Fanau Manuia programme: key findings from a co-design process using a Pacific family-based approach to address pre-diabetes risk among Pacific children, New Zealand by Ridvan Tupai-Firestone, Barry Borman, Marine Corbin, Jeremy Krebs, Te Kani Kingi, Anna Matheson, Tupou Pulu, Ngaire Lerwill, Veisinia Pulu, Layla Latu, Nia Aitaoto, Prachee Gokhale, Justice Firestone, Sera Tapu-Ta’ala, Akarere Henry, Raynald Samoa, Deborah Read, Kathryn Fuge

“…The families designed a programme that focused on issues that were important to them and could be addressed in a holistic manner that was culturally relevant. Pre- and post-programme data included body mass index, waist-to-hip ratio, a questionnaire that looked at different facets of health and how they self-perceived it, and a logbook that chronicled their experience in the programme. …”
Get full text

Oxytocin Improves Autistic Behaviors by Positively Shifting GABA Reversal Potential via NKCC1 in Early‐Postnatal‐Stage by Zi‐Hui Wang, Chang Xu, Yao‐Yao Ma, Wei‐Xuan Xue, Hao‐Yuan Wang, Lin‐Yao Fan, Chen‐Yu Zhang, Liang Li, Xiao‐Yang Zhang, Jing‐Ning Zhu, Qi‐Peng Zhang

“…Notably, significantly reduced oxytocin levels are identified specifically during the early postnatal stage in both valproic acid (VPA)‐exposed and Fmr1‐KO mouse brains, along with an impairment of the GABA reversal potential and downregulation of the Na+‐K+‐2Cl− cotransporter (NKCC1) post‐birth. Furthermore, chemogenetic activation of oxytocinergic neurons during the early rather than late postnatal stage effectively restored the aberrant NKCC1 expression and GABAA receptor reversal potential and consequently alleviated autistic‐like behaviors in VPA‐exposed mice. …”
Get full text

Single cell immunoprofile of synovial fluid in rheumatoid arthritis with TNF/JAK inhibitor treatment by Xuyang Xia, Chenjia He, Zhinan Xue, Yuelan Wang, Yun Qin, Zhixiang Ren, Yupeng Huang, Han Luo, Hai-Ning Chen, Wei-Han Zhang, Li-Bin Huang, Yunying Shi, Yangjuan Bai, Bei Cai, Lanlan Wang, Feng Zhang, Maoxiang Qian, Wei Zhang, Yang Shu, Geng Yin, Heng Xu, Qibing Xie

“…., JAK/STAT), and cell-cell communications in drug-specific manners in samples from patients pre-/post-treated with adalimumab/tofacitinib. Particularly, SPP1 + macrophages exhibit pronounced communication with CXCL13 + CD4 + T cells, which are abolished after treatment and correlate with treatment efficacy. …”
Get full text

Distribution of virulence factors in pathogenic Escherichia coli isolates from diarrheal piglets and their antibacterial resistance by ZHANG Jing, JIANG Zhongqi, YU Huizhen, WU Yongfu, JIANG Mingjun

“…Diarrhea in pre-weaning and post-weaning piglets is still a frequently occurring disease on scaled farms, and result in great economic losses. …”
Get full text

The impact of ultrasound-guided erector spinae plane block combined with paravertebral block on postoperative rebound pain following thoracoscopic lobectomy by Yihang He, Dongxu Chen, Youbo Zuo, Jing Lin

“…BackgroundThoracic paravertebral block (TPVB) is the mainstream analgesic regimen for post-video-assisted thoracoscopic surgery (VATS) pain management. …”
Get full text

Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation by Raghavi Sudharsan, Natalia Dolgova, Jennifer Kwok, Alexa Gray, Yu Sato, Agustin Luz Madrigal, Praveen Joseph Susaimanickam, Emil Kriukov, Petr Baranov, John H. Wolfe, Gustavo D. Aguirre, David M. Gamm, William A. Beltran

“…Single-cell RNA sequencing (scRNAseq) was performed on transplanted PRPCs 3 days post-transplantation into normal canine retinas, as well as on host retinal cells to identify molecular pathways associated with early donor cell loss. …”
Get full text

Multi-peak light sources can improve the physical and mechanical properties of a zirconia- and diatomite-based dental resin: an in vitro study by Jucivaldo Martins Gonçalves, Thalles Arievo Mota Sales, Cauã Santiago Figueiredo, Rafael Pinto de Mendonça, Jefferson Pires da Silva Júnior, Tânia Mara da Silva, Sérgio Eduardo de Paiva Gonçalves, Hércules Bezerra Dias

“…Data were analyzed using two-way ANOVA followed by Tukey’s post hoc test (5%), after verification of normality (Shapiro-Wilk test). …”
Get full text

Actionable loss of SLF2 drives B‐cell lymphomagenesis and impairs the DNA damage response by Le Zhang, Matthias Wirth, Upayan Patra, Jacob Stroh, Konstandina Isaakidis, Leonie Rieger, Susanne Kossatz, Maja Milanovic, Chuanbing Zang, Uta Demel, Jan Keiten‐Schmitz, Kristina Wagner, Katja Steiger, Roland Rad, Florian Bassermann, Stefan Müller, Ulrich Keller, Markus Schick

