Transcriptomic and histological characteristics of innate immune activation in brain parenchyma in a rat model of neonatal intraventricular hemorrhage by Miriam Zamorano, Sanjna Udtha, Aidan M. Collier, Erica Underwood, Razan El Sayed, Ankit Agarwal, Devin S. Hatchell, Chunfeng Tan, Paul J. Nietert, Scott D. Olson, Brandon A. Miller

“…There is no effective treatment for IVH other than supportive care and surgery for post-hemorrhagic hydrocephalus. We previously reported that the innate neuroimmune response in an animal model of IVH was dependent on developmental stage, only occurring in older animals. …”
Get full text

Reversal of Rocuronium Induced Muscle Relaxation with Sugammadex versus Neostigmine in Patients Undergoing General Anaesthesia: A Randomised Controlled Trial by Ankur Garg, Kirti Gupta, Richa Chandra, Jyoti Pathania, Malti Agrawal

“…Significant changes in Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Pressure (MAP) were observed post-extubation at 0, 5, and 10 minutes (p<0.05). group 1 had a lower incidence of postoperative nausea compared to group 2 (p<0.05). …”
Get full text

Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study by Mónica Espinar-García, Isabel María Vallejo-Bermúdez, María Ángeles Onieva-García, Irene Reina-Alfonso, Luis Llapa-Chino, Pablo Álvarez-Heredia, Inmaculada Salcedo, Rafael Solana, Alejandra Pera, Alexander Batista-Duharte

“…Antibody responses were measured pre- and 28 days post-Vaxigrip Tetra vaccination in young (18–35) and older (>65) adults, stratified by cytomegalovirus (CMV) serostatus. …”
Get full text

External validation of a prediction model for disability and pain after lumbar disc herniation surgery: a prospective international registry-based cohort study by Allan Abbott, Casper Friis Pedersen, Henrik Hedevik, Catharina Parai, Martin A Gorosito, Mikkel Andersen, Tor Ingebrigtsen, Tore K Solberg, Margreth Grotle, Bjørnar Berg

“…Conclusion: Predictive performance of machine learning models for treatment success/non-success in disability and pain at 12 months post-surgery for lumbar disc herniation showed acceptable discrimination ability, calibration, overall fit, and net benefit reproducible in similar international contexts. …”
Get full text

Exploring Ocular Fundus Changes and Biochemical Correlations in Pregnancy-Induced Hypertension: Two Year Observational Study in Tertiary Care Center, India by A. M. Raja, G Seema

“…Recurrence of retinal changes highlights the necessity of detailed patient history and regular follow-ups, as any persistent retinal abnormalities post-pregnancy may suggest chronic hypertension or renal disease, conditions that require continued management. …”
Get full text

Colistin Sulfate-Based Combination Therapy for Infections Caused by Carbapenem-Resistant Organisms in Intensive Care Units: A Multicenter, Prospective, Observational Clinical Trial by Fan Zhang, Danyang Peng, Faming He, Ying Liu, Binbin Zang, Yanqiu Gao, Chao Qin, Suping Guo, Yawei Qi, Xisheng Zheng, Lin Guo, Tingting Zhao, Yue Jin, Rongqi Su, Juan Du, Jiazhan Pan, Bingyu Qin, Huanzhang Shao

“…Nephrotoxicity was reported in 13.1% of patients not receiving continuous renal replacement therapy (CRRT), with no significant duration-dependent increase. Post-treatment serum creatinine (Scr) levels remained stable or improved across all renal function subgroups. …”
Get full text

Accelerated iTBS-Induced changes in resting-state functional connectivity correspond with cognitive improvement in amnestic MCI by Stephanie Aghamoosa, Sara A. Nolin, Andrew A. Chen, Kevin A. Caulfield, James Lopez, Katrina Rbeiz, Holly H. Fleischmann, Olivia Horn, Katrina Madden, Michael Antonucci, Gonzalo Revuelta, Lisa M. McTeague, Andreana Benitez

“…Methods: Eighteen patients with MCI received 3-day a-iTBS (8 sessions/day) to the left dorsolateral prefrontal cortex at Beam F3 (14,400 total pulses) and completed MRI and cognitive testing at pre- and post-treatment. Based on electric field models, we selected 3 stimulated target regions of interest (ROIs) which belonged to the frontoparietal (FPN), default mode (DMN), and ventral attention (VAT) networks (3 target networks). …”
Get full text

2025 Korean Thyroid Association Management Guidelines for Radioactive Iodine Therapy in Patients with Hyperthyroidism by Kyeong Jin Kim, Eyun Song, Mijin Kim, Hyemi Kwon, Eu Jeong Ku, Hyun Woo Kwon, Jee Hee Yoon, Eun Kyung Lee, Won Woo Lee, Young Joo Park, Dong-Jun Lim, Sun Wook Kim, Ho-Cheol Kang, Jae Hoon Chung, Tae Yong Kim, Sin Gon Kim, Dong Gyu Na, Jee Soo Kim

