Geology, mineralization and model of the giant Maoping carbonate-hosted Pb-Zn deposit (5 Mt), South China by Ye He, Bang-Tao Sun, Hai-Peng Wang, Jia-Xi Zhou, Yan-Jun Li, Foteini Drakou, Kai Luo, Saleh Ibrahim Bute

“…Three mineralization stages of carbonate minerals have been identified: (1) pre-sulfide stage 1, (2) syn-sulfide stage 2, and (3) post-sulfide stage 3. Trace elements and C-O-Sr isotopes of three stages’ carbonate minerals, together with S-Pb isotopes of sulfides, revealing that the metamorphic basement rocks played the role of the metal source during the early stage of Pb-Zn mineralization, whereas the metal contribution of the sedimentary wall rocks found to be more prominent during the late stage of Pb-Zn mineralization. …”
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Abstract 090: Delayed Cerebral Vasculopathy as a Complication of Pneumococcal Meningitis by Zaid R. Najdawi, Mohammad Aladawi, Mohamed Elfil, Pashayar Lookian, Steven Phillips

“…The release of bacterial wall components, cell surface proteins, free radicals, and pro‐inflammatory cytokines including IL‐1, TNF, IL‐6, IL‐8, and macrophage inflammatory protein might lead to para‐infectious vasculitis disrupting the blood‐brain barrier, which might cause vessel wall weakening and cerebral microhemorrhages. Post‐infectious vasculitis triggered by a delayed autoimmune response with the production of autoantibodies is another proposed mechanism. …”
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Differential involvement of neurotransmitter pathways in AD, bvFTD and MCI: Whole-brain MRI analysis by Ricardo Félix Morais, José Maria Sousa, Cemal Koba, Leon Andres, Tiago Jesus, Inês Baldeiras, Tiago Gil Oliveira, Isabel Santana

“…Group differences were assessed with Kruskal-Wallis tests followed by post-hoc analyses. Results: Volumetric analysis showed expected atrophy patterns in each group. …”
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Residual/recurrent lesions after cold-knife conization for high-grade cervical intraepithelial neoplasia: risk factor analysis and clinical management recommendations by Chenchun Wu, Peng Guo, Peng Guo, Pengchong Huang, Lili Guo, Lili Xiong

“…ObjectiveThis study aims to evaluate the risk factors of residual/recurrent lesions of cervical intraepithelial neoplasia 2/3 (CIN2/3) in patients who underwent cold-knife conization (CKC).MethodsA total of 976 patients with CIN2/3 who were treated with CKC were retrospectively analyzed. Post-CKC follow-up involved a thin-prep cytology test (TCT) and human papillomavirus (HPV) tests. …”
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Prevalence of chronic obstructive pulmonary disease in high-risk populations at low, intermediate, high altitudes: a population based cross-sectional study in Yunnan Province, Chin... by Geyi Wen, Jinliang Meng, Huadan Wang, Puxian Peng, Yanyan Xu, Ruiqi Wang, Zhengmao Yan, Bangyan Du, Aihan Wen, Guohong Luo, Wenlong Cui, Songyuan Tang, Yunhui Zhang

“…COPD was diagnosed based on post-bronchodilator test results. We utilized multivariate logistic regression models to examine the association between altitudes and COPD prevalence while controlling for demographic variables, lifestyle factors, and disease characteristics. …”
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Unraveling the role of HDAC3 as an immunotherapy prognostic biomarker and therapeutic target in advanced non-small cell lung cancer by Liyuan Dai, Liling Huang, Lin Li, Le Tang, Yuankai Shi, Xiaohong Han

“…Results We identified 127 differential AAbs, with five key AAbs (HDAC3, METTL21C, HSPB3, SPACA7, and SPPL2B) consistently linked to prognosis pre- and post-treatment (p < 0.05). A risk score model based on these AAbs effectively predicted progression-free survival. …”
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Estradiol Downregulates MicroRNA-193a to Mediate Its Angiogenic Actions by Lisa Rigassi, Mirel Adrian Popa, Ruth Stiller, Brigitte Leeners, Marinella Rosselli, Raghvendra Krishna Dubey

“…Moreover, these actions occur post-transcriptionally, as the expression of pri-miR-193a-3p was not affected. …”
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Unveiling Bifurcated Blue Straggler Sequences in NGC 2173: Insights from Binary Evolution by Li Wang, Dengkai Jiang, Chengyuan Li, Licai Deng, Antonino P. Milone, Long Wang

