Effects of rapid maxillary expansion and functional orthodontic treatment in children with sleep disordered breathing: a systematic review by Magdalena Piełunowicz, Jacek Kotuła, Krzysztof Kotuła, Mieszko Więckiewicz, Joanna Lis, Beata Kawala, Anna Ewa Kuc, Michał Sarul

“…The study design was defined in the PICO format—Population (P): non-syndromic prepubertal and adolescent patients requiring orthodontic treatment, who additionally have coexisting sleep disorders; Intervention (I): Orthodontic treatment of malocclusion with differentiated appliances; Comparison (C): evaluation of Apnea Hypopnea Index (AHI) and sleep questionnaires pre and post treatment; Outcome (O): effect of orthodontic treatment on sleep quality. …”
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Neutrophil- and Endothelial Cell-Derived Extracellular Microvesicles Are Promising Putative Biomarkers for Breast Cancer Diagnosis by Thayse Batista Moreira, Marina Malheiros Araújo Silvestrini, Ana Luiza de Freitas Magalhães Gomes, Kerstin Kapp Rangel, Álvaro Percínio Costa, Matheus Souza Gomes, Laurence Rodrigues do Amaral, Olindo Assis Martins-Filho, Paulo Guilherme de Oliveira Salles, Letícia Conceição Braga, Andréa Teixeira-Carvalho

“…In addition, the MVs of BC patients were analyzed before treatment and 6, 12, and 24 months post-treatment. Machine learning approaches were employed to determine the performance of MVs to identify BC and to propose BC classifier algorithms. …”
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Rationale and protocol of the LEAD 2.0 study: a randomized controlled trial assessing the feasibility of a virtually delivered 6-month exercise and nutrition intervention in older... by Bobby Neudorf, Noah Koblinsky, Krista Power, Malcom Binns, Alexandra J. Fiocco, Shlomit Rotenberg, Susan Marzolini, Paul Oh, Jane Thornton, Fatim Ajwani, Kylie Sullivan, Stéphanie Chevalier, Caryl Russell, Guylaine Ferland, Nicole D. Anderson, Laura E. Middleton

“…Assessments will be performed virtually at baseline, 6 months (post-intervention), and 12 months. Feasibility will be measured by recruitment rate, adherence, and retention. …”
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Combination of Whole Body MRI and MY-RADS: A Promising Standardised Approach for Treatment Response Evaluation in Multiple Myeloma Patients by Dipu Bhuyan, Hrishikesh Choudhury, Baloy Jyoti Talukdar, Subhosree Dey, Sushant Agarwal, Aditi Das, Rishabh

“…All participants adhered to a standardised MRI protocol employing uniform sequence parameters utilising the 3T Siemens Magnetom Skyra technology both pre-and post-treatment, with a burden score allocated to reflect the extent and severity of the disease. …”
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‘Super Rehab’: can we achieve coronary artery disease regression? A feasibility study protocol by David Murphy, Charalambos Antoniades, John Graby, Fiona Gillison, Amardeep Dastidar, Dylan Thompson, Theresa Smith, Oliver Peacock, Ali Khavandi, Hugh McLeod, Jonathan Carl Luis Rodrigues

“…However, many patients with coexistent cardiovascular risk factors, particularly those with metabolic syndrome (MetS), remain at heightened risk of future MACE despite current management.Cardiac rehabilitation is offered to patients post-revascularisation, however, there is no definitive evidence demonstrating its benefit in a primary prevention setting. …”
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Variation in Arterial CO2 is a Stronger Determinant of Brain Tissue Oxygenation Than its Synchronous Value in Critically Ill Patients With Acute Brain Injury by Joanie Martineau, MD, MSc, Francis Bernard, MD, Alexandrine Gagnon, MD, Virginie Williams, PhD, Sabrina Araujo de Franca, BSN, David Williamson, BPharm, PhD, Yiorgos Alexandros Cavayas, MD, Msc