“…Tumor cells lacking SLF2 are characterized by a high level of DNA damage, which leads to alterations of the post‐translational SUMOylation pathway as a safeguard. …”
Get full text

Music-induced cognitive change and whole-brain network flexibility: a pilot study by E. Lydia Wu-Chung, Melia E. Bonomo, Anthony K. Brandt, Bryan T. Denny, Christof Karmonik, Christof Karmonik, J. Todd Frazier, Karl Blench, Christopher P. Fagundes, Christopher P. Fagundes, Christopher P. Fagundes, Christopher P. Fagundes

“…Using a semi-randomized clinical trial design (ClinicalTrials.gov; NCT04137913), we examined whether (1) music creativity altered whole-brain network indices (modularity, flexibility) and (2) whether music-related effects on cognition depended on whole-brain network indices.MethodsFifty-two older adults (Mean age = 75 years; 54% female; 84% White) were randomized to a 6-week music creativity intervention (n = 25) or a no-treatment control condition (n = 27) and completed resting-state fMRI scans and the Montreal Cognitive Assessment at baseline and follow-up (post-intervention).ResultsThe music creativity intervention did not alter network flexibility or modularity over time. …”
Get full text

Toxoplasma gondii-induced host’s high secretion of 25-hydroxycholesterol for immunoprotection by Zi-Han Yang, Wei-Ling Wu, Jia-Jia Zheng, Chi Zhang, Ying-Ying Lu, Hong-Juan Peng

“…Methods The metabolic alterations in brain tissues of sv129 mice infected by T. gondii at 9 days post-infection (DPI) were analyzed through untargeted metabolomic detection. …”
Get full text

Tibetan medicine pain relieving plaster for treatment of knee osteoarthritis: protocol for a multi-center, randomized, and positive drug controlled trial by Yi Yuan, Ying-jie Wang, Ai Guo, Wei-guo Wang, Wei Wang, Pei-lai Liu, Zhi-xiu Shen, Jian-rong Xie, Kai-lie Liu, Min Zhao, Jing-ling Zuo, Kai Liu, Ze-yang Shi, Zhao-lan Liu, Xi-sheng Weng, Jian-ping Liu

“…All participants will undergo a 7-day treatment period followed by 14-day post-treatment monitoring. We will assess pain severity by the pain dimension score of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale, and evaluate knee joint function using the stiffness and joint function dimension scores of the WOMAC scale and knee joint range of motion. …”
Get full text

Transplantation of human embryonic stem cell-derived retinal pigment epithelial cells via injectable microfluidic-templated microgels for retinal regeneration by Ying Wei, Cong Ma, Chuanfeng An, Yujie Zhang, Haoyue Zhang, Qiyou Li, Li Kong, Huanan Wang, Xiang Ma

“…RCS rats treated with microcarriers showed significantly improved visual function, evidenced by increased B-wave amplitudes and the preservation of the inner nuclear layer at 8 weeks post-surgery. In conclusion, our innovative delivery system Fib@GHMS for hESC-RPE cell transplantation presents a potential therapeutic graft for retinal tissue engineering. …”
Get full text

Distinct immune responses to proton and photon radiotherapy: implications for anti-PD-L1 combination therapy in colorectal cancer by Hélène Burckel, Anaïs Nicol, Carole Mura, Marc Rousseau, Jolie Bou-Gharios, Lisa Froidurot, Corentin Richard, Véronique Morgand, Pierre-Antoine Laurent, Emeric Limagne, Romain Boidot, Georges Noël, Céline Mirjolet

“…Methods Balb/c mice bearing subcutaneous CT26 colon tumors were treated with RT or PT, delivered with 3 × 8 Gy. Seven days post-treatment, transcriptomic analysis and immune response assessments to characterize lymphoid cells, myeloid cells, and PD-L1 expression were performed. …”
Get full text

Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer by Lisa Veghini, Davide Pasini, Rui Fang, Pietro Delfino, Dea Filippini, Christian Neander, Caterina Vicentini, Elena Fiorini, Francesca Lupo, Sabrina L. D’Agosto, Carmine Carbone, Antonio Agostini, Geny Piro, Diego Rosa, Michele Bevere, Peter Markus, Diana Behrens, Claudio Luchini, Rita T. Lawlor, Aldo Scarpa, Giulia Biffi, Phyllis F. Cheung, Jens T. Siveke, Vincenzo Corbo

“…We integrate single-cell profiling of post-perturbation transcriptional responses from mouse models with cellular and spatial profiles of human tissues to define a MAPKhigh CAF (mapCAF) phenotype. …”
Get full text

Glutamine potentiates cefoperazone-sulbactam activity against Pseudomonas aeruginosa by increasing membrane permeability and cellular uptake by Jiao Xiang, Xin Wang, Huiyin Lin, Lifen Yang, Xiaoxia Huang, Yuetao Chen, Yingyue Zeng, Shaohua Li, Xianliang Zhao, Shiwen Wang, Yuan Tao, Huanzhe Fu, Zhengqi Shi, Kuihai Wu, Xuanxian Peng, Hui Li, Jin Tang, Zhuanggui Chen

