Prognostic value of circulating HPV cell-free DNA in cervical cancer using liquid biopsy by Ashna Gupta, Gunjan Dagar, Sumit Kr. Das, Ravi Chauhan, Abhishek Shankar, Daya Nand Sharma, Vaishali Suri, Maroof Ahmad Khan, Muzafar A. Macha, Ikhlak Ahmed, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat, Mayank Singh

“…Blood samples were collected from 60 cervical cancer patients (Stages I–IV) at AIIMS, New Delhi, at baseline and three months post-treatment. Samples from 10 healthy controls were also included. …”
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Comparison of Gait Parameters Collected Across Two Commercially Available Gait Systems in Older Adults by Alexandria Hoang, Jeannette Mahoney, Ying Jin, Sofiya Milman, Nir Barzilai, Joe Verghese, Emmeline Ayers

“…However, such parameters can vary across these widely used software applications due to differences in algorithms and post-processing techniques, making it potentially unsuitable to pool parameters acquired from different applications. …”
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Immune enhancement and disease resistance against Aeromonas hydrophila infection by dietary Lactobacillus plantarum-fermented Moringa oleifera leaves in Oreochromis niloticus by Ghada S. Abdelkader, El-Sayed Y. El-Naenaeey, Hossam M. Abdallah, Ehsan H. Abu-Zeid, Ibrahim F. Rehan, Ibrahim F. Rehan, Ibrahim F. Rehan, František Zigo, Gamal A. Elmowalid

“…In contrast, the expression of the IL-10 gene was markedly upregulated in the spleen and head kidney (anterior) post A. hydrophila challenge in the MOLF-groups than the MOLP-groups. …”
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Classification and identification of yeast strain A82-2 and its inhibitory effect on Rhizopus stolonifer by ZHOU Xiaohong, YAN Dong, LU Zhaoxin, LU Fengxia, SHEN Chang, BIE Xiaomei

“…Based on the above results, we concluded that P. anomala A82-2 significantly inhibited R. stolonifer, therefore it has an important application potential in biological control and post harvest preservation of fruit and vegetable.…”
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Civilian death and injury from airstrikes: evidence from the war in Tigray, Ethiopia by Mulugeta Gebregziabher, Akeza Awealom Asgedom, Hiluf Ebuy Abraha, Hale Teka, Abenezer Etsedingl, Tsegay Berihu, Gebru Hailu Redae, Nahom M. Gebreselassie, Araya Abrha Medhanyie, Hagos Godefay, Demoz Gebre-Egziabher, Hannah Wild

“…Enhanced collaboration between health and protection stakeholders can improve support to victims from immediate post-injury care as well as rehabilitation so that they can live as healthy, dignified, and productive citizens.…”
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Development of a Nomogram Model to Predict the Risk of Pneumothorax after CT-guided Coaxial Core Needle Lung Biopsy: A Cross-sectional Study by Mahitha J Alapati, C Nellaiappan, S Kalpana, SK Gopibagya

“…Results: A total of 51 (21.88%) patients developed pneumothorax post CT-guided lung biopsy among the development group, and 20 (19.60%) patients among the validation group also developed pneumothorax. …”
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Histological and inflammatory effects of 26.5 GHz quasi-millimeter wave exposure on rat skin by Etsuko Ijima, Akiko Nagai, Kun Li, Takashi Hikage, Naomi Kamizawa, Emi Hidaka, Yukina Tsuruta, Tatsuya Ishitake, Hiroshi Masuda

“…Furthermore, serum levels of prostaglandin E2 (PGE2), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were measured at each post-exposure time point.ResultsHistological analysis revealed burn-like tissue damage in the 500 W/m2 exposure group, characterized by subepidermal blister formation, epidermal thickening, and dermal edema, which increased in severity over time. …”
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Investigating the nutritional status, outcomes and needs of adolescents and young adults (AYA) following a cancer diagnosis: protocol for a mixed-methods study by Andrew Murnane, Erin Laing, Belinda Steer, Jeremy Lewin, Heather Gilbertson, Elizabeth Mount, Mary-Anne Silvers, Jenelle Loeliger, Jodie Bartle, Kristin Mellett, June Savva, Pasquale L. Fedele, Lisa M. Orme, Leanne Super, Karla Gough, Kate Thompson

