Living joint prosthesis with in-situ tissue engineering for real-time and long-term osteoarticular reconstruction by Wei Sun, Hongwei Wu, Yiyang Yan, Xianzhu Zhang, Xudong Yao, Rui Li, Jingyi Zuo, Wenyue Li, Hongwei Ouyang

“…In a rabbit model of total humerus resection, the designed “living prosthesis” achieved weight, macroscopic and microscopic morphologies that were comparable to those of undamaged native joints at 2 months post-implantation, with organized osteochondral tissues were regenerated both around and within the prosthesis. …”
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Gamma-irradiated fowl cholera vaccines formulated with different adjuvants induced antibody response and cytokine expression in chickens by Eyerusalem Belay, Molalegne Bitew, Saddam Mohammed Ibrahim, Bereket Dessalegn, Solomon Lulie Abey, Haileyesus Dejene, Mastewal Birhan, Dawit Duffera, Eyob Asefa, Liyuwork Tesfaw, Takele Abayneh, Kedir Sherefa, Wubet W/Medhin, Yeneneh Tesfaye, Keyru Tuki, Esayas Gelaye, Richard Thiga Kangethe, Viskam Wijewardana, Carla Bravo De Rueda

“…IgG titer substantially increased in all vaccinated groups two weeks post-booster dose. IgA response was induced by gamma-irradiated vaccines but not formalin-inactivated vaccines. …”
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A Europe-wide characterization of the external exposome: A spatio-temporal analysis by Kees de Hoogh, Gerard Hoek, Benjamin Flückiger, Alonso Bussalleu, Danielle Vienneau, Ayoung Jeong, Nicole Probst-Hensch, Maria Gabriela M. de Pinho, Joreintje D. Mackenbach, Jeroen Lakerveld, Joline WJ Beulens, Raphaele Castagné, Cyrille Delpierre, Michelle Kelly-Irving, Youchen Shen, Anke Huss, Payam Dadvand, Marta Cirach Pradas, Mark Nieuwenhuijsen, Jelle Vlaanderen, Roel Vermeulen

“…Methods: New fine spatial resolution Europe-wide models were developed for annual/monthly average air pollution, daily temperature, and annual-average road-traffic noise, combined with post-processing of existing data on green, blue, and grey spaces (imperviousness), walkability, light-at-night, and urbanicity. …”
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AI-Based Quantification of Enhancing Tumor Volume on Contrast-Enhanced MRI to Predict Pathologic Response and Prognosis in HCC After HAIC Plus Targeted Therapy and Immunotherapy by Zhou Y, Li J, Li Q, Liu L, Huang P, Mao Y, Yang Y, Lv F, Liu Z

“…An AI tool measured the tumor enhancement volume ratio (TEVR) on MRI scans and compared it with post-surgery pathology results. We focused on two questions: 1) Can TEVR reflect the proportion of surviving tumor cells? …”
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Mechanism-based modular psychotherapy versus cognitive behavioural therapy for adolescents and young adults with childhood trauma experiences: study protocol for a feasibility tria... by Till Bärnighausen, Hanna Zimmermann, Christian Schmahl, Stephanie Bauer, Beate Ditzen, Hans-Christoph Friederich, Markus W Haun, Astrid Berner-Rodoreda, Elisabeth Schramm, Svenja Taubner, Corina Aguilar-Raab, Sabine C Herpertz, Manuel Feisst, Frank Enning, Katja I Seitz, Niklas Schouler, Jan Hundertmark, Maximilian Wilhelm, Svea Franz, Christoph W Korn, Ruben Vonderlin, Eva Vonderlin, Josef Bailer, Elias Bopp, Sophia von Stockert, Laura Tabea Kristalis, Claudia Calvano

