Interhemispheric effects of iTBS on the fronto-parietal network: Evidence from dual-site stimulation by Isabell Int-Veen, Beatrix Barth, Ramona Täglich, Betti Schopp, Hans-Christoph Nuerk, Christian Plewnia, Stefanie De Smet, Marie-Anne Vanderhasselt, Andreas J. Fallgatter, Ann-Christine Ehlis, David Rosenbaum

“…Trait rumination emerged as a modulator of TBS effects: In study 1, significant interactions for FC between the right VLPFC and Somatosensory Association Cortex (SAC) when stimulating the left DLPFC emerged, while study 2 revealed similar interactions for FC between the left DLPFC and SAC and intra-SAC FC when stimulating the right VLPFC. Correlations between post-stress state rumination and FC changes further support these findings. …”
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The contextual adaptation and educational impacts of the mhGAP-IG to address child mental and behavioral disorder treatment gap in China: A mixed-method study by Meng Zheng, Yi Zhang, Feng Chen, Ang Chen, Di Kong, Kun Xie, Jie Li, Brian James Hall, Andre M.N. Renzaho, Jian-hui Gao, Dao-meng Cheng, Qing Zou, Xin-yuan Zhong, Qi-mei Yu, Wen Chen

“…The educational impacts of a two-day training based on the adapted CMBDs-mhGAP-IG were assessed using a pre-post design among 89 participants, including kindergarten teachers or doctors and GPs. …”
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A phase 3 randomized, open-label study evaluating the immunogenicity and safety of concomitant and staggered administration of a live, pentavalent rotavirus vaccine and an inactiva... by Shaomin Chen, Zhifang Ying, Yan Liu, Yuan Li, Yebin Yu, Meilian Huang, Zhuhang Huang, Zhiqiang Ou, Yuyi Liao, Yong Zhang, Guixiu Liu, Weiwei Zhao, Rong Fu, Qiong Shou, Minghuan Zheng, Xueyan Liao, Yingmei Tu, Jon Stek, Jonathan Hartzel, Changgui Li, Jikai Zhang

“…Antibody responses were measured at baseline and 1-month post-dose 3 (PD3). Parents/legal guardians recorded adverse events for 30 or 15 d after study vaccinations in the concomitant-use or staggered-use groups, respectively. …”
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Lymphodepletion, tumor-infiltrating lymphocytes, and high versus low dose IL-2 followed by pembrolizumab in patients with metastatic melanoma by Merve Hasanov, Simin Kiany, Marie-Andrée Forget, Roland Bassett, Michael A. Davies, Adi Diab, Jeffrey E. Gershenwald, Isabella C. Glitza, Jeffrey E. Lee, Anthony Lucci, Jennifer L. McQuade, Sapna P. Patel, Merrick I. Ross, Hussein A. Tawbi, Jennifer A. Wargo, Michael K. Wong, Chantale Bernatchez, Patrick Hwu, Cara Haymaker, Rodabe N. Amaria

“…Patients received pembrolizumab 200 mg IV starting 21 days post-TIL infusion, and every 3 weeks for up to 2 years. …”
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Biomass and nutrient release dynamics of decomposing rolling down legume cover crops in a steep-sloped Mediterranean vineyard by Cátia Brito, Cátia Brito, Sandra Martins, Sandra Martins, Francisco Saraiva, João Roque, Margarida Arrobas, Margarida Arrobas, Manuel Rodrigues, Manuel Rodrigues, Carlos Correia, Carlos Correia

“…The observed nutrient release from cover crop residues, particularly during the first 45 days post-termination, suggested a potential to support grapevine nutrient requirements, although direct uptake by grapevines was not assessed in this study. …”
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Modelling the liver’s regenerative capacity across different clinical conditions by Anh Thu Nguyen-Lefebvre, Soumita Ghosh, Cristina Baciu, Bima J. Hasjim, Sara Naimimohasses, Graziano Oldani, Elisa Pasini, Michael Brudno, Nazia Selzner, Jeffrey Wrana, Mamatha Bhat

“…Interestingly, fibrotic livers exhibited reduced collagen deposition and partial regression to stage 1 fibrosis post-hepatectomy. Transcriptomic and proteomic analyses revealed consistent downregulation of cell cycle genes in impaired regeneration. …”
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Transcriptome analysis provides new insights into the berry size in ‘Summer Black’ grape under a two-crop-a-year cultivation system by Peiyi Ni, Shengdi Yang, Yunzhang Yuan, Chunyang Zhang, Hengliang Zhu, Jing Ma, Shuangjiang Li, Guoshun Yang, Miao Bai

“…Phenotypic and histological analyses revealed fewer cell number occurring between 7 and 14 days post anthesis (DPA) in the second season fruits, which ultimately resulted in a smaller fruit size compared with the first season fruits. …”
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PODO447: a novel antibody to a tumor-restricted epitope on the cancer antigen podocalyxin by Blake Gilks, Martin Köbel, Diana Canals Hernaez, Michael R Hughes, Pamela Dean, Peter Bergqvist, Ismael Samudio, Ola Blixt, Katharina Wiedemeyer, Yicong Li, Chris Bond, Eric Cruz, Calvin D Roskelley, Kelly M McNagny

