Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial. by John A Todd, Marina Evangelou, Antony J Cutler, Marcin L Pekalski, Neil M Walker, Helen E Stevens, Linsey Porter, Deborah J Smyth, Daniel B Rainbow, Ricardo C Ferreira, Laura Esposito, Kara M D Hunter, Kevin Loudon, Kathryn Irons, Jennie H Yang, Charles J M Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I Tree, Mark Evans, Adrian P Mander, Simon Bond, Linda S Wicker, Frank Waldron-Lynch

“…Furthermore, there was a dose-dependent down modulation of one of the two signalling subunits of the IL-2 receptor, the β chain (CD122) (mean decrease = 58.0%, SE = 2.8%, range 9.8%-85.5%, n = 33), on Tregs and a reduction in their sensitivity to aldesleukin at 90 min and day 1 and 2 post-treatment. Due to blood volume requirements as well as ethical and practical considerations, the study was limited to adults and to analysis of peripheral blood only.…”
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Sex-Specific Associations Between Oral Function Impairment and Clinical Outcomes in Hospitalized Older Adults: A Retrospective Observational Study by Lee YY, Weng SC, Lee YS, Chou YY, Kuo FH, Yang SH, Yeh YH, Chu WM, Hsu CY, Lin SY, Lin CF

“…Yen-Yang Lee,1 Shuo-Chun Weng,1– 5 Yu-Shan Lee,1,6 Yin-Yi Chou,1,7 Fu-Hsuan Kuo,1– 3,6 Shu-Hui Yang,8 Ya-Hui Yeh,8 Wei-Min Chu,2– 4,9 Chiann-Yi Hsu,10 Shih-Yi Lin,1– 4,11,* Cheng-Fu Lin2,3,12,* 1Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan; 2Geriatrics and Gerontology Research Center, College of Medicine, National Chung Hsing University, Taichung, Taiwan; 3Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan; 4Institute of Clinical Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; 5Division of Nephrology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 6Department of Neurology, Neurological Institute, Taichung Veterans General Hospital, Taichung, Taiwan; 7Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 8Department of Nursing, Taichung Veterans General Hospital, Taichung, Taiwan; 9Department of Family Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 10Biostatistics Group, Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan; 11Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 12Health Management Center, Taichung Veterans General Hospital, Taichung, Taiwan*These authors contributed equally to this workCorrespondence: Shih-Yi Lin, Center for Geriatrics and Gerontology, Taichung Veterans General Hospital, Taichung, Taiwan, 1650 Taiwan Boulevard Sect. 4, Taichung, 407219, Taiwan, Tel +886-4-2359-2525 #83497, Fax +886-4-2359-5046, Email sylin@vghtc.gov.tw Cheng-Fu Lin, Health Management Center, Taichung Veterans General Hospital, Taichung, Taiwan, 1650 Taiwan Boulevard Sect. 4, Taichung, 407219, Taiwan, Tel +886-4-2359-2525 #83497, Fax +886-4-2359-5046, Email chengfue@gmail.comPurpose: Oral functional impairment is a critical factor influencing clinical outcomes in hospitalized older adults. …”
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Cortical asymmetry: catching an object in free fall Assimetria cortical: apreensão de um objeto em queda livre by Bruna Velasques, Sergio Machado, Cláudio Elidio Portella, Julio Guilherme Silva, Patrícia Terra, Camila Ferreira, Luis Basile, Mauricio Cagy, Roberto Piedade, Pedro Ribeiro

“…A two-way factor Anova was applied to compare pre and post moments related to the balls' drop and scalp regions (i.e., frontal and parieto-occipital cortices). …”
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Editorial by Rolando Medina Peña

“…Prácticamente la integración de estos estudios en proyectos de I+D+i se hace cada vez más necesaria desde los estudios ex-ante de formulación del proyecto, su seguimiento durante todo su ciclo y la necesaria evaluación ex-post. La investigación educativa debería ser abanderada de este enfoque, no se trata solamente de una noción para cerrar ciclos desde la generación del conocimiento hasta que se capitaliza en función de la sociedad. …”
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Abstract 232: Endovascular Thrombectomy for Distal Vessel Occlusions in Early vs Extended Time Window by Amol T. Mehta, Christopher M. Kellner, Tomoyoshi Shigematsu, Hazem Shoirah, Michael T. Caton, Thomas J. Oxley, Reade DeLeacy, J. Mocco, Johanna Fifi, Shahram Majidi