“…This proof-of-concept study aims to provide initial evidence for acceptability, feasibility and changes in self-rated and diagnostician-rated psychopathology (post-treatment and 3 months follow-up) of MeMoPsy and elucidate the mechanisms of change using psychotherapy process research, Ecological Momentary Assessment and functional magnetic resonance imaging (fMRI).Ethics and dissemination This RCT obtained approval from independent ethics committees of participating centres and is accompanied by a data and safety monitoring board. …”
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Music therapy embedded in the life of dementia inpatient care to help prevent and manage distress: a feasibility study to inform a future trial by Naomi Thompson, Naomi Thompson, Helen Odell-Miller, Helen Odell-Miller, Chris Pointon, Chris Pointon, Benjamin R. Underwood, Benjamin R. Underwood, Benjamin R. Underwood, Emma Wolverson, Emma Wolverson, Emma Wolverson, Rachel Hunt, Rachel Hunt, Joanne Inglis, Joanne Inglis, Abdulwarrith Olawale, Lucy Pickering, Lucy Pickering, Alison Wilkinson, Alison Wilkinson, Christine Wise, Christine Wise, Cansu Buyukulas, Robert Dudas, Robert Dudas, Jufen Zhang, Ming-Hung Hsu, Ming-Hung Hsu

“…Routinely collected data were gathered and interviews conducted post-intervention.ResultsThe MELODIC intervention was acceptable with high levels of treatment adherence. …”
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Antimicrobial efficacy of methylene blue-functionalized graphene oxide-mediated photodynamic therapy against Enterococcus faecalis in root canal disinfection by Rizwan Jouhar, FCPS, Mohamad Syahrizal Halim, M.Rest.Dent, Sayed A. Quadri, MD, Muhammad Adeel Ahmed, PhD, Faheem Shah, PhD

“…Sonic activation (groups 2, 4, and 6) was performed at 6000 cpm for 2 min, whereas laser activation (groups 3–6) was performed with a 650 nm, 200 mW laser for 2 min. Post-treatment CFU/mL counts and bacterial reduction percentages were recorded. …”
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Clinical diagnostic and prognostic value of homocysteine combined with hemoglobin [f (Hcy-Hb)] in cardio-renal syndrome caused by primary acute myocardial infarction by Min-Juan Zeng, Yan-Quan Liu, Ping Pang, Xiao-Jun Chen, He Huang, Rui-Na Huang, Shi-Sen Li, He-Hui Zhang, Yue Yin, Chang-Sen Wang, Jin-Da Lin, Lin Lin, Shao-Peng Chen, Li Xu, Liang-Qing Zhang

“…Results Correlation analysis revealed a significant negative correlation between f (Hcy-Hb) and eGFR in patients with post-MI treatment (r = -0.45, P < 0.05). The ROC curve demonstrated that f (Hcy-Hb) exhibited substantial diagnostic value for CRS (AUC = 0.786; 95% CI: 0.773–0.799). …”
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Quantifying Flavin mononucleotide: an internationally validated methodological approach for enhanced decision making in organ transplantationResearch in context by Keyue Sun, Chunbao Jiao, Rebecca Panconesi, Sangeeta Satish, Omer F. Karakaya, Femke H.C. De Goeij, Tobias Diwan, Khaled Ali, Lorenzo A. Cadinu, Beatrice Cazzaniga, Qiang Liu, Yuki Miyazaki, Alejandro Pita, Mazhar Khalil, JaeKeun Kim, Ahmed Hussein, Philipp C. Müller, Federico Aucejo, David H.C. Kwon, Eduardo Fernandes, Jamak Modaresi Esfeh, Jacek Cywinski, Masato Fujiki, Lidong Sun, Antonio Pinna, Philipp Dutkowski, Chase J. Wehrle, Robert L. Fairchild, David Meierhofer, Jeroen De Jonge, Charles Miller, Koji Hashimoto, Andrea Schlegel

“…These parameters often do not correlate with clinically relevant post-transplant outcomes. Methods: This article presents a detailed protocol for the spectrophotometric quantification of Flavin mononucleotide (FMN), a marker of mitochondrial injury. …”
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Improved injury detection through harmonizing multi-site neuroimaging data after experimental TBI: a Translational Outcomes Project in Neurotrauma consortium study by G. Kislik, R. Fox, A. V. Korotcov, A. V. Korotcov, J. Zhou, M. Febo, Babak Moghadas, Adnan Bibic, Adnan Bibic, Yunfan Zou, Jieru Wan, R. C. Koehler, T. Adebayo, T. Adebayo, M. P. Burns, J. T. McCabe, K. K. Wang, J. R. Huie, A. R. Ferguson, A. Paydar, I. B. Wanner, N. G. Harris, N. G. Harris, the TOP-NT Investigators