“…In contrast, the blue sequence BS binaries are formed through nonconservative post-MT processes, all involving white dwarf (WD) companions. …”
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Pain localization and response to botulinum toxin in cervical dystonia by Alexander S. Wang, Alexander S. Wang, Hanieh Agharazi, Hanieh Agharazi, Aetan Parmar, Camilla W. Kilbane, Camilla W. Kilbane, Lauren Cameron, Lauren Cameron, Aasef G. Shaikh, Aasef G. Shaikh, Aasef G. Shaikh, Steven A. Gunzler, Steven A. Gunzler

“…The locations of pain remained relatively stable in the post-treatment state.ConclusionWe confirmed that botulinum toxin is effective for treatment of pain related to CD. …”
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Outcome Following Chest Tube Removal with Respect to Phase of Respiration in Chest Trauma Patients: A Randomised Controlled Trial by Ritesh Kumar, Sandeep Chauhan, Mahavir Singh, Mohammed Faiz, Deepak, Gaurav Sharma, Manish Kumar Yadav, Sanjay Marwah

“…Materials and Methods: The present study was a randomised controlled trial conducted at the Department of Surgery, Pt. BD Sharma Post Graduate Institute of Medical Sciences, Rohtak, India, between 1st August 2020 and 31st July 2022. …”
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Changes in rapid HIV treatment initiation after national "treat all" policy adoption in 6 sub-Saharan African countries: Regression discontinuity analysis. by Olga Tymejczyk, Ellen Brazier, Constantin T Yiannoutsos, Michael Vinikoor, Monique van Lettow, Fred Nalugoda, Mark Urassa, Jean d'Amour Sinayobye, Peter F Rebeiro, Kara Wools-Kaloustian, Mary-Ann Davies, Elizabeth Zaniewski, Nanina Anderegg, Grace Liu, Nathan Ford, Denis Nash, IeDEA consortium

“…The rate of rapid ART initiation accelerated sharply following treat all policy adoption in Malawi, Uganda, and Zambia; slowed in Kenya; and did not change in Rwanda and Burundi. In post hoc analyses restricted to patients enrolling under treat all, young adults (16-24 years) and men were at increased risk of not rapidly initiating ART (compared to older patients and women, respectively). …”
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Altered brain structure age gap estimation in major depressive disorder patients with and without anhedonia: a machine learning-based study by Qingli Mu, Kejing Zhang, Yue Chen, Yuwei Xu, Shaohua Hu, Manli Huang, Peng Zhang, Dong Cui, Shaojia Lu

“…ANCOVAs revealed significant BSAGE differences among three groups in the bilateral putamen (PU), left cerebellar white matter (CB), left cuneus (CUN), left fusiform gyrus (FuG), left subcallosal area (SCA), left superior occipital gyrus (SOG), left triangular inferior frontal gyrus (IFG-Tri), right lateral ventricle (L-V), right superior frontal gyrus medial segment (SFG-SM), right opercular inferior frontal gyrus (IFG-Oper), right precuneus (pre-CUN), right posterior insula (INS-Post), and right superior temporal gyrus (STG). Compared to HCs, the MDD-WA group showed significant BSAGE increase in all of the aforementioned brain regions, while the MDD-WoA group showed limited BSAGE increase in the CB, FuG, and SCA of left hemisphere only. …”
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Development of BK polyomavirus-associated nephropathy risk prediction in kidney transplant recipients by Junji Yamauchi, Katalin Fornadi, Divya Raghavan, Duha Jweehan, Suayp Oygen, Silviana Marineci, Michelle Buff, Michael Fenlon, Motaz Selim, Michael Zimmerman, Miklos Z. Molnar

“…Background With the development of potential prevention therapies for BK polyomavirus (BKPyV)-associated nephropathy (BKPyVAN), risk prediction models are needed to identify kidney transplant recipients at high risk for BKPyVAN.Methods This single-center retrospective study aimed to develop a risk prediction model and an integer-based risk score for BKPyVAN development, defined as plasma BKPyV-DNA >10,000 copies/mL and/or biopsy-proven BKPyVAN, within 1-year post-transplant, using donor and recipient characteristics at the time of transplantation. …”
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Effects of electron beam irradiation on microbial loads, physicochemical properties, stability of active ingredients, and antioxidant activity in Angelica sinensis Radix by Yunxia Hu, Haijun Wang, Zhijun Xin, Wensheng Gou, Zhuanzi Wang, Xiao Liu, Xihong Lu, Aimei Yang, Xuehu Li, Libin Zhou

