day 8 post-model induction, mice were euthanized and colonic tissues collected for immunofluorescence and flow cytometric analysis to assess pTreg populations. …”
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Diagnosis and treatment of synthetic mid-urethral sling complications by Helen E. O’Connell, Christopher K. Harding, Gaurav Khatri, Phyllis Glanc, Eric Bautrant, Sarah Love-Jones, Karen Ward, Henry H. Yao, Ventia Hoe, Charlotte Korte, Nicolle Germano, Sanjeevan Kalavampara, Sherif Mourad, Hashim Hashim

“…Complications arise in a small proportion, occurring acutely in the perioperative stage, post-operatively and in a delayed fashion many years after implantation. …”
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Associations of neurodegenerative and cerebrovascular neuropathology with frailty in a diverse sample by Felipe Bozi-Soares, Márlon Juliano Romero Aliberti, Alberto Fernando Oliveira Justo, Renata E. P. Leite, Lea T. Grinberg, Vitor R. Paes, Roberta D. Rodriguez, Carlos A. Pasqualucci, Eduardo Ferrioli, Claudia Kimie Suemoto

“…Frailty was measured using a frailty index from 33 health deficits, and cognitive impairment was defined as a Clinical Dementia Rating ≥ 0.5, both based on post-mortem informant reports with the next of kin. …”
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Comparing the efficacy of hyaluronic acid products with various molecular weights as mono and combined with chondroitin sulfate regimens in treatment of patients with stage I–III k... by V. E. Bialik, M. A. Makarov, E. I. Bialik, S. A. Makarov, V. A. Nesterenko, M. R. Nurmukhametov

“…IA HA injections were performed 160 patients with primary and post-traumatic knee OA of the I–III stages at the department of traumatology-orthopedics, V.A. …”
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The Vertebral Bone Marrow clot as cell therapy and multifunctional bioscaffold for spinal fusion surgery: protocol for a randomized clinical trial by Maria Sartori, Giuseppe Tedesco, Paolo Spinnato, Antonio Mazzotti, Antonio Mazzotti, Alessandro Gasbarrini, Alessandro Gasbarrini, Cesare Faldini, Cesare Faldini, Marco Miceli, Gianluca Giavaresi, Francesca Salamanna

“…Complications are also recorded and classified as early (major and minor) or late, according to the time of occurrence and findings at 12 months post-surgery. Finally, the preclinical project outcome is to define the biological and anti-inflammatory properties of vBMA clot and demonstrate its antibacterial effect, assessing age and gender differences and including an examination of their interactions.Clinical trial registrationClinicalTrials.gov, identifier NCT05947175.…”
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Perceptions and satisfaction with the quality of clinical training placements among nursing and midwifery students in Northern Ghana by Abubakari Wuni, Mudasir Mohammed Ibrahim, Maximous Diebieri, Brenda Abena Nyarko, Mohammed Awal Salifu, Hussein Abubakar Abdul-Karim, Godfred Prince Kwaku Atiku, Tina Wepeamo Wepeba, Waliu Jawula Salisu, Sufyan Bakuri Suara, Iddrisu Sisala Mohammed

“…Hypothetical relationships between students’ perceptions of clinical training quality, satisfaction, and demographics were tested using One-way ANOVA, t-tests, and Pearson correlation. Tukey LSD post hoc analysis assessed pairwise differences, and statistical significance was pegged at P < 0.05. …”
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Proportion and factors associated with fertility desires among human immunodeficiency virus-positive adults receiving antiretroviral therapy in Northeast Ethiopia by Abel Endawkie, Biresaw Derese, Kidist Adamu, Getaw Walle

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Are treatment plans optimized on the basis of acuros XB dose calculation robust against anatomic changes during online adaptive radiotherapy for lung cancer regarding dose homogene... by Khouya Aymane, Santiago Alina, Ringbaek Toke, Guberina Nika, Guberina Maja, Gauler Thomas, Lübcke Wolfgang, Zylka Waldemar, Pöttgen Christoph, Stuschke Martin

“…The adaptive plans were verified on a subsequent post-adaptation CBCT (CBCT2) of the same dose fraction. …”
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Self-help plus and problem management plus – a qualitative study to assess acceptability and feasibility with rape and GBV survivors in South Africa by Samantha Willan, Zamakhoza Khoza, Sinqobile Mngadi, Jani Nothling, Thobeka Majola, Mpumelelo Mabhida, Tholsie Gounden, Mbalenhle Shabalala, Amanda Zembe, Gugu Gigaba, Rachel Jewkes, Naeemah Abrahams

“…We implemented both interventions as a stepped intervention, involving 10, 2–3-hour group sessions, and undertook interviews at baseline, 3- and 6-months post baseline. Similar to what was found in other studies both SH+ and PM+ appear to be feasible and acceptable. …”
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