Thrombocytosis and bleeding in myeloproliferative neoplasms: exploring clinical diversity and risk of acquired von Willebrand syndrome—insights from a UK center by Giulia Simini, Andrew Innes, Saravanan Vinayagam, Golzar Mobayen, Nilanthi Karawitage, Simone Claudiani, Zain Odho, Mike Laffan, Deepa J. Arachchillage

“…Interestingly, we found moderate negative correlation between baseline VWF ristocetin/antigen and activated partial thromboplastin time (P = .02; r = −.37) and prothrombin time (P = .009, r = −.45), suggesting other potential coagulation imbalances associated with bleeding diathesis in MPNs. Post cytoreduction, there was a significant increase in mean VWF ristocetin/antigen ratio (P = .0009). …”
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A comparative bio-mechanical performance assessment of additively manufactured bone scaffolds using different beta Ti alloys and Gyroid based cellular structure by Mudassar Rehman, Yanen Wang, Kashif Ishfaq, Ray Tahir Mushtaq, Aqib Mashood Khan, Mohammed Alkahtani, Aamer Nazir, Maimoona Afzal

“…An exponential rise in demand for artificial implants has emphasized the need for novel biomaterials with good biocompatibility and mechanical properties comparable to human cortical and cancellous bone, to mitigate stress shielding and other post implantation challenges. This study investigated the processing performance of biomedical β-Ti alloys (Ti-12Ta-23Nb-24Zr, Ti-32Nb-25Zr) fabricated via Laser Powder Bed Fusion (L-PBF) under optimal working conditions. …”
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Metabolomics reveals key biomarkers for ischemic stroke: a systematic review of emerging evidence by Lu Ding, Lu Ding, Meiling Zhang, Baochao Fan, Fuyuan Deng, Zhenyuan Li, Yixuan Han, Yifan Wu, Jingchun Zeng, Jingchun Zeng, Liming Lu

“…Glycine-serine-threonine and valine-leucine-isoleucine pathways were significant in diagnosing IS and AIS, and in differentiating ischemic and hemorrhagic strokes, as well as identifying post-stroke depression and cognitive impairment.ConclusionThis study confirms the potential diagnostic and prognostic value of changes in amino acids and lipids, as well as other metabolites and metabolic pathways, in IS. …”
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MiR‐182‐3p targets TRF2 and impairs tumor growth of triple‐negative breast cancer by Roberto Dinami, Luca Pompili, Eleonora Petti, Manuela Porru, Carmen D'Angelo, Serena Di Vito, Angela Rizzo, Virginia Campani, Giuseppe De Rosa, Alejandra Bruna, Violeta Serra, Miguel Mano, Mauro Giacca, Carlo Leonetti, Gennaro Ciliberto, Madalena Tarsounas, Antonella Stoppacciaro, Stefan Schoeftner, Annamaria Biroccio

“…By performing a high‐throughput luciferase screening of 54 candidate miRNAs, we identified miR‐182‐3p as a specific and efficient post‐transcriptional regulator of TRF2. Ectopic expression of miR‐182‐3p drastically reduced TRF2 protein levels in a panel of telomerase‐ or alternative lengthening of telomeres (ALT)‐positive cancer cell lines. …”
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Dynamic changes of iron metabolism and the effectiveness of health education among apheresis donors in Guangzhou under the GLMM framework by CHEN Xiaowen, LI Fanhai, ZHONG Bi, LIU Guanghuan, CHEN Jinyan, WANG Hao, LI Shijie

“…After health education, Hb levels remained unchanged, but SF increased compared to pre-intervention levels (mean difference: -18.571, P<0.05), though a declining trend persisted compared to baseline (mean difference from baseline to post-intervention: 23.068,P<0.05). [Conclusion] Female and number of donations are primary factors contributing to SF reduction in apheresis donors. …”
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Study on Susceptibility and Infection Characteristics of Dengue Virus in Cells Sourced from Different Tissues of Tree Shrews by LIU Xin, QI Mengdi, WANG Wenguang, HAN Yuanyuan, LU Meili, LI Na, DAI Jiejie, LU Caixia

“…C6/36, Vero, A549, and BHK-21 cells (commonly used for DENV propagation) were used as positive controls. Over 6 days post-infection, cellular cytopathic effects were monitored at 12-hour intervals using an inverted microscope, viral RNA loads in cell lysates were quantified by real-time fluorescent quantitative PCR to generate proliferation curves, and viral titers were determined by plaque assay. …”
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Effects of integrating Feldenkrais method with dynamic neuromuscular stabilization exercises on clinical outcomes in older women with nonspecific chronic low back pain: A randomize... by Farzaneh Saki, Marziyeh Ziya