“…DESIGN:. We performed a post hoc analysis of a prospective cohort study collecting arterial blood gas (ABG) values alongside synchronous neuromonitoring variables. …”
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Advanced 4-chamber echocardiography techniques enable clinically matched precise characterization of heart disease progression in mice by Ege Kacira, Mariam F. Oueis, Nawal H. Tamimi, Sarah L. Sturgill, Xianyao Xu, Thomas J. Hund, Mark T. Ziolo, Yuchi Han, Isabelle Deschênes, Ji-dong Fu

“…Results: Here we show that LAX-BP echocardiography demonstrates volumetric accuracy comparable to cardiac magnetic resonance (CMR) and detects significant LV functional decline within the first week post-TAC–changes that are not clearly captured by M-mode imaging. …”
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The enhanced integration of proven techniques to quantify the uncertainty of forecasting extreme flood events based on numerical weather prediction models by Mitra Tanhapour, Jaber Soltani, Hadi Shakibian, Bahram Malekmohammadi, Kamila Hlavcova, Silvia Kohnova, Peter Valent

“…A Multi-Model Ensemble (MME) system was developed using the Group Method of Data Handling (GMDH) and Weighted Average-Weighted Least Square Regression (WA-WLSR) models to post-process raw precipitation forecasts. We thereupon proposed an approach that combined the Hydrologiska Byråns Vattenbalansavdelning (HBV) hydrological model with the Long-Short Term Memory (LSTM) network (HBV-LSTM model) to enhance flood forecasting. …”
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Surgical effect and prognostic factors of myasthenia gravis with thymomas by Wenxin Tian, Xiao Li, Hongfeng Tong, Wenhan Weng, Fan Yang, Guanchao Jiang, Jun Wang

“…A total of 162 patients were evaluated for post intervention MG status. A total of 55 patients achieved complete stable remission; the overall effective rate was 84.5%. …”
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Implikasi terhadap Status Kepemilikan Hak atas Tanah dalam Transformasi UMKM Menjadi Perseroan Terbatas Perorangan by Dewinta Sukma Wijaya, Diyan Isnaeni

“…This study, through a normative juridical approach, reveals a regulatory gap that may affect the operational continuity of MSMEs post-conversion. Compared to previous literature that generally emphasizes administrative ease, this study highlights the often-overlooked implications of asset restructuring, particularly in land governance. …”
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Single-Bout Strength: Acute Mental Health Responses to Resistance Training in Active Adults by Manuel Amore, Adolfo Alfarano, Vincenzo Sorgente, Giulia Panconi, Sara Guarducci, Riccardo Bravi, Diego Minciacchi

“…A Quade ANCOVA confirmed that group assignment is significantly predictive for post-intervention anxiety levels (F(1, 54) = 8.46, <i>p</i> = 0.005), controlling for baseline values. …”
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Effects on choroid after repeated low-level red-light therapy in preclinical and clinical myopic children: a randomized controlled trial by Hongyu Wei, Sahil Thakur, Qin Zhu, Yanrong Zhou, Xuejun Cao, Shuyuan Xiao, Qin Chen, Min Hu, Hua Zhong

“…Improvements on choriocapillaris blood flow were evident at 3 months post-RLRL, yet these changes were not sustained and did not correlate with longer-term choroidal thickening. …”
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Optimising aesthetic outcome after nipple-areola complex-sparing mastectomy and immediate one-stage prosthetic reconstruction: A simple surgical trick to fix nipple-areola complex... by Luca Maione, Andrea Lisa, Federico Barbera, Mattia Siliprandi, Valeriano Vinci, Francesco Klinger, Marco Klinger

“…An optimum result obtained at the end of surgical procedure may be altered and compromised by skin redistribution and consequently NAC depositioning during the post-operative period in patients with medium-sized breasts and a moderate degree of ptosis. …”
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Ginkgo ketone ester tablets for the treatment of cognitive impairment associated with chemotherapy for breast cancer - a prospective cohort study by Jiajing Chen, Lixin Chen, Kexin Jiang, Dandan Wang, Chunyu Wu, Yuenong Qin, Sheng Liu