“…As expected, there was a striking difference seen in patients receiving IV thrombolysis between early (54.5%) and extended (4.5%) windows (χ²=48.48, p<0.001). Post‐operative hematoma also was not different between the early (23.8%) and extended (14.9%) windows (χ² = 0.69, p‐value = 0.40). …”
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Conocimientos, práctica y actitudes hacia la salud oral entre matronas de España by Yolanda Martínez-Beneyto, Andrea Poza Pascual, Cristina Carazo, Clara Serna-Muñoz, Amparo Pérez-Silva, Antonio José Ortiz-Ruiz

“…An initial questionnaire was administered to assess their knowledge and attitudes about oral health, followed by a lecture given by a dentist. Subsequently, a post-test was applied to measure the level of knowledge acquired. …”
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6-year treatment follow-up with an extended-release alkaline formulation (Sibnayal®) in primary distal renal tubular acidosis by Aurélia Bertholet-Thomas, Aurélie De Mul, Julie Bernardor, Gwenaëlle Roussey-Kesler, Ludmila Podracka, Robert Novo, François Nobili, Bertrand Knebelmann, Jérôme Harambat, Emilija Golubovic, Olivia Boyer, Massimo Di Maio, Mathilde Cailliez, Véronique Baudouin, Laure Chidler, Véronique Leblanc, Justine Bacchetta

“…Mean lumbar bone mineral density Z-score significantly increased from baseline (-1.1 ± 1.0) to EoF (-0.8 ± 1.0), p = 0.005, with significant improvement between baseline and EoF in pre- and post-pubertal patients (p = 0.035 and p < 0.001, respectively), whilst it was maintained in pubertal patients (p = NS). …”
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SUBSTANTIATION FOR PRINCIPLES OF AESTHETIC STOMATOLOGY by I.K. Lutskaya

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Enhancing impact toughness in 904L stainless steel welded joints using ultrasound-assisted laser welding without sacrificing the strength and ductility by Li Li, Ping Deng, Yuanbiao Tan, Wei Shi, Hao Fu, Shuang Hu, Xuanming Ji, Siyuan Wei, Fei Liu, Song Xiang

“…The impact mechanical properties of a 904L stainless steel plate after ultrasound-assisted laser welding were examined, with a focus on the post-weld microstructure. Experimental results demonstrate that ultrasonic assistance effectively refined the dendritic size, reduced element segregation along the interdendritic regions, as well as the second phase and the residual tensile stress in the weld seam. …”
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Endovascular Treatment in Stroke Patients of Working Age: A Multicenter Observational Study of Real-World Outcomes by Zhou Y, Mofatteh M, Zheng Z, Liu F, Zhou S, Ma J, Yan Z, Lai Y, Li W, Chen W, Abdalkader M, Regenhardt RW, Liu X

“…Modified thrombolysis in cerebral infarction (mTICI) score of 2b-3 was considered as successful recanalization. We used 3-months mRS post-EVT to evaluate the outcome; mRS of 0– 2 was defined as favorable outcome, whereas mRS of 3– 6 was considered unfavorable outcome.Results: The unfavorable outcome group consisted of 150 patients, and 159 patients were in the favorable outcome group. …”
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Subfoveal Choroidal Thickness After Successful Retinal Detachment Repair with Persistent Subretinal Fluid at the Macula by Mansour AM, Parodi MB, Uwaydat SH, Lima LH, Charbaji S, Casella AM, López-Guajardo L, Belotto S, Wu L, Schwartz SG, Smiddy WE, Hassoun MM, Pérez-Salvador García E, Mansour HA, Elnahry AG, Hamam RN