“…Assessments were conducted at baseline and post-intervention. Between-group differences were analyzed using analysis of covariance (ANCOVA) adjusted for baseline values, and paired t-tests were used to assess within-group changes (P≤0.05). …”
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A standardized method for vertical sleeve gastrectomy bariatric surgery investigations in cancer by Arvind V. Ramesh, Sydney C. Joseph, Margaret S. Bohm, Emily W. Grey, Joel H. Elasy, Brianne M. Hibl, Oluwatosin T. Asunloye, Ki-Suk Kim, Teri D. Doss, Joseph F. Pierre, Katherine L. Cook, Liza Makowski, Liza Makowski, Liza Makowski, Laura M. Sipe

“…This VSG protocol includes stringent pre- and post-operational measures to reduce stress-associated weight loss in obese mice to achieve rigorous and reproducible bariatric surgery-associated weight loss. …”
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Chronic lung tissue deposition of inhaled polyethylene microplastics may lead to fibrotic lesions by Wonkyun Jung, Mi-Jin Yang, Min-Sung Kang, Jin-Bae Kim, Kyung-Sik Yoon, Taekyung Yu, Cheolho Yoon, Hae Won Yang, Seong-Jin Choi, Eun-Jung Park

“…Given the expected increase in exposure to airborne microplastics, we here aimed to assess the acute and subchronic toxicity of inhaled polyethylene microplastics (PE-MPs). At 24 h post-exposure (0, 125, 250, and 500 μg/lung), PE-MPs were found within alveolar macrophages in the lungs of PE-MP-treated mice, along with an increase in the total number of pulmonary cells and higher pulmonary levels of LDH, CXCL-1, and CCL-2. …”
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The Efficacy of Fractional CO2 Laser in the Treatment of Genitourinary Syndrome of Menopause: A Large Prospective Observational Study by Violante Di Donato, Ottavia D'Oria, Andrea Giannini, Maria Scudo, Carmel Sher, Margherita Fischetti, Giorgia Perniola, Innocenza Palaia, Marco Monti, Ludovico Muzii, Pierluigi Benedetti Panici

“…Results: Data indicated a significant improvement of MBS (vaginal itching (p < 0.0001), post-coital vaginal bleeding (p < 0.002), vaginal dryness (p < 0.0001), dyspareunia (p < 0.0001) and dysuria (p < 0.0001), higher Vaginal Health Index Score (VHIS) (4.1 ± 1.21; 95% CI = 3.84–4.35) and reduces pH (–0.53 ± 0.24; 95% CI = 0.48–0.58) after CO2 laser treatment. …”
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Exercise-induced irisin ameliorates cognitive impairment following chronic cerebral hypoperfusion by suppressing neuroinflammation and hippocampal neuronal apoptosis by Weiping Xiao, Yibing Yang, Lu Bai, Peixuan Yang, Runze Li, Daizhi Yang, Fanying Li, Lingzhi Quan, Qiupeng Liang, Yan Yan, Tiewei Qi, Feng Liang

“…Additionally, expression of integrins αV and β5 in hippocampal neurons, microglia, and astrocytes decreased post-CCH. FAE effectively enhanced both peripheral and central irisin expression. …”
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Prenatal carrier screening for spinal muscular atrophy among pregnant Thai women by Chayada Tangshewinsirikul, Panyu Panburana, Maneerat Prakobpanich, Takol Chareonsirisuthigul, Donniphat Dejsuphong, Thipwimol Tim-Aroon, Chaiyos Khongkhatithum, Thanyachai Sura, Atchara Tunteeratum, Duangrurdee Wattanasirichaigoon

“…Only those having the test done and undergoing post-test counseling were asked to complete the questionnaire: Section IV—attitudes toward the screening process.ResultsThe preexisting knowledge about SMA was low (30.8%). …”
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Investigation of SiC MOSFET Structures for Surge Robustness in the Third Quadrant Under Various <inline-formula><tex-math notation="LaTeX">$V_{\text{GS}}$</tex-math></inline-formul... by Xinbin Zhan, Yanjing He, Xi Jiang, Hao Yuan, Qingwen Song, Xiaoyan Tang, Xiaowu Gong, Yuming Zhang