“…Thyroid function should be monitored at 4–6 weeks post-treatment, every 2–3 months until stabilized, and then every 6–12 months. …”
Get full text

Induction of lung mucosal immunity by a next-generation inhaled aerosol COVID-19 vaccine: an open-label, multi-arm phase 1 clinical trial by Mangalakumari Jeyanathan, Sam Afkhami, Michael R. D’Agostino, Imran Satia, Dominik K. Fritz, Kate Miyasaki, Jann C. Ang, Anna Zganiacz, Karen J. Howie, Marilyn Swinton, Emilio Aguirre, Michael B. Zheng, Natallia Kazhdan, Anna Dvorkin-Gheva, Lawrence Mbuagbaw, Maria Fe C. Medina, Nermin Diab, Danica L. Brister, Gail M. Gauvreau, Brian D. Lichty, Matthew S. Miller, Fiona Smaill, Zhou Xing

“…Ag-specific immune responses (secondary outcome) are assessed in peripheral blood and in respiratory tract via bronchoscopy at baseline and at timepoint(s) post-vaccination. Eighteen-65-year-old, healthy participants who have received at least 3 doses of mRNA COVID-19 vaccine are enrolled with those vaccinated with any Ad-vectored COVID-19 vaccine excluded. …”
Get full text

Age‐Dependent Associations Between Pulse Pressure and Long‐Term Outcomes After Myocardial Infarction by Congliang Miao, Dandan Zhao, Shuohua Chen, Lina Xu, Yusong Huang, Huimin Li, Huibiao Deng, Lili Wu, Yuchen Wang, Yu Fu, Guoyan Wu, Shouling Wu, Jiang Hong, Wen‐Yi Yang

“…Elevated PP is an independent predictor of recurrent cardiovascular outcomes in post‐MI patients, with particularly stronger associations observed in younger and middle‐aged adults. …”
Get full text

Differences between valve types in anatomic changes of the aortic root after surgical aortic valve replacementCentral MessagePerspective by Ai Kawamura, MD, PhD, Kazuo Shimamura, MD, PhD, Daisuke Yoshioka, MD, PhD, Yusuke Misumi, MD, PhD, Kizuku Yamashita, MD, PhD, Koichi Maeda, MD, PhD, Takuji Kawamura, MD, PhD, Masashi Kawamura, MD, PhD, Yutaka Matsuhiro, MD, Shumpei Kosugi, MD, Daisuke Nakamura, MD, Isamu Mizote, MD, PhD, Yasushi Sakata, MD, PhD, Shigeru Miyagawa, MD, PhD

“…We investigated the changes in the aortic root and evaluated the differences in changes between valve types. Methods: Pre- and post-SAVR computed tomography scans of 124 patients with aortic stenosis who underwent SAVR with various bioprosthetic valves were analyzed retrospectively. …”
Get full text

Validating the pathogenic mechanism of chronic obstructive pulmonary disease induced by negative emotions via Mendelian randomization and traditional Chinese medicine theory of emo... by Zhiying Wang, Yun Li, Zhixian Zhong, Ling Xu, Yi Zhong, Jian Chen

“…Multivariable MR demonstrated that anxiety remained independently associated with COPD after adjusting for smoking (P = 0.002), while associations with other negative emotions were attenuated post-adjustment. The mediation analysis revealed that CRP mediated 3.93% of the total effect of anxiety on COPD. …”
Get full text

Case Report: Decentralized trial of tolerability-adapted exercise therapy after severe Covid-19 by Jessica M. Scott, Jessica M. Scott, Zhuyu Qiu, Zhuyu Qiu, Jahan Rahman, Chaya S. Moskowitz, Meghan G. Michalski, Sarah Lehman, Catherine P. Lee, Jenna Harrison, Anthony F. Yu, Anthony F. Yu, Amira Marouf, Amira Marouf, Santosha Vardhana, Santosha Vardhana, Paul C. Boutros, Paul C. Boutros, Paul C. Boutros, Paul C. Boutros, Lee W. Jones, Lee W. Jones

“…Correlative proteomic and single-cell immune sequencing of peripheral blood samples revealed marked alterations in protein and immune phenotypes implicated in post COVID-19 condition. (ClinicalTrials.gov number, NCT04824443).…”
Get full text

Modulatory effects of synbiotic blend on selected human fecal bacteria and TNFα + LPS-induced inflammation in human intestinal epithelial cells by Anita Rawat, Arka Bhattacharya, Rupa Tharu, Ruchika Maurya, Sanjay Kumar Bhadada, Mahendra Bishnoi, Kanthi Kiran Kondepudi

Get full text

Cloning and expression profile of an ubiquitin-conjugating enzyme-like gene OsCROC-1A in rice (Oryza sativa L.) by WANG Ya, LIU Jianping, XU Mengyun, JI Weijie, TU Jumin, ZHANG Xiaobo

“…Protein ubiquitination is a fundamental post-translational modification event that serves as a signaling function in diverse biological processes. …”
Get full text