“…SFCT at 1-month was not different between pSRF (237.5± 77.2 μm) and no pSRF (213.7± 72.1 μm) in PPV groups (p=0.2).Conclusion: SFCT post PPV appeared similar in eyes with or without pSRF. …”
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Ashwagandha (Withania somnifera (L.) Dunal) for promoting recovery in long covid: protocol for a randomised placebo-controlled clinical trial (APRIL Trial) by Kamlesh Khunti, Shailen Sutaria, Poppy Alice Carson Mallinson, Sanjay Kinra, Rohini Mathur, Anoop SV Shah, Tim Clayton, Judith Lieber, Alexander Perkins, Shereen Allaham, Nick Birk, Lily Hopkins, Manisha Joshi, Mahesh Mathpathi, Arandeep Dhillon, Sidra S Beg, Archie Khan, Vanessa TW Kam, Galib R, S Rajagopala, Amarjeet Bhamra, Geetha Krishnan G Pillai, Tanuja Nesari

“…The primary outcome of the Post-COVID Functional Status Scale score at 3 months will be assessed by baseline-adjusted ordinal logistic regression, according to a pre-published statistical analysis plan. …”
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An overview on ceramic multi-material additive manufacturing: progress and challenges by Yifei Li, Annan Chen, Jin Su, Yinjin Li, Yue Zhang, Zhaoqing Li, Shixiang Zhou, Jinhan He, Zhaowenbo Cao, Yusheng Shi, Jian Lu, Chunze Yan

“…In this review, we discuss and summarize the research status of ceramic MMAM technology from the perspectives of feedstock selection, printing process, post-processing, component performance, and application. …”
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Myocardial native T1 and extracellular volume measurements at 5T: Feasibility study and initial experience by Yubo Guo, Lu Lin, Keting Xu, Shihai Zhao, Gan Sun, Yuyan Chen, Ke Xue, Yuxin Yang, Shuo Chen, Yan Zhang, Yanjie Zhu, Yining Wang

“…T1 mapping was acquired using a motion-corrected modified Look–Locker inversion recovery sequence [5(3)3 scheme for pre-contrast, (4(1)3(1)2) scheme for post-contrast] in three short-axis planes (base, middle, and apex). …”
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The effects of dance intervention on clinical symptoms and cognitive deficits in hospitalized patients with chronic schizophrenia: a randomized controlled trial by Gujing Li, Hui He, Kexin Gao, Yuanyuan Yu, Yayun Liu, Tianhuan Li, Ping Xi, Frank Pollick, Jing Lu, Lixue Yin, Dezhong Yao, Mingjun Duan, Li Mi, Cheng Luo

“…Results The PANSS total scores (P < 0.01**), PANSS negative scores (p < 0.001**), NOISE score (p < 0.001**), MCCB cognitive scores, and physiological indicators were significantly changed after the intervention in both groups compared with baseline. Post-hoc analysis revealed notable improvements in the specific cognitive subscales, including the Continuous Operation Test-identical pairs (CPT-IP, p = 0.026*), Hopkins Verbal Learning Test-Revised (HVLT-R, p = 0.019*) and the physiological indicators Cystatin C (CYS-C, p = 0.037*) in the dance intervention group. …”
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Comparative transcriptomics in B73-teosinte near-isogenic maize lines reveals key defense signaling and phytoalexins in response to Cercospora zeina infection by Xiaomeng Sun, Xiaomeng Sun, Ruiyu Zhang, Ruiyu Zhang, Zongping Wang, Zongping Wang, Haotian Zhang, Haotian Zhang, Hairun Wen, Hairun Wen, Junli Zhang, Naibin Yu, Naibin Yu, Zhe Wang, Zhe Wang, Huanhuan Tai, Huanhuan Tai, Qin Yang, Qin Yang