“…SiC JBSFET operates in a unipolar conduction mode prior to the surge current density threshold of 998.3 <inline-formula><tex-math notation="LaTeX">$\mathbf {A}/\mathbf {cm}^{\mathbf {2}}$</tex-math></inline-formula>, after which it transitions to a post-bipolar conduction mode, similar to SiC JBS diode. …”
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Knockout of thyroid hormone receptor alpha a (thraa) enhances cardiac regeneration in zebrafish through metabolic and hypoxic regulation by Man Yee Cheung, Chunmei Jiang, Imtiaz Ul Hassan, Hui Wang, Donghao Guo, Daniel Wuyang Dio, Huan Yan, Jianmin Sun, Xufeng Qi, Dongqing Cai, Wei Ge, Sheue-yann Cheng, Wai-Yee Chan, Hui Zhao

“…However, a comprehensive understanding of TH and its receptors, thyroid hormone receptors (TRs), orchestrating with other regulatory processes for heart regeneration, such as the hypoxia signaling pathway and post-injury metabolic switches, remains elusive. …”
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Effectiveness and Safety of DLBS3233 in Newly Diagnosed Type 2 Diabetes Mellitus: A 12-week Clinical Trial by Heri Nugroho, Nurmilawati Nurmilawati, Diana Novitasari, Lidia Rombeallo, Rambu Farah Effendi, Reski Reski, Intan Surayya, Nugroho Agung Daryanto, Solomon Putera, Raymond Rubianto Tjandrawinata

“…Various metabolic parameters, including fasting and post-meal plasma glucose levels at two hours, fasting insulin level, HOMA-IR, adiponectin level, lipid profile, superoxide dismutase (SOD) activity, GLUT-4 concentrations, and body weight measurements, were assessed at baseline, Week 6, and Week 12. …”
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Acute suicidal ideation in context: highlighting sentiment-based markers through the diary entries of a clinically depressed sample by Damien Lekkas, Amanda C. Collins, Michael V. Heinz, Tess Z Griffin, Arvind Pillai, Subigya K. Nepal, Daniel M. Mackin, Andrew T. Campbell, Nicholas C. Jacobson

“…Entry results were grouped based on phase trajectory type, and the Kruskal-Wallis test was employed with post-hoc multiple hypothesis correction to statistically compare SEANCE features between all group pairs. …”
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Dexmedetomidine protects against N-Nitrosodiethylamine induced acute hepatic damage by modulating autophagy and apoptosis through SIRT1 by Ruixin Wu, Sailan Tang, Aoxue Xu, Qi Xue, Shuwen He, Qizhi Liao, Chanjuan Chen, Dachen Zhou, Xianwen Hu, Nianliang Zhang, Gang Li, Ye Zhang, Chunxia Huang

“…Histopathological changes, inflammatory and oxidative responses were assessed 24 h post-DEN exposure. The roles of autophagy and SIRT1 were further examined using hepatocyte-specific SIRT1 knockout mice (SIRT1f/fALBcre+/−). …”
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Antimicrobial Susceptibility Patterns of Haemophilus influenzae and Streptococcus pneumoniae in Respiratory Tract Infections: A Retrospective Observational Real-world Database Stud... by V Balaji, Vishal Singh, Puja Nijhara, Krunal Dalal, Sanket Sawant, Sebin Thomas, Lindsey Teichman, Shilpa Patkar

“…The susceptibility patterns of both organisms remained consistent during the pre- and post Coronavirus Disease-2019 (COVID-19) pandemic periods, except for H. influenzae to cefixime {94.0% (n=252) to 63.7% (n=137)}. …”
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Randomised trial of assessing diagnostic yield in transbronchial biopsy with a guide sheath by Hao-Chun Chang, Yao-Wen Kuo, Ching-Kai Lin, Lih-Chyun Chang, You-Yi Chen, Ching-Yao Yang, Jung-Yien Chien, Chia-Lin Hsu, Tzu-Hsiu Tsai, Chao-Chi Ho, Jin-Yuan Shih, Chong-Jen Yu

“…The histopathology, cytology and microbiology yield rates, as well as procedure time and post-procedure adverse events, of the two groups were compared. …”
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A systematic review of histopathological assessments in Peste des petits ruminants by Saira Awaz, Iram Maqsood, Hanif Ur Rahman, Baitullah Khan, Gul Muhammad, Imtiaz Ali Shah, Asima Azam, Ayesha Hidayat, Almas Faryal Nizam

“…Information were the authors and publication year, research methodology and histopathological results linked to PPR, factors influencing these outcomes (including treatment type, immunisation technique, and time post-infection), and the authors' conclusions and recommendations. …”
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