“…Since pathways regulating post-translational modifications are frequently perturbed in cancer cells, we sought to produce novel anti-Podxl antibodies (Abs) that selectively recognize tumor-restricted glycoepitopes on the extracellular mucin domain of Podxl.Methods Splenic B cells were isolated from rabbits immunized with a Podxl-expressing human tumor cell line. …”
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A potent protective bispecific nanobody targeting Herpes simplex virus gD reveals vulnerable epitope for neutralizing by Jing Hu, Haoyuan Tan, Meihua Wang, Shasha Deng, Mengyao Liu, Peiyi Zheng, Anmin Wang, Meng Guo, Jin Wang, Jiayin Li, Huanwen Qiu, Chengbing Yao, Zhongliang Zhu, Chaolu Hasi, Dongli Pan, Hongliang He, Chenghao Huang, Yuhua Shang, Shu Zhu, Tengchuan Jin

“…Mechanistically, Nb14-32-Fc neutralizes HSVs at both the pre-and post-attachment stages and prevents cell-to-cell spread in vitro. …”
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Plasma Versus Whole Blood Tacrolimus Concentrations and Health-Related Quality of Life in Kidney Transplant Recipients by Svea Nolte, J. Casper Swarte, Tim J. Knobbe, Ilja M. Nolte, Tanja R. Zijp, Harmen R. Moes, Marco van Londen, Niels L. Riemersma, Johannes R. Björk, Rinse K. Weersma, Gea Drost, Stefan P. Berger, Daan J. Touw, Stephan J. L. Bakker

“…<b>Methods</b>: In this cross-sectional study, 898 kidney transplant recipients (KTRs) who were at least 12 months post-transplantation were included. Plasma and whole blood tacrolimus concentrations were compared using Passing–Bablok regression analyses and Bland–Altman plots. …”
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Microwave ablation combined with immune checkpoint inhibitor enhanced the antitumor immune activation and memory in rechallenged tumor mouse model by Fengkuo Xu, Jing Sang, Nan Wang, Meixiang Wang, Yahan Huang, Ji Ma, Huanan Chen, Qi Xie, Zhigang Wei, Xin Ye

“…In preclinical models, we established a tumor rechallenged model to address post-MWA recurrence and to delve into the underlying mechanisms of the combined therapy. …”
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Relationship between DTI-MRI derived metrics and radiotherapy dose range in the contralateral cerebrum in lower grade glioma by Justyna Kłos, Justyna Kłos, Hildebrand Dijkstra, Hiska L. van der Weide, Jan H. Potze, Peter F. Sinnige, Kelvin Ng Wei Siang, Kelvin Ng Wei Siang, Kelvin Ng Wei Siang, Rudi A. J. O. Dierckx, Rudi A. J. O. Dierckx, Ronald J. H. Borra, Ronald J. H. Borra, Miranda C. A. Kramer, Anouk van der Hoorn

“…WM and GM were segmented using automated software (cNeuro) and the mean FA and ADC were extracted per RT dose bin (0-10, 10-20, 20-30, 30-40, 40-50, &gt;50 Gy) of WM and GM. One way ANOVA with post-hoc Bonferroni’s test were used to analyse differences in FA and ADC between dose bins. …”
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Isolated small airways obstruction predicts future chronic airflow obstruction: a multinational longitudinal study by Andre F S Amaral, Thorarinn Gislason, Frits Franssen, Cosetta Minelli, James Potts, Christer Janson, Rune Nielsen, Andrei Malinovschi, Padukudru Anand Mahesh, Jaymini Patel, Meriam Denguezli, Parvaiz Koul, Asaad Ahmed Nafees, Peter GJ Burney, Rana Ahmed, Sonia Buist, Ben Knox-Brown, Dhiraj Agarwal, Valentina Quintero Santofimio, Najlaa Mohammed Abass, Jayaraj BS, Sanjay K Juvekar, Stefanni Nonna M Paraguas

“…We defined chronic airflow obstruction as post-bronchodilator FEV1/FVC&lt;LLN. We performed mixed effects regression analyses to model the association between baseline isolated small airways obstruction and chronic airflow obstruction at follow-up. …”
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Efficacy of subanaesthetic esketamine on the prevention of postoperative delirium in older adult patients after cardiovascular surgery: protocol for a single-centre, randomised, do... by Wei Zhang, Liang Zhao, Ju-Min Yan, Qing-Ren Liu, Jian-Jun Yang, Hong-Qi Lin, Zhao-Yu Wen, Hao-Ran Zhang, Yi-Xin Mei, Rui-Di Wang