“…Here we conducted transcriptome analyses on leaves from a pair of B73-teosinte near-isogenic lines (NILs) with contrasting Qgls8 alleles infected with C. zeina at 0, 4, 8, and 12 hours post inoculation (hpi). A total of 1225 up-regulated genes (URGs) were identified in the resistant line Qgls8-R compared with the susceptible line Qgls8-S across the four time points. …”
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Perampanel for alleviation of secondary injury in traumatic brain injury (PEACE-TBI): a protocol for a phase-II multicentre randomised clinical trial by Ryota Tamura, Yuki Kuranari, Yukina Morimoto, Masahiro Toda, Tokunori Kanazawa, Makoto Inaba, Ryo Yamamoto, Koichiro Homma, Takahiro Shoji, Junichi Sasaki, Masayuki Shimizu, Masato Nakaya, Satoshi Terao, Ryota Sasao, Makoto Katayama, Koichi Ueno, Yumiko Oishi, Akiyoshi Nakamura, Yo Kikuo, Ryosuke Murakami, Sota Wakahara, Konosuke Ishikawa, Kenzo Kosugi, Tatsuro Ozaki

“…The antiepileptic drugs can be increased, changed or added as necessary if early post-traumatic seizures are observed. The primary outcome is favourable neurological outcome, defined as a Glasgow Outcome Scale Extended score of ≥5 at 90 days after the TBI diagnosis, which will then be compared between the groups through an intention-to-treat analysis.Ethics and dissemination The present study has been approved by the Certified Review Board of Keio at the principal institution (approval number: N20240004). …”
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Ornidazole-Induced Liver Injury: The Clinical Characterization of a Rare Adverse Reaction and Its Implications from a Multicenter Study by Ali Rıza Çalışkan, Ilker Turan, Sezgin Vatansever, Jasmin Weninger, Emine Türkmen Şamdancı, Ayşe Nur Akatli, Elvan Işık, Esra Durmazer, Ayşenur Arslan, Nilay Danış, Hüseyin Kaçmaz, Sedat Cicek, Osman Sağlam, Dilara Turan Gökçe, Derya Arı, Sevinç Tuğçe Güvenir, Serkan Yaraş, Cumali Efe, Meral Akdoğan Kayhan, Murat Harputluoğlu, Ali Canbay, Ulus Salih Akarca, Zeki Karasu, Ramazan Idilman, Fulya Günşar

“…Corticosteroids were used in 24.8% of cases (n = 25) and were associated with higher ANA positivity and a 20% (n = 5) relapse rate post-discontinuation. Recovery was achieved in 87.7% of cases (n = 88), while 7.9% of cases (n = 8) required liver transplantation and 4% (n = 4) died. …”
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Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation by Lifeng Gan, Lifeng Gan, Lifeng Gan, Peiyue Luo, Peiyue Luo, Peiyue Luo, Junrong Zou, Junrong Zou, Wei Li, Wei Li, Wei Li, Qi Chen, Qi Chen, Qi Chen, Le Cheng, Le Cheng, Le Cheng, Fangtao Zhang, Fangtao Zhang, Fangtao Zhang, Haidong Zhong, Haidong Zhong, Haidong Zhong, Yiran Lu, Liying Zheng, Biao Qian, Biao Qian

“…Long-stranded non-coding RNAs (lncRNAs), defined as non-coding RNAs exceeding 200 nucleotides in length, regulate various cellular processes by modulating gene expression at transcriptional, post-transcriptional, and epigenetic levels. Evidence suggests that lncRNAs can be regulated by HIF at the transcriptional level. …”
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Do bulls experience pain or stress during electroejaculation? Evidence from electroencephalography, behavioral, hormonal, and metabolite profiling by Ubedullah Kaka, Nurhusien Yimer Degu, Pavan Kumar, Abubakar Ahmed Abubakar, Yong-Meng Goh, Muhammad Waseem Aslam, Khaleeq Ur Rehman Bhutto, Muhammad Abdul Basit, Wasim S. M. Qadi, Norazlan Mohmad Misnan, Ahmed Mediani, Khor Kuan Hua

“…Results: EE induced significant increases (p < 0.05) in stress hormones at ejaculation, which gradually returned to baseline 20 min post-procedure. EEG metrics, such as MF and Ptot, significantly increased during EE (p < 0.05), indicating heightened cortical activity associated with nociception. …”
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