“…Antioxidant activity remained elevated post-irradiation, correlating with the enrichment trends of volatile oil and phenolic acids. …”
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The differential expression of MAGI2 in glomerulopathies and its application as a molecular discriminator of podocytopathies by Florian Siegerist, Eleonora Hay, Elke Hammer, Anna Iervolino, Claudia Weber, Juan Saydou Dikou, Eleni Stamellou, Linus Butt, Thomas Benzing, Thorsten Wiech, Paul T. Brinkötter, Uwe Zimmerman, Giovambattista Capasso, Christos Chatziantoniou, Christos E. Chadjichristos, Tobias B. Huber, Uwe Völker, Maximilian Schindler, Nicole Endlich

“…This downregulation was also conserved in a zebrafish model of focal and segmental glomerulosclerosis (FSGS), and the podocyte-specific MAGI2 ortholog Magi2a was reduced post podocyte injury. CRISPR/Cas9-generated zebrafish mutants for magi2a exhibited marked glomerular filtration barrier defects and downregulation of nephrin, underscoring MAGI2's critical role in podocyte function. …”
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Evaluating treatment options for symptomatic uterine fibroids: a systematic review and meta-analysis of effectiveness, recovery, and long-term outcomes (MARIE WP1) by Elena Bedggood, Sun Jie, Snehal Ghosh, Vindya Pathiraja, Tharanga Mudalige, Nirmala Rathnayake, Heitor Cavalini, Om Kurmi, George Uchenna Eleje, Peter Phiri, Peter Phiri, Paula Briggs, Jian Qing Shi, Jian Qing Shi, Gayathri Delanerolle, Gayathri Delanerolle, Gayathri Delanerolle, Sohier Elneil

“…Three studies (n = 520) assessed HRQoL via UFS-QoL pre- and post-uterine artery embolisation and myomectomy. …”
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Uso do retalho miogorduroso segmentar do músculo latíssimo do dorso em decúbito único para reconstrução da mama pós-quadrantectomia externa Use of latissimus dorsi muscle segment w... by João Batista Fortaleza de Araújo, Luiz Gonzaga Porto Pinheiro, Sérgio Saboya Pinheiro de Sousa, João Ivo Xavier Rocha, Patrícia Lopes Gaspar, Leila Yasmim Maria Cidrão Fortaleza

“…In the case of external quadrant tumors, there is no option of rotation of the entire latissimus dorsi muscle, which usually exceeds the actions necessary for repairing lost volume. A new option for post-quadrantectomy reconstruction in external quadrants is proposed in this study. …”
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Sequential 90Y Selective Internal Radiation Therapy (SIRT) and Stereotactic Body Radiation Therapy (SBRT) using 90Y PET-based Absorbed Dose Maps: Interim Analysis of a Phase 1 Stud... by Daniel F. Polan, PhD, Justin K. Mikell, PhD, Kellen Fitzpatrick, MS, Joseph J. Gemmete, MD, Jared A. Christensen, MD, Hassan Anbari, MD, Molly Roseland, MD, Joseph R. Evans, MD, PhD, Daniel T. Chang, MD, Mamadou Sanogo, MD, Baljendra S. Kapoor, MD, Matthew J. Schipper, PhD, Yue Cao, PhD, Madhava P. Aryal, Theodore S. Lawrence, MD, PhD, Kyle C. Cuneo, MD, Yuni K. Dewaraja, PhD

“…Methods and Materials: In this ongoing, single-center prospective trial, patients received standard-of-care 90Y SIRT with glass microspheres for the treatment of unresectable primary or secondary liver cancer. Post-SIRT dosimetry was performed using 90Y positron emission tomography/computed tomography to calculate mean lesion absorbed doses. …”
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Analysis of the results of treatment of patients with malignant tumors of the salivary glands by V. T. Vayradyan, A. M. Mudunov, V. D. Ermilova, R. I. Azizyan, I. A. Zaderenko, S. B. Aliyeva, E. L. Dronova

“…In case of other MSGN localizations, prophylactic lymphadenectomy does not improve long-term outcomes. Radiotherapy in the post-op period significantly improves long-term results of treatment in comparison with a group of preoperative radiotherapy (local recurrence rates are 29.5 and 9.7 %, respectively, p = 0.0002). …”
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Supported implementation of tailored multicomponent fall prevention interventions in hospital: a feasibility study by Bethan Richards, Vasi Naganathan, Catherine Sherrington, Leanne Hassett, Matthew Jennings, Andrew Hallahan, Abby Haynes, Charlotte McLennan, Wendy Tilden, Tamsin McVeigh, Veethika Nayak

“…Reach: 28/38 (74%) survey respondents were aware of the multicomponent fall prevention interventions on their ward, with 24 (86%) reporting a positive impact on clinical practice post implementation. Adoption: delivery of multicomponent hospital fall prevention interventions increased 1.1/10 points between preimplementation (n=61) postimplementation (n=38) surveys. …”
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