“…Public disclosure is guaranteed post-trial, and the results will be published in a peer-reviewed scientific journal.Trial registration number ChiCTR2300074395.…”
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Perirenal fat as a potential marker and therapeutic target for metabolic syndrome: insights from a multicenter randomized controlled trial by Yang Hua, Meng-Huan Li, Meng-Huan Li, Yu-Xuan Lou, Ke-Rui Zhang, Jia-Ming Yang, Yan-Hui Sheng, Yu-Qing Zhang, Chuan-li Cheng, Chao Zou, Ting-ting Wu, Xiang-Qing Kong, Xiang-Qing Kong, Wei Sun, Wei Sun

“…This study aims to investigate the association between perirenal fat volume (PrFV) and MetS in Chinese adults.MethodsWe conducted a post-hoc cross-sectional analysis within a multicenter, randomized clinical trial. …”
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My Back Exercise app: an automated exercise intervention supported by educational notifications, a sleep programme and diet advice to improve function in people with chronic non-sp... by Manuela L Ferreira, Kim L Bennell, Christopher J Gordon, Josielli Comachio, Paulo Ferreira, Rachel K Nelligan, Serigne N Lo, Paula Beckenkamp, Anelise Moreti Cabral Silveira, Carlos Mesa-Castrillon, Katharine Roberts, Emma K Ho, Rowena J Field

“…The primary outcome will be self-reported physical function measured by the Patient-Specific Functional Scale at 6 weeks post-randomisation. Data will be analysed using the Student’s t-test or the non-parametric Mann-Whitney U test.Ethics and dissemination This trial was approved by the Human Research Ethics Committee (HREC) of The University of Sydney (HREC Approval No. 2023/HE000772). …”
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Clinical and Behavioral Correlates of Blood Acylcarnitine Profiles in Children with Autism Spectrum Disorder: A Cross-Sectional Analysis by Adriana Prato, Martina Randazzo, Maria Anna Messina, Giovanni Puglisi, Laura Rosy Aleo, Fiorella Ciantia, Lara Cirnigliaro, Renata Rizzo, Rita Barone

“…There was a significant difference in the severity of autism symptoms (ADOS CSS) related to the repetitive and restricted behaviors domain (CSS RRB) among the different groups (χ²(2) = 6.26; <i>p</i> = 0.044). The post hoc Dunn’s test with Bonferroni correction showed that ADOS-CSS RRB was significantly higher in ASD group A compared to ASD group B (<i>p</i> = 0.013). …”
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Increased dietary nutrient density did not restore growth performance in broiler chickens offered diets with high canola inclusion by Milan Kandel, Shemil P. Macelline, Robin R. Melwani, Mehdi Toghyani, Ruth N. Zadoks, Peter H. Selle, Sonia Y. Liu

“…Body weight gain (P < 0.001), feed intake (P < 0.001), FCR (P = 0.003), and body weight corrected FCR at 2.5 kg (P = 0.007) were influenced by the dietary treatment from 0 to 42 days post-hatch. Including high levels of canola product depressed feed intake by 7.5 % (4854 versus 4490 g/bird) and weight gain by 7.6 % (3301 versus 3049 g/bird); increased weight-corrected FCR from 1.485 to 1.538 g/g compared to control diets (T1). …”
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Gender-specific assessment of lipid profiles correlation with serum uric acid in non-dialysis chronic kidney disease patients: Prospective observational cross-sectional study by Yousuf Abdulkarim Waheed, Yousuf Abdulkarim Waheed, Huanhuan Yin, Jie Liu, Shifaa Almayahe, Maryam Bishdary, Karthick Kumaran Munisamy Selvam, Syed Muhammad Farrukh, Shulin Li, Shulin Li, Yanping Wang, Yanping Wang, Disheng Wang, Disheng Wang, Disheng Wang, Xinglei Zhou, Dong Sun, Dong Sun, Dong Sun

“…The age-stratified analysis indicated that LDL-c was higher in individuals aged ≥70 compared to younger groups (P&lt;0.002), while HDL-c was higher in the 20–29 age group; with (P&lt;0.031). Post-hoc univariate tests revealed significant between quartile differences for all lipid variables (all P ≤ 0.05).ConclusionIn CKD population, SUA levels were positively associated with LDL-c, TC, and TG, while inversely associated with HDL-c. …”
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Persistence and decay of neutralizing antibody responses elicited by SARS-CoV-2 infection and hybrid immunity in a Canadian cohort by Amy Nouanesengsy, Anthony Semesi, Kim Quach, Danton Ivanochko, Walter Byrne, Matthew Hwang, Maria-Rosa La Neve, Matilde Leon-Ponte, Alice Litosh, Nicole Wisener, Khosrow Adeli, Aaron Campigotto, Eyal Grunebaum, Allison McGeer, Theo J. Moraes, Lusia Sepiashvili, Julia Upton, Jean-Philippe Julien, Upton Allen

“…Additionally, we found an association between robust antibody responses and individuals with severe COVID-19 clinical symptoms during the first-month post-symptom onset. For individuals who achieved hybrid immunity, a robust increase in anti-S1 IgGs and neutralizing antibodies followed the first vaccination dose; however, there was a minimal increase in the anti-S1 IgGs and neutralizing antibody titers after administration of the second dose of the vaccine. …”
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