“…BackgroundChemotherapy-related cognitive impairment (CRCI) affects up to 75% of breast cancer patients during treatment, with 35% experiencing persistent post-treatment deficits. Current interventions show limited efficacy, creating urgent need for targeted therapies. …”
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Retrospective Analysis of Prognostic Factors and Pregnancy Outcomes in Patients with Moderate-to-Severe Intrauterine Adhesions Following Hysteroscopic Adhesiolysis and Modified Int... by Peng Q, Cao CX, Chen YN, Liu WC, Zhao RK, Jiang QJ, Zhou Q

“…A comprehensive follow-up period of 2 years post-stent removal was instituted.Results: The occurrence of adhesion recurrence increased progressively, demonstrating a recurrence rate of 11.54% at hysteroscopic reevaluation administrated in 3 months after surgery and surging to 32.69% during the 2-year follow-up period. …”
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Predicting IDH and 1p/19q molecular status of gliomas with multi-b values DWI by Shanshan Zhao, Peipei Wang, Eryuan Gao, Mengzhu Wang, Guang Yang, Shouhui Niu, Mengjiao Pan, Kai Zhao, Jingliang Cheng, Xiaoyue Ma

“…Multi-b-value DWI images were post-processed to generate parametric maps based on the mono-exponential (Mono), the intravoxel incoherent motion (IVIM), the stretched exponential model (SEM) and the continuous-time random walk (CTRW) models. …”
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Spatial Distribution of Cadmium in Avocado-Cultivated Soils of Peru: Influence of Parent Material, Exchangeable Cations, and Trace Elements by Richard Solórzano, Rigel Llerena, Sharon Mejía, Juancarlos Cruz, Kenyi Quispe

“…For data analysis, we applied (1) univariate statistics (skewness, kurtosis); (2) multivariate methods such as Spearman correlations and principal component analysis (PCA); (3) spatial modeling using the Geodetector tool; and (4) non-parametric testing (Kruskal–Wallis test with Dunn’s post hoc test). Our results indicated (1) the presence of hotspots with Cd concentrations exceeding 3 mg·kg⁻¹, displaying a leptokurtic distribution (skewness = 7.3); (2) dominant accumulation mechanisms involving co-adsorption and cation competition (Na⁺, Ca²⁺), as well as geogenic co-accumulation with Zn and Pb; and (3) significantly higher Cd concentrations in Leptosols derived from Cretaceous intermediate igneous rocks (diorites/tonalites), averaging 1.33 mg kg⁻¹ compared to 0.20 mg·kg⁻¹ in alluvial soils (<i>p</i> < 0.0001). …”
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Gene expression profiling in pure neural leprosy: insights into pathogenesis and diagnostic biomarkers by Mariana Martins de Athaide, Thyago Leal-Calvo, Tatiana Pereira Da Silva, Thabatta Leal Silveira Andrezo Rosa, Helen Ferreira, Bernardo Miguel de Oliveira Pascarelli, Ana Caroline Siquara de Sousa, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Roberta Olmo Pinheiro, Roberta Olmo Pinheiro, Roberta Olmo Pinheiro

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Association between vitamin D receptor gene polymorphisms and athletic performance in Chinese male youth soccer players by Shidong Yang, Wei Zhang, Meng Jia, Haichun Chen

“…One-way analysis of variance and Bonferroni’s post hoc test were implemented to analyze the differences in parameters among groups, and statistical significance was set at p ≤ 0.05. …”
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Computer vision applications for the detection or analysis of tuberculosis using digitised human lung tissue images - a systematic review by Kapongo D. Lumamba, Gordon Wells, Delon Naicker, Threnesan Naidoo, Adrie J. C. Steyn, Mandlenkosi Gwetu

“…Conclusion The literature indicates that post 1950s, TB was predominantly studied using animal models even though no animal model reflects the full spectrum of human pulmonary TB disease and does not reproducibly transmit Mtb infection to other animals (Hunter, 2011). …”
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