Refining precision prognostics in multiple myeloma: loss of miR-221/222 cluster in CD138+ plasma cells results in short-term progression and worse treatment outcome by Konstantinos Soureas, Panagiotis Malandrakis, Maria-Alexandra Papadimitriou, Christos Minopoulos, Ioannis Ntanasis-Stathopoulos, Christine-Ivy Liacos, Maria Gavriatopoulou, Efstathios Kastritis, Meletios-Athanasios Dimopoulos, Andreas Scorilas, Margaritis Avgeris, Evangelos Terpos

“…Our study identified the loss of miR-221/222 cluster as a powerful independent predictor of patients’ post-treatment progression, ameliorating prognosis and supporting precision medicine in MM.…”
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Rearrangement of Immunoglobulin Genes in Tumor Cells of Patients with Primary Mediastinal (Thymic) Large B-Cell Lymphoma by YaK Mangasarova, YuV Sidorova, AU Magomedova, BV Biderman, EE Nikulina, AB Sudarikov, AM Kovrigina, SK Kravchenko

“…Primary mediastinal (thymic) large B-cell lymphoma (PMBCL) is a malignant tumor with large atypical lymphoid cells expressing post-germinal differentiation markers. Rearrangements of immunoglobulin genes in PMBCL are revealed in 30–65 % of cases. …”
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Comparison of Effects of Glucagon-Like Peptide-1 Receptor Agonists Compared to Long-Acting Insulin, Added to Oral Anti-Diabetic Agents on Self-Management Behaviors, Anxiety, and Sl... by Song X, Yang X, Liu Q, Bian X, Gao L, Tao J

“…Notably, the oral medication combined with GLP-1RAs group demonstrated improved dietary control, medication adherence, anxiety and actual sleep time compared to the oral medication combined with long-acting insulin group.Conclusion: In this 3-month study, there were statistically significant differences in HbA1c, post-prandial glucose, weight, for self-management behaviors, for dietary control, medication adherence, anxiety, and actual sleep time in T2DM patients. …”
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Successful application of dietary ketogenic metabolic therapy in patients with glioblastoma: a clinical study by Andreas Kiryttopoulos, Athanasios E. Evangeliou, Irene Katsanika, Ioannis Boukovinas, Nikolaos Foroglou, Basilios Zountsas, Angeliki Cheva, Vaios Nikolopoulos, Thomas Zaramboukas, Tomas Duraj, Thomas N. Seyfried, Martha Spilioti

“…Of these patients, one patient passed away 43 months after diagnosis, achieving a survival of 3 years; another passed away at 36 months, narrowly missing the 3-year survival mark; and one is still alive at 33 months post-diagnosis but has yet to reach the 3-year milestone and is, therefore, not included in the final survival rate calculation. …”
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RETRACTED ARTICLE: Tamoxifen suppresses brain metastasis of estrogen receptor-deficient breast cancer by skewing microglia polarization and enhancing their immune functions by Shih-Ying Wu, Sambad Sharma, Kerui Wu, Abhishek Tyagi, Dan Zhao, Ravindra Pramod Deshpande, Kounosuke Watabe

“…For clinical validation study, brain metastasis specimens from pre- and post-menopause breast cancer patients were examined for microglia polarization by immunohistochemistry. …”
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SARS-CoV-2 (MA10) Infection Aggravates Cerebrovascular Pathology in Endothelial Nitric Oxide Synthase-Deficient Mice by Saifudeen Ismael, Meenakshi Umar, Blake Ouvrier, Gregory Hall, McKenzie Cummins, Arjun Sapkota, Grant Talkington, Amanda Louise White, Richard Milner, Damir B. Khismatullin, Gregory Bix

“…Mice were evaluated for weight loss, viral load, and markers of inflammation and senescence 3 days post-infection. eNOS^+/− mice showed more weight loss (~15%) compared to WT mice (~5%) and increased inflammatory markers (<i>Ccl2</i>, <i>Cxcl9</i>, <i>Cxcl10</i>, <i>IL-1β</i>, and <i>IL-6</i>) and senescence markers (p53 and p21). …”
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Sugammadex versus neostigmine on postoperative adverse respiratory events in elderly patients undergoing lung resection: study protocol for a randomized controlled trial by Yuxin Wang, Xiang Li, Huimin Deng, Di Feng, Liuyuan Zhao, Feihong Lin, Tian Jin, Sheng Wang, Xin Lv, Juan Wei

