Efficacy and safety of doravirine/lamivudine/tenofovir disoproxil fumarate in HIV treatment: a real-world single-center study in China by Aixin Li, Letian Liu, Hongwei Zhang, Xi Wang, Zaicun Li, An Liu, Lili Dai, Jingji Zhang, Yue Gao, Jiangzhu Ye, Jianwei Li, Lijun Sun, Lijun Sun

“…Among patients with central nervous system (CNS) symptom, both the Pittsburgh Sleep Quality Index (PSQI) and the Hospital Anxiety and Depression Scale (HADS) scores, as well as the proportion of patients with scores greater than 7 points, decreased significantly post-switch (p < 0.05).ConclusionWe provided an observational report on the effectiveness and safety of the short-term use of DOR/3TC/TDF in routine clinical practice.…”
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Durability and effectiveness of dual vs. triple therapy and tablet simplification in ART: findings from the Italian MOSAICO study by Daniele Mengato, Giacomo Berti, Giacomo Berti, Andrea Francavilla, Silvia Michielan, Linda Cappellazzo, Laura Agnoletto, Maria Chiara Silvani, Marco Chiumente, Dario Gregori, Maria Mazzitelli, Francesca Venturini, Anna Maria Cattelan, the SIFaCT MOSAICO Study Group, Salvatore Agosta, Marina Allegrini, Marina Assirelli, Maria Rita Badagliacca, Giuliana Battagin, Giorgia Bo, Jenny Bolcato, Cristina Bitello, Raffaella Binazzi, Arianna Cadeddu, Marila Camboni, Francesca Cammalleri, Anila Corja, Marta Cappellini, Linda Cappellazzo, Claudia Ciraldo, Nicolò de Gennaro, Maria Dell'Aera, Silvia Enisci, Giuseppina Emanuela Fassari, Sara Ferrari, Gabriele Fabbri, Michela Falciani, Roberta Fraccaroli, Anna Gagliardi, Giovanna Gandini, Veronica Gonzi, Giuseppe Greco, Clara La Bruna, Stefano Loiacono, Kety Luzi, Eleonora Magistrelli, Marina Malena, Paola Marini, Andrea Misin, Valentina Mureddu, Arianna Orcesi, Simonetta Palazzini, Clara Palmieri, Giulia Piazza, Mariantonietta Piccoli, Fabio Pieraccini, Francesco Pomarico, Giovanna Rametta, Roberta Rampazzo, Lucia Rossi, Aurora Scazzina, Chiara Scolamacchia, Martina Tegon, Sara Tordi, Dario Ventura, Salvatore Vitale, Anastasia Zoffoli

“…People were followed-up up to 48 months post-switch. Comparative analyses assessed virological suppression (HIV-RNA <50 copies/mL), CD4+ T cell count, CD4/CD8 ratio, and treatment discontinuation. …”
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Persistence of SARS-CoV-2-IgG antibody durability in convalescent COVID-19 patients 6 months after the natural infection by Qiaoli Hua, Peng Zhang, Shengle Qin, Bing Feng, Bin Xiao, Guangjuan Zheng, Taoyu Ye, Danwen Zheng, Danwen Zheng, Jiayi Mo, Yuntao Liu, Yuntao Liu, Yun Cai, Xiaohua Xu, Xiaohua Xu, Ji Hu, Banghan Ding, Banghan Ding, Yingrui Li, Yingrui Li, Yingrui Li, Yingrui Li, Jianwen Guo, Jun Wang, Jun Wang, Jun Wang, Hongzhi Cao, Hongzhi Cao, Hongzhi Cao, Zhongde Zhang, Zhongde Zhang, Zhongde Zhang

“…Through a generalized linear model and mediation analysis, older age, independent of disease severity, was found to be a key independent factor associated with higher post-infection RBD-IgG titers. Hypothesis-generating analyses through a genome-wide association study revealed that rs117929853 (p = 3.6 × 10−8), a variant located upstream of the xanthine dehydrogenase gene (XDH), was significantly associated with RBD-IgG persistence, suggesting a potential mechanistic link between XDH polymorphisms and sustained humoral immunity.ConclusionThe study underscores the significant role of age and genetic factors in the pathogenesis of sustained humoral immunity, which requires further validation.…”
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Prevalence of self-reported lifetime medical diagnosis of depression in Brazil: analysis of data from the 2019 Brazilian National Health Survey by Tiago N Munhoz, Rita Mattiello, Camila Ospina Ayala, Flaviana Freitas Pedron, Isabel Cristina Schutz Ferreira, Laura Lessa Gaudie Ley, Luciana Medeiros Paungartner, Maiara da Silva Martins, Maria Amélia Bagatini, Naycka Onofre Witt Batista, Priscila Oliveira Machado Cecagno, Sara Kvitko de Moura, Sergio López Tórrez, Iná S. Santos

