Acute severe hypertension in the emergency and acute medicine departments: developing a same-day emergency care (SDEC) hypertension pathway by James Steckelmacher, Barbara Onen, Abubaker Eltayeb, Dawud Masieh, Carmen Maniero, Gillian Fox, Dakshitha Hettiaratchi, Ajay Gupta

“…A comparative sample of ED patients pre-pathway, who would have met criteria for referral to the SDEC hypertension pathway, showed there was an approximately two times greater reduction in BP compared with standard care (discharge from ED directly back to GP) on remote follow-up of BP in the community (Figs 1 and 2); within a 6-month period from initial ED attendance, there were almost three times fewer ED re-attendances in the post- compared with the pre-SDEC cohort, with fewer converting to an acute admission (Fig 2). …”
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Salbutamol Nebulisation in Normal Saline versus Salbutamol Nebulisation in Hypertonic Saline (3%) in Children with Acute Asthma Exacerbation: An Open-labelled Randomised Controlled... by Mohanlal Kundu, Kapil Bhalla, Dinkar Yadav, Hunny Verma, Neeraj Kumar, Mukesh Saini, Mohit Yadav, Neha Yadav

“…Materials and Methods: This open-labelled randomised controlled trial was conducted in the Department of Paediatrics at Pandit BD Sharma Post Graduate Institute of Medical Science, Rohtak, Haryana, India. …”
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Genetic parameters and genomic prediction of egg production traits in ducks by Chengming Han, Linxi Zhu, Mengdie Wang, Jian Hu, Qinglei Yang, Zhenlin Liu, Zhengkui Zhou, Cong Li, Shuisheng Hou, Wentao Cai

“…Heritability during the early, peak, and post stages of cumulative egg production was 0.32, 0.15, and 0.24. …”
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The role of proactive therapeutic drug monitoring in guiding infliximab therapeutic optimization in pediatric patients with Crohn's disease: A retrospective study by Junya Song, Huihui Zhang, Huihua Zhang, Ximing Xu, Xiaohua Liang, Yongfang Liu, Xiaomei Song, Hong Guo, Xue Zhan, Jinlin Song, Xiaoqin Zhou

“…Shortening the treatment interval increased the infliximab TC (pre vs. post = 1.69 ± 0.8 vs. 12.03 ± 6.64, p = 0.001, n = 12) after 93.9 ± 37.47 days, decreased the pediatric Crohn's disease activity index and simplified endoscopic score for Crohn's disease, and increased the biochemical remission, clinical remission, endoscopic remission, and endoscopic response rates; however, there was no statistical significance. …”
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Systemic immunomodulation by irreversible electroporation versus stereotactic ablative body radiotherapy in locally advanced pancreatic cancer: the CROSSFIRE trial by Danielle Vos, Anita Stam, Tanja de Gruijl, Petrousjka van den Tol, Sinead Lougheed, Joyce Bakker, Bart Geboers, Florentine Timmer, Hester Scheffer, Alette Ruarus, Laurien Vroomen, Evelien Schouten, Robbert Puijk, Frank Lagerwaard, Jan de Vries, Anna Bruynzeel, Martijn Meijerink

“…We aimed to compare systemic immune responses between the treatments.Methods As part of the randomized phase II CROSSFIRE trial (NCT02791503), comparing the oncological efficacy of IRE to SABR in patients with LAPC, pre- and post-treatment (2 weeks and 3 months) peripheral blood samples were collected. …”
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Comparative Randomized Study of Tolerability, Reactogenicity, Immunogenicity and Safety of the Vaccine «BiVac Polio» (Oral Poliovirus Vaccine Type 1,3) by Yu. H. Khapchaev, O. E. Ivanova, M. F. Vorovitch, V. V. Romanenko, A. E. Makarov, S. G. Drozdov, A. A. Ishmukhametov

“…To enhance immunity to poliovirus types 1 and 3, to reduce the risk associated with the continued use of tOPV (forming of vaccine-derived polioviruses and the emergence of cases of post-vaccination complications), the WHO proposed its replacement with bivalent oral poliovirus vaccine (bOPV) in programs of mass immunization. …”
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Toward Large‐Scale Photonic Chips Using Low‐Anisotropy Thin‐Film Lithium‐Tantalate by Fei Huang, Xiaowan Shen, Siyuan Wang, Haochen Xu, Hongxuan Liu, Zexu Wang, He Gao, Xinmin Yao, Hengzhen Cao, Bin Chen, Xijie Wang, Jizhi Zhang, Zhile Wu, Mingyu Zhu, Hongzhi Xiong, Weike Zhao, Huan Li, Zejie Yu, Liu Liu, Yaocheng Shi, Daoxin Dai

