H3K14 lactylation exacerbates neuronal ferroptosis by inhibiting calcium efflux following intracerebral hemorrhagic stroke by Tingting Sun, Jian-Nan Zhang, Ting Lan, Lei Shi, Liye Hu, Liyan Yan, Chao Wei, Lisha Hei, Weihua Wu, Zhaoli Luo, Meng Liu, Xingmei Ren, Yamei Wang, Yabin Lu, Peipei Wang, Chenguang Zhang, Liheng Bian, Xingquan Zhao, Fei Yang, Qian Li

“…We discovered elevated lactate and histone lactylation post-ICH in mice, with a significant increase in H3K14la during the early stages of ferroptosis in hemin-challenged primary cortical neurons. …”
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Intrinsic tectal low grade astrocytomas: is surgical removal an alternative treatment? Long-term outcome of eight cases Astrocitomas tectais de baixo grau: o tratamento cirúrgico é... by Ricardo Ramina, Mauricio Coelho Neto, Yvens Barbosa Fernandes, Guilherme Borges, Donizeti Cesar Honorato, Walter Oleschko Arruda

“…No recurrence occurred after total removal. Post-surgical follow-up time ranged from 2 1/2 to 22 1/2 years (mean 9.9 ± 5.9 years). …”
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Cognitive behavioural therapy in comparison to treatment as usual in young adults at high risk of developing bipolar disorder (Bipolar At Risk): a randomised controlled trial to in... by Sophie Parker, Lydia Pearson, Rebekah Carney, Richard P. Bentall, Matthew R. Broome, Emma Cernis, Timothy Clarke, Steven Jones, Katherine Moran, Jonathan Wilson, Isabel Coleman, Catherine Hewitt, Wendy Jones, Heather Law, Sarah Peters, Gemma Shields, David Shiers, Luke Strachan, Anton Strong, Judith Watson, Chris J. Sutton

“…Outcome and mediational variables will be collected at baseline, 17-weeks (in treatment), 27-weeks (post-CBTBAR /TAU), and 52-weeks. Qualitative work will examine the perceived mechanisms of change and implementation of CBTBAR in the NHS. …”
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The comparative effects of ventilation shutdown with heat (VSDH), relative humidity (VSDHRh), or CO2 (VSDCO2) on broiler electroencephalogram (EEG), blood chemistry and gene expres... by Kari L. Harding, Emmillie Boot, Jackson O. Evans, Sanjay B. Shah, Ramon D. Malheiros, Kenneth E. Anderson

“…However, both VSDH and VSDHRh broilers had significantly greater (P<0.0001) post core body temperatures indicating hyperthermia being the mode of action rather than hypoxia which is the mode of action in VSDCO2. …”
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Screening of cytokines in blood serum and lacrimal liquid in wet and atrophic forms of age-related macular degeneration by V. V. Neroev, N. V. Balatskaya, N. V. Neroeva, A. G. Karmokova, M. V. Ryabina, I. G. Kulikova

“…Therapy-induced effects of post-treatment cytokine concentrations also need to be studied, both at long and short observation terms. …”
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Impact of Long-Acting Somatostatin Analogues on Glucose Metabolism in Acromegaly: A Hospital-Based Study by Ming Shen, Meng Wang, Wenqiang He, Min He, Nidan Qiao, Zengyi Ma, Zhao Ye, Qilin Zhang, Yichao Zhang, Yeping Yang, Yanjiao Cai, Yakupujiang ABuDuoReYiMu, Yun Lu, Bin Lu, Xuefei Shou, Yongfei Wang, Hongying Ye, Yiming Li, Shiqi Li, Yao Zhao, Xiaoyun Cao, Zhaoyun Zhang

“…Deterioration was associated with lower baseline BG120 (plasma glucose 120 min post-OGTT), less reduction of growth hormone (GH), and greater reduction of insulin secretion after SSA therapy. …”
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Changes in C-reactive protein， neutrophil-to-lymphocyte ratio， and hemoglobin levels in maintenance hemodialysis patients with tunnel catheter and arteriovenous fistula vascular ac... by Wang Zi-jing, Zhong Jie, Gong Xue-feng, Ru Xue

“…Renal function indicators （serum creatinine ［Scr］， blood urea nitrogen ［BUN］）， dialysis adequacy （single ventricular urea clearance index ［spKt/V］， urea reduction ratio［URR］， post-equilibrium urea clearance index［eKt/V］）， CRP， NLR， Hb and incidence of infection were compared between the two groups at baseline and at 6-month follow-up. …”
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Tunable electrical properties of lignin: morphology-dependent ionic conduction in Kraft and organosolv-derived materials by Rosarita D’Orsi, Sebastiano De Stefano, Ofelia Durante, Marianna Ambrico, Domenico Aceto, Paolo Francesco Ambrico, Nadia Martucciello, Filippo Giubileo, Sandra Rivas, Alessandra Operamolla, Antonio Di Bartolomeo

