Low-Dose Versus Standard-Dose Radioiodine Therapy in Differentiated Thyroid Cancer: Focus on Tolerability in a Retrospective Evaluation by Laura Musso, Cristina Maltese, Giulio Beretta, Ilaria Patelli, Stefano Raffa, Arnoldo Piccardo, Francesco Fiz, Lara Vera, Manuela Albertelli, Michele Minuto, Diego Ferone, Marcello Bagnasco, Stefano Gay

“…The aim of this study was to evaluate the occurrence of post-RAI therapy clinical and biochemical side effects with respect to its dosage. …”
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Generation of neutralizing and non-neutralizing monoclonal antibodies against H7N9 influenza virus by Fan Yang, Yixin Xiao, Rufeng Lu, Bin Chen, Fumin Liu, Liyan Wang, Hangping Yao, Nanping Wu, Haibo Wu

“…The mAb 1H10 was most efficacious, even if the treatment-time was as late as 72 h post-infection, or the therapeutic dose was as low as 1 mg/kg; and it was confirmed to have haemagglutination inhibition and neutralizing activity on both LP-and HP-H7N9 strains. …”
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Social media-based bibliotherapy for improving the mental health of informal caregivers of people with dementia: a randomized controlled trial by Shanshan Wang, Daphne Sze Ki Cheung, Sze Him Isaac Leung, Avis Yat Ngar Fan, Wenjing Ning, Angela Yee Man Leung

“…Outcomes were assessed at baseline and immediately after the intervention. Post-intervention interviews were conducted to explore participants’ experiences with this intervention. …”
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Global pharmacovigilance reporting of the first monoclonal antibody for canine osteoarthritis: a case study with bedinvetmab (Librela™) by Beatriz P. Monteiro, Anthony Simon, Oliver Knesl, Kristen Mandello, Steven Nederveld, Natasha J. Olby, Natasha J. Olby, John F. Innes, B. Duncan X. Lascelles

“…IntroductionContinuous product monitoring post approval builds on the knowledge gained during clinical studies to aid in understanding a product’s safety and efficacy profile. …”
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Model-based estimation of tokamak plasma profiles and physics parameters: algorithm overview and application to ITER by S. Van Mulders, F. Felici, S.C. McIntosh, F. Carpanese, C.E. Contré, R. Coosemans, O. Kudláček, F. Pastore, S.D. Pinches, M. Reisner, O. Sauter

“…In this work, a model-based estimation algorithm is proposed to improve real-time and post-shot estimation of tokamak plasma profiles. …”
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Postinfectious epilepsy: clinical and diagnostical features by А. V. Vasilenko, А. Yu. Ulitin, L. S. Onishchenko, N. I. Ananyeva, R. V. Grebenshchikova, О. N. Gaykova, А. V. Ivanenko, S. S. Kolosov, S. А. Turanov, S. N. Chudievich

“…The study included observations of 1500 patients with locally induced epilepsy admitted and treated from 2007 to 2017 in various medical inpatient and outpatient institutions. Post-infection locally induced epilepsy with clear causality link between previous neuroinfection and onset of epileptic seizure was found in 127 patients (Group 1). …”
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10 kHz spinal cord stimulation vs. traditional low-frequency spinal cord stimulation for the treatment of diabetes peripheral neuropathic pain: study protocol for a multi-center ra... by Chen Li, Chen Li, Chun-Hua Liu, Chun-Hua Liu, Yi-Fan Li, Hui-Min Hu, Hui-Min Hu, Qing Shi, Qing Shi, An-Xiang Liu, An-Xiang Liu, Wen-Hui Liu, Wen-Hui Liu, Yi Zhang, Peng Mao, Bi-Fa Fan

“…The primary outcome is the treatment efficacy rate, defined as ≥50% reduction in numeric rating scale (NRS) scores at 3 months post-intervention. Secondary outcomes include improvements in quality of life (Short Form 12), sleep quality (Athens Insomnia Scale), psychological status (Beck Depression Inventory), neuropathy severity (Michigan Neuropathy Screening Instrument), and microcirculatory parameters assessed via infrared thermography. …”
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p27^Kip1 and Tumors: Characterization of <i>CDKN1B</i> Variants Identified in MEN4 and Breast Cancer by Debora Bencivenga, Emanuela Stampone, Jahanzaib Azhar, Daniela Parente, Waqar Ali, Vitale Del Vecchio, Fulvio Della Ragione, Adriana Borriello