“…The present study examined fractional anisotropy data computed from diffusion weighted imaging data at 3 and 30 days post-controlled cortical impact injury from 184 adult rats across four sites as part of the Translational-Outcome-Project-in-Neurotrauma (TOP-NT) Consortium. …”
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A phase II/III, randomized, double-blind, placebo-controlled trial to evaluate immunogenicity and safety of the Gam-COVID-Vac combined vector vaccine in the prophylactic treatment... by Ahmed A.K. AlHammadi, Amna H. Alzaabi, Haneen B. Choker, Ahmed A. Ibrahim, Asma Bin Ishaq, Ahmed E. Mahboub, Reem S. Al Dhaheri, Mohamed N. Alzaabi, Timothy A. Collyns, Gehad ElGhazali, Stefan Weber, Basel K. Al-Ramadi

“…Current trial aimed to assess the safety and immunogenicity of the Gam-COVID-Vac combined vector vaccine against SARS-CoV-2-induced coronavirus infection up to 6 months post vaccination. Research design and methods: Participants ≥18 years of age with no prior SARS-COV-2 infection or vaccination were randomized on a 3:1 ratio to receive heterologous recombinant human adenovirus-vectored vaccines or placebo, respectively. …”
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Serotonin 5-HT2A receptor expression is chronically decreased in the anterior cerebral cortex of male rats following repetitive low-level blast exposure by Rita De Gasperi, Rita De Gasperi, Georgina Perez Garcia, Georgina Perez Garcia, Miguel A. Gama Sosa, Miguel A. Gama Sosa, Gissel M. Perez, Rania Abutarboush, Rania Abutarboush, Usmah Kawoos, Usmah Kawoos, Patrick R. Hof, Patrick R. Hof, Patrick R. Hof, Carolyn W. Zhu, Carolyn W. Zhu, Carolyn W. Zhu, Stephen T. Ahlers, Gregory A. Elder, Gregory A. Elder, Gregory A. Elder, Gregory A. Elder

“…IntroductionMany Veterans who experienced blast-related traumatic brain injuries (TBIs) in Iraq and Afghanistan currently suffer from chronic cognitive and mental health problems that include depression and post-traumatic stress disorder (PTSD). Male rats exposed to repetitive low-level blast develop chronic cognitive and PTSD-related behavioral traits that are present for more than 1 year after exposure. …”
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The effects of Astragalus, Epimedium, and Fructus Ligustri Lucidi extract on the antioxidant capacity, and immune status of goslings under stress conditions by Qing Qu, Qing Qu, Qing Qu, Yihong Sun, Yihong Sun, Yihong Sun, Yayan Liang, Yayan Liang, Yayan Liang, Yongsheng Nie, Yongsheng Nie, Yongsheng Nie, Yongsheng Nie, Ming Gao, Ming Gao, Ming Gao, Yaohui Yuan, Wei Wang, Wei Wang, Wei Wang, Shuo Zhou, Shuo Zhou, Shuo Zhou

“…Supplementing with AEF and LP post-stress alleviated stress-induced the expression of inflammatory factors (TGF-β, TNF-α, IL-1β, IL-6), and improve L*, a*, b*, Ph45 (min), Ph24 (h) and drip loss in pectoral (p &lt; 0.05). …”
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Genetic characterization of influenza A viruses circulating in Hong Kong, China, 2023: the first influenza epidemic after the lifting of 2.5 years of COVID-19 non-pharmaceutical in... by Jingyuan Bian, Joshua Fung, Lam-Kwong Lee, Wing-Yin Tam, Leo Chun-Hei Wong, Cyrus Ka-Wo Wong, Maverick Yu-Xuan Lau, Bei Jiang, Nicky Ho-Laam Tang, Alex Yat-Man Ho, Miranda Chong-Yee Yau, Jason Chi-Ka Cheng, Kristine Shik Luk, May Kin-Ping Lee, Jimmy Yiu-Wing Lam, Sandy Ka-Yee Chau, Qing Xiong, Gilman Kit-Hang Siu, Franklin Wang-Ngai Chow