“…Abstract Photonic manipulation of large‐capacity data with the advantages of high speed and low power consumption is a promising solution for explosive growth demands in the era of post‐Moore. A well‐developed lithium‐niobate‐on‐insulator (LNOI) platform has been widely explored for high‐performance electro‐optic (EO) modulators to bridge electrical and optical signals. …”
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Postoperative complications following salvage neck dissection after (chemo)radiotherapy for head and neck squamous cell carcinoma: which patients are at high risk? by Arash Navran, Zeno A. R. Gouw, Willem M. Klop, Willem H. Schreuder, Maarten L. Donswijk, Emilia Owers, Jan Paul de Boer, Laura Smit, Luc Karssemakers, Michiel van den Brekel, Abrahim Al-Mamgani

“…However, the available literature could not identify potential groups at higher risk of post-operative complications because of the missing demographic information and the heterogeneity in studies and outcome data. …”
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High rate of persistent HPV detection after diagnostic cervical excision in older screen‐positive women by Line Winther Gustafson, Louise Krog, Bayan Sardini, Mette Tranberg, Lone Kjeld Petersen, Berit Andersen, Pinar Bor, Anne Hammer

“…However, little is known on treatment efficacy and post‐treatment surveillance for older women. We aimed to investigate the proportion of women testing negative for human papillomavirus (HPV) following a diagnostic cervical excision due to an abnormal screening test. …”
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Sex‐specific disparities in COVID‐19 outcomes by Zubaid Rafique, Valerie Durkalski‐Mauldin, William F. Peacock, Kabir Yadav, Joshua C. Reynolds, Clifton W. Callaway

“…Blood samples were collected on day 0 (pre‐/post‐infusion), 15, and 30 to measure Ab levels with the Broad Institute using the Plaque Reduction Neutralization Test assay. …”
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Inflammation and platelet hyperresponsiveness in coronary artery disease and the influence of Talin-1/αIIbβ3-mediated bidirectional signaling pathway by Shengnan Shi, Jiaming Gao, Yehao Zhang, Min Zhan, Zhanfei Tan, Peili Wang, Jianhua Fu, Jianxun Liu

“…Through systematic bioinformatics analysis of differential gene expression patterns and pathway activation in CHD patients, this study aims to elucidate key molecular regulators of platelet hyperactivity, establishing a theoretical framework for developing precision therapeutic strategies to mitigate post-CHD complications.MethodsThis randomized controlled study included 16 CHD patients and 16 healthy controls. …”
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The delaying effect of toripalimab on disease progression in patients with advanced hepatocellular carcinoma and changes in serum tumor markers by Zhuo Yin, Yaomin Xiao, Jiangxue Gu, Pei Hu, Jiandu Jing, Xia Wang, Yao Liu, Shirong Yan

“…Results The intervention group exhibited significantly higher ORR compared to controls (70.0% vs. 35.0%, P = 0.002), with complete response (CR) in 25.0% of patients. Post-treatment tumor markers declined markedly in the intervention group: AFP (412.3 ± 98.5 to 156.7 ± 45.2 ng/mL, P < 0.001), HSP90α (68.4 ± 12.3 to 34.2 ± 8.7 ng/mL, P < 0.001), and CEA (15.2 ± 3.1 to 6.8 ± 1.9 ng/mL, P = 0.003). …”
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HIPEC after Interval Debulking Surgery as Best Clinical Practice in Ovarian Cancer Patients: Case Series and Literature Review by Stefano Restaino, Jessica Mauro, Stefano Cianci, Alessandro Buda, Claudia Andreetta, Elena Poletto, Enrico Maria Pasqual, Alice Poli, Cosimo Vittorio Agrimi, Doriana Armenise, Alice Buzzelli, Domenico Caccamo, Lorenza Driul, Giuseppe Vizzielli

“…Conclusions: The addition of HIPEC to interval debulking surgery should be offered to all eligible patients, considering that the association of HIPEC to IDS seems to improve patients’ outcomes in terms of OS and DFS, without increasing post-operative morbidity .…”
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A time-course comparative clinical and immune response evaluation study between the human pathogenic Orientia tsutsugamushi strains: Karp and Gilliam in a rhesus macaque (Macaca mu... by Manutsanun Inthawong, Piyanate Sunyakumthorn, Sirima Wongwairot, Tippawan Anantatat, Susanna J Dunachie, Rawiwan Im-Erbsin, James W Jones, Carl J Mason, Luis A Lugo, Stuart D Blacksell, Nicholas P J Day, Piengchan Sonthayanon, Allen L Richards, Daniel H Paris