Contributory factors to partial implementation of prevention of mother to child transmission policy in South Africa by Hermina Manjekana Dyeshana, Sibusiso Memory Zuma

“…This study ascertained identified gaps as follows: Of 163 accounted for pregnant women participants, 82(53.0%) booked before 20 weeks of gestational dates for their first ANC booking as advocated for by the PMTCT policy,81 were late bookers who had potential for not having their viral load suppressed, with high risk of MTCT.15 were missing and unaccounted for. 91 of 101 (89.11%) pregnant HIV positive women commenced ART on the day of their diagnosis, during their first ANC attendance. 67 were known HIV positive pregnant women already on ART who came for their first booking The remaining 10 pregnant HIV positive women did not begin ART early in their pregnancy and have the potential of not being virally suppressed Viral load was poorly monitored—25.0% had no viral load testing done at their first ANC booking,47% were tested at delivery and 49.0% tested at 6-months after delivery.150 of 164 HIV positive women who were eligible for a routine six-to-twelve-week post-partum were missed opportunities.100 of 178 (56.2%) HIV exposed babies were given NVP and AZT prophylaxis Baby Polymerase Chain Reaction(PCR) testing:Of 178 HIV exposed babies, 122 (69%) were tested at birth, 113 of 178(63%) were tested at 10 weeks There was 6 (3.5%) of babies who seroconverted after 103 of 178 (58%) were tested. at 6-months. …”
Get full text

TaPUB57 confers drought tolerance, governs grain size and salt sensitivity by ubiquitinating TaEXPB3 in rice by Chunmei Yu, Min Wang, Long Li, Yuying Li, Yanfei Zhang, Jie Zhang, Xin Chen, Lili Yang, Chaonan Li, Jingyi Wang, Guangchao Liu, Matthew P Reynolds, Qi Xie, Ruilian Jing, Xinguo Mao

“…Ubiquitination is a major type of post-translational modification in eukaryotes. The plant U-Box (PUB) protein is the smallest family in the E3 ligase superfamily, and involved in the responses to various environmental stimuli. …”
Get full text

Second Edition of the Scientists of Tomorrow/Cientistas do Amanhã Project: advancing scientific thinking, methodology, and equitable education by Érika Bevilaqua Rangel, Victoria Tomaz, André Luiz Teles e Silva, Érica Kássia de Sousa Vidal, Isabella de Sousa Nóbrega, Alexandre Giannecchini Romagnolo, Olívia Furiama Metropolo Dias, Marcella Liciani Franco, Guilherme Ferreira de Britto Evangelista, Pedro Cancello, Thiago Pinheiro Arrais Aloia, Guilherme Martelossi Cebinelli, Lorrayne Belotti, Letícia Yamawaka de Almeida, Ilana Eshriqui Oliveira, Daiana Bonfim, Raymundo Machado de Azevedo Neto, Ronaldo Hueb Baroni, Marcella Zuliani Lopes Soares, Priscilla Cerullo Hashimoto, Thomaz Bittencourt Couto, João Carlos Barbosa, Luciana Cintra, Camila Hernandes, Elisa Harumi Kozasa, Eliseth Ribeiro Leão, Lionel Fernel Gamarra, Luciano Cesar Pontes de Azevedo, Luiz Vicente Rizzo

“…Diverse teaching strategies enhanced learning, as evidenced by theory-practical classes, pre- and post-tests (p<0.05), Kahoot! quizzes, design thinking, and real-time feedback. …”
Get full text

The Effect of Postoperative Tranexamic Acid and Dexamethasone on Quality of Recovery After Arthroscopic Rotator Cuff Repair: a Double-Blinded, Randomized Controlled Trial by Jiang X, Xu C, Yuan C, Gao W, Liu W, Wang Y, Wang H, Yu W, He Y

“…The primary outcome was the Quality of Recovery-15 (QoR-15) score at 24 hours post-surgery. Secondary outcomes included mean visual analog scale (VAS) scores every four hours within 24 hours, postoperative blood test results the day after surgery, and American Shoulder and Elbow Surgeons (ASES) score at 3 months postoperatively.Results: No significant differences in QoR-15 scores at 24 hours were observed among the groups [control, 127.0 (112.8, 138.0); TXA, 125.0 (116.5, 136.8); TXA+DEX, 132.0 (120.3, 140.8), p = 0.176]. …”
Get full text

Vécu émotionnel de patients victimes de lésion cérébrale acquise après apprentissage de régulation émotionnelle : une étude qualitative. by Perrine Roulin, Lola Marmisse, Marie Kuppelin, Charone Attias, Salomé Klein, Marie-Eve Isner-Horobeti, Hélène D'Apote Vassiliadou, Agata Krasny-Pacini

“…Conclusion : Il est donc primordial d'intégrer le vécu émotionnel des participants et leurs objectifs dans une perspective de croissance post-traumatique et de reconstruction identitaire, en accordant une attention particulière à cette dimension en rééducation orthophonique. …”
Get full text