“…These findings underscore Hong Kong’s high post–COVID–19 influenza diversity and the need for ongoing molecular surveillance to monitor emerging viral variants.…”
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Вплив удобрення на формуванняпродуктивності ячменю ярого в короткоротаційних сівозмінах by Марія ЩЕРБА, Оксана КАЧМАР, Ангеліна ДУБИЦЬКА, Оксана ВАВРИНОВИЧ, Оксана ТАРАВСЬКА

“…The use of intensive (manure + mineral fertilizers) and alternative (green mass of post-harvest oil radish + precursor by-products + mineral fertilizers) fertilization systems restrained the compaction process and provided 4.46–2.65 % lower values of capacity after winter wheat and by 3.5– 1.72 % after potatoes compared to the control without fertilizer. …”
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Guidance for the gastrointestinal evaluation and management of iron deficiency in Sub-Saharan Africa by W M Simmonds, Y Awuku, C Barrett, M Brand, K Davidson, D Epstein, E Fredericks, S Gabriel, S Grobler, C Gounden, L Katsidzira, V J Louw, V Naidoo, C Noel, E Ogutu, N Ramonate, N Seabi, M Setshedi, J Van Zyl, G Watermeyer, C Kassianides

“…As iron deficiency (ID) anaemia in men and post-menopausal women is mostly caused by gastrointestinal blood loss or malabsorption, the initial evaluation of a patient with ID anaemia involves referral to a gastroenterologist. …”
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Competition in the product market, CEO's power, and readability of financial reports by Shokrollah Khajavi, Soraya Weysihesar, Ali Asghar Dehghani Saadi

“…Regarding the time dimension of the data, it is retrospective and post-event. To achieve the objectives of the research, 105 companies listed on the Tehran Stock Exchange were examined for the period from 2016 to 2022. …”
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The Effect of Rabdosia rubescens on Radiotherapy-Induced Oral Mucositis in Nasopharyngeal Carcinoma Patients: A Phase II Clinical Study by Lu Li MS, Yecai Huang MD, Jun Yin MD, Peng Xu MS, Mei Lan MD, Churong Li MS, Yunxiang Qi MD, Ke Xu MS, Bosen Li MS, Yukun Luo MS, Qinghua Jiang MS, Shanshan Peng MS, Jinyi Lang MD, Mei Feng MD

“…Grade 3 oral mucositis was associated with body weight, BMI, NRS2002 score, and albumin levels. Post-treatment, there was a decrease in CD4 + /CD8 + , CD3 + , and CD4 + immune cells, but an increase in CD8 + cells. …”
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SCREEN FORMS AT BIENNIALS OF CONTEMPORARY ART / ЭКРАННЫЕ ФОРМЫ НА БИЕННАЛЕ СОВРЕМЕННОГО ИСКУССТВА by KARTSEVA EKATERINA A. / КАРЦЕВА Е.А.

“…Video today is a popular tool for artists of postmodern, poststructuralist, post-conceptual orientations. These practices have not yet developed their economic model and have spread mainly through biennials and festivals of contemporary art, as the main form of their comprehension and display. …”
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High anal swab viral load predisposes adverse clinical outcomes in severe COVID-19 patients by Haibo Li, Lili Ren, Lulu Zhang, Yeming Wang, Li Guo, Conghui Wang, Yan Xiao, Ying Wang, Jian Rao, Xinming Wang, Ying Liu, Chaolin Huang, Xiaoying Gu, Guohui Fan, Hui Li, Binghuai Lu, Bin Cao, Jianwei Wang

“…The positivity and viral load in AS were higher in non-survivors than that of survivors at week 2 post symptom onset (P = 0.006). A high initial viral load in AS was associated with death (OR 1.368, 95% CI 1.076–1.741, P = 0.011), admission to the intensive care unit (OR 1.237, 95% CI 1.001–1.528, P = 0.049) and need for invasive mechanical ventilation (OR 1.340, 95% CI 1.076–1.669, P = 0.009). …”
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