“…<h4>Methodology/principle findings</h4>We evaluated the clinical outcomes and host immune responses of the two most relevant human pathogenic strains of O. tsutsugamushi; Karp (n = 4) and Gilliam (n = 4) in a time-course study over 80 days post infection (dpi) in a standardized scrub typhus non-human primate rhesus macaque model. …”
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Screening and Risk Analysis of Atrial Fibrillation After Radiotherapy for Breast Cancer: Protocol for the Cross-Sectional Cohort Study “Watch Your Heart (WATCH)” by Laura Saint-Lary, Baptiste Pinel, Loic Panh, Gaelle Jimenez, Julien Geffrelot, Youlia Kirova, Jeremy Camilleri, David Broggio, Marie-Odile Bernier, Corinne Mandin, Christelle Levy, Serge Boveda, Juliette Thariat, Sophie Jacob

“…Cross-sectional screening for AF at the time of the scheduled 5-year post-RT visit will be conducted by recording data from a Withings ScanWatch smartwatch for 1 month, confirmed by an electrocardiogram (ECG), and validated by a physician. …”
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Succession characteristics and assembly process of soil microbiome at reclaimed farmlands in coal mining area by Jianhua Li, Jianhua Li, Zixu Li, Yanwen Sun, Jinjing Lu, Jinjing Lu, Qiang Zhang, Xinhua He, Xinhua He, Xinhua He, Minggang Xu, Minggang Xu

“…We analyzed soil microbial diversity, composition, co-occurrence network structure, and assembly processes using 16S rDNA/ITS sequencing and null models at 0 (R0), 1 (R1), 6 (R6), and 10 (R10) years of post-reclamation. Results showed that (1) Compared to R0, the R10 treatment resulted in significant increases in soil organic matter (SOM), total nitrogen (TN), available phosphorus (AP), and available potassium (AK) by 2.1-fold, 1.3-fold, 1.5-fold, and 0.4-fold, and also in activities of β-glucosidase (BG), N-acetyl-β-glucosaminidase (NAG), and leucine aminopeptidase (LAP), by 17-fold, 8.7-fold, and 1.8-fold, respectively (p &lt; 0.05). (2) Rising bacterial diversity (Shannon, Chao1) over time, contrasting with fungal diversity that declined initially before recovering. (3) As the reclamation progressed, the network complexity was increased for both bacteria and fungi, improving stability. …”
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The growth mechanism and corrosion resistance of laser-assisted plasma electrolytic oxidation (PEO) composite coating on AZ31B magnesium alloy by Guolong Wu, Lin Li, Xianghui Chen, Lebin Zhu, Ye Wang, Chen Wen, Jianhua Yao

“…The results demonstrated that laser-assisted irradiation not only induced plasma discharge on the anode surface, but also limited the plasma discharge size in the post-processing stage, which significantly increased the proportion of corrosion-resistant phase Mg2SiO4 (the proportion of Mg2SiO4 increased from 23.70% to 39.22%), thickness and density in the coating, and obviously reduced the oxygen vacancy defects and microcracks in the coating. …”
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Does constipation affect the effectiveness of washed microbiota transplantation in treating autism spectrum disorders? by Zihao Pan, Zheng Gao, Junyi Chen, Yongxi Quan, Jiating Xu, Xiaofeng Liang, Wenrui Xie, Xingxiang He, Xingxiang He, Lihao Wu, Lihao Wu

“…After one course of WMT, constipation group showed an obvious increase in microbial diversity and a significant increase in the relative abundance of Bifidobacteria compared to non-constipation group.ConclusionPost WMT, core symptoms and sleep disorders were significantly improved in both groups. …”
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Methylation of a group of microRNA genes as a marker for the diagnosis and prognosis of non-small cell lung cancer by V. I. Loginov, M. S. Gubenko, A. M. Burdennyy, I. V. Pronina, P. V. Postnikov, Yu. A. Efimova, F. V. Radus, E. S. Mochalova, T. P. Kazubskaya

“…MicroRNAs, which function as post-transcriptional regulators of the expression of protein-coding genes, including those associated with oncogenesis, are involved in the processes of cell proliferation, differentiation, and apoptosis. …”
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Gender Disparities in COVID-19 Survivors with Impaired Quality of Life, Effort Intolerance, and Cardiopulmonary Symptoms: A Prospective Cohort Study by Krista Zachariah, Dustin Wessells, Prianca Tawde, Mahniz Reza, Caitlin Chiu, Pablo Villar Calle, Alexander Volodarskiy, Evelyn M. Horn, Parag Goyal, Jonathan Weinsaft, Jiwon Kim

“…Conclusion: Whereas males have greater morbidity during acute COVID hospitalization, females are disproportionately impacted by post-COVID impaired functional status despite higher biventricular ejection fraction and smaller infarct size.…”
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