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Milk fatty acids and rumen composition as proxy measures of enteric methane by Timothy P. Bilton, Sharon M. Hickey, Arjan Jonker, Kathryn McRae, Melanie K. Hess, Benjamin J. Perry, Brooke Bryson, Hannah Henry, Wendy Bain, Fern Booker, Barry Veenvliet, Jacqueline Peers-Adams, Gerrard Pile, Erin Waller, Peter H. Janssen, Kathryn M. Tiplady, Peter Reid, Stefan Muetzel, Michael Agnew, Ken G. Dodds, John C. McEwan, Suzanne J. Rowe

“…Four hundred genotyped lactating ewes from a sheep research flock bred specifically for high and low-methane emissions had methane measured and rumen and milk samples collected approximately 6 wk post-lambing across 4 lactation years. Rumen samples were processed to generate VFA and metagenomic profiles of the rumen microbial community, and fatty acid profiles and mid-infrared spectra were generated for the milk samples. …”
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Development mechanism and practical significance of deep coalbed methane (coal rock gas) infiltration and displacement by Lihong ZHOU, Xia YAN, Hongtao LIU, Xianyue XIONG, Feng WANG, Shuguang LI, Jiyuan ZHANG, Chuanqing LIU, Xiong HU, Pu YUAN, Qianli MA, Xueguang ZHU

“…For 2 nm pores under reservoir and post-fracturing pressure conditions, strong hydrophilic (30° contact angle) and weakly hydrophilic (70°) pores generated capillary forces exceeding 40.1 MPa and 15.8 MPa, respectively, creating intense imbibition driving forces. …”
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Clinical benefit of tafasitamab plus lenalidomide in relapsed or refractory diffuse large Bcell lymphoma: real-world data from the EarlyMIND study by Gabriel Brisou, Jérôme Paillassa, Sophie Bernard, Olivier Tournilhac, Luc-Matthieu Fornecker, Frédéric Maloisel, Lauris Gastaud, Eric Durot, Adrian Tempescul, Thorsten Braun, Vadim Ivanov, Brieuc Cherel, Caroline Serrier, Jeremy Delage, Abderrazak El Yamani, Baptiste Delapierre, Laure Lebras, Elsa Lestang, Camille Villesuzanne, Philippe Agape, Guillaume Escure, Ludovic Fouillet, Christophe Nicol, Gaëlle Olivier, Anthony Levy, Anne-Sophie Le Bris, Ophélie Cassuto, Laura Jacquemelle, Corinne Haioun, Charles Herbaux

“…Outcomes were analyzed overall and according to number of previous lines. Post hoc analyses were conducted on subgroups based on prognostic factors, performance status, primary refractoriness, cell of origin, and treatment response. …”
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Protective role of anti-SARS-CoV-2 antibody responses against vital organ related long COVID symptoms by Jhosiene Yukari Magawa, Lucas Cauê Jacintho, Marcelo Alves Ferreira, Jamille Ramos Oliveira, Rafael Rahal Guaragna Machado, Andreia Kuramoto Takara, Renata Moreno Lima de Oliveira, Ariane Cesario Lima, Greyce Luri Sasahara, Flávia Lopes Adami, Giuliana Xavier Medeiros, Juliana de Souza Apostolico, Edgar Ruz Fernandes, Danielle Bruna Leal de Oliveira, Edison Luiz Durigon, Pedro Giavina Bianchi, Silvia Beatriz Boscardin, Daniela Santoro Rosa, Edecio Cunha-Neto, Jorge Kalil, Verônica Coelho, Keity Souza Santos

“…We studied a cohort of 137 convalescents following predominantly mild COVID-19 during the first pandemic wave (2020) and up to one-year post-infection. We found 45% of LC cases that were associated with a greater number and duration of acute-phase symptoms. …”
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Time dependency of thrombectomy for large artery atherosclerosis versus cardioembolic stroke subtypes: evidence from the ANGEL-ACT registry by Yue Yin, Hanlin Chen, Anxin Wang, Anxin Wang, Anxin Wang, Xiaoli Zhang, Xiaoli Zhang, Xiaoli Zhang, Miao Li, Ligang Song, Ligang Song, Ligang Song, Baixue Jia, Baixue Jia, Baixue Jia, Ning Ma, Ning Ma, Ning Ma, Dapeng Mo, Dapeng Mo, Dapeng Mo, Xuan Sun, Xuan Sun, Xuan Sun, Feng Gao, Feng Gao, Feng Gao, Yiming Deng, Yiming Deng, Yiming Deng, Zhongrong Miao, Zhongrong Miao, Zhongrong Miao