“…Structurally, the protein is largely unfolded, a feature that strongly increases its plasticity and interactors and enhances the number of regulated cellular processes. p27^Kip1, like other intrinsically unstructured proteins, is post-translationally modified on several residues. …”
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Exosomes derived from hypoxia-preconditioned M2 macrophages alleviate degeneration in knee osteoarthritis through the miR‑124‑3p/STAT3 axis by Hao Li, Yuze Yang, Yuanpeng Gao, Bo Li, Jiaju Yang, Pengyu Liu, Min Zhang, Guangzhi Ning

“…The underlying molecular mechanism is associated with increased delivery of miR-124-3p to chondrocytes, which subsequently inhibits the post-transcriptional expression of STAT3. This provides a promising therapeutic strategy for the clinical intervention of OA.…”
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Chemotherapeutic drug scavenger-based combination therapy toward treating triple-negative breast cancer by Qingqing Yin, Yutong Zhong, Mengchun Chen, Weian Mao, Yuan Yang, Li Li, Dongyan Tian, Shuangshuang Liu, Ying Chen, Jiale Quan, Shiyu Li, Deli Zhuge, Xufei Zhang, Ledan Wang, Fang Wang, Yiming Chen, Xiaosheng Lu, Xiaoji Lin, Yijie Chen, Linzhi Yan

“…Such a high Dox dose enabled by CDS pretreatment significantly inhibited the post-operative residual/metastasized 4T1 tumor growth, regardless of the early or later stages of the tumor. …”
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Experimental Study of Neuroprotective Properties of Inhaled Argon-Oxygen Mixture in a Photoinduced Ischemic Stroke Model by E. A. Boeva, D. N. Silachev, E. I. Yakupova, M. A. Milovanova, L. A. Varnakova, S. N. Kalabushev, S. O. Denisov, V. V. Antonova, I. A. Ryzhkov, K. N. Lapin, A. A. Grebenchikova

“…Statistically significant differences in LPT scores between SP, Stroke, and Stroke+iAr groups were revealed on day 3 post-stroke: (scores: 14 (13; 14), 6.5 (4; 8), and 5 (3; 8), respectively, P=0.027). …”
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Iron overload phenotypes and HFE genotypes in white hemochromatosis and iron overload screening study participants without HFE p.C282Y/p.C282Y. by James C Barton, J Clayborn Barton, Ronald T Acton

“…<h4>Methods</h4>We studied white participants who had IO phenotypes without p.C282Y/p.C282Y in post-screening clinical examinations (CE). We defined IO phenotypes as a) elevated serum ferritin (SF) and transferrin saturation (TS) at screening and CE, and b) absence of IO treatment, anemia, transfusion >10 units, alcohol intake >30 g/d, hepatitis B or C, and pregnancy. …”
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Chemical composition and insecticidal potential of botanical fractionation extracts for the management of Sitophilus zeamais Motschulsky, 1855 (Coleoptera: Curculionidae) in stored... by Fikadu Kifle, Melaku Girma, Araya Gebresilassie, Yitbarek Woldehawariat, Estifanos Ele

“…All fractions exhibited insecticidal activity, which increased with higher doses and longer post treatment periods. At a dose of 15 g/kg, the hexane, chloroform and methanol fractions of E. globulus caused a mortality rate of 100 % at 48 h of exposure and an inhibition rate of more than 100 % in progeny production. …”
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Gestational Inulin Supplementation in Low-/High-Fat Sow Diets: Effects on Growth Performance, Lipid Metabolism, and Meat Quality of Offspring Pigs by Pan Zhou, Yachao Wu, Jianbo Shen, Tao Duan, Long Che, Yong Zhang, Yang Zhao, Honglin Yan

“…After mating, sixty multiparous sows (Landrace × Yorkshire; parity 2–3) were assigned to a 2 × 2 factorial arrangement with inulin (0% vs. 1.5%) and fat (0% or 5%) supplementation until farrowing. Post-weaning, five litters (10 piglets per litter) per treatment were selected and maintained in their original litter for fattening under standardized feeding. …”
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Targeting miRNA‐1a and miRNA‐15b: A Novel Combinatorial Strategy to Drive Adult Cardiac Regeneration by Ting Yuan, Meiqian Wu, Chaonan Zhu, Hao Yu, Minh Duc Pham, Katharina Bottermann, Yijie Mao, Yue Wang, Mathias Langner, Mirko Peitzsch, Arka Provo Das, Silke Kauferstein, Jonathan Ward, Peter Mirtschink, Andreas Michael Zeiher, Stefanie Dimmeler, Jaya Krishnan

