Intracoronary acetylcholine for vasospasm provocation in women with ischemia and no obstructive coronary artery disease by Benita Tjoe, Christine Pacheco, Nissi Suppogu, Bruce Samuels, Panteha Rezaeian, Balaji Tamarappoo, Daniel S. Berman, Behzad Sharif, Michael Nelson, R. David Anderson, John Petersen, Carl J. Pepine, Louise E.J. Thomson, C. Noel Bairey Merz, Janet Wei

“…Vasospasm was defined as ≥75 % artery diameter reduction compared to post-nitroglycerin diameter and related to QoL and LGE on CMRI. …”
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Inhibitory effect of curcumin on duck tembusu virus by Dongdong Yin, Yayun Liu, Wei Liu, Guijun Wang, Lei Yin, Jieru Wang, Yin Dai, Xuehuai Shen, Ruihong Zhao, Kai Zhan, Xiaocheng Pan

“…Further analysis revealed that curcumin exerted its antiviral effect primarily at the post-adsorption stage of the viral life cycle. In vivo, curcumin treatment improved the survival rate of DTMUV-infected ducklings and alleviated virus-associated pathology. …”
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Surface damages of ITER-like W/Cu monoblocks in the lower divertor of EAST by Yang Wang, Dahuan Zhu, Chuanshi Feng, Zongxiao Guo, Pengfei Zi, Changjun Li, Chuannan Xuan, Chunyu He, Wenxue Fu, Binfu Gao, Baoguo Wang, Rui Ding, Junling Chen, the EAST Team

“…After three plasma campaigns, post-mortem analysis identified significant surface damages, including crust formation, increased surface roughness, macrocracks, and other types of damage. …”
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Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment by Meng Li, Huaping Huang, Xiaofei Wei, Huajuan Li, Jun Li, Bingchen Xie, Yuze Yang, Xingyue Fang, Lei Wang, Xiaona Zhang, Heyu Wang, Mengdi Li, Yuting Lin, Dezhi Wang, Yinyin Wang, Tongbiao Zhao, Jianqiu Sheng, Xinbao Hao, Muyang Yan, Lu Xu, Zhijie Chang

“…Remarkably, two patients with advanced post-inflammatory pulmonary fibrosis exhibited clinically significant regression on serial CT scans after hUCMSC-EVs therapy. …”
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Tumor gene expression signatures associated with outcome in large B−cell lymphoma treated with CD19-directed CAR T−cell therapy (axicabtagene ciloleucel) by Yuan Tian, Justin Budka, Frederick L. Locke, Jason R. Westin, Christina To, Gayatri Tiwari, Daqin Mao, Davide Bedognetti, Rhine R. Shen, Jorge Andrade, Simone Filosto

“…The 6-GES was reduced, whereas the 17-GES was elevated at progression post axi-cel, consistent with the notion that these signatures represent features relevant for response and resistance to CAR T-cell therapy.ConclusionOur transcriptomic analysis identified gene expression signatures potentially predictive of outcome with CD19-directed CAR T-cell therapy, and these findings are informative for risk stratification and development of next-generation products.…”
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Prevalence and management of ectopic and molar pregnancies in 17 countries in Africa and Latin America and the Caribbean: a secondary analysis of the WHO multi-country cross-sectio... by Renato T Souza, José Guilherme Cecatti, Özge Tunçalp, Veronique Filippi, Jean-Paul Dossou, Vanessa Brizuela, Adama Baguiya, Philip Govule, Hedieh Mehrtash, Kwame Adu-Bonsaffoh, Luis Bahamondes, Luiz Francisco Baccaro, Charles M'poca Charles, Camila Ayume Amano Cavalari, Luis Henrique Leão

“…Facility-level data on post-abortion care (PAC) capabilities were also collected, and facilities were classified accordingly. χ2 or Fisher’s exact tests were used to compare categorical data.Results The total number of women with EP and MP across both regions was 9.9% (2 415/24 424) where EP accounted for 7.8% (1 904/24 424) and MP for 2.1% (511/24 424). …”
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Mesenchymal stromal cells conditioned by peripheral blood mononuclear cells exert enhanced immunomodulation capacities and alleviate a model of Myasthenia Gravis by Alexandra C. Bayer, Natalia Pinzón, Axel You, Cinthia Bergman, Nadine Dragin, Aurélien Corneau, Frédérique Truffault, Danièle Noël, Christophe Martinaud, Rozen Le Panse, Sonia Berrih-Aknin, Jean-Thomas Vilquin