“…Methods: Study participants were selected from the Endovascular Treatment Key Technique and Emergency Workflow Improvement of Acute Ischemic Stroke Registry to conduct a post-hoc analysis of a prospective, observational study. …”
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Multiomics analysis unveils key biomarkers during dynamic progress of IAV infection in mice by Huan Lei, Huan Lei, Huan Lei, Yixi Xu, Yixi Xu, Yixi Xu, Hao Zhang, Hao Zhang, Hao Zhang, Bin Zhang, Wenjun Luo, Wenjun Luo, Wenjun Luo, Xiao Liu, Xiao Liu, Xiao Liu, Haijun Zhang, Haijun Zhang, Haijun Zhang, Jinming Yang, Jinming Yang, Jinming Yang, Wen Wen, Wen Wen, Wen Wen, Ping Wang, Ping Wang, Ping Wang, Shijun Xu, Shijun Xu, Shijun Xu

“…We employed the DIABLO multi-omics integration method to analyze dynamic changes in the lung transcriptome, metabolome, and serum metabolome from mild to severe stages of infection.ResultsOur analysis highlighted the critical importance of intervention within the first 6 days post-infection to prevent severe disease. We identified several novel biomarkers associated with disease progression, including Ccl8, Pdcd1, Gzmk, kynurenine, L-glutamine, and adipoyl-carnitine. …”
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Assessing environmental change and population declines of large wading birds in southwestern India by K.M. Aarif, Aymen Nefla, K.A. Rubeena, Yanjie Xu, Zakher Bouragaoui, M. Nasser, C.T. Shifa, T.R. Athira, K. Jishnu, Jasmine Anand, Seerangan Manokaran, P.P. Moosa, Anu Gopinath, Omer R. Reshi, K.M. Rajaneesh, H. Byju, Thadickal V. Joydas, Karuppasamy P. Manikandan, Mohd Irfan Naikoo, Christian Sonne, Sabir Bin Muzaffar

“…Densities of all the studied wader species decreased significantly from 2010 to 2019, with highest densities in agroecosystems or estuarine habitats and in post-monsoon seasons but lowest in mudflats and in monsoon seasons. …”
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Study on the risk factors for colorectal polyp recurrence: a cross-sectional retrospective cohort study by Fang Li, Fang Li, Mengge Lu, Mengge Lu, Bo Xu, Zheng Xiang, Zheng Xiang, Yuan Zhang, Yuan Zhang, Boran Cao, Xuewei Li, Xuewei Li, Yanan Wu, Yanan Wu, Rongrong Zheng, Rongrong Zheng, Qin Cai, Qin Cai, Jun Shen, Pengfei Xin, Pengfei Xin, Lianbo Xiao, Lianbo Xiao, Yanqin Bian, Yanqin Bian

“…The risk prediction model can be used to predict post-surgical recurrence of colorectal polyps with a sensitivity of 0.88 and specificity of 0.56. …”
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Overdose education and naloxone distribution in jails: Examining the impact of the Communities That HEAL intervention in 4 states by Timothy Hunt, Carrie B. Oser, Peter D. Friedmann, Nicole Mack, Peter Balvanz, Bridget Freisthler, Redonna K Chandler, Karli Hochstatter, Daniel R. Harris, LaShawn Glasgow, Lauren D’Costa, Mary R. Russo, Barry Eggleston, Arnie Aldridge, Paul Bellair, Allyson G. Cogan, James L. David, Nabila El-Bassel, Dawn Goddard-Eckrich, Steve Gomori, Holly Hagan, Steve Hanson, JaNae Holloway, Elizabeth N. Kinnard, Charlie Knott, Michael W. Konstan, Sharon L. Walsh, Patricia A. LeBaron, Michael S. Lyons, Margaret McGladrey, Joan Papp, Sean M. Murphy, Sandra Springer, Emmanuel Oga, Michele Staton, Elizabeth Schady, Fernando Montero, Hilary L. Surratt, Danelle Stevens-Watkins, John Winhusen, Gary A. Zarkin, Greer A. Hamilton, Joel G. Sprunger