“…Glutamine slows the development of SCF resistance, delays the post-antibiotic effect, and reduces mutation frequency. …”
Get full text

It takes two: Aberrant repair and low-grade inflammation characterize bronchiolitis obliterans syndrome after lung transplantation in serum proteomic analysis by Eline A. van der Ploeg, Alen Faiz, Greta J. Teitsma, Alejandro Sánchez Brotons, Natalia Govorukhina, Jannie M.B. Sand, Diana J. Leeming, Barbro N. Melgert, Peter Horvatovich, Janette K. Burgess, C. Tji Gan

“…Only patients for whom lung function and longitudinal serum samples post-LTx were available were included. Enzyme-linked immunosorbent assays were performed for neoepitopes of collagen types I, III, and VI and osteoprotegerin (OPG) in serum. …”
Get full text

Autoimmune neutropenia: a rare complication of allogeneic hematopoietic stem cell transplantation? by María Isabel Benítez Carabante, María Isabel Benítez Carabante, Mariona Morell Daniel, Mariona Morell Daniel, María Luz Uría Oficialdegui, María Luz Uría Oficialdegui, Enric Casanovas López, Melissa Panesso Romero, Melissa Panesso Romero, Laura Alonso García, Laura Alonso García, Cristina Díaz-de-Heredia, Cristina Díaz-de-Heredia

“…We identified two patients with specific human neutrophil alloantigen antibodies (anti-HNA), one of whom had a secondary graft failure.ConclusionsAIN may be a more frequent complication in post-HSCT pediatric patients than previously reported. …”
Get full text

OsMas1, a novel maspardin protein gene, confers tolerance to salt and drought stresses by regulating ABA signaling in rice by Fei-bing WANG, Chen-zhong WAN, Hao-fei NIU, Ming-yang QI, Gang LI, Fan ZHANG, Lai-bao HU, Yu-xiu YE, Zun-xin WANG, Bao-lei PEI, Xin-hong CHEN, Cai-yong YUAN

“…OsMas1-OE plants exhibited enhanced hypersensitivity, while OsMas1-RNAi plants showed less sensitivity to exogenous ABA treatment at both germination and post-germination stages. ABA, proline and K+ contents and superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), and photosynthesis activities were significantly increased. …”
Get full text

Long-Term Efficacy of Chlorine-Based Disinfectants Vs Multi-Enzymatic Detergent with Hypochlorous Acid for Waterline Disinfection in Inactive Dental Chair Units by Zheng YY, Wang YY, Guo Q, Shen CY, Huang R, Wang L, Sun H

“…Yu-Ying Zheng,1,2,* Yuan-Yuan Wang,1,3,* Qian Guo,1,4 Chan-Yuan Shen,1,5 Rong Huang,1,2 Li Wang,1,6 Huan Sun1,2 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, People’s Republic of China; 2Department of Comprehensive Emergency, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, 430079, People’s Republic of China; 3Center for Oral and Maxillofacial Surgery, School & hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 4Center for Orthodontics and Pediatric Dentistry, School & hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 5Department of Center for Emergency and General Dentistry, School & hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 6Department of Nursing, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, 430079, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huan Sun, Department of Comprehensive Emergency, School & Hospital of Stomatology, Wuhan University, No. 237 of Luoyu Road, Hongshan District, Wuhan, 430079, Hubei Province, People’s Republic of China, Tel +86 13986003844, Email sunhuansh01@163.com Li Wang, Department of Nursing Department, School & Hospital of Stomatology, Wuhan University, No. 237 of Luoyu Road, Hongshan District, Wuhan, 430079, Hubei Province, People’s Republic of China, Tel +86 027-87686387, Email liwangwlwl@126.comObjective: This study aimed to evaluate the long-term efficacy of two disinfection methods for waterline systems in inactive dental chair units (DCUs).Methods: On-site sampling and quantitative bacterial analysis were conducted to compare the effectiveness of chlorine-based disinfectants and a combination of multi-enzymatic detergent with hypochlorous acid in controlling microbial contamination in waterline systems of inactive DCUs.Results: No statistically significant differences in disinfection efficacy were observed between the treatment and control groups immediately after disinfection or on the third day post-disinfection (p > 0.05). However, significant differences were observed on the fifth day and seventh day following disinfection (p < 0.001).Conclusion: Both chlorine-based disinfectants and the combination of multi-enzymatic detergent with hypochlorous acid effectively controlled contamination in waterline systems for DCUs inactive for up to three days. …”
Get full text

Removing seasonal confectionery from prominent store locations and purchasing behaviour within a major UK supermarket: Evaluation of a nonrandomised controlled intervention study. by Carmen Piernas, Georgina Harmer, Susan A Jebb

“…Multivariable hierarchical models were used to investigate pre/post differences in weekly sales of confectionery in intervention versus control stores. …”
Get full text