“…To confirm immunomodulation efficacy in vivo, cMSC were administrated to our humanized mouse model of Myasthenia Gravis and the treatment significantly halved disease severity from 2 weeks post-injection. Conclusions This integrative study establishes distinct conditioning signatures, suggests molecular mechanisms, and underscores the therapeutic potential of cMSC, offering a robust framework for advancing cell-based therapies in autoimmune diseases.…”
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Beam Energy Re-calibration of Beijing HI-13 Tandem Accelerator by LUO Tianpeng1, LIN Chengjian1, 2, MA Nanru1, LI Kangning1, KAN Chaoxin1, WANG Xiaofei1, BAO Yiwen1, YANG Lei1, JIA Huiming1, YANG Feng1, WEN Peiwei1, PANG Tingtao1, CHEN Si1, HUANG Zhijie1, CHANG Chang1, YIN Cheng1, YANG Jionghe1, 2, DUAN Hairui1, ZHU Songxian1, FAN Zerui1, WANG Haorui1, FU Lingyi1, LI Huiyan1, SHI Guangjun1, ZHANG Zihao1, LI Zhi1

“…Since 2007, the accelerator has undergone several upgrades and modifications, especially the installation of the superconducting linear post-accelerator in 2019, wherein the analyzing magnet was disassembled and reassembled, and the magnetic field measurement instrument was changed from the previous nuclear magnetic resonance frequency meter to a Gauss meter. …”
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Epigenetic silencing and CRISPR-mediated reactivation of tight junction protein claudin10b (CLDN10B) in renal cancer by Sarah Arroyo Villora, Yufen Zhao, Paula Castellanos Silva, Alba A. Hahn, Vivien Olanin, David Groll, Sandra Maurer, Vera Roetzer, Witold Szymanski, Tara Procida-Kowalski, Niklas Philipp, Aline Koch, Marek Bartkuhn, Johannes Graumann, Richard Volckmann, Jan Koster, Oliver Rossbach, Denise Salzig, Reinhard Dammann, Cornelia Sigges, Jan Halbritter, Silke Haerteis, Antje Maria Richter

“…We identified the epigenetic silencing of the Claudin 10 gene isoform B (CLDN10B) through DNA hypermethylation in renal cancers, including clear cell (ccRCC), papillary (pRCC) and post-transplantation renal carcinoma (PT-ccRCC). …”
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A New Risk Prediction Tool for Bleeding and Adverse Cardiovascular Events in Patients with Pre-Existing Coronary Stents Undergoing Gastrointestinal Cancer Surgery by Xu ZY, Hao XY, Zhang Z, Zhang J, Gao L, Li T, Wang XX

“…Net reclassification index (NRI) and integrated discrimination improvement (IDI) were used to interpret the strengths. Within 30 days post-surgery, we compared the bleeding events and MACEs.Results: Among 3127 patients, 437 (13.9%) developed MACEs and 565 (18.1%) developed bleeding events. …”
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Novel variants of tick-borne encephalitis virus from patient and tick samples in Norway by Urusha Maharjan, Hilde Kristin Skudal, Naveed Asghar, Arnulf Soleng, Magnus Johansson, Heidi Elisabeth Heggen Lindstedt, Anita Koskela von Sydow, John H.-O. Pettersson, Wenche Johansen, Børre Fevang, Randi Bjerkreim, Suyog Basnet, Rose Vikse, Åshild K. Andreassen, Kristian Alfsnes

“…However, clinical samples with intact virus are rare because TBE is usually diagnosed by serology in the post-viremic phase, when the viral load is low and undetectable by molecular methods such as polymerase chain reaction (PCR). …”
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Investigation on current situation of Chinese patent medicines for children in China based on the national drug coding database by Hui Liu, Hui Liu, Ping Rong, Ping Rong, Yatong Zhang, Yatong Zhang, Yuqiong You, Yuqiong You, Qianfang Fu, Qianfang Fu, Lili Cai, Lili Cai, Juan Wei, Juan Wei, Rong Ma, Rong Ma

“…Recommendations include developing new Chinese patent medicines for children, improving drug suitability, conducting post-marketing evaluations, and refining drug labeling to ensure safe and rational pediatric medication use.…”
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Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model by David Boll, Simon Reiss, Heidi R. Cristina Schmitz, Christian Weber, Julien Thielmann, Felix Spreter, Kian Tadjalli Mehr, Diana Chiang, Markus Jäckel, Lukas Heger, Jonathan Rilinger, Dirk Westermann, Constantin von zur Mühlen, Timo Heidt, Michael Bock, Alexander Maier

“…CMR was performed at a clinical 3 T system including functional imaging, T1 and T2 mapping and late gadolinium enhancement (LGE) 2–5 h or three days post-reperfusion. Ventricular fibrillation (VF) was a recurrent event, which was counteracted with amiodarone, high blood potassium levels and in one case with propranolol. …”
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Abstract 109: Endonasal Endoscopic Approach Associated Cerebral Vasospasm and Management: A Case Report by Nefize P. Turan, Matthew Bower, Abdullah Bin Zahid, Ryan P. Lee, Shih‐Chun Lin, Murugappan Ramanathan Jr, Adam Schiavi, Justin M. Caplan