“…Study assessments will be undertaken at four time-points (recruitment, and 2- 4- and 6-months post-recruitment) and will include screening for nutrition risk (PNST or MST); assessment of nutritional status (PG-SGA, mid-upper arm circumference); assessment of muscle strength (hand-grip strength); frequency of dietitian referral, nutrition support and symptoms; and assessment of health-related quality of life (AQoL-6D); (2) Qualitative study using focus groups with AYA to assess access to nutrition related care and preference for nutrition services; (3) Qualitative study, utilising focus groups with oncology healthcare professionals (OHP) to explore and assess current access to nutrition-related care for AYA following a cancer diagnosis along with OHP nutrition education needs, service delivery and research priority areas. …”
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In situ insights into antibody-mediated neutralization of a pre-fusion Junin virus glycoprotein complex by Lily J. Taylor, Michael R. Sawaya, Jonna B. Westover, Chenyi Wang, Frederick Jimenez, Aldo J. Muñoz, Julian Whitelegge, Brian B. Gowen, Gustavo F. Helguera, Roger Castells-Graells, Jose A. Rodriguez

“…The 3.8 Å resolution in situ structures of the antibody-neutralized, 3-fold symmetric JUNV GPC reveal its ectodomain architecture, signal peptide-bound transmembrane region, zinc-binding luminal domain, and post-translational modifications. JUNV-GPC sequence variants highlight the functional importance of the signal peptide transmembrane helix register for virus infection and attenuating Candid#1-associated variants. …”
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Comparative Survival Analysis of Anti‐Angiogenic Agent Plus Immunochemotherapy in NSCLC Patients After Frontline EGFR‐TKI Treatment: A Retrospective Cohort Study by Yi‐Tse Su, Shu‐Farn Tey, Chung‐Ta Lee, Chien‐Yu Lin, Jeng‐Shiuan Tsai, Chien‐Chung Lin, Chin‐Wei Kuo

“…Survival outcomes were assessed through progression‐free survival (PFS) and overall survival post‐TKI failure (OSpTKI). Propensity score was employed to match patients, with Kaplan–Meier curve and multivariable Cox regression analysis determining the survival benefits. …”
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Tourniquet use in total knee arthroplasty and the risk of infection: a meta‐analysis of randomised controlled trials by A. A. Magan, O. Dunseath, P. Armonis, A. Fontalis, B. Kayani, F. S. Haddad

“…However, tourniquet use has recently been linked with increased post‐operative pain, reduced range of motion, and slower functional recovery. …”
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QUALITY OF LIFE OUTCOMES FOLLOWING ULTRASONIC DISSECTOR-ASSISTED VS. ELECTROCAUTERY DISSECTION IN MODIFIED RADICAL MASTECTOMY: PROSPECTIVE OBSERVATIONAL COHORT by Nazgul Dzhantemirova, Marat Mauletbaev, Asiya Kukanova, Aizhan Bekisheva, Abay Makishev

“…QoL was assessed using the EORTC QLQ-C30 and QLQ-BR45 questionnaires at baseline, 3-, 6-, and 9-months post-treatment. Statistical analysis included chi-square tests for categorical variables and independent t-tests for continuous variables, with p<0.05 significancy. …”
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Maximal and sub-maximal exercise tests alter PBMC microRNA expression: insights into sport- and sex-specific variations by Guy Shalmon, Guy Shalmon, Guy Shapira, Guy Shapira, Rawan Ibrahim, Ifat Israel-Elgali, Meitar Grad, Rani Shlayem, Ilan Youngster, Ilan Youngster, Mickey Scheinowitz, Mickey Scheinowitz, Noam Shomron, Noam Shomron

“…Participants underwent VO2max and time-to-exhaustion tests, with blood samples collected pre- and post-exercise to analyze PBMC microRNA levels.ResultsRunners exhibited a higher microRNA response than cyclists or controls, with significant sex-based differences. …”
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Induction of Apoptosis by Ethanol, Methanol, and Ethyl Acetate Extracts from Cyperus Rotundus' Leaf on In Vitro Human Ovarian, Cervix, and Breast Cancer Cell Lines by Mahdi Moradi Kooshkmeydani, Arezoo Khoradmehr, Ali Dehghani Firoozabadi, Alireza Tavassoli, Farzad Mohammad Rezazadeh, Gholamhossein Mohebbi, Asset A Kaliyev, Nadiar Mussin, Mojtaba Farjam, Kulyash R.Zhilisbayeva, Amin Tamadon

“…Further analysis of these treatment groups revealed that the transcription and translation of BAX, Caspase-3, Caspase-8, and Caspase-9 increased overall, whereas Bcl-2 decreased in all cell lines.Conclusion: Hydroalcoholic extracts from C. rotundus’ leaf may enhance the apoptosis of cancer cells by modulat­ing the transcription, translation, and post-translation of proteins, with minimal impact on the growth and survival of non-cancerous cells.…”
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Fall risk perception toolkit based on “digital human” for community-dwelling older patients with stroke: development and validation by Jiang Nan, Yi Hou, Manyao Sun, Xueying Huang, Jing Gao, Xueqiong Zou, Zhongyi Chen, Yuyu Jiang