“…This study investigates the composition, morphology, and DC electrical behavior of three distinct lignins: two derived from the Kraft extraction process and differing in their post-treatment ( L 1, L 2) and one ( L 3) extracted from Cynara cardunculus using an ethanolic organosolv process catalyzed by aqueous ammonia. …”
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Traditional Chinese Medicine Borneol‐Based Polymeric Micelles Intracerebral Drug Delivery System for Precisely Pathogenesis‐Adaptive Treatment of Ischemic Stroke by Yanan Wang, Xutao Ma, Xinyuan Wang, Liru Liu, Xue Zhang, Qiuyue Wang, Yingfei Zhu, Huanhua Xu, Liangmin Yu, Zhiyu He

“…In MCAO mice, the nanoformulation (polymer: 3.2 mg·kg−1, BAPTA‐AM: 400 µg·kg−1) reversibly opened the BBB and achieved high brain biodistribution up to 12.7%ID/g of the total administered dose after 3 h post single injection, effectively restoring intracellular Ca2+ and redox homeostasis, improving cerebral histopathology, and inhibiting mitochondrial PI3K/Akt/Bcl‐2/Bax/Cyto‐C/Caspase‐3,9 apoptosis pathway for rescuing dying neurons (reduced apoptosis cell from 59.5% to 7.9%). …”
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Impact of COVID-19 vaccination on symptoms and immune phenotypes in vaccine-naïve individuals with Long COVID by Connor B. Grady, Bornali Bhattacharjee, Julio Silva, Jillian Jaycox, Lik Wee Lee, Valter Silva Monteiro, Mitsuaki Sawano, Daisy Massey, César Caraballo, Jeff R. Gehlhausen, Alexandra Tabachnikova, Tianyang Mao, Carolina Lucas, Mario A. Peña-Hernandez, Lan Xu, Tiffany J. Tzeng, Takehiro Takahashi, Jeph Herrin, Diana Berrent Güthe, Athena Akrami, Gina Assaf, Hannah Davis, Karen Harris, Lisa McCorkell, Wade L. Schulz, Daniel Griffin, Hannah Wei, Aaron M. Ring, Leying Guan, Charles Dela Cruz, Harlan M. Krumholz, Akiko Iwasaki

“…Simultaneously, SARS-CoV-2-reactive TCR enrichment, SARS-CoV-2-specific antibody responses, antibody responses to other viral and self-antigens, and circulating cytokines were quantified before vaccination and at 6 and 12 weeks after vaccination. Results At 12 weeks post-vaccination, self-reported improved health is seen in 10 out of 16 participants, 3 have no change, and 3 have worse health although 2 report transient improvement after vaccination. …”
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The endoplasmic reticulum stress status of CD4+ T lymphocytes and its association with mTOR-mediated autophagic-lysosomal disorder in elderly sepsis patients by Wei Cheng, Jiahui Zhang, Dongkai Li, Yawen Xie, Xianli Lei, Hao Wang, Na Cui

“…Peripheral blood mononuclear cells (PBMCs) were isolated within 24 hours post-enrollment. flow cytometry was used to quantify the expression levels of ERS markers (CHOP and GRP78) and mTOR-mediated autophagic-lysosomal fusion markers (mTOR, LC3II and P62) on CD4+ T lymphocytes. …”
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Baseline serum EV-miR-1-3p as a protective factor and biomarker for hepatocellular carcinoma development after HCV eradication by Wei Teng, Wei-Ting Ku, Po-Ting Lin, Guan-Ting Chen, LiChieh Julie Chu, Hsuan Liu, Yung-Chang Lin, Chun-Yen Lin

“…Reliable biomarkers for predicting the post-SVR HCC risk are lacking. This study aimed to identify baseline serum extracellular vesicle microRNAs (EV-miRNAs) associated with HCC development following SVR. …”
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Comorbid anxiety, loneliness, and chronic pain as predictors of intervention outcomes for subclinical depressive symptoms in older adults: evidence from a large community-based stu... by Stephanie Ming Yin Wong, Dara Kiu Yi Leung, Tianyin Liu, Zuna Loong Yee Ng, Gloria Hoi Yan Wong, Wai Chi Chan, Terry Yat Sing Lum