“…Introduction Endoscopic endonasal approach(EEA) techniques have been increasingly utilized and have been associated with development of cerebrospinal fluid(CSF) leak, meningitis, diabetes insipidus post‐operatively. Cerebral vasospasm following EEA has rarely been described. …”
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Organizing pneumonia in hospitalized COVID-19 patients: risk factors and long-term outcomes by Sandra Cuerpo, Fernanda Hernandez-Gonzalez, Mariana Benegas, Nuria Albacar, Alejandra Lopez-Giraldo, Inés Cobo, Samara Suarez, Verónica Torres, Adelaido Salazar, Nestor Soler, María Noboa-Sevilla, Alejandro Frino-García, Nancy Pérez-Rodas, Joel Francesqui, Xavier Alsina-Restoy, Ana María Muñoz Fernández, Nuria Roger, Sergio Prieto, Alexandru Vlagea, Estibaliz Ruiz, Rosa Faner, Joan Albert Barberà, Alex Soriano, Joan Ramon Badia, María Molina-Molina, Oriol Sibila, Marcelo Sánchez, Alvar Agustí, Judith Garcia-Aymerich, Jacobo Sellares

“…Abstract Background Some patients develop post-COVID-19 organizing pneumonia (OP) that is responsive to corticosteroid treatment. …”
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Increasing Prevalence of Occult HBV Infection in Adults Vaccinated Against Hepatitis B at Birth by Ge Zhong, Zhi-Hua Jiang, Xue-Yan Wang, Qin-Yan Chen, Lu-Juan Zhang, Li-Ping Hu, Mei-Lin Huang, Yu-Bi Huang, Xue Hu, Wei-Wei Zhang, Tim J. Harrison, Zhong-Liao Fang

“…However, the prevalence of OBI increases with age in those vaccinated at birth, raising a new issue of how to prevent and control OBI in the post-universal infant vaccination era.…”
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Melatonin Implantation Improves the Reproductive Performance of Estrus-Synchronized Ewes During Seasonal Anestrus and Enhances the Antioxidant and Steroidogenic Capacities of Granu... by Zengyi Duan, Menghao Liu, Junjin Li, Kexiong Liu, Qi Qi, Zhixuan Yu, Hadia Akber Samoo, Chunxin Wang, Jian Hou

“…The results demonstrated that MT implantation significantly improved serum levels of total antioxidant capacity (T-AOC), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and glutathione peroxidase (GSH-Px), increased post-ovulatory luteal diameter and serum P4 levels, and reduced ovarian apoptosis. …”
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A Cyclic-di-AMP Adjuvanted CPAF Protein Vaccine Is Immunogenic in Swine, but It Fails to Reduce Genital <i>Chlamydia trachomatis</i> Burden by Leonie Bettin, Maria Stadler, Christine Unterweger, Maximiliane Dippel, Jonathan M. Harris, Andrea Buzanich-Ladinig, Taylor B. Poston, Toni Darville, Tobias Käser

“…Each week, the systemic T cell response was assessed via IFN-γ and IL-17 ELISpots, as well as multi-parameter flow cytometry on 0, 14, and 28 days post vaccination (dpv). The humoral immune response was analyzed by measuring CPAF-specific antibody levels and avidity via ELISAs. …”
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Our experience with management of congenital urological pathologies in adulthood: What pediatric urologists should know and adult urologists adopt in pediatric practice experience by Leon Chertin, Binyamin B. Neeman, Jawdat Jaber, Guy Verhovsky, Amnon Zisman, Ariel Mamber, Ilan Kafka, Ala Eddin Natsheh, Dmitry Koulikov, Ofer Z. Shenfeld, Boris Chertin, Stanislav Koucherov, Amos Neheman

“…The median follow-up period after surgery was 33 months (interquartile range, 12–54). Post-operative complications occurred in 5 patients (Clavien-Dindo 1–2). …”
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Exosomal BMPR2 Macromolecule Facilitates Alveolar Epithelial Cell Repair Through Functional Complex Formation with BMPR1B in Acute Lung Injury by Yun X, Chen Z, Li F, Shen F, Zhang L, Yuan J

“…The characterized macrophage-derived exosomes (163.6 ± 70.2 nm) demonstrated efficient pulmonary targeting, with peak accumulation occurring at 4 hours post-administration. Mechanistically, the formation of the BMPR2-BMPR1B complex activated SMAD1-dependent signaling pathways, as evidenced by strong BMPR1B-SMAD1 colocalization (correlation coefficient 0.94 ± 0.02) and enhanced ID1 expression.Conclusion: The BMPR2-BMPR1B interaction was demonstrated to accelerate type II to type I alveolar epithelial cell transdifferentiation, thereby facilitating tissue repair in ALI. …”
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