“…The usability test contained Post-Study System Usability Questionnaire (PSSUQ), Customer Effort Score (CES), Net Promoter Score (NPS), and user interviews. …”
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Vitamin A attenuates PFOS-induced neurotoxicity and alters early proximity patterns to conspecifics in zebrafish larvae by Peiyun Jiang, Jingyu Wang, Xiaoying Wang, Li Zou, Li Zou, Di Wu, Qu Xu, Yue Jiang, Mengmeng Yao, Mengmeng Yao, Qin Hong, Qin Hong, Xia Chi, Xia Chi

“…This study investigates vitamin A’s neuroprotective capacity against PFOS-induced toxicity, particularly focusing on social behavior deficits—a core phenotype of autism spectrum disorder (ASD).MethodsZebrafish larvae were exposed to 1 μM or 5 μM PFOS (with/without 5 nM vitamin A co-treatment) from 24–144 hours post-fertilization (hpf). Control groups received 0.01% DMSO (vehicle) or 5 nM vitamin A alone. …”
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Size-dependent interactions between calciprotein particles and vascular endothelium by Zeping Zhang, Xinyue Wang, Caihao Huang, Meixia Wang, Wei Cui, Liang Hao, Rui Yang, Hong-hui Wang, Xing Zhang

“…Two primary types of CPP1 were studied: small-sized CPP1 (S-CPP1, <50 nm) and larger CPP1 (L-CPP1, <100 nm), detected three and five weeks post-surgery, respectively. By adjusting the amounts of Ca2+, HPO42− and H2PO4− ions in Dulbecco's Modified Eagle Medium supplemented with 10 % (V/V) fetal bovine serum and 1 % (V/V) Pen-Strep solution, S-CPP1 (<50 nm) with an elliptical shape, L-CPP1 (50–100 nm), and secondary CPPs (CPP2, >100 nm) with a needle-like crystalline structure, resembling endogenous CPPs, were synthesized. …”
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Full-scale test and numerical study on seismic performance of bridge piers with 650 MPa grade steel bars by Yong Li, Dezhang Sun, Junwu Dai, Yuxuan Peng, Dali Fang, Tao Jiang, Hongyu Lei

“…Then, a four-segment piecewise model is developed through systematic parameterization of experimental skeleton curves, delineating sequential behavioral phases: elastic deformation, crack initiation, yielding plateau, and post-peak strength degradation. Numerical simulations in OpenSees successfully replicates the hysteretic behavior of HRB650E bridge piers. …”
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Sintilimab and anlotinib with gemcitabine plus cisplatin in advanced biliary tract cancer: SAGC a randomized phase 2 trial by Jingjing Li, Shurui Zhou, Xiaoqing Xu, Qinhong Zheng, Fabiao Zhang, Cong Luo, Da Li, Xing Sun, Zhe Han, Wei Wu, Junrong Yan, Yang Shao, Yuhua Zhang, Bingchen Wu, Qing Wei, Xinbao Wang, Yiwen Zhou, Weijing Sun, Qi Xu, Jieer Ying

“…At 13.4-month median follow-up, SAGC significantly improved median progression-free survival (8.5 vs. 6.3 months; HR 0.48, 95% CI 0.22–0.64, p = 0.005) and objective response rate (51.4% vs. 29.4%), with higher grade 3/4 adverse events (75.0% vs. 43.6%). Post hoc analysis showed enhanced efficacy with anlotinib 8 mg versus 10 mg (ORR 54.5% vs. 38.8%). …”
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STORCH Brazil: multicenter cohort study protocol to investigate neurodevelopmental paths and functioning in infants exposed to STORCH in Brazil by Daniele Almeida Soares-Marangoni, Amanda de Oliveira Arguelho, Ayrles Silva Gonçalves Barbosa Mendonça, Carine Carolina Wiesiolek, Carolina Daniel de Lima-Alvarez, Eloá Maria dos Chiquetti, Everton Falcão de Oliveira, Márcio José de Medeiros, Silvana Alves Pereira, Renata Hydee Hasue

“…A proposed total sample size of 296 infants will be included at 3 months (12–15 weeks post term). They will be equitably divided into: (a) an exposed group (n = 148), consisting of those diagnosed with any congenital STORCH infection or whose mothers experienced prenatal STORCH infection; (b) an unexposed group (n = 148). …”
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