“…Those with non-remission and non-response showed more depression-related functional impairments and poorer health-related quality of life post-intervention. Conclusions Older adults with subclinical depressive symptoms showing comorbid anxiety, higher loneliness, need for informal care, and chronic pain may be offered more targeted interventions in future services. …”
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Outcomes and prognostic factors in patients with Burkitt lymphoma/leukemia in adolescents and adults: an experience from hematology cancer consortium by Akhil Rajendra, Manju Sengar, Anu Korula, Prasanth Ganesan, Hasmukh Jain, Divya K, Prasanna Samuel, Jayachandran Perumal Kalaiyarasi, Gaurav Prakash, M. Joseph John, Rasmi Palassery, Chandran K. Nair, Tanuja Shet, Sushil Selvarajan, Lingaraj Nayak, Parathan Karunakaran, N. A. Fouzia, Om Prakash, Bhausaheb Bagal, Nikita Mehra, Saranya Kumaran, Sridhar Epari, Jayshree Thorat, Venkatraman Radhakrishnan, Aby Abraham

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Energy doses for paediatric defibrillation in cardiac arrest: systematic review and meta-analysis by Jason Acworth, Jimena del Castillo, Lokesh Kumar Tiwari, Dianne Atkins, Allan de Caen, Arun Bansal, Thomaz Bittencourt Couto, Stephan Katzenschlager, Monica Kleinman, Jesus Lopez-Herce, Ryan W. Morgan, Michelle Myburgh, Vinay Nadkarni, Janice A. Tijssen, Barnaby R. Scholefield

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Steroid hormones and influence of therapeutic drugs in Chinese postmenopausal rheumatoid arthritis patients by Ying-ying Zhang, Ying-ying Zhang, Na Yang, Na Yang, Hua-yong Zhang, Jia-jia Ge, Si-min Yan, Si-min Yan, Dan Han, Dan Han, Qian-ye Qiu, Wei-hong Ge, Wei-hong Ge, Qing Shu, Qing Shu

“…Group comparisons employed non-parametric Kruskal-Wallis test for multi-group comparisons, with post-hoc Mann-Whitney U tests and false discovery rate (FDR) correction for multiple comparisons. …”
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Second primary malignancies following CAR T-cell therapy in patients with hematologic malignancies by Elvira Umyarova, Charles Pei, William Pellegrino, Qiuhong Zhao, Nidhi Sharma, Don Benson, Francesca Cottini, Evandro Bezerra, Jonathan Brammer, Naresh Bumma, Hannah Choe, Nathan Denlinger, Srinivas Devarakonda, Abdullah Khan, Sam Penza, Ashley Rosko, Sumithira Vasu, Sarah Wall, Lapo Alinari, Robert Baiocchi, David A. Bond, Beth Christian, Walter Hanel, Kami Maddocks, John Reneau, Yazeed Sawalha, Alma Habib, Audrey Sigmund, Timothy J. Voorhees, Marcos de Lima, Narendranath Epperla

“…The distinct pattern of SPMs suggests potential CAR-T-related risks, warranting vigilant post-treatment surveillance. Further studies are necessary to elucidate underlying mechanism and predictive factors and guide long-term management of SPM risk in CAR-T survivors.…”
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Incorporation of tritium by pepper and eggplant cultures with short-term exposure to tritium oxide by E. N. Polivkina, E. S. Sysoyeva, E. V. Romanenko, L. F. Subbotina, A. V. Panitskiy, F. F. Zhamaldinov, L. B. Kenzhina

“…By the time the fruits were fully ripe, a significant decrease in the activity of tissue free water tritium (the main source of the formation of organically bound tritium in the post-exposure period) in all plant parts was observed. …”
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Deciphering the tumor ecosystem dynamics undergoing immunochemotherapy therapy across multiple cancer types unveils the immunosuppressive role of S100A4 in fibroblasts by promoting... by Bo Yang, Bo Yang, Ruiji Chen, Ruiji Chen, Mali Zu, Jie Yao, Hong Ren, Hong Ren, Yingxue Lin, Yingxue Lin, Bo Zhang, Tianjiao Ji, Yang Liu

“…Fibroblasts underwent significant state transitions post-treatment, marked by hypoxia-associated gene upregulation (e.g., S100A4) and immunosuppressive pathways. …”
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The potential of radionuclide diagnostic imaging in diffuse liver disease and portal hypertension by E. V. Migunova, M. Sh. Khubutiya, N. E. Kudryashova, O. G. Sinyakova, G. A. Berdnikov, S. I. Rey, M. S. Novruzbekov, O. D. Olisov

“…The radionuclide method, being highly reproducible one, can be recommended for an objective assessment of liver function and the detection of portal hypertension in hepatitis and cirrhosis, as well as for post-transplant monitoring of the liver function to prevent complications in the early and late postoperative periods.…”
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