“…The primary outcome is a composite of AREs occurring in the post-anaesthesia care unit (PACU). Secondary outcomes include time from neuromuscular to extubation, the composite of ARE and rescue measures, PACU length of stay, postoperative pulmonary and extra-pulmonary complications, unplanned intensive care unit (ICU) admission, chest drainage tube duration, hospital length of stay, and mortality. …”
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Ultra-endurance race performance and muscle mass as predictors of cognitive capacity by Deina Vilite, Diana Lismane, Jelena Raudeniece, Jelena Raudeniece, Linda Laizane, Linda Laizane, Gita Gersone, Gita Gersone, Ilze Barone, Ilze Barone, Ilze Justamente, Ilze Justamente, Kristiana Kovtuna, Kristiana Kovtuna, Bart Roelands, Bart Roelands, Bart Roelands, Maksims Zolovs, Maksims Zolovs, Maksims Zolovs, Dace Reihmane, Dace Reihmane

“…341 km over 18 h, with cognitive function assessed using a three-stage Stroop Test before, immediately after, and 24 h post-race. For each stage, results from the three time points were combined and analyzed using regression analyses to examine their relationship with various anthropometric, metabolic, and performance-related parameters.ResultsHigher average race speed was associated with improved simple reaction time, while longer race duration predicted better performance in more cognitively demanding tasks, such as inhibitory control. …”
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The advantages of artificial intelligence-assisted total hip arthroplasty: A randomized controlled trial followed by 12 months by Gang Zhang, Zixuan Liu, Diaodiao Wang, Zhuang Tian, Qi Yao

“…The operation time for AI-assisted total hip arthroplasty was 104.32 ± 18.10 min, which was shorter than that of the traditional two-dimensional X-ray planning group (P < 0.05). At 3 months post-operation, the grade of Harris score for hip function in the AI planning group was significantly better than that in the traditional two-dimensional X-ray planning group (P < 0.05). …”
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The Surrealism of Men’s Rights Discourses on Sexual Assault Allegations: A Feminist Reading of Kafka’s The Trial by Meg Danielle Lonergan

“… Being a feminist in the contemporary Canadian context, post-Ghomeshi, can lead to existential crises. In this paper I investigate this relationship of feminist activism and reality, men’s rights activism (MRA) and surrealism, and the Absurd via the work of surrealist novelist Franz Kafka. …”
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The value of microvascular obstruction according to contrast-enhanced cardiac magnetic resonance imaging in assessing the prognosis of patients with acute ST-segment elevation myoc... by M. A. Terenicheva, R. M. Shakhnovich, O. V. Stukalova, D. V. Pevzner, I. S. Yavelov, Yu. O. Shalaginova, S. K. Ternovoy

“…MVOs was associated with post-infarction LV aneurysm. An increase in MVO size correlated with a decrease in LVEF and an increase in LVEDV both in the acute period and one year after MI.…”
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Effects of Nontraditional Division III Lacrosse Participation on Movement Pattern Quality and Dynamic Postural Control by Christopher Rosenborough, Sean M. Collins, Edward Smith, Thomas G Bowman

“…Outcome measures included individual Functional Movement Screen™ (FMS™) scores, self-reported perceived movement pattern quality scores, lower and upper extremity Y-Balance Test (YBT) measurements, and active dorsiflexion range of motion (ROM) before the start and again at the end of the fall lacrosse season. Pre- and post-season measurements were assessed using paired t-tests and chi-squared analyses…”
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Carotenoid Supplementation in Poultry Nutrition: Canthaxanthin’s Role in Improving Egg Yolk Pigmentation and Production Efficiency by Baluh Medyabrata Atmaja, Rifqi Hidayatulloh, Muhammad Irvan Ali, Amelia Lulu Rosalin Hutabarat, Alief Rahmania Safitri, Abdul Muta Ali, Wenni Meika Lestari