“…Abstract Despite its promise, cardiac regenerative therapy remains clinically elusive due to the difficulty of spatio‐temporal control of proliferative induction, and the need to coordinately reprogram multiple regulatory pathways to overcome the strict post‐mitotic state of human adult cardiomyocytes. …”
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Associations of social determinants of health on likelihood of systemic hormone therapy use in midlife women by Juliana M. Kling, Anna E. Abraham, Ekta Kapoor, Kristin Cole, Mariam Saadedine, Chrisandra Shufelt, Stacey J. Winham, Stephanie S. Faubion

“…In univariate analysis, women were less likely to be using HT if they had higher BMI (per 1 kg/m2 increase, OR = 0.97, 95% 0.95–0.99, p = 0.002) were unpartnered (OR = 0.66, 95% CI 0.45–0.99, p = 0.04) had lower education (compared to post graduate studies, high school graduate/GED or less: OR = 0.45, 95% CI 0.24–0.85, p = 0.01; some college/2 year degree: OR = 0.69, 95% CI 0.49–0.96,p = 0.03), or were a smoker (compared to those who never smoked, current smoker: OR = 0.38, 95% CI 0.18–0.83, p = 0.02; former smoker: OR = 0.71, 95% CI 0.52–0.96, p = 0.03). …”
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Genomic Insights into Plant Growth-Promoting Traits of <i>Lysinibacillus fusiformis</i> and <i>Bacillus cereus</i> from Rice Fields in Panama by Celestino Aguilar, Rito Herrera, José L. Causadías, Betzaida Bernal, Oris Chavarria, Claudia González, Jessica Gondola, Ambar Moreno, Alexander A. Martínez

“…Moreover, diverse and novel biosynthetic clusters (BCGs) have included non-ribosomal peptides (NRPs), polyketides (PKs), bacteriocins, and ribosomally synthesized and post-transcriptionally modified peptides (RiPPs). …”
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The Role of Robot-Assisted Technique in Treating Adult Degenerative Scoliosis with Circumferential Minimal Invasive Correction Surgery &amp;ndash; A Retrospective Analysis of 51 Co... by Zhang Q, Chen Z, Lin Y, Zhang X, Wu W, Liang Y

“…Clinical outcomes like the operation time, radiation exposure, pressure curve and post-operation VAS score were recorded. 3D-CT scan was also performed to evaluate the accuracy of the screws.Results: The average preparation time were much higher in group A (23.4 ± 2.8 vs 3.1 ± 1.0 min, p &lt; 0.0001). …”
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Recurrent gastric cancer sustaining a partial response after the nivolumab discontinuation because of immune-related adverse events: a case report by Takaaki Arigami, Daisuke Matsushita, Keishi Okubo, Takako Tanaka, Ken Sasaki, Masahiro Noda, Yoshiaki Kita, Shinichiro Mori, Yusuke Tsuruda, Hiroshi Kurahara, Takao Ohtsuka

“…Nevertheless, during adjuvant chemotherapy 1-year post-surgery, computed tomography (CT) revealed lymph node swelling in station no. 9. …”
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Effect of environmentally relevant concentrations of estrogens on the aggressive response of male zebrafish by Ying–Ying Zhang, Ying–Ying Zhang, Hong Tao, Hong Tao, Yan–Jun Shen, Yan–Jun Shen, Qi–Liang Chen, Qi–Liang Chen, Zhi–Hao Liu, Zhi–Hao Liu

“…In this study, adult male zebrafish were exposed to EE2-low (5.55 ng/L), EE2-high (11.1 ng/L), and Mix (4-NP, 62.2 ng/L; BPA, 250 ng/L; E1, 4.56 ng/L; E2, 5.53 ng/L; E3, 39.6 ng/L, with an estrogenic potency equal to EE2-low) for 60 days. Post-exposure assays (mirror test and dyadic interaction) revealed that Mix significantly reduced the frequency of approaching mirror, the attack mirror duration, and the frequency of chasing un-exposed fish, indicating a decrease in aggressive behaviour in Mix-fish. …”
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