“…Conclusions The CTH intervention engaging community coalitions to deploy evidence-based practices was effective in increasing OEND implementation in jails, helping address elevated overdose risks for individuals during and post-release from incarceration. Partnerships between state, community, and jail-based stakeholders are needed to assure expanded access to this lifesaving, evidence-based approach.…”
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Fálétí’s Philosophical Sensibility by Adeshina Afolayan

“…In her “Literature in Yorùbá: poetry and prose; traveling theater and modern drama,” in the same volume, Karin Barber seems to redress this imbalance when she gives a place to Fálétí in her discussion of post-Fágúnwà writers. According to her, In the late 1960s and throughout the 1970s there was an explosion of literary creativity, with many new authors emerging and pioneering new styles and themes. …”
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Early introduction of IL-10 weakens BCG revaccination’s protection by suppressing CD4+Th1 cell responses by Qing Lei, Hui Fu, Zongjie Yao, Zijie Zhou, Yueqing Wang, Xiaosong Lin, Yin Yuan, Qi Ouyang, Xinyue Xu, Jinge Cao, Mengze Gan, Xionglin Fan

“…IL-10 expression peaked in the lungs 3–6 weeks post-revaccination and was also detected in lymph nodes and spleen as early as 2 weeks following the booster dose, regardless of the intervals between the prime and booster vaccinations. …”
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Mapping the global risk of chikungunya virus endemicity and autochthonous transmission following importation by Yu-Feng Yang, Yun-Bo Qiu, Qiang Xu, Rui-Cheng Gao, Tian Tang, Yao Tian, Yan-He Wang, Sheng-Hong Lin, Yun-Dong Shi, Long-Tao Chen, Yan Zhang, Jun Ma, Chen-Long Lv, Guo-Lin Wang, Hai-Feng Pan, Wei Liu, Li-Qun Fang

“…Conclusions: This study assesses the potential risks of endemic occurrence and post-import autochthonous transmission of CHIKV, respectively. …”
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基于患者指南的健康教育对缺血性卒中患者二级预防用药依从性的影响(Effects of Health Education Based on the Patient Version of Guidelines on Medication Compliance in Secondary Prevention among Patients with Ischemic... by 王瑞香1，朱思静1，梁嘉贵2，晏利姣3，蓝远霞1 (WANG Ruixiang1, ZHU Sijing1, LIANG Jiagui2, YAN Lijiao3, LAN Yuanxia1 )

“…The scores of disease knowledge and post-intervention nursing satisfaction of the two groups were collected before and after intervention. …”
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Analytical investigation of the patrimonial law and inheritance of women in Sassanid era marriages by Parvin Davari, Esmaeil Sangari

“…In this study, in addition to referring to Pahlavi texts remaining from the Sassanian and post-Sassanian periods, such as the Mādayān ī Hazār Dādestān, the narration of Ādhar Farnbagh Farrokhzādān, the narration of Omid Ashvahishtan, the Dādestān ī Dēnīg, the eighth Dēnkard, and others as the primary sources of Zoroastrian jurisprudential data, works of modern researchers, including Matsukh, Pirkhaniān, and Yerild, were also reviewed. …”
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Influence of Movement Restriction During the COVID-19 Pandemic on Uptake of DMPA-SC and Other Injectable Contraceptive Methods in Nigeria by Adefalu AA, Bankole OA, Olabode F, Afolabi MB, Buba MA, Dafe V, Kalu MN, Watkins E

“…This increase persisted post-restriction, with mean consumption reaching 124,561 units. …”
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Inhibition of interferon regulatory factor 4 orchestrates T cell dysfunction, extending mouse cardiac allograft survival by Wenjia Yuan, Hedong Zhang, Longkai Peng, Chao Chen, Chen Feng, Zhouqi Tang, Pengcheng Cui, Yaguang Li, Tengfang Li, Xia Qiu, Yan Cui, Yinqi Zeng, Jiadi Luo, Xubiao Xie, Yong Guo, Xin Jiang, Helong Dai, Sihan Zhou, Xiuyuan Hao

“…Combining ultra-low-dose Trametinib (0.1 mg·kg−1·day−1) and Rapamycin (0.1 mg·kg−1·day−1) demonstrably extended graft survival, with 4 out of 5 mice exceeding 100 days post-transplantation. Moreover, analysis of grafts at day 7 confirmed sustained IFN regulatory factor 4 (IRF4) inhibition, enhanced PD-1 expression, and suppressed IFN-γ secretion, reinforcing the in vivo efficacy of this IRF4-targeting approach. …”
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