“…Duncan’s multiple range test was used post hoc to identify significant differences between treatment groups. …”
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Modelling dynamic transitions in neurological functional disability in patients with intracerebral haemorrhage: a prospective cohort study using a multistate Markov model by Ke Ma, Yang Song, Zheng Yan, Dezhi Kang, Shuna Huang, Shaowei Lin, Siying Wu, Minghuan Liu, Shiying Lin, Jialiang Xu, Xiaowan Zhou, Hang Zeng, Huangyuang Li, Xiao-Xu Xie

“…A person with no disability post-ICH can expect to spend 19.42 (12.87~29.30) months in that state, and 9.99 (8.39~11.89) months in state S2 and 8.87 (7.79~10.09) months in state 3 during their lifetime.Conclusions In the year following treatment and discharge, the neurological functional disability of most patients with ICH tends to remain stable. …”
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Chemical constitutes and anti-hypertension potential of Gaocha (Acer ginnala Maxim) in spontaneously hypertensive rat by Wenzhao Wang, Jing Ma, Yafeng Ma, Yumeng Bao, Zijiang Long, Shengping Lei, Yan Xu, Qianying Dai, Liping Gao, Haiyan Wang

“…The results of tail artery systolic blood pressure (SBP) showed the Gaocha-treated groups had significantly lower SBP than the model group. Post-treatment abdominal aorta blood samples showed that the serum PGI2, Angiotensin II, ET, and NO levels in Gaocha-treated groups were significantly higher than these in the model group. …”
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Preliminary evaluation of a raceway photobioreactor for mass culture of microalgae for Peruvian scallop, Argopecten purpuratus postlarvae by Rafael Octavio Crisóstomo-Gamboa, Rafael Octavio Crisóstomo-Gamboa, Renzo Pepe-Victoriano, Renzo Pepe-Victoriano, Jordan I. Huanacuni, Jordan I. Huanacuni, Jordan I. Huanacuni, Sheda Méndez-Ancca, Sheda Méndez-Ancca, Sheda Méndez-Ancca, Olger Acosta-Angulo, Edgardo Cruces

“…Feeding microalgae during the larval and post-larval stages of bivalve mollusks is necessary to overcome the high mortality rates that occur during metamorphosis. …”
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Accelerated Non-Contrast-Enhanced Three-Dimensional Cardiovascular Magnetic Resonance Deep Learning Reconstruction by Sukran Erdem, Orhan Erdem, M. Tarique Hussain, F. Gerald Greil, Qing Zou

“…For a statistical comparison of image quality across these three image sets, the nonparametric Friedman test was performed, followed by Dunn's post-hoc test. …”
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Baseline functional connectivity of the basal forebrain-cortical circuit predict taVNS treatment response in primary insomnia: a randomized controlled trial and fMRI study by Meng Qi, Yiting Huang, Runru Mai, Zhaoxian Yan, Biyun Xu, Bo Liu, Yue Zhang

“…FC of the bilateral BF subregions (Ch_123, Ch_4) was analyzed, and pre-to-post intervention changes in FC and clinical scores were compared between groups. …”
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A New Method for Inducing Mental Fatigue: A High Mental Workload Task Paradigm Based on Complex Cognitive Abilities and Time Pressure by Lei Ren, Lin Wu, Tingwei Feng, Xufeng Liu

“…Furthermore, reaction times in the psychomotor vigilance test (PVT) were significantly prolonged, and the number of lapses significantly increased between pre- and post-task assessments. <b>Conclusions</b>: The BS task paradigm based on complex cognitive abilities and time pressure could effectively induce an HMW state. …”
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Measurable residual disease in hematologic malignancies: a biomarker in search of a standard by Namrata S. Chandhok, Mikkael A. Sekeres

“…Further, it can be used to monitor disease in both pre- and post-transplant settings, enabling earlier relapse detection before clinical or routine laboratory signs of disease appear. …”
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